Whole body metabolic tumor volume is a prognostic marker in patients with newly diagnosed stage 3B non-small cell lung cancer, confirmed with external validation
dc.contributor.author | Dashevsky, Brittany Z. | |
dc.contributor.author | Zhang, Chenpeng | |
dc.contributor.author | Yan, Li | |
dc.contributor.author | Yuan, Cindy | |
dc.contributor.author | Xiong, Lingyun | |
dc.contributor.author | Liu, Yongmei | |
dc.contributor.author | Liu, Haiyan | |
dc.contributor.author | Spring Kong, Feng-Ming | |
dc.contributor.author | Pu, Yonglin | |
dc.contributor.department | Medical and Molecular Genetics, School of Medicine | en_US |
dc.date.accessioned | 2018-11-26T14:46:13Z | |
dc.date.available | 2018-11-26T14:46:13Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Purpose: TNM Stage 3B encompasses a wide range of primary tumor and nodal metastatic tumor burden. This study aimed to evaluate the prognostic value of quantitative FDG PET/CT parameters in patients with newly diagnosed Stage 3B Non-Small Cell Lung Cancer (NSCLC). Materials and Methods: Institutional review board approved retrospective study identified patients diagnosed with Stage 3B NSCLC (8th edition TNM classification) on baseline FDG PET/CT at two medical centers (Medical centers A and B), between Feb 2004 and Dec 2014. Patients were excluded if they had prior NSCLC treatment or recent diagnosis of a second primary cancer. Quantitative FDG PET/CT parameters including whole body metabolic tumor volume (MTVwb), total lesion glycolysis (TLGwb), and maximum standardized uptake value (SUVmaxwb) were measured from baseline PET/CT using Edge method with Mimvista software. The primary endpoint was overall survival (OS). Cox proportional hazard regression and Kaplan-Meier overall survival analyses were used to test for an association between OS and quantitative FDG PET/CT parameters. The distributions of MTVwb, TLGwb, SUVmaxwb were skewed, so a natural logarithm transformation was applied and the transformed variables [(ln(MTVwb), ln(TLGwb), and ln(SUVmaxwb)] were used in the analysis. Results: The training set included 110 patients from center A with Stage 3B NSCLC. 78.2% of patients expired during follow-up. Median OS was 14 months. 1-year, 2-year, and 5-year OS was 56.5%, 34.6% and 13.9%, respectively. Univariate Cox regression analysis showed no significant difference in OS on the basis of age, gender, histology, ln(TLGwb), or ln(SUVmaxwb). ln(MTVwb) was positively associated with OS [hazard ratio (HR) of 1.23, p = 0.037]. This association persisted on multivariate Cox regression analysis (HR 1.28, p = 0.043), with adjustments for age, gender, treatment and tumor histology. External validation with 44 patients from center B confirmed increasing MTVwb was associated significantly worse OS. An MTVwb cut-off point of 85.6 mL significantly stratified Stage 3B NSCLC patient prognosis. Conclusion: MTVwb is a prognostic marker for OS in patients with Stage 3B NSCLC, independent of age, gender, treatment, and tumor histology. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Dashevsky, B. Z., Zhang, C., Yan, L., Yuan, C., Xiong, L., Liu, Y., Liu, H., Kong, F. S., … Pu, Y. (2017). Whole body metabolic tumor volume is a prognostic marker in patients with newly diagnosed stage 3B non-small cell lung cancer, confirmed with external validation. European journal of hybrid imaging, 1(1), 8. | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/17823 | |
dc.language.iso | en_US | en_US |
dc.publisher | SpringerOpen | en_US |
dc.relation.isversionof | 10.1186/s41824-017-0013-z | en_US |
dc.relation.journal | European journal of hybrid imaging | en_US |
dc.rights | Attribution 3.0 United States | |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | |
dc.source | PMC | en_US |
dc.subject | FDG | en_US |
dc.subject | PET/CT | en_US |
dc.subject | Lung cancer | en_US |
dc.subject | Tumor volume | en_US |
dc.title | Whole body metabolic tumor volume is a prognostic marker in patients with newly diagnosed stage 3B non-small cell lung cancer, confirmed with external validation | en_US |
dc.type | Article | en_US |
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