• Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases 

  Ross, Michael H.; Esser, Alison K.; Fox, Gregory C.; Schmieder, Anne H.; Yang, Xiaoxia; Hu, Grace; Pan, Dipanjan; Su, Xinming; Xu, Yalin; Novack, Deborah V.; Walsh, Thomas; Colditz, Graham A.; Lukaszewicz, Gabriel H.; Cordell, Elizabeth; Novack, Joshua; Fitzpatrick, James. A.J.; Waning, David L.; Mohammad, Khalid S.; Guise, Theresa A.; Lanza, Gregory M.; Weilbaecher, Katherine N. (American Association for Cancer Research, 2017-11-15)

  Bone metastases occur in approximately 70% of metastatic breast cancer patients, often leading to skeletal injuries. Current treatments are mainly palliative and underscore the unmet clinical need for improved therapies. ...
• Patiromer to Enable Spironolactone Use in the Treatment of Patients with Resistant Hypertension and Chronic Kidney Disease: Rationale and Design of the AMBER Study 

  Agarwal, Rajiv; Rossignol, Patrick; Garza, Dahlia; Mayo, Martha R.; Warren, Suzette; Arthur, Susan; Romero, Alain; White, William B.; Williams, Bryan (Karger Publishers, 2018)

  BACKGROUND: While chronic kidney disease (CKD) is common in resistant hypertension (RHTN), prior studies -evaluating mineralocorticoid receptor antagonists excluded patients with reduced kidney function due to risk of ...
• A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies 

  Maertens, Ophélia; McCurrach, Mila E.; Braun, Benjamin S.; De Raedt, Thomas; Epstein, Inbal; Huang, Tannie Q.; Lauchle, Jennifer O.; Lee, Hyerim; Wu, Jianqiang; Cripe, Timothy P.; Clapp, D. Wade; Ratner, Nancy; Shannon, Kevin; Cichowski, Karen (American Association for Cancer Research, 2017-11-01)

  Preclinical studies using genetically engineered mouse models (GEMM) have the potential to expedite the development of effective new therapies; however, they are not routinely integrated into drug development pipelines. ...
• WNT-mediated Modulation of Bone Metabolism: Implications for WNT Targeting to Treat Extraskeletal Disorders 

  Bullock, Whitney A.; Robling, Alexander G. (SAGE Publications, 2017-10)

  The WNT-signaling pathway is involved in cellular and tissue functions that control such diverse processes as body axis patterning, cellular proliferation, differentiation, and life span. The long list of molecules that ...
• 2018 Physician Assistant Data Report 

  Maxey, Hannah; Vaughn, Sierra (Indiana University, 2019-06-25)

  Identifying supply and distribution of the physician assistant workforce is crucial in understanding the capacity to meet medical needs and improve overall population health of Indiana citizens. The emergence of physician ...

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