Novel genetic loci associated with hippocampal volume

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dc.contributor.authorHibar, Derrek P.
dc.contributor.authorAdams, Hieab H.H.
dc.contributor.authorJahanshad, Neda
dc.contributor.authorChauhan, Ganesh
dc.contributor.authorStein, Jason L.
dc.contributor.authorHofer, Edith
dc.contributor.authorRenteria, Miguel E.
dc.contributor.authorBis, Joshua C.
dc.contributor.authorArias-Vasquez, Alejandro
dc.contributor.authorIkram, M. Kamran
dc.contributor.authorDesrivières, Sylvane
dc.contributor.authorVernooij, Meike W.
dc.contributor.authorAbramovic, Lucija
dc.contributor.authorAlhusaini, Saud
dc.contributor.authorAmin, Najaf
dc.contributor.authorAndersson, Micael
dc.contributor.authorArfanakis, Konstantinos
dc.contributor.authorAribisala, Benjamin S.
dc.contributor.authorArmstrong, Nicola J.
dc.contributor.authorAthanasiu, Lavinia
dc.contributor.authorAxelsson, Tomas
dc.contributor.authorBeecham, Ashley H.
dc.contributor.authorBeiser, Alexa
dc.contributor.authorBernard, Manon
dc.contributor.authorBlanton, Susan H.
dc.contributor.authorBohlken, Marc M.
dc.contributor.authorBoks, Marco P.
dc.contributor.authorBralten, Janita
dc.contributor.authorBrickman, Adam M.
dc.contributor.authorCarmichael, Owen
dc.contributor.authorChakravarty, Mallar
dc.contributor.authorChen, Qiang
dc.contributor.authorChing, Christopher R.K.
dc.contributor.authorChouraki, Vincent
dc.contributor.authorCuellar-Partida, Gabriel
dc.contributor.authorCrivello, Fabrice
dc.contributor.authorDen Braber, Anouk
dc.contributor.authorDoan, Nhat Trung
dc.contributor.authorEhrlich, Stefan
dc.contributor.authorGiddaluru, Sudheer
dc.contributor.authorGoldman, Aaron L.
dc.contributor.authorGottesman, Rebecca F.
dc.contributor.authorGrimm, Oliver
dc.contributor.authorGriswold, Michael E.
dc.contributor.authorGuadalupe, Tulio
dc.contributor.authorGutman, Boris A.
dc.contributor.authorHass, Johanna
dc.contributor.authorHaukvik, Unn K.
dc.contributor.authorHoehn, David
dc.contributor.authorHolmes, Avram J.
dc.contributor.authorHoogman, Martine
dc.contributor.authorJanowitz, Deborah
dc.contributor.authorJia, Tianye
dc.contributor.authorJørgensen, Kjetil N.
dc.contributor.authorKarbalai, Nazanin
dc.contributor.authorKasperaviciute, Dalia
dc.contributor.authorKim, Sungeun
dc.contributor.authorKlein, Marieke
dc.contributor.authorKraemer, Bernd
dc.contributor.authorLee, Phil H.
dc.contributor.authorLiewald, David C.M.
dc.contributor.authorLopez, Lorna M.
dc.contributor.authorLuciano, Michelle
dc.contributor.authorMacare, Christine
dc.contributor.authorMarquand, Andre F.
dc.contributor.authorMatarin, Mar
dc.contributor.authorMather, Karen A.
dc.contributor.authorMattheisen, Manuel
dc.contributor.authorMcKay, David R.
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorManiega, Susana Muñoz
dc.contributor.authorNho, Kwangsik
dc.contributor.authorNugent, Allison C.
dc.contributor.authorNyquist, Paul
dc.contributor.authorLoohuis, Loes M.
dc.contributor.authorOosterlaan, Jaap
dc.contributor.authorPapmeyer, Martina
dc.contributor.authorPirpamer, Lukas
dc.contributor.authorPütz, Benno
dc.contributor.authorRamasamy, Adaikalavan
dc.contributor.authorRichards, Jennifer S.
dc.contributor.authorRisacher, Shannon L.
dc.contributor.authorRoiz-Santiañez, Roberto
dc.contributor.authorRommelse, Nanda
dc.contributor.authorRopele, Stefan
dc.contributor.authorRose, Emma J.
dc.contributor.authorRoyle, Natalie A.
dc.contributor.authorRundek, Tatjana
dc.contributor.authorSämann, Philipp G.
dc.contributor.authorSaremi, Arvin
dc.contributor.authorSatizabal, Claudia L.
dc.contributor.authorSchmaal, Lianne
dc.contributor.authorSchork, Andrew J.
dc.contributor.authorShen, Li
dc.contributor.authorShin, Jean
dc.contributor.authorShumskaya, Elena
dc.contributor.authorSmith, Albert V.
dc.contributor.authorSprooten, Emma
dc.contributor.authorStrike, Lachlan T.
dc.contributor.authorTeumer, Alexander
dc.contributor.authorTordesillas-Gutierrez, Diana
dc.contributor.authorToro, Roberto
dc.contributor.authorTrabzuni, Daniah
dc.contributor.authorTrompet, Stella
dc.contributor.authorVaidya, Dhananjay
dc.contributor.authorVan der Grond, Jeroen
dc.contributor.authorVan der Lee, Sven J.
dc.contributor.authorVan der Meer, Dennis
dc.contributor.authorVan Donkelaar, Marjolein M. J.
dc.contributor.authorVan Eijk, Kristel R.
dc.contributor.authorVan Erp, Theo G.M.
dc.contributor.authorVan Rooij, Daan
dc.contributor.authorWalton, Esther
dc.contributor.authorWestlye, Lars T.
dc.contributor.authorWhelan, Christopher D.
dc.contributor.authorWindham, Beverly G.
dc.contributor.authorWinkler, Anderson M.
dc.contributor.authorWittfeld, Katharina
dc.contributor.authorWoldehawariat, Girma
dc.contributor.authorWolf, Christiane
dc.contributor.authorWolfers, Thomas
dc.contributor.authorYanek, Lisa R.
dc.contributor.authorYang, Jingyun
dc.contributor.authorZijdenbos, Alex
dc.contributor.authorZwiers, Marcel P.
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorAlmasy, Laura
dc.contributor.authorAmes, David
dc.contributor.authorAmouyel, Philippe
dc.contributor.authorAndreassen, Ole A.
dc.contributor.authorArepalli, Sampath
dc.contributor.authorAssareh, Amelia A.
dc.contributor.authorBarral, Sandra
dc.contributor.authorBastin, Mark E.
dc.contributor.authorBecker, Diane M.
dc.contributor.authorBecker, James T.
dc.contributor.authorBennett, David A.
dc.contributor.authorBlangero, John
dc.contributor.authorvan Bokhoven, Hans
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorBrodaty, Henry
dc.contributor.authorBrouwer, Rachel M.
dc.contributor.authorBrunner, Han G.
dc.contributor.authorBuckner, Randy L.
dc.contributor.authorBuitelaar, Jan K.
dc.contributor.authorBulayeva, Kazima B.
dc.contributor.authorCahn, Wiepke
dc.contributor.authorCalhoun, Vince D.
dc.contributor.authorCannon, Dara M.
dc.contributor.authorCavalleri, Gianpiero L
dc.contributor.authorCheng, Ching-Yu
dc.contributor.authorCichon, Sven
dc.contributor.authorCookson, Mark R.
dc.contributor.authorCorvin, Aiden
dc.contributor.authorCrespo-Facorro, Benedicto
dc.contributor.authorCurran, Joanne E.
dc.contributor.authorCzisch, Michael
dc.contributor.authorDale, Anders M.
dc.contributor.authorDavies, Gareth E.
dc.contributor.authorDe Craen, Anton J.M.
dc.contributor.authorDe Geus, Eco J.C.
dc.contributor.authorDe Jager, Philip L.
dc.contributor.authorDe Zubicaray, Greig I.
dc.contributor.authorDeary, Ian J.
dc.contributor.authorDebette, Stéphanie
dc.contributor.authorDeCarli, Charles
dc.contributor.authorDelanty, Norman
dc.contributor.authorDepondt, Chantal
dc.contributor.authorDeStefano, Anita
dc.contributor.authorDillman, Allissa
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorDonohoe, Gary
dc.contributor.authorDrevets, Wayne C.
dc.contributor.authorDuggirala, Ravi
dc.contributor.authorDyer, Thomas D.
dc.contributor.authorEnzinger, Christian
dc.contributor.authorErk, Susanne
dc.contributor.authorEspeseth, Thomas
dc.contributor.authorFedko, Iryna O.
dc.contributor.authorFernández, Guillén
dc.contributor.authorFerrucci, Luigi
dc.contributor.authorFisher, Simon E.
dc.contributor.authorFleischman, Debra A.
dc.contributor.authorFord, Ian
dc.contributor.authorFornage, Myriam
dc.contributor.authorForoud, Tatiana M.
dc.contributor.authorFox, Peter T.
dc.contributor.authorFrancks, Clyde
dc.contributor.authorFukunaga, Masaki
dc.contributor.authorGibbs, J. Raphael
dc.contributor.authorGlahn, David C.
dc.contributor.authorGollub, Randy L.
dc.contributor.authorGöring, Harald H.H.
dc.contributor.authorGreen, Robert C.
dc.contributor.authorGruber, Oliver
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorGuelfi, Sebastian
dc.contributor.authorHåberg, Asta K.
dc.contributor.authorHansell, Narelle K.
dc.contributor.authorHardy, John
dc.contributor.authorHartman, Catharina A.
dc.contributor.authorHashimoto, Ryota
dc.contributor.authorHegenscheid, Katrin
dc.contributor.authorHeinz, Andreas
dc.contributor.authorLe Hellard, Stephanie
dc.contributor.authorHernandez, Dena G.
dc.contributor.authorHeslenfeld, Dirk J.
dc.contributor.authorHo, Beng-Coon
dc.contributor.authorHoekstra, Pieter J.
dc.contributor.authorHoffman, Wolfgang
dc.contributor.authorHofman, Albert
dc.contributor.authorHolsboer, Florian
dc.contributor.authorHomuth, Georg
dc.contributor.authorHosten, Norbert
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorHuentelman, Matthew
dc.contributor.authorPol, Hilleke E. Hulshoff
dc.contributor.authorIkeda, Masashi
dc.contributor.authorJack Jr., Clifford R.
dc.contributor.authorJenkinson, Mark
dc.contributor.authorJohnson, Robert
dc.contributor.authorJönsson, Erik G.
dc.contributor.authorJukema, J. Wouter
dc.contributor.authorKahn, René S
dc.contributor.authorVardarajan, Badri N.
dc.contributor.authorVellas, Bruno
dc.contributor.authorVeltman, Dick J.
dc.contributor.authorVölzke, Henry
dc.contributor.authorWalter, Henrik
dc.contributor.authorWardlaw, Joanna M.
dc.contributor.authorWassink, Thomas H.
dc.contributor.authorWeale, Michael E.
dc.contributor.authorWeinberger, Daniel R.
dc.contributor.authorWeiner, Michael W.
dc.contributor.authorKanai, Ryota
dc.contributor.authorKloszewska, Iwona
dc.contributor.authorKnopman, David S.
dc.contributor.authorKochunov, Peter
dc.contributor.authorKwok, John B.
dc.contributor.authorLawrie, Stephen M.
dc.contributor.authorLemaître, Hervé
dc.contributor.authorLiu, Xinmin
dc.contributor.authorLongo, Dan L.
dc.contributor.authorLopez, Oscar L.
dc.contributor.authorLovestone, Simon
dc.contributor.authorMartinez, Oliver
dc.contributor.authorMartinot, Jean-Luc
dc.contributor.authorMattay, Venkata S.
dc.contributor.authorMcDonald, Colm
dc.contributor.authorMcIntosh, Andrew M.
dc.contributor.authorMcMahon, Francis J.
dc.contributor.authorMcMahon, Katie L.
dc.contributor.authorMecocci, Patrizia
dc.contributor.authorMelle, Ingrid
dc.contributor.authorMeyer-Lindenberg, Andreas
dc.contributor.authorMohnke, Sebastian
dc.contributor.authorMontgomery, Grant W.
dc.contributor.authorMorris, Derek W.
dc.contributor.authorMosley, Thomas H.
dc.contributor.authorMühleisen, Thomas W.
dc.contributor.authorMüller-Myhsok, Bertram
dc.contributor.authorNalls, Michael A.
dc.contributor.authorNauck, Matthias
dc.contributor.authorNichols, Thomas E.
dc.contributor.authorNiessen, Wiro J.
dc.contributor.authorNöthen, Markus M.
dc.contributor.authorNyberg, Lars
dc.contributor.authorPurohit, Kazutaka
dc.contributor.authorOlvera, Rene L.
dc.contributor.authorOphoff, Roel A.
dc.contributor.authorPandolfo, Massimo
dc.contributor.authorPaus, Tomas
dc.contributor.authorPausova, Zdenka
dc.contributor.authorPenninx, Brenda W. J. H.
dc.contributor.authorPike, G. Bruce
dc.contributor.authorPotkin, Steven G.
dc.contributor.authorPsaty, Bruce M.
dc.contributor.authorReppermund, Simone
dc.contributor.authorRietschel, Marcella
dc.contributor.authorRoffman, Joshua L.
dc.contributor.authorRomanczuk-Seiferth, Nina
dc.contributor.authorRotter, Jerome I.
dc.contributor.authorRyten, Mina
dc.contributor.authorSacco, Ralph L.
dc.contributor.authorSachdev, Perminder S.
dc.contributor.authorSaykin, Andrew J.
dc.contributor.authorSchmidt, Reinhold
dc.contributor.authorSchmidt, Helena
dc.contributor.authorSchofield, Peter R.
dc.contributor.authorSigursson, Sigurdur
dc.contributor.authorSimmons, Andrew
dc.contributor.authorSingleton, Andrew
dc.contributor.authorSisodiya, Sanjay M.
dc.contributor.authorSmith, Colin
dc.contributor.authorSmoller, Jordan W.
dc.contributor.authorSoininen, Hilkka
dc.contributor.authorSteen, Vidar M.
dc.contributor.authorStott, David J.
dc.contributor.authorSussmann, Jessika E.
dc.contributor.authorThalamuthu, Anbupalam
dc.contributor.authorToga, Arthur W.
dc.contributor.authorTraynor, Bryan J.
dc.contributor.authorTroncoso, Juan
dc.contributor.authorTsolaki, Magda
dc.contributor.authorTzourio, Christophe
dc.contributor.authorUitterlinden, Andre G.
dc.contributor.authorValdés Hernández, Maria C.
dc.contributor.authorVan der Brug, Marcel
dc.contributor.authorvan der Lugt, Aad
dc.contributor.authorvan der Wee, Nic J. A.
dc.contributor.authorVan Haren, Neeltje E. M.
dc.contributor.authorvan't Ent, Dennis
dc.contributor.authorVan Tol, Marie-Jose
dc.contributor.authorWen, Wei
dc.contributor.authorWestman, Eric
dc.contributor.authorWhite, Tonya
dc.contributor.authorWong, Tien Y.
dc.contributor.authorWright, Clinton B.
dc.contributor.authorZielke, Ronald H.
dc.contributor.authorZonderman, Alan B.
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorVan Duijn, Cornelia M.
dc.contributor.authorWright, Margaret J.
dc.contributor.authorLongstreth, W. T.
dc.contributor.authorSchumann, Gunter
dc.contributor.authorGrabe, Hans J.
dc.contributor.authorFranke, Barbara
dc.contributor.authorLauner, Lenore J.
dc.contributor.authorMedland, Sarah E.
dc.contributor.authorSeshadri, Sudha
dc.contributor.authorThompson, Paul M.
dc.contributor.authorArfan, M.
dc.contributor.departmentDepartment of Radiology and Imaging Sciences, IU School of Medicineen_US
dc.date.accessioned2017-06-23T13:41:55Z
dc.date.available2017-06-23T13:41:55Z
dc.date.issued2017-01-18
dc.description.abstractThe hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.en_US
dc.eprint.versionFinal Published Version
dc.identifier.citationHibar, D. P., Adams, H. H. H., Jahanshad, N., Chauhan, G., Stein, J. L., Hofer, E., … Ikram, M. A. (2017). Novel genetic loci associated with hippocampal volume. Nature Communications, 8, 13624. http://doi.org/10.1038/ncomms13624en_US
dc.identifier.urihttps://hdl.handle.net/1805/13160
dc.language.isoen_USen_US
dc.publisherSpringerNatureen_US
dc.relation.isversionof10.1038/ncomms13624en_US
dc.relation.journalNature Communicationsen_US
dc.rightsAn error occurred on the license name.
dc.rights.uriAn error occurred getting the license - uri.
dc.sourcePMCen_US
dc.subjectHippocampal formationen_US
dc.subjectBrainen_US
dc.subjectNeuropsychiatric disordersen_US
dc.subjectHippocampal abnormalitiesen_US
dc.subjectGenesen_US
dc.subjectLocien_US
dc.subjectHippocampal volumeen_US
dc.titleNovel genetic loci associated with hippocampal volumeen_US
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