School of Medicine

Recent Submissions

  • Barreto, Rafael; Mandili, Giorgia; Witzmann, Frank A.; Novelli, Francesco; Zimmers, Teresa A.; Bonetto, Andrea (Frontiers, 2016)
    Cachexia represents one of the primary complications of colorectal cancer due to its effects on depletion of muscle and fat. Evidence suggests that chemotherapeutic regimens, such as Folfiri, contribute to cachexia-related ...
  • Bowen Center for Health Workforce Research and Policy (2016)
  • Bowen Center for Health Workforce Research and Policy (2015)
  • The Bowen Center for Health Workforce Research and Policy (2017-01)
    Identifying supply and distribution of the pharmacist workforce is foundational to understanding Indiana’s capacity to strengthen overall population health. Data presented in this report provide a snapshot of key demographic ...
  • Bowen Center for Health Workforce Research and Policy (2016-11)
    Identifying supply and distribution of the Physician Assistant (PA) workforce is crucial in understanding the capacity to meet health care needs and improve overall population health of Indiana citizens. Data presented ...
  • Bowen Center for Health Workforce Research and Policy (2016)
    This report describes the verification protocol conducted by researchers for verification of primary care physicians, psychiatrists, and dentists in Indiana.
  • Fang, Fang; Munck, Joanne; Tang, Jessica; Taverna, Pietro; Wang, Yinu; Miller, David F. B.; Pilrose, Jay; Choy, Gavin; Azab, Mohammad; Pawelczak, Katherine S.; VanderVere-Carozza, Pamela; Wagner, Michael; Lyons, John; Matei, Daniela; Turchi, John J.; Nephew, Kenneth P. (American Association for Cancer Research, 2014-12-15)
    PURPOSE: To investigate SGI-110 as a "chemosensitizer" in ovarian cancer and to assess its effects on tumor suppressor genes (TSG) and chemoresponsiveness-associated genes silenced by DNA methylation in ovarian ...
  • VanDusen, Nathan J.; Casanovas, Jose; Vincentz, Joshua W.; Firulli, Beth A.; Osterwalder, Marco; Lopez-Rios, Javier; Zeller, Rolf; Zhou, Bin; Grego-Bessa, Joaquim; De La Pompa, José Luis; Shou, Weinian; Firulli, Anthony B. (Elsevier, 2014-12-24)
    The basic-helix-loop-helix (bHLH) transcription factor Hand2 plays critical roles during cardiac morphogenesis via expression and function within myocardial, neural crest, and epicardial cell populations. Here, we show ...
  • Wu, Yuehan; Lee, Suk-Hee; Williamson, Elizabeth A.; Reinert, Brian L.; Cho, Ju Hwan; Xia, Fen; Jaiswal, Aruna Shanker; Srinivasan, Gayathri; Patel, Bhavita; Brantley, Alexis; Zhou, Daohong; Shao, Lijian; Pathak, Rupak; Hauer-Jensen, Martin; Singh, Sudha; Kong, Kimi; Wu, Xaiohua; Kim, Hyun-Suk; Beissbarth, Timothy; Gaedcke, Jochen; Burma, Sandeep; Nickoloff, Jac A.; Hromas, Robert A. (Public Library of Science (PloS), 2015-12)
    Replication fork stalling and collapse is a major source of genome instability leading to neoplastic transformation or cell death. Such stressed replication forks can be conservatively repaired and restarted using homologous ...
  • Bunda, Severa; Burrell, Kelly; Heir, Pardeep; Zeng, Lifan; Alamsahebpour, Amir; Kano, Yoshihito; Raught, Brian; Zhang, Zhong-Yin; Zadeh, Gelareh; Ohh, Michael (Nature Publishing Group, 2015-11-30)
    Ras is phosphorylated on a conserved tyrosine at position 32 within the switch I region via Src kinase. This phosphorylation inhibits the binding of effector Raf while promoting the engagement of GTPase-activating protein ...
  • Celestino-Soper, Patrícia B. S.; Doytchinova, Anisiia; Steiner, Hillel A.; Uradu, Andrea; Lynnes, Ty C.; Groh, William J.; Miller, John M.; Lin, Hai; Gao, Hongyu; Wang, Zhiping; Liu, Yunlong; Chen, Peng-Sheng; Vatta, Matteo (Public Library of Science (PloS), 2015)
    BACKGROUND: The etiology of conduction disturbances necessitating permanent pacemaker (PPM) implantation is often unknown, although familial aggregation of PPM (faPPM) suggests a possible genetic basis. We developed a ...
  • Bhat, Mamatha; Skill, Nicolas; Marcus, Victoria; Deschenes, Marc; Tan, Xianming; Bouteaud, Jeanne; Negi, Sarita; Awan, Zuhier; Aikin, Reid; Kwan, Janet; Amre, Ramila; Tabaries, Sebastien; Hassanain, Mazen; Seidah, Nabil G.; Maluccio, Mary; Siegel, Peter; Metrakos, Peter (Springer (Biomed Central Ltd.), 2015-12-16)
    BACKGROUND: The management of hepatocellular carcinoma (HCC) is limited by the lack of adequate screening biomarkers and chemotherapy. In response, there has been much interest in tumor metabolism as a therapeutic target. ...
  • Suvannasankha, Attaya; Tompkins, Douglas R.; Edwards, Daniel F.; Petyaykina, Katarina V.; Crean, Colin D.; Fournier, Pierrick G.; Parker, Jamie M.; Sandusky, George E.; Ichikawa, Shoji; Imel, Erik A.; Chirgwin, John M. (Oncotarget, 2015-08-14)
    Multiply myeloma (MM) grows in and destroys bone, where osteocytes secrete FGF23, a hormone which affects phosphate homeostasis and aging. We report that multiple myeloma (MM) cells express receptors for and respond to ...
  • Allen, D. B.; Backeljauw, P.; Bidlingmaier, M.; Biller, B. M. K.; Boguszewski, M.; Burman, P.; Butler, G.; Chihara, K.; Christiansen, J.; Cianfarani, S.; Clayton, P.; Clemmons, D.; Cohen, P.; Darendeliler, F.; Deal, C.; Dunger, D.; Erfurth, E. M.; Fuqua, J. S.; Grimberg, A.; Haymond, M.; Higham, C.; Ho, K.; Hoffman, A. R.; Hokken-Koelega, A.; Johannsson, G.; Juul, A.; Kopchick, J.; Lee, P.; Pollak, M.; Radovick, S.; Robison, L.; Rosenfeld, R.; Ross, R. J.; Savendahl, L.; Saenger, P.; Toft Sorensen, H.; Stochholm, K.; Strasburger, C.; Swerdlow, A.; Thorner, M. (Bioscientifica, 2016-02)
    Recombinant human GH (rhGH) has been in use for 30 years, and over that time its safety and efficacy in children and adults has been subject to considerable scrutiny. In 2001, a statement from the GH Research Society (GRS) ...
  • Salinas, Joel; Sprinkhuizen, Sara M.; Ackerson, Teri; Bernhardt, Julie; Davie, Charlie; George, Mary G.; Gething, Stephanie; Kelly, Adam G.; Lindsay, Patrice; Liu, Liping; Martins, Sheila C. O.; Morgan, Louise; Norrving, Bo; Ribbers, Gerard M.; Silver, Frank L.; Smith, Eric E.; Williams, Linda S.; Schwamm, Lee H. (Ovid Technologies Wolters Kluwer – American Heart Association, 2016-01)
    BACKGROUND AND PURPOSE: Value-based health care aims to bring together patients and health systems to maximize the ratio of quality over cost. To enable assessment of healthcare value in stroke management, an international ...
  • King-Stephens, David; Mirro, Emily; Weber, Peter B.; Laxer, Kenneth D.; Van Ness, Paul C.; Salanova, Vicenta; Spencer, David C.; Heck, Christianne N.; Goldman, Alica; Jobst, Barbara; Shields, Donald C.; Bergey, Gregory K.; Eisenschenk, Stephan; Worrell, Gregory A.; Rossi, Marvin A.; Gross, Robert E.; Cole, Andrew J.; Sperling, Michael R.; Nair, Dileep R.; Gwinn, Ryder P.; Park, Yong D.; Rutecki, Paul A.; Fountain, Nathan B.; Wharen, Robert E.; Hirsch, Lawrence J.; Miller, Ian O.; Barkley, Gregory L.; Edwards, Jonathan C.; Geller, Eric B.; Berg, Michel J.; Sadler, Toni L.; Sun, Felice T.; Morrell, Martha J. (Wiley Blackwell (Blackwell Publishing), 2015-06)
    OBJECTIVE: Patients with suspected mesial temporal lobe (MTL) epilepsy typically undergo inpatient video-electroencephalography (EEG) monitoring with scalp and/or intracranial electrodes for 1 to 2 weeks to localize and ...
  • Zaiyang, Long; Yue-Ming, Jiang; Xiang-Rong, Li; William, Fadel; Jun, Xu; Chien-Lin, Yeh; Li-Ling, Long; Hai-Lan, Luo; Jaroslaw, Harezlak; James B, Murdoch; Wei, Zheng; Ulrike, Dydak (Elsevier, 2014-12)
    Increased manganese (Mn) exposure is known to cause cognitive, psychiatric and motor deficits. Mn exposure occurs in different occupational settings, where the airborne Mn level and the size of respirable particulates may ...
  • Chen, Lili; Chen, Wei; Mysliwski, Maria; Serio, Justin; Ropa, James; Abulwerdi, Fardokht A.; Chan, Rebecca J.; Patel, Jay P.; Tallman, Martin S.; Paietta, Elisabeth; Melnick, Ari; Levine, Ross L.; Abdel-Wahab, Omar; Nikolovska-Coleska, Zaneta; Muntean, Andrew G. (Nature Publishing Group, 2015-06)
    PTPN11 encodes the Shp2 non-receptor protein-tyrosine phosphatase implicated in several signaling pathways. Activating mutations in Shp2 are commonly associated with juvenile myelomonocytic leukemia but are not as well ...
  • Musey, Paul I.; Linnstaedt, Sarah D.; Platts-Mills, Timothy F.; Miner, James R.; Bortsov, Andrey V.; Safdar, Basmah; Bijur, Polly; Rosenau, Alex; Tsze, Daniel S.; Chang, Andrew K.; Dorai, Suprina; Engel, Kirsten; Feldman, James A.; Fusaro, Angela M.; Lee, David C.; Rosenberg, Mark; Keefe, Francis J.; Peak, David A.; Nam, Catherine S.; Patel, Roma G.; Fillingim, Roger B.; McLean, Samuel A. (Wiley Blackwell (Blackwell Publishing), 2014-12)
    Pain is a leading public health problem in the United States, with an annual economic burden of more than $630 billion, and is one of the most common reasons that individuals seek emergency department (ED) care. There is ...
  • Sahu, Ravi P.; Ocana, Jesus A.; Harrison, Kathleen A.; Ferracini, Matheus; Touloukian, Christopher E.; Al-Hassani, Mohammed; Sun, Louis; Loesch, Mathew; Murphy, Robert C.; Althouse, Sandra K.; Perkins, Susan M.; Speicher, Paul J.; Tyler, Douglas S.; Konger, Raymond L.; Travers, Jeffrey B. (American Association for Cancer Research, 2014-12-01)
    Oxidative stress suppresses host immunity by generating oxidized lipid agonists of the platelet-activating factor receptor (PAF-R). Because many classical chemotherapeutic drugs induce reactive oxygen species (ROS), we ...

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