• 2019 Bowen Biweekly Bill Brief 4-22-2019 

  Bowen Center for Health Workforce Research & Policy (2019-04-22)
• A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter. 

  Smith, W C; Nakshatri, H; Leroy, P; Rees, J; Chambon, P (EMBO Press, 1991-08)

  Genomic and cDNA sequences for the mouse cellular retinol binding protein I (mCRBPI) are presented. A specific cis-acting element responsible for retinoic acid (RA) inducibility of the mCRBPI promoter was identified and ...
• Functional role of BK virus tumor antigens in transformation. 

  Nakshatri, H; Pater, M M; Pater, A (American Society for Microbiology, 1988-12)

  We have examined the role of the human papovavirus BK virus (BKV) tumor (T) antigen(s) in the maintenance of transformation and have identified the domain of T antigen essential for transformation. BKV-transformed BHK 21 ...
• Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element. 

  Leroy, P; Nakshatri, H; Chambon, P (National Academy of Sciences, 1991-11-15)

  We have characterized the promoter of the mouse retinoic acid receptor alpha 2 (mRAR-alpha 2) isoform. This promoter contains a retinoic acid response element (RARE) that closely resembles the RARE that is present in the ...
• The directly repeated RG(G/T)TCA motifs of the rat and mouse cellular retinol-binding protein II genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers. 

  Nakshatri, H.; Chambon, P. (American Society for Biochemistry and Molecular Biology, 1994-01-04)

  We show here that the element which was previously characterized as a retinoid X receptor (RXR)-specific response element (RXRE) in the rat cellular retinol-binding protein II (CRBPII) gene is not conserved in the mouse ...
• Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth. 

  Nakshatri, H; Bhat-Nakshatri, P; Martin, D A; Goulet, R J; Sledge, G W (American Society for Microbiology, 1997-07)

  Breast cancers often progress from a hormone-dependent, nonmetastatic, antiestrogen-sensitive phenotype to a hormone-independent, antiestrogen- and chemotherapy-resistant phenotype with highly invasive and metastatic growth ...
• RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo. 

  Nagpal, S; Friant, S; Nakshatri, H; Chambon, P (EMBO Press, 1993-06)

  We have previously reported that the AB regions of retinoic acid receptors (RARs and RXRs) contain a transcriptional activation function capable of modulating the activity of the ligand-dependent activation function present ...
• Retinoid receptors and binding proteins 

  Lohnes, David; Dierich, Andrée; Ghyselinck, Norbert; Kastner, Phillipe; Lampron, Carmen; LeMEUR, Marianne; Lufkin, Thomas; Mendelsohn, Cathy; Nakshatri, Hari; Chambon, Pierre (Company of Biologists, 1992-01-01)

  Skip to Next Section Retinoids, in particular all-trans retinoic acid (T-RA), are essential for normal development and homeostasis of vertebrates. Although many effects of retinoids, particularily with regard to teratogenicity, ...
• Subunit Association and DNA Binding Activity of the Heterotrimeric Transcription Factor NF-Y Is Regulated by Cellular Redox 

  Nakshatri, Harikrishna; Bhat-Nakshatri, Poornima; Currie, R. Alexander (American Society for Biochemistry and Molecular Biology, 1996-11-15)

  NF-Y is a heterotrimeric transcription factor that specifically recognizes a CCAAT box motif found in a variety of eukaryotic promoter and enhancer elements. The subunit association and DNA binding properties of the NF-Y ...
• Negative Regulation of Transactivation Function but Not DNA Binding of NF-κB and AP-1 by IκBβ1 in Breast Cancer Cells 

  Newton, Thomas R.; Patel, Nikhil M.; Bhat-Nakshatri, Poornima; Stauss, Carmen R.; Goulet, Robert J.; Nakshatri, Harikrishna (1999-06-25)

  The transcription factor NF-κB regulates the expression of genes involved in cancer cell invasion, metastasis, angiogenesis, and resistance to chemotherapy. In normal cells NF-κB is maintained in the cytoplasm by protein-protein ...
• Multiple parameters determine the specificity of transcriptional response by nuclear receptors HNF-4, ARP-1, PPAR, RAR and RXR through common response elements. 

  Nakshatri, H; Bhat-Nakshatri, P (Oxford University Press, 1998-05-15)

  A number of nuclear receptors, including retinoic acid receptors (RARs), retinoid-X receptors (RXRs), hepatocyte nuclear factor 4 (HNF-4), chicken ovalbumin upstream promoter transcription factor I (COUP-TFI), apolipoprotein ...
• Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance 

  Campbell, Robert A.; Bhat-Nakshatri, Poornima; Patel, Nikhil M.; Constantinidou, Demetra; Ali, Simak; Nakshatri, Harikrishna (American Society for Biochemistry and Molecular Biology, 2001-03-30)

  Estrogen receptors (ERs) mediate most of the biological effects of estrogen in mammary and uterine epithelial cells by binding to estrogen response elements in the promoter region of target genes or through protein-protein ...
• Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB. 

  Nagarajan, R P; Chen, F; Li, W; Vig, E; Harrington, M A; Nakshatri, H; Chen, Y (Portland Press, 2000-06-15)

  Activation of transforming growth factor-beta (TGF-beta) and activin receptors leads to phosphorylation of Sma- and Mad-related protein 2 (Smad2) and Smad3, which function as transcription factors to regulate gene expression. ...
• NF-κB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1α 

  Bhat-Nakshatri, Poornima; Newton, Thomas R.; Goulet, Robert; Nakshatri, Harikrishna (National Academy of Sciences, 1998-06-09)

  Several angiogenic factors and extracellular matrix-degrading enzymes that promote invasion and metastasis of cancer are produced by stromal fibroblasts that surround cancer cells. The expression of genes that code for ...
• CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency 

  Cohen, P. S.; Nakshatri, H.; Dennis, J.; Caragine, T.; Bianchi, M.; Cerami, A.; Tracey, K. J. (Proceedings of the National Academy of Sciences of the United States of America, 1996-04-30)

  Tumor necrosis factor (TNF) mediates a wide variety of disease states including septic shock, acute and chronic inflammation, and cachexia. Recently, a multivalent guanylhydrazone (CNI-1493) developed as an inhibitor of ...
• Interaction of Oct-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter 

  Nakshatri, Harikrishna; Nakshatri, Poornima; Currie, R. Alexander (American Society for Biochemistry and Molecular Biology, 1995-08-18)

  The ubiquitous human POU domain protein, Oct-1, and the related B-cell protein, Oct-2, regulate transcription from a variety of eukaryotic genes by binding to a common cis-acting octamer element, 5′-ATTTGCAT-3′. The binding ...
• Methods for the Bowen Center for Health Workforce Research & Policy (Bowen) Bi-weekly Bill Brief (B4) 

  Bowen Center for Health Workforce Research & Policy (2019-04-16)
• An Assessment of Obstetricians/Gynecologists in Indiana 

  Bowen Center for Health Workforce Research and Policy (Indiana University, 2019-04-15)

  After physicians’ license renewal period (the most recent occurring in 2017), the Bowen Center for Health Workforce Research and Policy collects their license and survey data from the Indiana Professional Licensing Agency ...
• Interleukin-1α Promotes Tumor Growth and Cachexia in MCF-7 Xenograft Model of Breast Cancer 

  Kumar, Suresh; Kishimoto, Hiromitsu; Chua, Hui Lin; Badve, Sunil; Miller, Kathy D.; Bigsby, Robert M.; Nakshatri, Harikrishna (Elsevier, 2003-12)

  Progression of breast cancer involves cross-talk between epithelial and stromal cells. This cross-talk is mediated by growth factors and cytokines secreted by both cancer and stromal cells. We previously reported expression ...
• The Platelet-activating Factor Receptor Protects Epidermal Cells from Tumor Necrosis Factor (TNF) α and TNF-related Apoptosis-inducing Ligand-induced Apoptosis through an NF-κB-dependent Process 

  Southall, Michael D.; Isenberg, Jason S.; Nakshatri, Harikrishna; Yi, Qiaofang; Pei, Yong; Spandau, Dan F.; Travers, Jeffrey B. (American Society for Biochemistry and Molecular Biology, 2001-12-07)

  A number of chemical mediators can induce human keratinocytes and epidermal-derived carcinomas to undergo apoptosis, or programmed cell death. Recent evidence suggests pro-inflammatory cytokines, such as interleukin-1β or ...

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