• DNA copy number variations in children with vesicoureteral reflux and urinary tract infections 

  Liang, Dong; McHugh, Kirk M.; Brophy, Pat D.; Shaikh, Nader; Manak, J. Robert; Andrews, Peter; Hakker, Inessa; Wang, Zihua; Schwaderer, Andrew L.; Hains, David S. (PLOS, 2019-08-12)

  Vesicoureteral reflux (VUR) is a complex, heritable disorder. Genome-wide linkage analyses of families affected by VUR have revealed multiple genomic loci linked to VUR. These loci normally harbor a number of genes whose ...
• Novel drug targets based on metallobiology of Alzheimer's disease 

  Bandyopadhyay, Sanghamitra; Huang, Xudong; Lahiri, Debomoy K.; Rogers, Jack T. (Taylor & Francis, 2010-11)

  IMPORTANCE OF THE FIELD: Increased localization of Zn, Fe, Cu and Al within the senile plaques (SP) exacerbates amyloid beta (Aβ)-mediated oxidative damage, and acts as catalyst for Aβ aggregation in Alzheimer's disease ...
• Encoding of the Intent to Drink Alcohol by the Prefrontal Cortex Is Blunted in Rats with a Family History of Excessive Drinking 

  Lisenbardt, David N.; Timme, Nicholas M.; Lapish, Christopher C. (Society for Neuroscience, 2019)

  The prefrontal cortex (PFC) plays a central role in guiding decision making, and its function is altered by alcohol use and an individual's innate risk for excessive alcohol drinking. The primary goal of this work was to ...
• Drosophila homer is required in a small set of neurons including the ellipsoid body for normal ethanol sensitivity and tolerance 

  Urizar, Nancy L.; Yang, Zhiyong; Edenberg, Howard J.; Davis, Ronald L. (Society for Neuroscience, 2007-04-25)

  The molecular mechanisms occurring in the nervous system that underlie behavioral responses to ethanol remain poorly understood. Here, we report that molecular requirements for two of these responses, initial sensitivity ...
• Prognostic Impact of Peritransplant Serum Sodium Concentrations in Liver Transplantation 

  Mihaylov, Plamen; Nagai, Shunji; Ekser, Burcin; Mangus, Richard; Fridell, Jonathan; Kubal, Chandrashekhar (International Scientific Information, 2019-07-16)

  BACKGROUND Serum sodium (Na) is considered to reflect the severity of liver cirrhosis. In the last few years, much effort has been made to integrate this association into prognostic models after liver transplantation. The ...
• Spatial‐Temporal Assessment of Environmental Factors Related to Dengue Outbreaks in São Paulo, Brazil 

  Ogashawara, I.; Li, L.; Moreno-Madriñán, M. J. (Wiley, 2019-08)

  Dengue fever, a disease caused by a vector‐borne flavivirus, is endemic to tropical countries, but its occurrence has been reported worldwide. This study aimed to understand important factors contributing to the spatial ...
• Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS): study protocol for a randomized placebo-controlled trial in Ugandan children with sickle cell anemia 

  Datta, Dibyadyuti; Namazzi, Ruth; Conroy, Andrea L.; Cusick, Sarah E.; Hume, Heather A.; Tagoola, Abner; Ware, Russell E.; Opoka, Robert O.; John, Chandy C. (BioMed Central, 2019-07-26)

  BACKGROUND: Sickle cell anemia (SCA) is the most common inherited hemoglobinopathy worldwide. Infection is a major cause of illness and death in children with SCA, especially in sub-Saharan Africa where an estimated ...
• Graft-Versus-Host Disease-Free Antitumoral Signature After Allogeneic Donor Lymphocyte Injection Identified by Proteomics and Systems Biology 

  Liu, Xiaowen; Yue, Zongliang; Cao, Yimou; Taylor, Lauren; Zhang, Qing; Choi, Sung W.; Hanash, Samir; Ito, Sawa; Chen, Jake Y.; Wu, Huanmei; Paczesny, Sophie (American Society of Clinical Oncology, 2019)

  PURPOSE: As a tumor immunotherapy, allogeneic hematopoietic cell transplantation with subsequent donor lymphocyte injection (DLI) aims to induce the graft-versus-tumor (GVT) effect but often also leads to acute ...
• Quantitative Prediction of CYP3A4‐ and CYP3A5‐Mediated Drug Interactions 

  Guo, Yingying; Lucksiri, Aroonrut; Dickinson, Gemma L.; Vuppalanchi, Raj K.; Hilligoss, Janna K.; Hall, Stephen D. (Wiley, 2019)

  We verified a physiologically‐based pharmacokinetic (PBPK) model to predict cytochrome P450 3A4/5‐mediated drug‐drug interactions (DDIs). A midazolam (MDZ)–ketoconazole (KTZ) interaction study in 24 subjects selected by ...
• Biofluid modeling of the coupled eye-brain system and insights into simulated microgravity conditions 

  Salerni, Fabrizia; Repetto, Rodolfo; Harris, Alon; Pinsky, Peter; Prud'homme, Christophe; Szopos, Marcela; Guidoboni, Giovanna (PLOS, 2019-08-14)

  This work aims at investigating the interactions between the flow of fluids in the eyes and the brain and their potential implications in structural and functional changes in the eyes of astronauts, a condition also known ...
• Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts 

  Nawa, Nobutoshi; Hirata, Katsuya; Kawatani, Keiji; Nambara, Toshihiko; Omori, Sayaka; Banno, Kimihiko; Kokubu, Chikara; Takeda, Junji; Nishimura, Ken; Ohtaka, Manami; Nakanishi, Mahito; Okuzaki, Daisuke; Taniguchi, Hidetoshi; Arahori, Hitomi; Wada, Kazuko; Kitabatake, Yasuji; Ozono, Keiichi (PLOS, 2019)

  Chromosome abnormalities induces profound alterations in gene expression, leading to various disease phenotypes. Recent studies on yeast and mammalian cells have demonstrated that aneuploidy exerts detrimental effects on ...
• Profiling molecular regulators of recurrence in chemorefractory triple-negative breast cancers 

  Hancock, Bradley A.; Chen, Yu-Hsiang; Solzak, Jeffrey P.; Ahmad, Mufti N.; Wedge, David C.; Brinza, Dumitru; Scafe, Charles; Veitch, James; Gottimukkala, Rajesh; Short, Walt; Atale, Rutuja V.; Ivan, Mircea; Badve, Sunil S.; Schneider, Bryan P.; Lu, Xiongbin; Miller, Kathy D.; Radovich, Milan (BioMed Central, 2019-08-05)

  BACKGROUND: Approximately two thirds of patients with localized triple-negative breast cancer (TNBC) harbor residual disease (RD) after neoadjuvant chemotherapy (NAC) and have a high risk-of-recurrence. Targeted therapeutic ...
• BERMUDA: a novel deep transfer learning method for single-cell RNA sequencing batch correction reveals hidden high-resolution cellular subtypes 

  Wang, Tongxin; Johnson, Travis S.; Shao, Wei; Lu, Zixiao; Helm, Bryan R.; Zhang, Jie; Huang, Kun (BioMed Central, 2019-08-12)

  To fully utilize the power of single-cell RNA sequencing (scRNA-seq) technologies for identifying cell lineages and bona fide transcriptional signals, it is necessary to combine data from multiple experiments. We present ...
• Integration of molecular features with clinical information for predicting outcomes for neuroblastoma patients 

  Han, Yatong; Ye, Xiufen; Wang, Chao; Liu, Yusong; Zhang, Siyuan; Feng, Weixing; Huang, Kun; Zhang, Jie (BioMed Central, 2019-08-23)

  BACKGROUND: Neuroblastoma is one of the most common types of pediatric cancer. In current neuroblastoma prognosis, patients can be stratified into high- and low-risk groups. Generally, more than 90% of the patients in ...
• CYP2B6 Genotype‐Dependent Inhibition of CYP1A2 and Induction of CYP2A6 by the Antiretroviral Drug Efavirenz in Healthy Volunteers 

  Metzger, Ingrid F.; Dave, Nimita; Kreutz, Yvonne; Lu, Jessica B. L.; Galinsky, Raymond E.; Desta, Zeruesenay (ASCPT, 2019)

  We investigated the effect of efavirenz on the activities of cytochrome P450 (CYP)1A2, CYP2A6, xanthine oxidase (XO), and N‐acetyltransferase 2 (NAT2), using caffeine as a probe. A single 150 mg oral dose of caffeine was ...
• Adolescent Intermittent Ethanol Increases the Sensitivity to the Reinforcing Properties of Ethanol and the Expression of Select Cholinergic and Dopaminergic Genes within the Posterior Ventral Tegmental Area 

  Hauser, Sheketha R.; Knight, Christopher P.; Truitt, William A.; Waeiss, R. Aaron; Holt, Ian S.; Carvajal, Gustavo B.; Bell, Richard L.; Ross, Zachary A. (Wiley, 2019-09)

  Background Although not legally allowed to consume alcohol, adolescents account for 11% of all alcohol use in the United States and approximately 90% of adolescent intake is in the form of an alcohol binge. The adolescent ...
• Effects of Statin Treatment on Outcomes after Traumatic Brain Injury 

  Whyte, John; Ketchum, Jessica M.; Bogner, Jenny; Brunner, Robert C.; Hammond, Flora M.; Zafonte, Ross; Whiteneck, Gale G.; Weintraub, Alan (Liebert, 2018)

  Neuroprotective treatments that have shown promise in reducing secondary injury and improving recovery in animal models of traumatic brain injury (TBI) have not been found effective to date in humans. One reason may be the ...
• Patient and caregiver perspectives on guideline adherence: the case of endocrine and bone health recommendations for Duchenne muscular dystrophy 

  Denger, Brian; Kinnett, Kathi; Martin, Ann; Grant, Sean; Armstrong, Courtney; Khodyakov, Dmitry (BioMed Central, 2019-08-20)

  BACKGROUND: Clinical care guidelines are typically developed by clinicians and researchers. Including patient and caregiver voices in guideline development may help create guidelines that are more useful for patients ...
• Polygenic risk scores in psychiatry: Will they be useful for clinicians? 

  Fullerton, Janice M.; Nurnberger, John I. (F1000 Research, 2019-07-31)

  Major psychiatric disorders are heritable but they are genetically complex. This means that, with certain exceptions, single gene markers will not be helpful for diagnosis. However, we are learning more about the large ...
• Phase Field Modeling of Coupled Phase Separation and Diffusion-Induced Stress in Lithium Iron Phosphate Particles Reconstructed From Synchrotron Nano X-ray Tomography 

  Wu, Linmin; Xiao, Xianghui; Zhang, Jing (ASME, 2019-11)

  In this study, the phase separation phenomenon and diffusion-induced stresses in lithium iron phosphate (LiFePO4) particles under a potentiostatic discharging process have been simulated using the phase field method. The ...

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