Accurate Identification of RNA Editing Events Using Matched RNA and DNA Sequenced Samples Uncovers the Contribution of the Editing Landscape to Disease Progression in Glioblastoma Patients

Abstract

RNA editing event is increasingly appreciated as an important posttranscriptional regulatory mechanism in mammals. Adenosine deaminases that act on RNA (ADARs) are the enzymes that catalyze adenosine (A) to inosine (I) editing events. Human brain RNA is reported to have highest number of editing events. Many neurotransmitter receptors and ion channels undergo editing within exonic regions which generates a different protein than that encoded by the genome. ALU repeats in introns and untranslated regions of brain mRNAs are often targeted by editing events and result in altered splicing and post-transcriptional gene regulation.