• Characterization of a Novel Fis1 Interactor Required for Peripheral Distribution of the Mitochondrion of Toxoplasma Gondii 

  Jacobs, Kylie (2021-02)

  Toxoplasma’s singular mitochondrion is extremely dynamic and undergoes morphological changes throughout the parasite’s life cycle. While intracellular‚ the mitochondrion is maintained in a lasso shape that stretches ...
• The Transcriptional Regulation and Function of IL-9 in Allergic Lung Inflammation and Tumor Growth 

  Fu, Yongyao (2021-01)

  IL-9 is a pleiotropic cytokine that mediates allergic airway inflammation and lung tumor growth. Th9 cells are the major IL-9 producers. BATF is one of the major IL-9 inducers in Th9 cells. BATF is expressed and functions ...
• The Eukaryotic SMC5/6 Complex Represses the Replicative Program of High-Risk Human Papillomavirus 

  Gibson, Ryan Taylor (2020-10)

  Human papillomaviruses (HPVs) are non-enveloped, circular double-stranded DNA viruses that infect basal keratinocytes of stratified squamous epithelia. High-risk HPV (HR-HPV) infection causes nearly all cervical cancers ...
• Genetic Determinants of Coxsackievirus B3 Pathogenesis 

  Barnard, April L. (2020-10)

  Enteric viruses are among the most common infectious human viruses worldwide, causing an estimated 10-15 million infections per year in the United States. Among enteric viruses, Coxsackievirus is commonly isolated and can ...
• Differential Recruitment of Host Proteins to the Coxiella Burnetii Vacuole in the Absence of the Sterol Reductase CBU1206 

  Ratnayake, Rochelle Chashmi (2020-08)

  Q fever is a heavily underdiagnosed and underreported infection caused by the obligate intracellular pathogen Coxiella burnetii. Following entry into the host cell, Coxiella replicates in the acidic phagolysosome-like ...
• Roles of Transcription Factors NMP4 and FOXP3 in Regulating Airway Inflammation 

  Yang, Shuangshuang (2020-08)

  Airway inflammation is the most common and important component of respiratory diseases, such as influenza and asthma. Severe influenza A virus infection typically triggers detrimental lung inflammation with massive immune ...
• Exploring the Bacterial Diversity of the Male Urethra During Idiopathic Urethritis 

  Farrell, Rowan Micah (2020-08)

  Idiopathic urethritis (IU) comprises up to 50% of symptomatic cases of male urethritis in clinical settings. The syndrome is of an unknown etiology but may be due to an as yet unidentified bacterial pathogen(s). We were ...
• Investigating the Function and Therapeutic Potential of the GCN5b Bromodomain in Toxoplasma Gondii 

  Hanquier, Jocelyne Nicole (2020-06)

  The obligate intracellular protozoan parasite Toxoplasma gondii is a medically relevant pathogen that has infected a third of the world’s population. Toxoplasma is the causative agent of toxoplasmosis, which can have severe ...
• The Role of Osteomacs in Regulating Stem Cell Function and the Hematopoietic Niche 

  Mohamad, Safa F. (2020-02)

  Maintenance of hematopoietic stem cell (HSC) function is an orchestrated event requiring the participation of multiple cell types within the hematopoietic niche. Among the key cellular components of the niche are a group ...
• Guanabenz Reduces Hyperactivity and Neuroinflammation Caused by Latent Toxoplasmosis in Mice 

  Martynowicz, Jennifer Marie (2020-02)

  Toxoplasma gondii is an intracellular parasite that causes persistent, lifelong infection in one-third of humans worldwide. The parasite converts from a lytic, actively replicating form (tachyzoite) into a latent tissue ...
• Inhibiting Glycolysis Enhances T Follicular Helper Cell Differentiation and Survival upon Human Immunodeficiency Virus Infection 

  Rane, Sushmita Shirish (2020-01)

  Human immunodeficiency virus (HIV) primarily infects T helper (Th) cells. Decrease in the number of Th cells is the hallmark of HIV infection. Latent reservoirs of human immunodeficiency virus (HIV) are the leading barrier ...
• Biological Functions of Intracellular Hepatitis B e Antigen 

  Mitra, Bidisha (2019-09)

  The function(s) of the intracellular form of HBeAg, previously reported as the preCore protein intermediate (p22) without the N-terminal signal peptide, remains elusive. Here, we propose to elucidate the translocation ...
• Identifying Factors Controlling Cell Shape and Virulence Gene Expression in Borrelia Burgdorferi 

  Grothe, Amberly Nicole (2019-08)

  Lyme disease is a multi-system inflammatory disorder that is currently the fastest growing arthropod-borne disease in the United States. The Lyme disease pathogen, Borrelia burgdorferi, exists within an enzootic cycle ...
• T Follicular Regulatory Cells Promote the Germinal Center Reaction and Allergic IgE Response While Repressing Abnormal Differentiation of T Follicular Helper Cells 

  Xie, Ming (2019-05)

  Follicular T helper (TFH) and regulatory (TFR) cells are two key classes of CD4+ T cells found in germinal centers (GCs). The primary role of TFH cells is to help B cells form GCs to produce high-affinity antibodies during ...
• Vaccina Virus Binding and Infection of Primary Human B Cells 

  Shepherd, Nicole Elizabeth (2018-12)

  Vaccinia virus (VACV), the prototypical poxvirus, was used to eradicate smallpox worldwide and, in recent years, has received considerable attention as a vector for the development of vaccines against infectious diseases ...
• DEK Protein as a Potential Radio-protective Agent for Hematopoietic Stem Cells (HSCs) and Hematopoietic Progenitor Cells (HPCs) in Mice 

  Sharma, Itee (2018-07-26)

  Studies performed by our lab have investigated the potential radioprotective effect of rDEK protein. Although roles played by DEK in cell differentiation, DNA repair, DNA binding, chromatin regulating and different ...
• Transcription factors and cis-acting elements in T helper cell cytokine expression 

  Koh, Byunghee (2017-12-15)

  The immune system provides resistance to the myriad of pathogens in the environment, but can also respond inappropriately causing allergic inflammation and autoimmune disease. CD4+ T cells, which play a crucial role in ...
• ST2/MYD88 signaling is a therapeutic target alleviating murine acute graft-versus-host disease sparing T regulatory cell function 

  Griesenauer, Brad (2018-01-10)

  Acute graft-versus-host disease (aGVHD) hinders the efficacy of allogeneic hematopoietic cell transplantation (HCT). Plasma levels of soluble serum stimulation-2 (sST2) are elevated during human and murine aGVHD and are ...
• Recruitment and function of ORP1L on the Coxiella burnetii parasitophorous vacuole 

  Justis, Anna Victoria (2017-12-07)

  Coxiella burnetii, the zoonotic agent of human Q fever and chronic endocarditis, is an obligate intracellular bacterial pathogen. The Coxiella intracellular niche, a large, lysosome-like parasitophorous vacuole (PV), is ...
• Investigating the presence of Pfkelch gene mutations in Ugandan children with severe malaria 

  Gopinadhan, Adnan (2017)

  Artemisinin resistance was first observed in Southeast Asia (SEA) and could pose a threat to malaria treatment all over the world. Recently mutations in the propeller region of Pfkelch13 gene have been used as a genetic ...

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