• The Role of Osteomacs in Regulating Stem Cell Function and the Hematopoietic Niche 

  Mohamad, Safa F. (2020-02)

  Maintenance of hematopoietic stem cell (HSC) function is an orchestrated event requiring the participation of multiple cell types within the hematopoietic niche. Among the key cellular components of the niche are a group ...
• Guanabenz Reduces Hyperactivity and Neuroinflammation Caused by Latent Toxoplasmosis in Mice 

  Martynowicz, Jennifer Marie (2020-02)

  Toxoplasma gondii is an intracellular parasite that causes persistent, lifelong infection in one-third of humans worldwide. The parasite converts from a lytic, actively replicating form (tachyzoite) into a latent tissue ...
• Inhibiting Glycolysis Enhances T Follicular Helper Cell Differentiation and Survival upon Human Immunodeficiency Virus Infection 

  Rane, Sushmita Shirish (2020-01)

  Human immunodeficiency virus (HIV) primarily infects T helper (Th) cells. Decrease in the number of Th cells is the hallmark of HIV infection. Latent reservoirs of human immunodeficiency virus (HIV) are the leading barrier ...
• Biological Functions of Intracellular Hepatitis B e Antigen 

  Mitra, Bidisha (2019-09)

  The function(s) of the intracellular form of HBeAg, previously reported as the preCore protein intermediate (p22) without the N-terminal signal peptide, remains elusive. Here, we propose to elucidate the translocation ...
• Identifying Factors Controlling Cell Shape and Virulence Gene Expression in Borrelia Burgdorferi 

  Grothe, Amberly Nicole (2019-08)

  Lyme disease is a multi-system inflammatory disorder that is currently the fastest growing arthropod-borne disease in the United States. The Lyme disease pathogen, Borrelia burgdorferi, exists within an enzootic cycle ...
• T Follicular Regulatory Cells Promote the Germinal Center Reaction and Allergic IgE Response While Repressing Abnormal Differentiation of T Follicular Helper Cells 

  Xie, Ming (2019-05)

  Follicular T helper (TFH) and regulatory (TFR) cells are two key classes of CD4+ T cells found in germinal centers (GCs). The primary role of TFH cells is to help B cells form GCs to produce high-affinity antibodies during ...
• Vaccina Virus Binding and Infection of Primary Human B Cells 

  Shepherd, Nicole Elizabeth (2018-12)

  Vaccinia virus (VACV), the prototypical poxvirus, was used to eradicate smallpox worldwide and, in recent years, has received considerable attention as a vector for the development of vaccines against infectious diseases ...
• DEK Protein as a Potential Radio-protective Agent for Hematopoietic Stem Cells (HSCs) and Hematopoietic Progenitor Cells (HPCs) in Mice 

  Sharma, Itee (2018-07-26)

  Studies performed by our lab have investigated the potential radioprotective effect of rDEK protein. Although roles played by DEK in cell differentiation, DNA repair, DNA binding, chromatin regulating and different ...
• Transcription factors and cis-acting elements in T helper cell cytokine expression 

  Koh, Byunghee (2017-12-15)

  The immune system provides resistance to the myriad of pathogens in the environment, but can also respond inappropriately causing allergic inflammation and autoimmune disease. CD4+ T cells, which play a crucial role in ...
• ST2/MYD88 signaling is a therapeutic target alleviating murine acute graft-versus-host disease sparing T regulatory cell function 

  Griesenauer, Brad (2018-01-10)

  Acute graft-versus-host disease (aGVHD) hinders the efficacy of allogeneic hematopoietic cell transplantation (HCT). Plasma levels of soluble serum stimulation-2 (sST2) are elevated during human and murine aGVHD and are ...
• Recruitment and function of ORP1L on the Coxiella burnetii parasitophorous vacuole 

  Justis, Anna Victoria (2017-12-07)

  Coxiella burnetii, the zoonotic agent of human Q fever and chronic endocarditis, is an obligate intracellular bacterial pathogen. The Coxiella intracellular niche, a large, lysosome-like parasitophorous vacuole (PV), is ...
• Investigating the presence of Pfkelch gene mutations in Ugandan children with severe malaria 

  Gopinadhan, Adnan (2017)

  Artemisinin resistance was first observed in Southeast Asia (SEA) and could pose a threat to malaria treatment all over the world. Recently mutations in the propeller region of Pfkelch13 gene have been used as a genetic ...
• Leukotriene B4 levels determine staphylococcus aureus skin infection outcome 

  Brandt, Stephanie Lillian (2017-08-18)

  Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of severe skin infections and due to antibiotic resistance there is an intrinsic need to develop new immunotherapeutic strategies. Skin immune responses ...
• HPV replication regulation by acetylation of a conserved lysine in the E2 protein 

  Thomas, Yanique Serge Gillana (2017-06-26)

  Papillomaviruses (PVs) are non-enveloped DNA viruses that are the primary etiological agents of cervical and oropharyngeal cancers. Vaccines for H(human)PV have proven to be effective prophylactic treatments; however, ...
• Generation of conditional mutants to dissect essential gene fuction in chlamydia trachomatis 

  Brothwell, Julie Ann (2016-12-07)

  Chlamydia trachomatis is the leading cause of bacterial sexually transmitted disease. Chlamydia spp. are all obligate intracellular organisms that undergo a biphasic developmental cycle within a vacuole termed the ...
• PARP14 in allergic inflammation 

  Krishnamurthy, Purna (2017-01-13)

  Allergic inflammation is a result of damaging immune responses stimulated by innocuous proteins and is mediated by a complex interplay between inflammatory cells including eosinophils, basophils, neutrophils, mast ...
• The identification and characterization of novel persistence genes in chlamydia trachomatis 

  Muramatsu, Matthew Kazuyuki (2016-11-30)

  Chlamydia trachomatis is an obligate intracellular bacterial pathogen that can infect the eyes, genital tract, and disseminate to lymph nodes in humans. Many C. trachomatis infections are clinically asymptomatic and ...
• MIR193BHG: a novel hypoxia-inducible long noncoding RNA involved in the fine-tuning of cholesterol metabolism 

  Wu, Xue (2016-09-22)

  The human genome generates a vast number of functionally and structurally diverse noncoding transcripts, incorporated into complex networks which modulate the activity of classic pathways. Long noncoding RNAs (lncRNA) have ...
• Role of STAT3 and SDF-1/CXCL 12 in mitochondrial function in hematopoietic stem and progenitor cells 

  Messina-Graham, Steven V. (2016-08-10)

  Mitochondria are the major ATP producing source within cells. There is increasing data supporting a direct involvement of mitochondria and mitochondrial function in regulating stem cell pluripotency. Mitochondria have also ...
• Heat shock protein 90, a potential biomarker for type I diabetes: mechanisms of release from pancreatic beta cells 

  Ocaña, Gail Jean (2016-05-23)

  Heat shock protein (HSP) 90 is a molecular chaperone that regulates diverse cellular processes by facilitating activities of various protein clients. Recent studies have shown serum levels of the alpha cytoplasmic HSP90 ...

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