• Transcription factors and cis-acting elements in T helper cell cytokine expression 

  Koh, Byunghee (2017-12-15)

  The immune system provides resistance to the myriad of pathogens in the environment, but can also respond inappropriately causing allergic inflammation and autoimmune disease. CD4+ T cells, which play a crucial role in ...
• ST2/MYD88 signaling is a therapeutic target alleviating murine acute graft-versus-host disease sparing T regulatory cell function 

  Griesenauer, Brad (2018-01-10)

  Acute graft-versus-host disease (aGVHD) hinders the efficacy of allogeneic hematopoietic cell transplantation (HCT). Plasma levels of soluble serum stimulation-2 (sST2) are elevated during human and murine aGVHD and are ...
• Recruitment and function of ORP1L on the Coxiella burnetii parasitophorous vacuole 

  Justis, Anna Victoria (2017-12-07)

  Coxiella burnetii, the zoonotic agent of human Q fever and chronic endocarditis, is an obligate intracellular bacterial pathogen. The Coxiella intracellular niche, a large, lysosome-like parasitophorous vacuole (PV), is ...
• Investigating the presence of Pfkelch gene mutations in Ugandan children with severe malaria 

  Gopinadhan, Adnan (2017)

  Artemisinin resistance was first observed in Southeast Asia (SEA) and could pose a threat to malaria treatment all over the world. Recently mutations in the propeller region of Pfkelch13 gene have been used as a genetic ...
• HPV replication regulation by acetylation of a conserved lysine in the E2 protein 

  Thomas, Yanique Serge Gillana (2017-06-26)

  Papillomaviruses (PVs) are non-enveloped DNA viruses that are the primary etiological agents of cervical and oropharyngeal cancers. Vaccines for H(human)PV have proven to be effective prophylactic treatments; however, ...
• Leukotriene B4 levels determine staphylococcus aureus skin infection outcome 

  Brandt, Stephanie Lillian (2017-08-18)

  Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of severe skin infections and due to antibiotic resistance there is an intrinsic need to develop new immunotherapeutic strategies. Skin immune responses ...
• Generation of conditional mutants to dissect essential gene fuction in chlamydia trachomatis 

  Brothwell, Julie Ann (2016-12-07)

  Chlamydia trachomatis is the leading cause of bacterial sexually transmitted disease. Chlamydia spp. are all obligate intracellular organisms that undergo a biphasic developmental cycle within a vacuole termed the ...
• PARP14 in allergic inflammation 

  Krishnamurthy, Purna (2017-01-13)

  Allergic inflammation is a result of damaging immune responses stimulated by innocuous proteins and is mediated by a complex interplay between inflammatory cells including eosinophils, basophils, neutrophils, mast ...
• The identification and characterization of novel persistence genes in chlamydia trachomatis 

  Muramatsu, Matthew Kazuyuki (2016-11-30)

  Chlamydia trachomatis is an obligate intracellular bacterial pathogen that can infect the eyes, genital tract, and disseminate to lymph nodes in humans. Many C. trachomatis infections are clinically asymptomatic and ...
• MIR193BHG: a novel hypoxia-inducible long noncoding RNA involved in the fine-tuning of cholesterol metabolism 

  Wu, Xue (2016-09-22)

  The human genome generates a vast number of functionally and structurally diverse noncoding transcripts, incorporated into complex networks which modulate the activity of classic pathways. Long noncoding RNAs (lncRNA) have ...
• Role of STAT3 and SDF-1/CXCL 12 in mitochondrial function in hematopoietic stem and progenitor cells 

  Messina-Graham, Steven V. (2016-08-10)

  Mitochondria are the major ATP producing source within cells. There is increasing data supporting a direct involvement of mitochondria and mitochondrial function in regulating stem cell pluripotency. Mitochondria have also ...
• Heat shock protein 90, a potential biomarker for type I diabetes: mechanisms of release from pancreatic beta cells 

  Ocaña, Gail Jean (2016-05-23)

  Heat shock protein (HSP) 90 is a molecular chaperone that regulates diverse cellular processes by facilitating activities of various protein clients. Recent studies have shown serum levels of the alpha cytoplasmic HSP90 ...
• Regulation of the germinal center reaction by T helper cells and T regulatory cells 

  Wu, Hao (2016-04-11)

  Germinal Centers (GCs) are transient lymphoid structures that arise in lymphoid organs in response to T cell-dependent antigen. Within the GC, follicular T helper (TFH) cells promote GC B cell differentiation and in turn ...
• CD166 modulates disease progression and osteolytic disease in multiple myeloma 

  Xu, Linlin (2016-03-16)

  Multiple myeloma (MM) is an incurable malignancy characterized by the proliferation of neoplastic plasma cells in the bone marrow (BM) and by multiple osteolytic lesions throughout the skeleton. We previously reported that ...
• Role of S6K1 in regulating self-renewal of hematopoietic stem cells and propagatoin of leukemia 

  Ghosh, Joydeep (2015-12-15)

  The development and function of hematopoietic stem cells (HSCs) is regulated by numerous signaling pathways including Akt-mechanistic target of rapamycin complex1 (mTORC1) pathway. Dysregulation of this pathway results in ...
• Phosphoethanolamine transferases in Haemophilus ducreyi modify lipid A and contribute to human defensin resistance 

  Trombley, Michael P. (2015-04)

  Haemophilus ducreyi resists the cytotoxic effects of human antimicrobial peptides (APs), including α-defensins, β-defensins, and the cathelicidin LL-37. Resistance to LL-37, mediated by the sensitive to antimicrobial ...
• HIF-1α regulates CD55 expression in airway epithelium 

  Pandya, Pankita Hemant (2015-06-08)

  Rationale: CD55 down-regulation on airway epithelium correlates with local complement activation observed in hypoxia-associated pulmonary diseases. Therefore, we hypothesized that induction of hypoxia inducible factor 1 ...
• The stimulatory role of ICOS in the development of CD146+CCR5+ T cells co-expressing IFN-γ and IL-17 during graft-versus-host disease 

  Liu, Liangyi (2015)

  Graft-versus-host disease (GVHD) remains the major complication after allogeneic hematopoietic stem cell transplantation (HSCT), resulting from immunological attack on target organs such as gastrointestinal (GI) tract, ...
• Relative contributions of the stringent response mediators (p)ppGpp and DksA to Haemophilus ducreyi virulence in humans 

  Holley, Concerta Leigh (2015-06-17)

  Haemophilus ducreyi causes chancroid, a sexually transmitted genital ulcerative disease that facilitates the transmission of HIV-1. H. ducreyi also causes non-sexually transmitted cutaneous ulcers in children in tropical ...
• Regulation of papillomavirus E2 protein by posttranslational modification 

  Culleton, Sara Poirier (2015-04-24)

  Papillomaviruses (PVs) are small, double-stranded DNA viruses. Hundreds of species have evolved to replicate in mammals, birds, and reptiles. Approximately two hundred species are estimated to infect humans alone, and these ...

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