Alzheimer's disease genetic risk variants beyond APOE ε4 predict mortality
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2017-08-24
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American English
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Elsevier
Abstract
• A genetic risk score from 21 non-APOE late-onset Alzheimer's disease risk variants predicts mortality.
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The genetic risk score likely confers risk for mortality through its effect on dementia incidence.
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Late-onset Alzheimer's disease risk loci effect estimates from genome-wide association unlikely suffer from selection bias.
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APOE, Adult Changes in Thought (ACT), Alzheimer's disease, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), Collider stratification bias, Genetic risk score, enome-wide association study (GWAS), Health and Retirement Study (HRS), Longevity, Mortality, Selection bias, Survival analysis, Survivor bias
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Cite As
Mez, J., Marden, J. R., Mukherjee, S., Walter, S., Gibbons, L. E., Gross, A. L., … Glymour, M. M. (2017). Alzheimer’s disease genetic risk variants beyond APOE ε4 predict mortality. Alzheimer’s & Dementia : Diagnosis, Assessment & Disease Monitoring, 8, 188–195. https://doi.org/10.1016/j.dadm.2017.07.002
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2352-8729
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Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
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PMC
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Final published version