This study explores the factors that influence the data reuse behaviors of scientists and identifies the generalized patterns that occur in data reuse across various disciplines. This research employed an integrated theoretical framework combining institutional theory and the theory of planned behavior. The combined theoretical framework can apply the institutional theory at the individual level and extend the theory of planned behavior by including relevant contexts. This study utilized a survey method to test the proposed research model and hypotheses. Study participants were recruited from the Community of Science’s (CoS) Scholar Database, and a total of 1,528 scientists responded to the survey. A multilevel analysis method was used to analyze the 1,237 qualified responses. This research showed that scientists’ data reuse intentions are influenced by both disciplinary level factors (availability of data repositories) and individual level factors (perceived usefulness, perceived concern, and the availability of internal resources). This study has practical implications for promoting data reuse practices. Three main areas that need to be improved are identified: Educating scientists, providing internal supports, and providing external resources and supports such as data repositories.