The molecular architecture of amyloids formed in vivo can be interrogated using luminescent conjugated oligothiophenes (LCOs), a unique class of amyloid dyes. When bound to amyloid, LCOs yield fluorescence emission spectra ...

Current and future supercomputers have tens of thousands of compute nodes interconnected with high-dimensional networks and complex network topologies for improved performance. Application developers are required to write ...

Visualizations of data provide a proven method for analysts to explore and make data-driven discoveries. However, current visualization tools provide only limited support for hypothesis-driven analyses, and often lack ...

Disruption of the Gys2 gene encoding the liver isoform of glycogen synthase generates a mouse strain (LGSKO) that almost completely lacks hepatic glycogen, has impaired glucose disposal, and is pre-disposed to entering the ...

Background: Fluconazole (FLZ) is a drug commonly used for the treatment of Candida infections. However, β-glucans in the extracellular matrices (ECMs) hinder FLZ penetration into Candida biofilms, while extracellular DNA ...

A fundamental question in evolutionary biology is how developmental processes are modified to produce morphological innovations while abiding by functional constraints. Here we address this question by investigating the ...

In the current research, we explored whether informing women about gender bias in science, technology, engineering, and mathematics (STEM) would enhance their identification with a female scientist and whether this increased ...

AbstractBob Fosse directedLenny (1974), about the profane American comedian Lenny Bruce, who died in 1966, at a time when he had won complete artistic control over his films. As an intermedial artist, with equal facility ...

A novel Suzuki-Miyaura protocol is described that enables the exhaustive alkylation of polychlorinated pyridines. This method facilitates a formal synthesis of normuscopyridine and the rapid assembly of a dumbbell shaped ...