IUPUIScholarWorks: Recent submissions

  • Both MisR (CpxR) and MisS (CpxA) Are Required for Neisseria gonorrhoeae Infection in a Murine Model of Lower Genital Tract Infection 
    Gangaiah, Dharanesh; Raterman, Erica L.; Wu, Hong; Fortney, Kate R.; Gao, Hongyu; Liu, Yunlong; Jerse, Ann E.; Spinola, Stanley M. (American Society for Microbiology, 2017-08-18)
    During infection, Neisseria gonorrhoeae senses and responds to stress; such responses may be modulated by MisRS (NGO0177 and NGO0176), a two-component system that is a homolog of CpxRA. In Escherichia coli, CpxRA senses ...
  • A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch 
    Ramsden, Christopher E.; Domenichiello, Anthony F.; Yuan, Zhi-Xin; Sapio, Matthew R.; Keyes, Gregory S.; Mishra, Santosh K.; Gross, Jacklyn R.; Majchrzak-Hong, Sharon; Zamora, Daisy; Horowitz, Mark S.; Davis, John M.; Sorokin, Alexander V.; Dey, Amit; LaPaglia, Danielle M.; Wheeler, Joshua J.; Vasko, Michael R.; Mehta, Nehal N.; Mannes, Andrew J.; Iadarola, Michael J. (American Association for the Advancement of Science, 2017-08-22)
    Chronic pain and itch are common hypersensitivity syndromes that are affected by endogenous mediators. We applied a systems-based, translational approach to predict, discover, and characterize mediators of pain and itch ...
  • Activation State-Dependent Substrate Gating in Ca2+/Calmodulin-Dependent Protein Kinase II 
    Johnson, D. E.; Hudmon, A. (Hindawi Publishing Corporation, 2017)
    Calcium/calmodulin-dependent protein kinase II (CaMKII) is highly concentrated in the brain where its activation by the Ca2+ sensor CaM, multivalent structure, and complex autoregulatory features make it an ideal translator ...
  • Mobile critical care recovery program (m-CCRP) for acute respiratory failure survivors: study protocol for a randomized controlled trial 
    Khan, Sikandar; Biju, Ashok; Wang, Sophia; Gao, Sujuan; Irfan, Omar; Harrawood, Amanda; Martinez, Stephanie; Brewer, Emily; Perkins, Anthony; Unverzagt, Frederick W.; Lasiter, Sue; Zarzaur, Ben; Rahman, Omar; Boustani, Malaz; Khan, Babar (BioMed Central, 2018-02-07)
    BACKGROUND: Patients admitted to intensive care units (ICU) with acute respiratory failure (ARF) face chronic complications that can impede return to normal daily function. A mobile, collaborative critical care model ...
  • Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria 
    Conroy, Andrea L.; Hawkes, Michael T.; Elphinstone, Robyn; Opoka, Robert O.; Namasopo, Sophie; Miller, Christopher; John, Chandy C.; Kain, Kevin C. (BioMed Central, 2018-02-15)
    BACKGROUND: Chitinase-3-like 1 (CHI3L1) is a glycoprotein elevated in paediatric severe malaria, and an emerging urinary biomarker of acute kidney injury (AKI). Based on the hypothesis that elevated CHI3L1 levels in ...
  • Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration 
    Taylor, Laura M.; McMillan, Pamela J.; Liachko, Nicole F.; Strovas, Timothy J.; Ghetti, Bernardino; Bird, Thomas D.; Keene, C. Dirk; Kraemer, Brian C. (BioMed Central, 2018-02-06)
    BACKGROUND: Progressive neuron loss in the frontal and temporal lobes of the cerebral cortex typifies frontotemporal lobar degeneration (FTLD). FTLD sub types are classified on the basis of neuronal aggregated protein ...
  • Laquinimod attenuates inflammation by modulating macrophage functions in traumatic brain injury mouse model 
    Katsumoto, Atsuko; Miranda, Aline S.; Butovsky, Oleg; Teixeira, Antônio L.; Ransohoff, Richard M.; Lamb, Bruce T. (BioMed Central, 2018-01-30)
    BACKGROUND: Traumatic brain injury (TBI) is a critical public health and socio-economic problem worldwide. A growing body of evidence supports the involvement of inflammatory events in TBI. It has been reported that ...
  • Randomized, Noncomparative, Phase II Trial of Early Switch From Docetaxel to Cabazitaxel or Vice Versa, With Integrated Biomarker Analysis, in Men With Chemotherapy-Naïve, Metastatic, Castration-Resistant Prostate Cancer 
    Antonarakis, Emmanuel S.; Tagawa, Scott T.; Galleti, Giuseppe; Worroll, Daniel; Ballman, Karla; Vanhuyse, Marie; Sonpavde, Guru; North, Scott; Albany, Costantine; Tsao, Che-Kai; Stewart, John; Zaher, Atef; Szatrowski, Ted; Zhou, Wei; Gjyrezi, Ada; Tasaki, Shinsuke; Portella, Luigi; Bai, Yang; Lannin, Timothy B.; Suri, Shalu; Gruber, Conor N.; Pratt, Erica D.; Kirby, Brian J.; Eisenberger, Mario A.; Nanus, David M.; Saad, Fred; Giannakakou, Paraskevi; TAXYNERGY Investigators (American Society of Clinical Oncology, 2017-10-01)
    Purpose The TAXYNERGY trial ( ClinicalTrials.gov identifier: NCT01718353) evaluated clinical benefit from early taxane switch and circulating tumor cell (CTC) biomarkers to interrogate mechanisms of sensitivity or resistance ...
  • Design and Rationale of a Randomized Trial of a Care Transition Strategy in Patients With Acute Heart Failure Discharged From the Emergency Department: GUIDED-HF (Get With the Guidelines in Emergency Department Patients With Heart Failure). 
    Fermann, Gregory J.; Levy, Phillip D.; Pang, Peter; Butler, Javed; Ayaz, S. Imran; Char, Douglas; Dunn, Pat; Jenkins, Cathy A.; Kampe, Christy; Khan, Yosef; Kumar, Vijaya A.; Lindenfeld, JoAnn; Liu, Dandan; Miller, Karen; Peacock, W. Frank; Rizk, Samaa; Robichaux, Chad; Rothman, Russell L.; Schrock, Jon; Singer, Adam; Sterling, Sarah A.; Storrow, Alan B.; Walsh, Cheryl; Wilburn, John; Collins, Sean P. (American Heart Association, 2017-02)
    GUIDED-HF (Get With the Guidelines in Emergency Department Patients With Heart Failure) is a multicenter randomized trial of a patient-centered transitional care intervention in patients with acute heart failure (AHF) who ...
  • In Vivo siRNA Delivery and Rebound of Renal LRP2 in Mice 
    Eadon, Michael T.; Cheng, Ying-Hua; Hato, Takashi; Benson, Eric A.; Ipe, Joseph; Collins, Kimberly S.; De Luca, Thomas; El-Achkar, Tarek M.; Bacallao, Robert L.; Skaar, Todd C.; Dagher, Pierre C. (Hindawi Publishing Corporation, 2017)
    siRNA stabilized for in vivo applications is filtered and reabsorbed in the renal proximal tubule (PT), reducing mRNA expression transiently. Prior siRNA efforts have successfully prevented upregulation of mRNA in response ...
  • Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer's disease 
    Casali, Brad T.; Reed-Geaghan, Erin G.; Landreth, Gary E. (BioMed Central, 2018-02-15)
    BACKGROUND: Alzheimer's disease (AD) is a highly prevalent neurodegenerative disorder characterized by pathological hallmarks of beta-amyloid plaque deposits, tau pathology, inflammation, and cognitive decline. Treatment ...
  • Role of Apamin-Sensitive Calcium-Activated Small-Conductance Potassium Currents on the Mechanisms of Ventricular Fibrillation in Pacing-Induced Failing Rabbit Hearts 
    Yin, Dechun; Hsieh, Yu-Cheng; Tsai, Wei-Chung; Wu, Adonis Zhi-Yang; Jiang, Zhaolei; Chan, Yi-Hsin; Xu, Dongzhu; Yang, Na; Shen, Changyu; Chen, Zhenhui; Lin, Shien-Fong; Chen, Peng-Sheng; Everett, Thomas H., IV (American Heart Association, 2017-02)
    BACKGROUND: Ventricular fibrillation (VF) during heart failure is characterized by stable reentrant spiral waves (rotors). Apamin-sensitive small-conductance calcium-activated potassium currents (IKAS) are heterogeneously ...
  • Country Report 2018: Italy 
    Rametta, Raffaella (2018)
    The Italian Constitution guarantees the fundamental freedoms of peaceful assembly (art. 17), association (art. 18), religion (art. 19), expression (art. 21), establishment of trade unions (art. 39) and establishment of ...
  • Practice Makes Perfect: The Rest of the Story in Testicular Cancer as a Model Curable Neoplasm 
    Tandstad, Torgrim; Kollmannsberger, Christian K.; Roth, Bruce J.; Jeldres, Claudio; Gillessen, Silke; Fizazi, Karim; Daneshmand, Siamak; Lowrance, William T.; Hanna, Nasser H.; Albany, Costantine; Foster, Richard; Cedermark, Gabriella Cohn; Feldman, Darren R.; Powles, Thomas; Lewis, Mark A.; Grimison, Peter Scott; Bank, Douglas; Porter, Christopher; Albers, Peter; De Santis, Maria; Srinivas, Sandy; Bosl, George J.; Nichols, Craig R. (American Society of Clinical Oncology, 2017-11-01)
  • Country Report 2018: Hungary 
    Hartay, Eszter (2018)
    The Hungarian legislation ensures the right to everyone to establish and join organizations and communities based on freedom of association. The two traditional legal forms of nonprofit organizations are the association ...
  • Country Report 2018: Ukraine 
    Vinnikov, Oleksandr (2018)
    Ukraine is a unitary republic, and the legal procedures for POs incorporation are the same in all its jurisdictions. Associations, religious organizations and endowments that are not legal entities are allowed in Ukraine. ...
  • Country Report 2018: Portugal 
    Marques, Ricardo André Mendonça (2018)
    There is freedom granted by the Constitution of the Portuguese Republic that safeguards fundamental rights and freedoms. Freedom of Association is recognized in Article 46 of the Constitution provided such associations are ...
  • Country Report 2018: Slovakia 
    Strečanský, Boris (2018)
    The Constitution of the Slovak Republic guarantees the “right to associate with others in clubs, societies, or other associations” Article 29 (1) of the Consitution of the Slovak Republic, and in general, individuals can ...
  • Country Report 2018: Poland 
    Arczewska, Magdalena (2018)
    Polish law permits individuals to act collectively through unregistered groups or organizations. Article 12 of the Constitution of the Republic of Poland from 1997 provides that “The Republic of Poland shall ensure freedom ...
  • Country Report 2018: Bulgaria 
    Panov, Luben (2018)
    The Bulgarian Constitution guarantees freedom of association, and the Law on Legal Entities with Nonprofit Purposes (NGO Law) provides that both Bulgarian and foreign legal entities and individuals with legal capacity can ...