• Psoriasiform Hailey-Hailey Disease Presenting as Erythematous Psoriasiform Plaques Throughout the Body: A Case Report 

  Ni, Jonathan; Gilbert, Kathleen E.; Manalo, Ivie F.; Wu, Jashin J. (Permanente Press, 2017)

  INTRODUCTION: Hailey-Hailey disease is an adult-onset skin condition characterized by lesions in the intertriginous regions of the body. The lesions can be pruritic, painful, and associated with physical and social ...
• How the discovery of ISS-N1 led to the first medical therapy for spinal muscular atrophy 

  Singh, Natalia N.; Howell, Matthew D.; Androphy, Elliot J.; Singh, Ravindra N. (Nature Publishing group, 2017-09)

  Spinal muscular atrophy (SMA), a prominent genetic disease of infant mortality, is caused by low levels of survival motor neuron (SMN) protein owing to deletions or mutations of the SMN1 gene. SMN2, a nearly identical copy ...
• How Wounding via Lasers Has Potential Photocarcinogenic Preventative Effects via Dermal Remodeling 

  Krbanjevic, Aleksandar; Travers, Jeffrey B.; Spandau, Dan F (Springer Verlag, 2016-09)

  As the incidence of non-melanoma skin cancer (NMSC) is increasing, there is a growing need to identify effective preventive strategies. A recently proposed hypothesis states that NMSC photocarcinogenesis is tightly linked ...
• Insulin‐like growth factor‐1 receptor regulates repair of ultraviolet B‐induced DNA damage in human keratinocytes in vivo 

  Loesch, Mathew M.; Collier, Ann E.; Southern, David H.; Ward, Rachel E.; Tholpady, Sunil S.; Lewis, Davina A.; Travers, Jeffrey B.; Spandau, Dan F. (Wiley, 2016-10)

  The activation status of the insulin‐like growth factor‐1 receptor (IGF‐1R) regulates the cellular response of keratinocytes to ultraviolet B (UVB) exposure, both in vitro and in vivo. Geriatric skin is deficient in IGF‐1 ...
• Diseases of the lips 

  Greenberg, Sophie A.; Schlosser, Bethanee J.; Mirowski, Ginat W. (Elsevier, 2017-10)

  Heath care providers should be comfortable with normal as well as pathologic findings in the lips, because the lips are highly visible and may display clinical manifestations of local, as well as systemic inflammatory, ...
• Optimization of a series of heterocycles as survival motor neuron gene transcription enhancers 

  Choi, Sungwoon; Calder, Alyssa N.; Miller, Eliza H.; Anderson, Kierstyn P.; Fiejtek, Dawid K.; Rietz, Anne; Li, Hongxia; Cherry, Jonathan J.; Quist, Kevin M.; Xing, Xuechao; Glicksman, Marcie A.; Cuny, Gregory D.; Lorson, Christian L.; Androphy, Elliot A.; Hodgetts, Kevin J. (Elsevier, 2017-12)

  Spinal muscular atrophy (SMA) is a neurodegenerative disorder that results from mutations in the SMN1 gene, leading to survival motor neuron (SMN) protein deficiency. One therapeutic strategy for SMA is to identify compounds ...
• Molecular advancements in the development of thermostable phytases 

  Rebello, Sharrel; Jose, Leny; Sindhu, Raveendran; Aneesh, Embalil Mathachan (Springer, 2017-04)

  Since the discovery of phytic acid in 1903 and phytase in 1907, extensive research has been carried out in the field of phytases, the phytic acid degradatory enzymes. Apart from forming backbone enzyme in the multimillion ...
• Capecitabine-induced lichenoid drug eruption: a case report 

  Gehlhausen, Jeff R.; Strausburg, Matthew B.; Aouthmany, Mouhammad; Katona, Terrence M.; Turner, Matthew J. (University of California, 2017)

  Capecitabine is a 5-fluorouracil basedchemotherapeutic drug widely used in the treatmentof solid tumors, especially colorectal and breast. Someof the most common side effects of capecitabine arecutaneous in nature, including ...
• Multifocal Rosai-Dorfman disease with involvement of the pinna 

  Hirt, Molly B.; Heskett, Jordan; Veerula, Vindhya; Warren, Simon; Avashia-Khemka, Nidhi; Mark, Lawrence A. (Elsevier, 2017-05)
• Epithelioid Malignant Mesothelioma Metastatic to the Skin: A Case Report and Review of the Literature 

  Ward, Rachel Elizabeth; Ali, Stefanie Ann; Kuhar, Matthew (Wiley, 2017)

  Malignant mesothelioma (MM) is an aggressive and invasive neoplasm primarily affecting the pleura, peritoneum and pericardium. While mesothelioma commonly metastasizes to visceral organs, it has rarely been documented to ...
• Small Molecules in Development for the Treatment of Spinal Muscular Atrophy 

  Calder, Alyssa N.; Androphy, Elliot J.; Hodgetts, Kevin J. (ACS, 2016-08)

  Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease resulting from pathologically low levels of survival motor neuron (SMN) protein. The majority of mRNA from the SMN2 allele undergoes alternative ...
• Peters anomaly in PHACE syndrome 

  Shabeeb, Nadine M.; Plager, David A.; Haggstrom, Anita N. (Elsevier, 2017-08)

  PHACE syndrome is a rare neurocutaneous disorder, with a complex pathogenesis. It presents with a large facial hemangioma associated with anomalies of the posterior fossa of the brain, arterial anomalies, cardiac anomalies, ...
• Altered mRNA Splicing in SMN-Depleted Motor Neuron-Like Cells 

  Custer, Sara K.; Gilson, Timra D.; Li, Hongxia; Todd, A. Gary; Astroski, Jacob W.; Lin, Hai; Liu, Yunlong; Androphy, Elliot J. (Public Library of Science (PLoS), 2016)

  Spinal muscular atrophy (SMA) is an intractable neurodegenerative disease afflicting 1 in 6-10,000 live births. One of the key functions of the SMN protein is regulation of spliceosome assembly. Reduced levels of the SMN ...
• A PGC1β genetic variant associated with nevus count and melanoma mortality 

  Li, Xin; Liu, Hongliang; Amos, Christopher I.; Lee, Jeffrey E.; Thomas, Nancy E.; Wei, Qingyi; Han, Jiali (Wiley, 2017-08)
• Rosacea Fulminans Precipitated by Acute Stress: A Case Report Describing an Integrative Approach for a Patient Reluctant to Use Isotretinoin 

  Veerkamp, Patrick; Mousdicas, Nico; Bednarek, Robert (InnoVision Health Media, 2016-12)

  CONTEXT: Rosacea fulminans is a rare skin disorder with a multifactorial etiology. Stress is one of the common precipitating factors of this condition but is not often targeted in treatment. Isotretinoin is considered ...
• Human keratinocyte differentiation requires translational control by the eIF2α kinase GCN2 

  Collier, Ann E.; Wek, Ronald C.; Spandau, Dan F. (Elsevier, 2017)

  Appropriate and sequential differentiation of keratinocytes is essential for all functions of the human epidermis. While transcriptional regulation has proven to be important for keratinocyte differentiation, little is ...
• α-COP binding to the survival motor neuron protein SMN is required for neuronal process outgrowth 

  Li, Hongxia; Custer, Sara K.; Gilson, Timra; Hao, Le Thi; Beattie, Christine E.; Androphy, Elliot J. (Oxford University Press, 2015-12-20)

  Spinal muscular atrophy (SMA), a heritable neurodegenerative disease, results from insufficient levels of the survival motor neuron (SMN) protein. α-COP binds to SMN, linking the COPI vesicular transport pathway to SMA. ...
• Radiation therapy generates platelet-activating factor agonists 

  Sahu, Ravi P.; Harrison, Kathleen A.; Weyerbacher, Jonathan; Murphy, Robert C.; Konger, Raymond L.; Garrett, Joy Elizabeth; Chin-Sinex, Helen Jan; Johnston II., Michael Edward; Dynlacht, Joseph R.; Mendonca, Marc; McMullen, Kevin; Li, Gengxin; Spandau, Dan F.; Travers, Jeffrey B. (Impact Journals, 2016-04-12)

  Pro-oxidative stressors can suppress host immunity due to their ability to generate oxidized lipid agonists of the platelet-activating factor-receptor (PAF-R). As radiation therapy also induces reactive oxygen species, the ...
• Cross-generational impact of a male murine pheromone 2-sec-butyl-4,5- dihydrothiazole in female mice 

  Koyama, Sachiko; Soini, Helena A.; Wager-Miller, James; Alley, William R.; Pizzo, Matthew J.; Rodda, Cathleen; Alberts, Jeffrey; Crystal, Jonathon D.; Lai, Cary; Foley, John; Novotny, Milos V. (The Royal Society, 2015-07-22)

  The current understanding of the activity of mammalian pheromones is that endocrine and behavioural effects are limited to the exposed individuals. Here, we demonstrate that the nasal exposure of female mice to a male ...
• Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor 

  Sahu, Ravi P.; Ocana, Jesus A.; Harrison, Kathleen A.; Ferracini, Matheus; Touloukian, Christopher E.; Al-Hassani, Mohammed; Sun, Louis; Loesch, Mathew; Murphy, Robert C.; Althouse, Sandra K.; Perkins, Susan M.; Speicher, Paul J.; Tyler, Douglas S.; Konger, Raymond L.; Travers, Jeffrey B. (American Association for Cancer Research, 2014-12-01)

  Oxidative stress suppresses host immunity by generating oxidized lipid agonists of the platelet-activating factor receptor (PAF-R). Because many classical chemotherapeutic drugs induce reactive oxygen species (ROS), we ...

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