• Multifocal Rosai-Dorfman disease with involvement of the pinna 

  Hirt, Molly B.; Heskett, Jordan; Veerula, Vindhya; Warren, Simon; Avashia-Khemka, Nidhi; Mark, Lawrence A. (Elsevier, 2017-05)
• Epithelioid Malignant Mesothelioma Metastatic to the Skin: A Case Report and Review of the Literature 

  Ward, Rachel Elizabeth; Ali, Stefanie Ann; Kuhar, Matthew (Wiley, 2017)

  Malignant mesothelioma (MM) is an aggressive and invasive neoplasm primarily affecting the pleura, peritoneum and pericardium. While mesothelioma commonly metastasizes to visceral organs, it has rarely been documented to ...
• Small Molecules in Development for the Treatment of Spinal Muscular Atrophy 

  Calder, Alyssa N.; Androphy, Elliot J.; Hodgetts, Kevin J. (ACS, 2016-08)

  Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease resulting from pathologically low levels of survival motor neuron (SMN) protein. The majority of mRNA from the SMN2 allele undergoes alternative ...
• Peters anomaly in PHACE syndrome 

  Shabeeb, Nadine M.; Plager, David A.; Haggstrom, Anita N. (Elsevier, 2017-08)

  PHACE syndrome is a rare neurocutaneous disorder, with a complex pathogenesis. It presents with a large facial hemangioma associated with anomalies of the posterior fossa of the brain, arterial anomalies, cardiac anomalies, ...
• Altered mRNA Splicing in SMN-Depleted Motor Neuron-Like Cells 

  Custer, Sara K.; Gilson, Timra D.; Li, Hongxia; Todd, A. Gary; Astroski, Jacob W.; Lin, Hai; Liu, Yunlong; Androphy, Elliot J. (Public Library of Science (PLoS), 2016)

  Spinal muscular atrophy (SMA) is an intractable neurodegenerative disease afflicting 1 in 6-10,000 live births. One of the key functions of the SMN protein is regulation of spliceosome assembly. Reduced levels of the SMN ...
• A PGC1β genetic variant associated with nevus count and melanoma mortality 

  Li, Xin; Liu, Hongliang; Amos, Christopher I.; Lee, Jeffrey E.; Thomas, Nancy E.; Wei, Qingyi; Han, Jiali (Wiley, 2017-08)
• Rosacea Fulminans Precipitated by Acute Stress: A Case Report Describing an Integrative Approach for a Patient Reluctant to Use Isotretinoin 

  Veerkamp, Patrick; Mousdicas, Nico; Bednarek, Robert (InnoVision Health Media, 2016-12)

  CONTEXT: Rosacea fulminans is a rare skin disorder with a multifactorial etiology. Stress is one of the common precipitating factors of this condition but is not often targeted in treatment. Isotretinoin is considered ...
• Human keratinocyte differentiation requires translational control by the eIF2α kinase GCN2 

  Collier, Ann E.; Wek, Ronald C.; Spandau, Dan F. (Elsevier, 2017)

  Appropriate and sequential differentiation of keratinocytes is essential for all functions of the human epidermis. While transcriptional regulation has proven to be important for keratinocyte differentiation, little is ...
• α-COP binding to the survival motor neuron protein SMN is required for neuronal process outgrowth 

  Li, Hongxia; Custer, Sara K.; Gilson, Timra; Hao, Le Thi; Beattie, Christine E.; Androphy, Elliot J. (Oxford University Press, 2015-12-20)

  Spinal muscular atrophy (SMA), a heritable neurodegenerative disease, results from insufficient levels of the survival motor neuron (SMN) protein. α-COP binds to SMN, linking the COPI vesicular transport pathway to SMA. ...
• Radiation therapy generates platelet-activating factor agonists 

  Sahu, Ravi P.; Harrison, Kathleen A.; Weyerbacher, Jonathan; Murphy, Robert C.; Konger, Raymond L.; Garrett, Joy Elizabeth; Chin-Sinex, Helen Jan; Johnston II., Michael Edward; Dynlacht, Joseph R.; Mendonca, Marc; McMullen, Kevin; Li, Gengxin; Spandau, Dan F.; Travers, Jeffrey B. (Impact Journals, 2016-04-12)

  Pro-oxidative stressors can suppress host immunity due to their ability to generate oxidized lipid agonists of the platelet-activating factor-receptor (PAF-R). As radiation therapy also induces reactive oxygen species, the ...
• Cross-generational impact of a male murine pheromone 2-sec-butyl-4,5- dihydrothiazole in female mice 

  Koyama, Sachiko; Soini, Helena A.; Wager-Miller, James; Alley, William R.; Pizzo, Matthew J.; Rodda, Cathleen; Alberts, Jeffrey; Crystal, Jonathon D.; Lai, Cary; Foley, John; Novotny, Milos V. (The Royal Society, 2015-07-22)

  The current understanding of the activity of mammalian pheromones is that endocrine and behavioural effects are limited to the exposed individuals. Here, we demonstrate that the nasal exposure of female mice to a male ...
• Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor 

  Sahu, Ravi P.; Ocana, Jesus A.; Harrison, Kathleen A.; Ferracini, Matheus; Touloukian, Christopher E.; Al-Hassani, Mohammed; Sun, Louis; Loesch, Mathew; Murphy, Robert C.; Althouse, Sandra K.; Perkins, Susan M.; Speicher, Paul J.; Tyler, Douglas S.; Konger, Raymond L.; Travers, Jeffrey B. (American Association for Cancer Research, 2014-12-01)

  Oxidative stress suppresses host immunity by generating oxidized lipid agonists of the platelet-activating factor receptor (PAF-R). Because many classical chemotherapeutic drugs induce reactive oxygen species (ROS), we ...
• Rice consumption and cancer incidence in US men and women 

  Zhang, Ran; Zhang, Xuehong; Wu, Kana; Wu, Hongyu; Sun, Qi; Hu, Frank B.; Han, Jiali; Willett, Walter C.; Giovannucci, Edward L. (Wiley Blackwell (John Wiley & Sons), 2016-02-01)

  While both the 2012 and 2014 Consumer Reports concerned arsenic levels in US rice, no previous study has evaluated long-term consumption of total rice, white rice and brown rice in relation to risk of developing cancers. ...
• The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2. 

  DeSmet, Marsha; Kanginakudru, Sriramana; Rietz, Anne; Wu, Wai-Hong; Roden, Richard; Androphy, Elliot J. (PLOS, 2016-10)

  The origin recognition complex (ORC) coordinates a series of events that lead to initiation of DNA strand duplication. As a nuclear double stranded DNA plasmid, the papillomavirus (PV) genome resembles a mini-chromosome ...
• Human papillomavirus oncogenic E6 protein regulates human β-defensin 3 (hBD3) expression via the tumor suppressor protein p53. 

  DasGupta, Twishasri; Nweze, Emeka I.; Yue, Hong; Wang, Liming; Jin, Jessica; Ghosh, Santosh K.; Kawsar, Hameem I.; Zender, Chad; Androphy, Elliot J.; Weinberg, Aaron; McCormick, Thomas S.; Jin, Ge (Impact Journals, 2016-05-10)

  Human β-defensin-3 (hBD3) is an epithelial cell-derived innate immune regulatory molecule overexpressed in oral dysplastic lesions and fosters a tumor-promoting microenvironment. Expression of hBD3 is induced by the ...
• Pediatric positional sitting dermatitis: a new form of pediatric contact dermatitis 

  Isaacs, Michael J.; Strausburg, Matthew B.; Mousdicas, Nico (Wiley, 2016-05)

  We report on four pediatric patients who presented with localized dermatitis in areas subject to repetitive friction due to their sitting positions. We propose that the cause of the eruption was irritant contact dermatitis ...
• Ferroxitosis: a cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma 

  Lakhter, Alexander J.; Hamilton, James; Dagher, Pierre C.; Mukkamala, Suresh; Hato, Takashi; Dong, X. Charlie; Mayo, Lindsey D.; Harris, Robert A.; Shekhar, Anantha; Ivan, Mircea; Brustovetsky, Nickolay; Naidu, Samisubbu R. (Impact Journals, LLC, 2014-12-30)

  Reliance on glycolysis is a characteristic of malignancy, yet the development of resistance to BRAF inhibitors in melanoma is associated with gain of mitochondrial function. Concurrent attenuation of oxidative phosphorylation ...
• Translational Repression Protects Human Keratinocytes from UVB-Induced Apoptosis through a Discordant eIF2 Kinase Stress Response 

  Collier, Ann E.; Wek, Ronald C.; Spandau, Dan F. (Nature Publishing Group, 2015-10)

  This study delineates the mechanisms by which UVB regulates protein synthesis in human keratinocytes and the importance of translational control in cell survival. Translation initiation is regulated by phosphorylation of ...
• Levels of the E2 interacting protein TopBP1 modulate papillomavirus maintenance stage replication 

  Kanginakudru, Sriramana; DeSmet, Marsha; Thomas, Yanique; Morgan, Iain M.; Androphy, Elliot J. (Elsevier, 2015-04)

  The evolutionarily conserved DNA topoisomerase II beta-binding protein 1 (TopBP1) functions in DNA replication, DNA damage response, and cell survival. We analyzed the role of TopBP1 in human and bovine papillomavirus ...
• Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility 

  Yin, Xianyong; Low, Hui Qi; Wang, Ling; Li, Yonghong; Ellinghaus, Eva; Han, Jiali; Estivill, Xavier; Sun, Liangdan; Zuo, Xianbo; Shen, Changbing; Zhu, Caihong; Zhang, Anping; Sanchez, Fabio; Padyukov, Leonid; Catanese, Joseph J.; Krueger, Gerald G.; Duffin, Kristina Callis; Mucha, Sören; Weichenthal, Michael; Weidinger, Stephan; Lieb, Wolfgang; Foo, Jia Nee; Li, Yi; Sim, Karseng; Liany, Herty; Irwan, Ishak; Teo, Yikying; Theng, Colin T. S.; Gupta, Rashmi; Bowcock, Anne; De Jager, Philip L.; Qureshi, Abrar A.; de Bakker, Paul I. W.; Seielstad, Mark; Liao, Wilson; Ståhle, Mona; Franke, Andre; Zhang, Xuejun; Liu, Jianjun (Nature Publishing Group, 2015-04-23)

  Psoriasis is a common inflammatory skin disease with complex genetics and different degrees of prevalence across ethnic populations. Here we present the largest trans-ethnic genome-wide meta-analysis (GWMA) of psoriasis ...

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