• A Multi-Objective Bayesian Networks Approach for Joint Prediction of Tumor Local Control and Radiation Pneumonitis in Non-Small-Cell Lung Cancer (NSCLC) for Response-Adapted Radiotherapy 

  Luo, Yi; McShan, Daniel L.; Matuszak, Martha M.; Ray, Dipankar; Lawrence, Thodore S.; Jolly, Shruti; Kong, Feng-Ming; Ten Haken, Randall K.; El Naqa, Issam (Wiley, 2018)

  Purpose Individualization of therapeutic outcomes in NSCLC radiotherapy is likely to be compromised by the lack of proper balance of biophysical factors affecting both tumor local control (LC) and side effects such as ...
• Challenges of dosimetry of ultra-short pulsed very high energy electron beams 

  Subiel, Anna; Moskvin, Vadim; Welsh, Gregor H.; Cipiccia, Silvia; Reboredo, David; DesRosiers, Colleen; Jaroszynski, Dino A. (Elsevier, 2017-10-01)

  Very high energy electrons (VHEE) in the range from 100 to 250MeV have the potential of becoming an alternative modality in radiotherapy because of their improved dosimetric properties compared with 6–20MV photons generated ...
• Survival and complications of stereotactic radiosurgery 

  Fetcko, Kaleigh; Lukas, Rimas V.; Watson, Gordon A.; Zhang, Lingjiao; Dey, Mahua (Lippincott, Williams & Wilkins, 2017-10-27)

  Background: Utilization of stereotactic radiosurgery (SRS) for treatment of high-grade gliomas (HGGs) has been slowly increasing with variable reported success rates. Objective: Systematic review of the available data ...
• Effect of Midtreatment PET/CT-Adapted Radiation Therapy With Concurrent Chemotherapy in Patients With Locally Advanced Non–Small-Cell Lung Cancer 

  Kong, Feng-Ming; Ten Haken, Randall K.; Schipper, Matthew; Frey, Kirk A.; Hayman, James; Gross, Milton; Ramnath, Nithya; Hassan, Khaled A.; Matuszak, Martha; Ritter, Timothy; Bi, Nan; Wang, Weili; Orringer, Mark; Cease, Kemp B.; Lawrence, Theodore S.; Kalemkerian, Gregory P. (American Medical Association, 2017-10-01)

  IMPORTANCE Our previous studies demonstrated that tumors significantly decrease in size and metabolic activity after delivery of 45 Gy of fractionated radiatiotherapy (RT), and that metabolic shrinkage is greater than ...
• Principal component analysis identifies patterns of cytokine expression in non-small cell lung cancer patients undergoing definitive radiation therapy 

  Ellsworth, Susannah G.; Rabatic, Bryan M.; Chen, Jie; Zhao, Jing; Campbell, Jeffrey; Wang, Weili; Pi, Wenhu; Stanton, Paul; Matuszak, Martha; Jolly, Shruti; Miller, Amy; Kong, Feng-Ming (PLOS, 2017-09-21)

  Background/Purpose Radiation treatment (RT) stimulates the release of many immunohumoral factors, complicating the identification of clinically significant cytokine expression patterns. This study used principal component ...
• Laser-plasma generated very high energy electrons (VHEEs) in radiotherapy 

  Kokurewicz, Karolina; Welsh, G. H.; Brunetti, E.; Wiggins, S. Mark; Boyd, M.; Sorensen, A.; Chalmers, A.; Schettino, G.; Subiel, Anna; DesRosiers, Colleen; Jaroszynski, Dino A. (SPIE, 2017-05)

  As an alternative modality to conventional radiotherapy, electrons with energies above 50 MeV penetrate deeply into tissue, where the dose can be absorbed within a tumour volume with a relatively small penumbra. We investigate ...
• Locoregional and systemic therapy for hepatocellular carcinoma 

  Gbolahan, Olumide B.; Beckley, Eric W.; LaRoche, Thomas P.; O’Neil, Bert H.; Pyko, Maximilian; Schacht, Michael A. (AME, 2017-04)

  The management of hepatocellular carcinoma (HCC) remains challenging due to late presentation and the presence of accompanying liver dysfunction. As such, most patients are not eligible for curative resection and liver ...
• Irradiated Human Endothelial Progenitor Cells Induce Bystander Killing in Human Non-Small Cell Lung and Pancreatic Cancer Cells 

  Turchan, William T.; Shapiro, Ronald H.; Sevigny, Garrett V.; Chin-Sinex, Helen; Pruden, Benjamin; Mendonca, Marc S. (Taylor and Francis, 2016-08)

  Purpose To investigate whether irradiated human endothelial progenitor cells (hEPCs) could induce bystander killing in the A549 non-small cell lung cancer (NSCLC) cells and help explain the improved radiation-induced tumor ...
• Circulating Antibodies to Linear Peptide Antigens Derived from ANXA1 and FOXP3 in Lung Cancer 

  Wang, Weili; Zhong, Wen; Chen, Cairen; Meng, Qingyong; Wei, Jun (IIAR, 2017-06)

  Background: Our previous studies revealed that concentrations of circulating antibodies to annexin A1 (ANXA1) and forkhead-box P3 (FOXP3) increased significantly in patients with non-small cell lung cancer (NSCLC). This ...
• Evaluation of initial setup errors of two immobilization devices for lung stereotactic body radiation therapy (SBRT) 

  Ueda, Yoshihiro; Teshima, Teruki; Cárdenes, Higinia; Das, Indra J. (Wiley, 2017-07)

  The aim of this study was to investigate the accuracy and efficacy of two commonly used commercial immobilization systems for stereotactic body radiation therapy (SBRT) in lung cancer. This retrospective study assessed the ...
• Augmentation of the anticancer activity of CYT997 in human prostate cancer by inhibiting Src activity 

  Teng, Yong; Cai, Yafei; Pi, Wenhu; Gao, Lixia; Shay, Chloe (Springer Nature, 2017-06-12)

  BACKGROUND: Abnormalities of tubulin polymerization and microtubule assembly are often seen in cancer, which make them very suitable targets for the development of therapeutic approach against rapidly dividing and ...
• DMAPT inhibits NF-κB activity and increases sensitivity of prostate cancer cells to X-rays in vitro and in tumor xenografts in vivo 

  Mendonca, Marc S.; Turchan, William T.; Alpuche, Melanie E.; Watson, Christopher N.; Estabrook, Neil C.; Chin-Sinex, Helen; Shapiro, Jeremy B.; Imasuen-Williams, Imade E.; Rangel, Gabriel; Gilley, David P.; Huda, Nazmul; Crooks, Peter A.; Shapiro, Ronald H. (Elsevier, 2017-11)

  Constitutive activation of the pro-survival transcription factor NF-κB has been associated with resistance to both chemotherapy and radiation therapy in many human cancers, including prostate cancer. Our lab and others ...
• MiR-770-5p inhibits cisplatin chemoresistance in human ovarian cancer by targeting ERCC2 

  Zhao, Henan; Yu, Xiaotang; Ding, Yanfang; Zhao, Jinyao; Wang, Guang; Wu, Xian; Jiang, Jiyong; Peng, Chun; Guo, Gordon Zhuo; Cui, Shiying (Impact Journals, 2016-08-16)

  In this study, we examined the role of the miRNA miR-770-5p in cisplatin chemotherapy resistance in ovarian cancer (OVC) patients. miR-770-5p expression was reduced in platinum-resistant patients. Using a 6.128-fold in ...
• Variation of kQclin,Qmsr (fclin,fmsr) for the small-field dosimetric parameters percentage depth dose, tissue-maximum ratio, and off-axis ratio 

  Francescon, Paolo; Beddar, Sam; Satariano, Ninfa; Das, Indra J. (Wiley, 2014-10)

  Purpose: Evaluate the ability of different dosimeters to correctly measure the dosimetric parameters percentage depth dose (PDD), tissue-maximum ratio (TMR), and off-axis ratio (OAR) in water for small fields. Method ...
• Survival impact of postoperative therapy modalities according to margin status in non–small cell lung cancer patients in the United States 

  Smeltzer, Matthew P.; Lin, Chun Chieh; Kong, Feng-Ming; Jemal, Ahmedin; Osarogiagbon, Raymond U. (Elsevier, 2017)

  Objective Unlike complete (R0) resection guidelines, current National Comprehensive Cancer Network (NCCN) adjuvant therapy guidelines after incomplete (R1/R2) resection of non–small cell lung cancer (NSCLC) are based ...
• Rapid RBE-Weighted Proton Radiation Dosimetry Risk Assessment 

  Qutub, Mohammad A. Z.; Klein, Susan B.; Buchsbaum, Jeffrey C. (Sage, 2016-10)

  Proton therapy dose is affected by relative biological effectiveness differently than X-ray therapies. The current clinically accepted weighting factor is 1.1 at all positions along the depth–dose profile. However, the ...
• CT and MRI fusion for postimplant prostate brachytherapy evaluation 

  Dehghan, Ehsan; Le, Yi; Lee, Junghoon; Song, Danny; Prince, Jerry L.; Fichtinger, Gabor (IEEE, 2016-04)

  Postoperative evaluation of prostate brachytherapy is typically performed using CT, which does not have sufficient soft tissue contrast for accurate anatomy delineation. MR-CT fusion enables more accurate localization of ...
• Improved human observer performance in digital reconstructed radiograph verification in head and neck cancer radiotherapy. 

  Sturgeon, Jared D.; Cox, John A.; Mayo, Lauren L.; Gunn, G. Brandon; Zhang, Lifei; Balter, Peter A.; Dong, Lei; Awan, Musaddiq; Kocak-Uzel, Esengul; Mohamed, Abdallah Sherif Radwan; Rosenthal, David I.; Fuller, Clifton David (Springer, 2015-10)

  Purpose: Digitally reconstructed radiographs (DRRs) are routinely used as an a priori reference for setup correction in radiotherapy. The spatial resolution of DRRs may be improved to reduce setup error in fractionated ...
• Computed tomography imaging parameters for inhomogeneity correction in radiation treatment planning 

  Das, Indra J.; Cheng, Chee-Wai; Cao, Minsong; Johnstone, Peter A. S. (Medknow Publications, 2016-01)

  Modern treatment planning systems provide accurate dosimetry in heterogeneous media (such as a patient' body) with the help of tissue characterization based on computed tomography (CT) number. However, CT number depends ...
• Intensity-modulated radiation therapy dose verification using fluence and portal imaging device 

  Sumida, Iori; Yamaguchi, Hajime; Das, Indra J.; Kizaki, Hisao; Aboshi, Keiko; Tsujii, Mari; Yamada, Yuji; Suzuki, Osamu; Seo, Yuji; Isohashi, Fumiaki; Ogawa, Kazuhiko (2016)

  Patient-specific quality assurance for intensity-modulated radiation therapy (IMRT) dose verification is essential. The aim of this study is to provide a new method based on the relative error distribution by comparing the ...

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