• Prognostic Significance of Tumor-Associated Macrophages in Chondroblastoma and Their Association with Response to Adjuvant Radiotherapy 

  Zheng, Bo-Wen; Yang, Min-Liang; Huang, Wei; Zheng, Bo-Yv; Zhang, Tao-Lan; Li, Jing; Lv, Guo-Hua; Yan, Yi-Guo; Zou, Ming-Xiang (Dovepress, 2021-05-17)

  Objective: Chondroblastoma (CB) is a rare and locally growing cartilage-derived tumor. Currently, clinical implications of tumor-associated macrophages (TAMs) in CB remain unclear. In this study, we sought to analyze the ...
• β-Lapachone Selectively Kills Hepatocellular Carcinoma Cells by Targeting NQO1 to Induce Extensive DNA Damage and PARP1 Hyperactivation 

  Zhao, Wenxiu; Jiang, Lingxiang; Fang, Ting; Fang, Fei; Liu, Yingchun; Zhao, Ye; You, Yuting; Zhou, Hao; Su, Xiaolin; Wang, Jiangwei; Liu, Sheng; Chen, Yaomin; Wan, Jun; Huang, Xiumei (Frontiers, 2021)

  Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death globally. Currently there is a lack of tumor-selective and efficacious therapies for hepatocellular carcinoma. β-Lapachone (ARQ761 in ...
• National trends in management of adult myxopapillary ependymomas 

  Scarpelli, Daphne B.; Turina, Claire B.; Kelly, Patrick D.; Khudanyan, Arpine; Jaboin, Jerry J.; McClelland, Shearwood, III. (Elsevier, 2020-03)

  Myxopapillary ependymomas (MPE) are WHO Grade I ependymomas that annually occur in 0.05–0.08 per 100,000 people. Surgical resection is the recommended first line therapy. Due to the rarity of the disease, there is a ...
• Patient-Specific Lymphocyte Loss Kinetics as Biomarker of Spleen Dose in Patients Undergoing Radiation Therapy for Upper Abdominal Malignancies 

  Yalamanchali, Anirudh; Zhang, Hong; Huang, Ke Colin; Mohan, Radhe; Lin, Steven H.; Zhu, Cong; Grossman, Stuart A.; Jin, Jian-Yue; Ellsworth, Susannah G. (Elsevier, 2020-08-10)

  Purpose: Radiation therapy (RT)-induced lymphopenia (RIL) is linked with inferior survival in esophageal and pancreatic cancers. Previous work has demonstrated a correlation between spleen dose and RIL risk. The present ...
• Radiation oncology should be a partner to medical oncology in end-of-life care 

  McClelland, Shearwood, III.; Mitin, Timur (Elsevier, 2020)
• FLASH Irradiation Results in Reduced Severe Skin Toxicity Compared to Conventional-Dose-Rate Irradiation 

  Soto, Luis A.; Casey, Kerriann M.; Wang, Jinghui; Blaney, Alexandra; Manjappa, Rakesh; Breitkreutz, Dylan; Skinner, Lawrie; Dutt, Suparna; Ko, Ryan B.; Bush, Karl; Yu, Amy S.; Melemenidis, Stavros; Strober, Samuel; Englemann, Edgar; Maxim, Peter G.; Graves, Edward E.; Loo, Billy W., Jr. (BioOne, 2020-12-01)

  Radiation therapy, along with surgery and chemotherapy, is one of the main treatments for cancer. While radiotherapy is highly effective in the treatment of localized tumors, its main limitation is its toxicity to normal ...
• Evaluating the Reproducibility of Mouse Anatomy under Rotation in a Custom Immobilization Device for Conformal FLASH Radiotherapy 

  Ko, Ryan B.; Soto, Luis A.; von Eyben, Rie; Melemenidis, Stavros; Rankin, Erinn B.; Maxim, Peter G.; Graves, Edward E.; Loo, Billy W., Jr. (BioOne, 2020-12-01)

  The observation of an enhanced therapeutic index for FLASH radiotherapy in mice has created interest in practical laboratory-based FLASH irradiators. To date, systems capable of 3D conformal FLASH irradiation in mice have ...
• Initial Steps Towards a Clinical FLASH Radiotherapy System: Pediatric Whole Brain Irradiation with 40 MeV Electrons at FLASH Dose Rates 

  Breitkreutz, Dylan Yamabe; Shumail, Muhammad; Bush, Karl K.; Tantawi, Sami G.; Maxim, Peter G.; Loo, Billy W., Jr. (BioOne, 2020-12-01)

  In this work, we investigated the delivery of a clinically acceptable pediatric whole brain radiotherapy plan at FLASH dose rates using two lateral opposing 40-MeV electron beams produced by a practically realizable linear ...
• Clinical application and mechanism of traditional Chinese medicine in treatment of lung cancer 

  Su, Xiao-Lin; Wang, Jiang-Wei; Che, Hui; Wang, Chang-Fu; Jiang, Hai; Lei, Xia; Zhao, Wan; Kuang, Hai-Xue; Wang, Qiu-Hong (Wolters Kluwer, 2020-12)

  Lung cancer is a malignant tumor characterized by a rapid proliferation rate, less survivability, high mortality, and metastatic potential. This review focuses on updated research about the clinical application of traditional ...
• Abdominal FLASH irradiation reduces radiation-induced gastrointestinal toxicity for the treatment of ovarian cancer in mice 

  Levy, Karen; Natarajan, Suchitra; Wang, Jinghui; Chow, Stephanie; Eggold, Joshua T.; Loo, Phoebe E.; Manjappa, Rakesh; Melemenidis, Stavros; Lartey, Frederick M.; Schüler, Emil; Skinner, Lawrie; Rafat, Marjan; Ko, Ryan; Kim, Anna; Al-Rawi, Duaa H.; von Eyben, Rie; Dorigo, Oliver; Casey, Kerriann M.; Graves, Edward E.; Bush, Karl; Yu, Amy S.; Koong, Albert C.; Maxim, Peter G.; Loo, Billy W., Jr.; Rankin, Erinn B. (Springer Nature, 2020-12-10)

  Radiation therapy is the most effective cytotoxic therapy for localized tumors. However, normal tissue toxicity limits the radiation dose and the curative potential of radiation therapy when treating larger target volumes. ...
• Improving the Clinical Treatment of Vulnerable Populations in Radiation Oncology 

  McClelland, Shearwood, III.; Petereit, Daniel G.; Zeitlin, Ross; Takita, Cristiane; Suneja, Gita; Miller, Robert C.; Deville, Curtiland; Siker, Malika L. (Elsevier, 2020-08-06)

  The increasing role of radiation oncology in optimal cancer care treatment brings to mind the adage that power is never a gift, but a responsibility. A significant part of the responsibility we in radiation oncology bear ...
• Greater Reduction in Mid-treatment FDG-PET Volume May Be Associated with Worse Survival in Non-Small Cell Lung Cancer 

  Kong, Feng-Ming (Spring); Li, Ling; Wang, Weili; Campbell, Jeff; Waller, Jennifer L.; Piert, Morand; Gross, Milton; Cheng, Monica; Owen, Dawn; Stenmark, Matthew; Huang, Colin; Frey, Kirk A.; Ten Haken, Randall K.; Lawrence, Theodore S. (Elsevier, 2019-03)

  Background and purpose: This study tested the hypotheses that 1) changes in mid-treatment fluorodeoxyglucose (FDG)-positron emission tomography (PET) parameters are predictive of overall survival (OS) and 2) mid-treatment ...
• The effect of distance from cancer facility on advanced clinical stage at diagnosis in patients with cervical cancer 

  Steele, Ethan M.; Robertson, Sharon E.; Holmes, Jordan A. (Elsevier, 2020)

  Purpose/Objectives In the United States, cervical cancer remains a significant cause of morbidity and mortality. The effect of distance has a complicated relationship with disease characteristics and outcomes in other ...
• Analysis of Virtual Versus In-Person Prospective Peer Review Workflow in a Multisite Academic Radiation Oncology Department 

  McClelland, Shearwood III; Amy Achiko, Flora; Bartlett, Gregory K.; Watson, Gordon A.; Holmes, Jordan A.; Rhome, Ryan M.; DesRosiers, Colleen M.; Hutchins, Karen M.; Shiue, Kevin; Agrawal, Namita (Elsevier, 2021-11)

  Purpose In radiation oncology, peer review is a process where subjective treatment planning decisions are assessed by those independent of the prescribing physician. Before March 2020, all peer review sessions occurred ...
• Radiation shielding and safety implications following linac conversion to an electron FLASH‐RT unit 

  Poirier, Yannick; Mossahebi, Sina; Becker, Becker; Koger, Brandon; Xu, Junliang; Lamichhane, Narrotam; Maxim, Peter G.; Sawant, Amit (American Association of Physicists in Medicne, 2021-09)

  Purpose Due to their finite range, electrons are typically ignored when calculating shielding requirements in megavoltage energy linear accelerator vaults. However, the assumption that 16 MeV electrons need not be considered ...
• Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy 

  Prasanna, Pataje G.; Citrin, Deborah E.; Hildesheim, Jeffrey; Ahmed, Mansoor M.; Venkatachalam, Sundar; Riscuta, Gabriela; Xi, Dan; Zheng, Guangrong; van Deursen, Jan; Goronzy, Jorg; Kron, Stephen J.; Anscher, Mitchell S.; Sharpless, Norman E.; Campisi, Judith; Brown, Stephen L.; Niedernhofer, Laura J.; O’Loghlen, Ana; Georgakilas, Alexandros G.; Paris, Francois; Gius, David; Gewirtz, David A.; Schmitt, Clemens A.; Abazeed, Mohamed E.; Kirkland, James L.; Richmond, Ann; Romesser, Paul B.; Lowe, Scott W.; Gil, Jesus; Mendonca, Marc S.; Burma, Sandeep; Zhou, Daohong; Coleman, C. Norman (Oxford, 2021-10)

  Cellular senescence is an essential tumor suppressive mechanism that prevents the propagation of oncogenically activated, genetically unstable, and/or damaged cells. Induction of tumor cell senescence is also one of the ...
• RTHP-06. IMPACT OF THE AMERICAN TAX PAYER RELIEF ACT ON STEREOTACTIC RADIOSURGERY UTILIZATION IN THE UNITED STATES 

  McClelland III, Shearwood; Degnin, Catherine; Chen, Yiyi; Watson, Gordon; Jaboin, Jerry (Oxford Academic, 2019-11)

  INTRODUCTION For brain metastases, single-fraction stereotactic radiosurgery (SRS) spares appropriately chosen patients from the invasiveness of operative intervention and the permanent cognitive morbidity of whole brain ...
• RTHP-12. NATIONWIDE DISTRIBUTION OF LINEAR ACCELERATOR VERSUS GAMMA KNIFE STEREOTACTIC RADIOSURGERY UTILIZATION FOR METASTATIC BRAIN DISEASE IN ACADEMIC VERSUS COMMUNITY HOSPITALS 

  McClelland III, Shearwood; Degnin, Catherine; Chen, Yiyi; Watson, Gordon; Jaboin, Jerry (Oxford Academic, 2019-11)

  INTRODUCTION Single-fraction stereotactic radiosurgery (SRS) is often the preferred treatment modality for metastatic brain disease, particularly when patients have a small enough volume of disease to preclude whole brain ...
• RARE-01. NATIONWIDE TRENDS IN MANAGEMENT OF ADULT MYXOPAPILLARY EPENDYMOMA 

  Baracena, Daphne; Kelly, Patrick; Khudanyan, Arpine; Turina, Claire; Jaboin, Jerry; McClelland III, Shearwood (Oxford Academic, 2019-11)

  INTRODUCTION Myxopapillary ependymomas (MPE) are WHO Grade I ependymomas that occur in the spine and have an annual incidence of 0.05–0.08 per 100,000 people. Maximal, safe surgical resection is the recommended first line ...
• Predictors of linear accelerator versus Gamma Knife stereotactic radiosurgery use for brain metastases in the United States 

  McClelland, Shearwood, III.; Degnin, Catherine; Chen, Yiyi; Watson, Gordon A.; Jaboin, Jerry J. (Oxford Academic, 2019-11)

  INTRODUCTION Stereotactic radiosurgery (SRS) for brain metastases is predominantly delivered via single-fraction Gamma Knife SRS (GKRS) or linear accelerator (LINAC) in 1–5 fractions. Predictors of SRS modality have been ...

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