• Neurosurgical Management of Self-Inflicted Cranial Crossbow Injury 

  Kulwin, Charles G.; DeNardo, Andrew; Khairi, Saad; Payner, Troy (Elsevier, 2018-08)

  Background Although gun-related penetrating traumatic brain injuries make up the majority of cranial missile injuries, low-velocity penetrating injuries present significant clinical difficulties that cannot necessarily ...
• The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury 

  Al-Ali, Hassan; Ding, Ying; Slepak, Tatiana; Wu, Wei; Sun, Yan; Martinez, Yania; Xu, Xiao-Ming; Lemmon, Vance P.; Bixby, John L. (Society for Neuroscience, 2017-07-26)

  The mammalian target of rapamycin (mTOR) positively regulates axon growth in the mammalian central nervous system (CNS). Although axon regeneration and functional recovery from CNS injuries are typically limited, knockdown ...
• Neurenteric cyst at the dorsal craniocervical junction in a child: Case report 

  Lai, Pui Man Rosalind; Zaazoue, Mohamed A.; Francois, Roosevelt; Dupervil, Daniel G.; Berkowitz, Aaron L.; Alexandrescu, Sanda; Proctor, Mark R. (Elsevier, 2018)

  Neurenteric cysts, also known as enterogenous cysts, are uncommon, benign, congenital lesions that usually occur in the posterior mediastinum but can be seen at any level of the neuraxis. Here, we report a pediatric patient ...
• Post-Injury Treatment of 7,8-Dihydroxyflavone Promotes Neurogenesis in the Hippocampus of the Adult Mouse 

  Zhao, Shu; Yu, Alex; Wang, Xiaoting; Gao, Xiang; Chen, Jinhui (Mary Ann Liebert, 2016-11-15)

  Traumatic brain injury (TBI) at the moderate level of impact induces massive cell death and results in extensive dendrite degeneration in the brain, leading to persistent cognitive, sensory, and motor dysfunction. Our ...
• In Vivo Microscopy in Neurosurgical Oncology 

  Osman, Hany; Georges, Joseph; Elsahy, Deena; Hattab, Eyas; Yocom, Steven; Cohen-Gadol, Aaron A. (Elsevier, 2018)

  Intraoperative neurosurgical histopathologic diagnoses rely on evaluation of rapid tissue preparations such as frozen sections and smears with conventional light microscopy. Though useful, these techniques are time consuming ...
• Acridine Orange as a Novel Photosensitizer for Photodynamic Therapy in Glioblastoma 

  Osman, Hany; Elsahy, Deena; Saadatzadeh, M. Reza; Pollok, Karen E.; Yocom, Steven; Hattab, Eyas; Georges, Joseph; Cohen-Gadol, Aaron A. (Elsevier, 2018)

  Object Photodynamic therapy is an exciting treatment modality that combines the effects of a chemical agent with the physical energy from light or radiation to result in lysis of cells of interest. Acridine orange is a ...
• A Tissue Displacement-based Contusive Spinal Cord Injury Model in Mice 

  Wu, Xiangbing; Zhang, Yi Ping; Qu, Wenrui; Shields, Lisa B. E.; Shields, Christopher B.; Xu, Xiao-Ming (JoVE, 2017-06-18)

  Producing a consistent and reproducible contusive spinal cord injury (SCI) is critical to minimizing behavioral and histological variabilities between experimental animals. Several contusive SCI models have been developed ...
• CCL2 produced by the glioma microenvironment is essential for the recruitment of regulatory T cells and myeloid-derived suppressor cells 

  Chang, Alan L.; Miska, Jason; Wainwright, Derek A.; Dey, Mahua; Rivetta, Claudia V.; Yu, Dou; Kanojia, Deepak; Pituch, Katarzyna C.; Qiao, Jian; Pytel, Peter; Han, Yu; Wu, Meijing; Zhang, Lingjiao; Horbinski, Craig M.; Ahmed, Atique U.; Lesniak, Maciej S. (AACR Publications, 2016-10-01)

  In many aggressive cancers, such as glioblastoma multiforme (GBM), progression is enabled by local immunosuppression driven by the accumulation of regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSC). ...
• HIV Tat Impairs Neurogenesis through Functioning As a Notch Ligand and Activation of Notch Signaling Pathway 

  Fan, Yan; Gao, Xiang; Chen, Jinhui; Liu, Ying; He, Johnny J. (Society for Neuroscience., 2016-11-02)

  Alterations in adult neurogenesis have been noted in the brain of HIV-infected individuals and are likely linked to HIV-associated neurocognitive deficits, including those in learning and memory. But the underlying molecular ...
• Optogenetics and its application in neural degeneration and regeneration 

  Ordaz, Josue D.; Wu, Wei; Xu, Xiao-Ming (Wolters Kluwer, 2017-08)

  Neural degeneration and regeneration are important topics in neurological diseases. There are limited options for therapeutic interventions in neurological diseases that provide simultaneous spatial and temporal control ...
• Cervical cancer metastasis to the brain: A case report and review of literature 

  Fetcko, Kaleigh; Gondim, Dibson D.; Bonnin, Jose M.; Dey, Mahua (Medknow Publications, 2017-08-09)

  Background: Intracranial metastasis from cervical cancer is a rare occurrence. Methods: In this study we describe a case of cervical cancer metastasis to the brain and perform an extensive review of literature from ...
• AAV-KLF7 Promotes Descending Propriospinal Neuron Axonal Plasticity after Spinal Cord Injury 

  Li, Wen-Yuan; Wang, Ying; Zhai, Feng-Guo; Sun, Ping; Cheng, Yong-Xia; Deng, Ling-Xiao; Wang, Zhen-Yu (hindawi publishing corporation, 2017)

  DPSN axons mediate and maintain a variety of normal spinal functions. Unsurprisingly, DPSN tracts have been shown to mediate functional recovery following SCI. KLF7 could contribute to CST axon plasticity after spinal cord ...
• Systemic epothilone D improves hindlimb function after spinal cord contusion injury in rats 

  Sandner, Beatrice; Puttagunta, Radhika; Motsch, Melanie; Bradke, Frank; Ruschel, Jörg; Blesch, Armin; Weidner, Norbert (Elsevier, 2018)

  Following a spinal cord injury (SCI) a growth aversive environment forms, consisting of a fibroglial scar and inhibitory factors, further restricting the already low intrinsic growth potential of injured adult central ...
• Reduction in overt and silent stroke recurrence rate following cerebral revascularization surgery in children with sickle cell disease and severe cerebral vasculopathy 

  Hall, Erin M.; Leonard, Jeffrey; Smith, Jodi L.; Guilliams, Kristin P.; Binkley, Michael; Fallon, Robert J.; Hulbert, Monica L. (Wiley, 2016-08)

  Background Children with sickle cell disease (SCD) and moyamoya may benefit from indirect cerebral revascularization surgery in addition to chronic blood transfusion therapy for infarct prevention. We sought to compare ...
• Superior Segment Facet Joint Violation During Instrumented Lumbar Fusion is Associated With Higher Reoperation Rates and Diminished Improvement in Quality of Life 

  Levin, Jay M.; Alentado, Vincent J.; Healy, Andrew T.; Steinmetz, Michael P.; Benzel, Edward C.; Mroz, Thomas E. (Wolters Kluwer, 2018-02)

  Study Design: A retrospective cohort study at a single tertiary care center. Objective: To determine the impact of superior segment facet joint violation (FJV) during lumbar fusion on reoperation rates and quality of ...
• Impact of the 2006 Massachusetts health care insurance reform on neurosurgical procedures and patient insurance status 

  Villeli, Nicolas W.; Das, Rohit; Yan, Hong; Huff, Wei; Zou, Jian; Barbaro, Nicholas M. (2017-01)

  OBJECTIVE The Massachusetts health care insurance reform law passed in 2006 has many similarities to the federal Affordable Care Act (ACA). To address concerns that the ACA might negatively impact case volume and reimbursement ...
• Immune System, Friend or Foe of Oncolytic Virotherapy? 

  Filley, Anna C.; Dey, Mahua (Frontiers, 2017-05-23)

  Oncolytic viruses (OVs) are an emerging class of targeted anticancer therapies designed to selectively infect, replicate in, and lyse malignant cells without causing harm to normal, healthy tissues. In addition to direct ...
• Subarachnoid-to-Subarachnoid Shunt for Correction of Nonfunctioning Baclofen Pump in a Severe Case of Chronic Debilitating Post–Spinal Cord Injury Spasticity 

  Bakare, Adewale A.; Weyhenmeyer, Jonathan; Lee, Albert (Elsevier, 2018-02)

  Background Perhaps the most disabling condition seen in patients with spinal cord injury (SCI) is spasticity. Spasticity is characterized as hyperreflexia and hypertonicity as a result of damage to the supraspinal tracts ...
• Increased threshold of short-latency motor evoked potentials in transgenic mice expressing Channelrhodopsin-2 

  Wu, Wei; Xiong, Wenhui; Zhang, Ping; Chen, Lifang; Fang, Jianqiao; Shields, Christopher; Xu, Xiao-Ming; Jin, Xiaoming (PLoS, 2017-05-31)

  Transgenic mice that express channelrhodopsin-2 or its variants provide a powerful tool for optogenetic study of the nervous system. Previous studies have established that introducing such exogenous genes usually does not ...
• Neuropathic pain after spinal cord injury: the impact of sensorimotor activity 

  Nees, Timo A.; Finnerup, Nanna B.; Blesch, Armin; Weidner, Norbert (Wolters Kluwer, 2017-03)

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