• Anterior communicating artery complex aneurysms: anatomic characteristics as predictors of surgical outcome in 300 cases 

  Bohnstedt, Bradley N.; Conger, Andrew R.; Edwards, John; Ziemba-Davis, Mary; Edwards, Gary; Brom, Jacqueline; Shah, Kushal; Cohen-Gadol, Aaron A. (Elsevier, 2018)

  OBJECTIVE Anterior communicating artery (ACoA) complex aneurysms are challenging to treat microsurgically. The authors report their experience with microsurgical treatment of ACoA aneurysms and examine the anatomic ...
• An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury 

  Chen, Chen; Zhang, Yi Ping; Sun, Yan; Xiong, Wenhui; Shields, Lisa B. E.; Shields, Christopher B.; Jin, Xiaoming; Xu, Xiao-Ming (Journal of Visualized Experiments, 2017-12-31)

  Spinal cord injury (SCI) causes significant vascular disruption at the site of injury. Vascular pathology occurs immediately after SCI and continues throughout the acute injury phase. In fact, endothelial cells appear to ...
• Surgical Management of Trigeminal Neuralgia in Children 

  Chicoine, Nicole H.; Yaacoub, Alan P.; Jea, Andrew; Raskin, Jeffrey S. (Elsevier, 2019-01)

  Background Trigeminal neuralgia (TN) is a well-recognized facial pain syndrome. Discrete forms with disparate pain symptoms include classic and atypical. However, atypical facial pain includes neuralgiform pain along a ...
• Hospital Length of Stay and Readmission Rate for Neurosurgical Patients 

  Ansari, Shaheryar F.; Yan, Hong; Zou, Jian; Worth, Robert M.; Barbaro, Nicholas M. (Oxford, 2018-02)

  BACKGROUND Hospital readmission rate has become a major indicator of quality of care, with penalties given to hospitals with high rates of readmission. At the same time, insurers are increasing pressure for greater ...
• Delayed and progressive damages to juvenile mice after moderate traumatic brain injury 

  Zhao, Shu; Wang, Xiaoting; Gao, Xiang; Chen, Jinhui (Nature Publishing Group, 2018-05-09)

  Symptoms are commonly more severe in pediatric traumatic brain injury (TBI) patients than in young adult TBI patients. To understand the mechanism, juvenile mice received a controlled cortical impact (CCI) injury at moderate ...
• Cervical spine surgery for tandem spinal stenosis: The impact on low back pain 

  Alvin, Matthew D.; Alentado, Vincent J.; Lubelski, Daniel; Benzel, Edward C.; Mroz, Thomas E. (Elsevier, 2018-03)

  Objective Tandem spinal stenosis (TSS) can present similarly to cervical myelopathy, but often has a worse prognosis. Few studies have investigated outcomes and compared treatment approaches for patients with TSS. We ...
• Variability in Surgical Treatment of Spondylolisthesis Among Spine Surgeons 

  Lubelski, Daniel; Alentado, Vincent J.; Williams, Seth K.; O'Rourke, Colin; Obuchowski, Nancy A.; Wang, Jeffrey C.; Steinmetz, Michael P.; Melillo, Alfred J.; Benzel, Edward C.; Modic, Michael T.; Quencer, Robert; Mroz, Thomas E. (Elsevier, 2018)

  Background There are a multitude of treatments for low-grade lumbar spondylolisthesis. There are no clear guidelines for the optimal approach. Objective To identify the surgical treatment patterns for spondylolisthesis ...
• Prospective comparison of long-term pain relief rates after first-time microvascular decompression and stereotactic radiosurgery for trigeminal neuralgia 

  Wang, Doris D.; Raygor, Kunal P.; Cage, Tene A.; Ward, Mariann M.; Westcott, Sarah; Barbaro, Nicholas M.; Chang, Edward F. (AANS, 2018-01)

  OBJECTIVE Common surgical treatments for trigeminal neuralgia (TN) include microvascular decompression (MVD), stereotactic radiosurgery (SRS), and radiofrequency ablation (RFA). Although the efficacy of each procedure has ...
• Delay Differential Analysis of Seizures in Multichannel Electrocorticography Data 

  Lainscsek, Claudia; Weyhenmeyer, Jonathan; Cash, Sydney S.; Sejnowski, Terrence J. (MIT, 2017-12)

  High-density electrocorticogram (ECoG) electrodes are capable of recording neurophysiological data with high temporal resolution with wide spatial coverage. These recordings are a window to understanding how the human brain ...
• The Impact of the 2006 Massachusetts Healthcare Reform on Spine Surgery Patient Payer-Mix and Age 

  Villelli, Nicolas W.; Yan, Hong; Zou, Jian; Barbaro, Nicholas M. (AANS, 2017-12)

  OBJECTIVE Several similarities exist between the Massachusetts health care reform law of 2006 and the Affordable Care Act (ACA). The authors’ prior neurosurgical research showed a decrease in uninsured surgeries without ...
• Recurrent glioma clinical trial, CheckMate-143: the game is not over yet 

  Filley, Anna C.; Henriquez, Mario; Dey, Mahua (Impact Journals, 2017-10-06)

  Glioblastoma (GBM) is the most common, and aggressive, primary brain tumor in adults. With a median patient survival of less than two years, GBM represents one of the biggest therapeutic challenges of the modern era. Even ...
• The Effect of Pet Therapy and Artist Interactions on Quality of Life in Brain Tumor Patients: A Cross-Section of Art and Medicine in Dialog 

  Petranek, Stefan; Pencek, Jennifer; Dey, Mahua (MDPI, 2018-04-27)

  With the evolution of modern medical treatment strategies, there also comes the realization that many times we reach a point where traditional goals of medical care, such as overall survival or disease-free survival, are ...
• History of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and Its Use for Spinal Cord Injury Repair 

  Walker, Melissa J.; Xu, Xiao-Ming (MDPI, 2018-06-13)

  Following an initial mechanical insult, traumatic spinal cord injury (SCI) induces a secondary wave of injury, resulting in a toxic lesion environment inhibitory to axonal regeneration. This review focuses on the glial ...
• Pathophysiological and behavioral deficits in developing mice following rotational acceleration-deceleration traumatic brain injury 

  Wang, Guoxiang; Zhang, Yi Ping; Gao, Zhongwen; Shields, Lisa B. E.; Li, Fang; Chu, Tianci; Lv, Huayi; Moriarty, Thomas; Xu, Xiao-Ming; Yang, Xiaoyu; Shields, Christopher B.; Cai, Jun (Company of Biologists:, 2018-01-30)

  Abusive head trauma (AHT) is the leading cause of death from trauma in infants and young children. An AHT animal model was developed on 12-day-old mice subjected to 90° head extension-flexion sagittal shaking repeated 30, ...
• Neurosurgical Management of Self-Inflicted Cranial Crossbow Injury 

  Kulwin, Charles G.; DeNardo, Andrew; Khairi, Saad; Payner, Troy (Elsevier, 2018-08)

  Background Although gun-related penetrating traumatic brain injuries make up the majority of cranial missile injuries, low-velocity penetrating injuries present significant clinical difficulties that cannot necessarily ...
• The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury 

  Al-Ali, Hassan; Ding, Ying; Slepak, Tatiana; Wu, Wei; Sun, Yan; Martinez, Yania; Xu, Xiao-Ming; Lemmon, Vance P.; Bixby, John L. (Society for Neuroscience, 2017-07-26)

  The mammalian target of rapamycin (mTOR) positively regulates axon growth in the mammalian central nervous system (CNS). Although axon regeneration and functional recovery from CNS injuries are typically limited, knockdown ...
• Neurenteric cyst at the dorsal craniocervical junction in a child: Case report 

  Lai, Pui Man Rosalind; Zaazoue, Mohamed A.; Francois, Roosevelt; Dupervil, Daniel G.; Berkowitz, Aaron L.; Alexandrescu, Sanda; Proctor, Mark R. (Elsevier, 2018)

  Neurenteric cysts, also known as enterogenous cysts, are uncommon, benign, congenital lesions that usually occur in the posterior mediastinum but can be seen at any level of the neuraxis. Here, we report a pediatric patient ...
• Post-Injury Treatment of 7,8-Dihydroxyflavone Promotes Neurogenesis in the Hippocampus of the Adult Mouse 

  Zhao, Shu; Yu, Alex; Wang, Xiaoting; Gao, Xiang; Chen, Jinhui (Mary Ann Liebert, 2016-11-15)

  Traumatic brain injury (TBI) at the moderate level of impact induces massive cell death and results in extensive dendrite degeneration in the brain, leading to persistent cognitive, sensory, and motor dysfunction. Our ...
• In Vivo Microscopy in Neurosurgical Oncology 

  Osman, Hany; Georges, Joseph; Elsahy, Deena; Hattab, Eyas; Yocom, Steven; Cohen-Gadol, Aaron A. (Elsevier, 2018)

  Intraoperative neurosurgical histopathologic diagnoses rely on evaluation of rapid tissue preparations such as frozen sections and smears with conventional light microscopy. Though useful, these techniques are time consuming ...
• Acridine Orange as a Novel Photosensitizer for Photodynamic Therapy in Glioblastoma 

  Osman, Hany; Elsahy, Deena; Saadatzadeh, M. Reza; Pollok, Karen E.; Yocom, Steven; Hattab, Eyas; Georges, Joseph; Cohen-Gadol, Aaron A. (Elsevier, 2018)

  Object Photodynamic therapy is an exciting treatment modality that combines the effects of a chemical agent with the physical energy from light or radiation to result in lysis of cells of interest. Acridine orange is a ...

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