Department of Microbiology and Immunology

 

Collections in this community

Recent Submissions

  • Cole, Jennifer M.; Dahl, Richard; Cowden Dahl, Karen D. (MDPI, 2021-01-13)
    Ovarian cancer (OC) cells survive in the peritoneal cavity in a complex microenvironment composed of diverse cell types. The interaction between tumor cells and non-malignant cells is crucial to the success of the metastatic ...
  • Cheng, Danhong; Lv, Huiying; Yao, Yong; Cheng, Sen; Huang, Qian; Wang, Hua; Liu, Xiaoyun; Bae, Taeok; Li, Min; Liu, Qian (American Society for Microbiology, 2020-07-09)
    In Enterococcus faecalis, the site 2 protease Eep generates sex pheromones, including cAM373. Intriguingly, in Staphylococcus aureus, a peptide similar to cAM373, named cAM373_SA, is produced from the camS gene. Here, we ...
  • Wyatt-Johnson, Season K.; Brutkiewicz, Randy R. (Frontiers Media, 2020-11-19)
    In the naïve mouse brain, microglia and astrocytes are the most abundant immune cells; however, there is a complexity of other immune cells present including monocytes, neutrophils, and lymphocytic cells, such as natural ...
  • Broxmeyer, H.E. (Wiley, 2011-04)
    Objectives:  To review information on cord blood banking and transplantation with respect to the author’s studies, and in context of this field of investigation. Results:  Cord blood transplantation has been successfully ...
  • Shepherd, Nicole; Lan, Jie; Rane, Sushmita; Yu, Qigui (American Society for Microbiology, 2019-09-12)
    Vaccinia virus (VACV), the prototypical member of the poxvirus family, was used as a live-virus vaccine to eradicate smallpox worldwide and has recently received considerable attention because of its potential as a prominent ...
  • Xu, Jerry Z.; Kumar, Ramesh; Gong, Haoli; Liu, Luyao; Ramos-Solis, Nicole; Li, Yujing; Derbigny, Wilbert A. (American Society for Microbiology, 2019-09)
    Reproductive tract pathology caused by Chlamydia trachomatis infection is an important global cause of human infertility. To better understand the mechanisms associated with Chlamydia-induced genital tract pathogenesis in ...
  • Cao, Qiao; Yang, Nana; Wang, Yanhui; Xu, Chenchen; Zhang, Xue; Fan, Ke; Chen, Feifei; Liang, Haihua; Zhang, Yingchao; Deng, Xin; Feng, Youjun; Yang, Cai-Guang; Wu, Min; Bae, Taeok; Lan, Lefu (AAAS, 2020-11)
    Genetic mutations are a primary driving force behind the adaptive evolution of bacterial pathogens. Multiple clinical isolates of Pseudomonas aeruginosa, an important human pathogen, have naturally evolved one or more ...
  • Cheon, I. S.; Li, C.; Son, Y. M.; Goplen, N. P.; Wu, Y.; Cassmann, T.; Wang, Z.; Wei, X.; Tang, J.; Li, Y.; Marlow, H.; Hughes, S.; Hammel, L.; Cox, T. M.; Goddery, E.; Ayasoufi, K.; Weiskopf, D.; Boonyaratanakornkit, J.; Dong, H.; Li, H.; Chakraborty, R.; Johnson, A. J.; Edell, E.; Taylor, J. J.; Kaplan, M. H.; Sette, A.; Bartholmai, B. J.; Kern, R.; Vassallo, R.; Sun, J. (AAAS, 2021-11)
    Severe coronavirus disease 2019 (COVID-19) pneumonia survivors often exhibit long-term pulmonary sequelae, but the underlying mechanisms or associated local and systemic immune correlates are not known. Here, we have ...
  • Bickett, Thomas E.; Knitz, Michael W.; Piper, Miles; Oweida, Ayman J.; Gadwa, Jacob; Darragh, Laurel B.; Nguyen, Diemmy; Bhatia, Shilpa; Bhuvane, Shiv; Phan, Andy V.; Van Court, Benjamin; Corbo, Sophia; Pham, Tiffany; Dent, Alexander L.; Lenz, Laurel; Karam, Sana D. (Elsevier, 2021)
    STAT3 signaling has been shown to regulate cellular function and cytokine production in the tumor microenvironment (TME). Within the head and neck squamous cell carcinoma (HNSCC) TME, we previously showed that therapeutic ...
  • Condotta, Stephanie A.; Downey, Jeffrey; Pardy, Ryan D.; Valbon, Stefanie F.; Tarrab, Esther; Lamarre, Alain; Divangahi, Maziar; Richer, Martin J. (AAI, 2020-04)
    CD8+ T cell–mediated immunity is critical for host defense against viruses and requires mitochondria-mediated type I IFN (IFN-I) signaling for optimal protection. Cyclophilin D (CypD) is a mitochondrial matrix protein that ...
  • Toh, Evelyn; Gao, Xiang; Williams, James A.; Batteiger, Teresa A.; Coss, Lisa A.; LaPradd, Michelle; Ren, Jie; Geisler, William M.; Xing, Yue; Dong, Qunfeng; Nelson, David E.; Jordan, Stephen J. (Wolters Kluwer, 2022-01)
    Background In men with nongonococcal urethritis (NGU), clinicians and patients rely on clinical cure to guide the need for additional testing/treatment and when to resume sex, respectively; however, discordant clinical ...
  • Gibson, Ryan T.; Androphy, Elliot J. (MDPI, 2020-09)
    The multi-subunit structural maintenance of chromosomes (SMC) 5/6 complex includes SMC6 and non-SMC element (NSE)3. SMC5/6 is essential for homologous recombination DNA repair and functions as an antiviral factor during ...
  • Liu, Qiang; Xu, Haijun; Zhang, Yan; Yang, Jing; Du, Jimei; Zhou, Yan; Yang, X. Frank; Lou, Yongliang (Frontiers, 2020-10-26)
    The two-component response regulator Rrp2 is a key activator controlling the production of numerous virulence factors of Borrelia burgdorferi, the Lyme disease pathogen. Previously it was shown that the cognate histidine ...
  • Marchetti, Alexander L.; Guo, Haitao (MDPI, 2020-11-06)
    The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as ...
  • Keating, Rachael; Johnson, Jenny L.; Brice, David C.; Labombarde, Jocelyn G.; Dent, Alexander L.; McGargill, Maureen A. (ASM, 2020-11-03)
    It is estimated that 250,000 to 650,000 individuals worldwide die each year from seasonal influenza A virus (IAV) infections. Current vaccines provide little protection against newly emerging strains. Thus, considerable ...
  • Khan, Mike; Harms, Jerome S.; Liu, Yiping; Eickhoff, Jens; Tan, Jin Wen; Hu, Tony; Cai, Fengwei; Guimaraes, Erika; Oliveira, Sergio Costa; Dahl, Richard; Cheng, Yong; Gutman, Delia; Barber, Glen N.; Splitter, Gary A.; Smith, Judith A. (PloS, 2020-10-27)
    Brucellosis, caused by a number of Brucella species, remains the most prevalent zoonotic disease worldwide. Brucella establish chronic infections within host macrophages despite triggering cytosolic innate immune sensors, ...
  • Morrison, Sandra G.; Giebel, Amanda M.; Toh, Evelyn; Banerjee, Arkaprabha; Nelson, David E.; Morrison, Richard P. (ASM, 2020-11-03)
    Chlamydia is the most common sexually transmitted bacterial infection in the United States. Most chlamydia genital infections resolve without serious consequences; however, untreated infection in women can cause pelvic ...
  • Zhang, Yan; Chen, Tong; Raghunandanan, Sajith; Xiang, Xuwu; Yang, Jing; Liu, Qiang; Edmondson, Diane G.; Norris, Steven J.; Yang, X. Frank; Lou, Yongliang (Public Library of Science, 2020-10-13)
    Borrelia burgdorferi, the Lyme disease pathogen causes persistent infection by evading the host immune response. Differential expression of the surface-exposed lipoprotein VlsE that undergoes antigenic variation is a key ...
  • Fu, Yongyao; Wang, Jocelyn; Panangipalli, Gayathri; Ulrich, Benjamin J.; Koh, Byunghee; Xu, Chengxian; Kharwadkar, Rakshin; Chu, Xiaona; Wang, Yue; Gao, Hongyu; Wu, Wenting; Tepper, Robert S.; Zhou, Baohua; Janga, Sarath Chandra; Yang, Kai; Kaplan, Mark H. (Nature Publishing Group, 2020-09-28)
    T helper cell differentiation requires lineage-defining transcription factors and factors that have shared expression among multiple subsets. BATF is required for development of multiple Th subsets but functions in a ...
  • Park, Sungtae; Griesenauer, Brad; Jiang, Hua; Adom, Djamilatou; Mehrpouya-Bahrami, Pegah; Chakravorty, Srishti; Kazemian, Majid; Imam, Tanbeena; Srivastava, Rajneesh; Hayes, Tristan A.; Pardo, Julian; Janga, Sarath Chandra; Paczesny, Sophie; Kaplan, Mark H.; Olson, Matthew R. (American Society for Clinical Investigation, 2020-08-18)
    Acute graft-versus-host disease (aGVHD) can occur after hematopoietic cell transplant in patients undergoing treatment for hematological malignancies or inborn errors. Although CD4+ T helper (Th) cells play a major role ...

View more