Department of Microbiology and Immunology

Department of Microbiology and Immunology

 

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  • Almanan, Maha; Raynor, Jana; Ogunsulire, Ireti; Malyshkina, Anna; Mukherjee, Shibabrata; Hummel, Sarah A.; Ingram, Jennifer T.; Saini, Ankur; Xie, Markus M.; Alenghat, Theresa; Way, Sing Sing; Deepe, George S.; Divanovic, Senad; Singh, Harinder; Miraldi, Emily; Zajac, Allan J.; Dent, Alexander L.; Hölscher, Christoph; Chougnet, Claire; Hildeman, David A. (American Association for the Advancement of Science, 2020-07-29)
    Aging results in profound immune dysfunction, resulting in the decline of vaccine responsiveness previously attributed to irreversible defects in the immune system. In addition to increased interleukin-6 (IL-6), we found ...
  • Robinson, Christopher M (Elsevier, 2019-08-01)
    Enteric viruses infect the mammalian gastrointestinal tract which is home to a diverse community of intestinal bacteria. Accumulating evidence suggests that certain enteric viruses utilize these bacteria to promote infection. ...
  • Zang, Ruochen; Case, James Brett; Yutuc, Eylan; Ma, Xiucui; Shen, Sheng; Gomez Castro, Maria Florencia; Liu, Zhuoming; Zeng, Qiru; Zhao, Haiyan; Son, Juhee; Rothlauf, Paul W.; Kreutzberger, Alex J. B.; Hou, Gaopeng; Zhang, Hu; Bose, Sayantan; Wang, Xin; Vahey, Michael D.; Mani, Kartik; Griffiths, William J.; Kirchhausen, Tom; Fremont, Daved H.; Guo, Haitao; Diwan, Abhinav; Wang, Yuqin; Diamond, Michael S.; Whelan, Sean P. J.; Ding, Siyuan (NAS, 2020-12)
    Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-stimulated gene that shows broad antiviral activities against a wide range of enveloped viruses. Here, using an IFN-stimulated gene screen against vesicular stomatitis ...
  • Spinola, Stanley M.; Broderick, Camilla; Zimet, Gregory D.; Ott, Mary A. (Oxford, 2021-01)
    This manuscript explores the ethics of human inoculation experiments in young healthy adults with wild-type severe acute respiratory sydrome coronavirus 2 (SARS-CoV-2) as a tool to evaluate vaccine efficacy in the context ...
  • Ropa, James; Cooper, Scott; Capitano, Maegan L.; Van't Hof, Wouter; Broxmeyer, Hal E. (Springer, 2021-02)
    Despite evidence that SARS-CoV-2 infection is systemic in nature, there is little known about the effects that SARS-CoV-2 infection or exposure has on many host cell types, including primitive and mature hematopoietic ...
  • Batteiger, Teresa A.; Jordan, Stephen J.; Toh, Evelyn; Fortenberry, Lora; Williams, James A.; LaPradd, Michelle; Katz, Barry; Fortenberry, J. Dennis; Dodge, Brian; Arno, Janet; Batteiger, Byron E.; Nelson, David E. (Wolters Kluwer, 2019-07-01)
    Background. Rectal infection with Chlamydia trachomatis (CT) is frequent in women who deny receptive anal sex and is thought to arise from autoinoculation of the rectum from vaginal secretions. An alternate hypothesis is ...
  • Broxmeyer, Hal E. (Elsevier, 2019-08)
    Calcium ions (Ca2+), ubiquitous signaling and second messenger molecules, are communicators for the transmission of messages in numerous cell functions. In this issue of Cell Stem Cell, Luchsinger et al. (2019) provide ...
  • Ballen, Karen; Broxmeyer, Hal E.; McCullough, Jeffrey; Piaciabello, Wanda; Rebulla, Paolo; Verfaillie, Catherine M.; Wagner, John E. (Elsevier, 2001-12-01)
    Cord blood (CB) transplantation has expanded the ability of the transplantation community to meet the growing needs of their patients. Clinical data over the last decade show promising results in CB transplantation using ...
  • Jun, Hyo Won; La, Su Jin; Kim, Ji Young; Heo, Suk Kyeung; Kim, Ju Yang; Wang, Sa; Kim, Kack Kyun; Lee, Ki Man; Cho, Hong Rae; Lee, Hyeon Woo; Kwon, Byungsuk; Kim, Byung Sam; Kwon, Byoung Se (Springer Nature, 2003-12-01)
    Herpes virus entry mediator (HVEM) is a newly discovered member of the tumor necrosis factor receptor (TNFR) superfamily that has a role in herpes simplex virus entry, in T cell activation and in tumor immunity. We generated ...
  • Nanbakhsh, Arash; Srinivasamani, Anupallavi; Holzhauer, Sandra; Riese, Matthew J.; Zheng, Yongwei; Wang, Demin; Burns, Robert; Reimer, Michael H.; Rao, Sridhar; Lemke, Angela; Tsaih, Shirng-Wern; Flister, Michael J.; Lao, Shunhua; Dahl, Richard; Thakar, Monica S.; Malarkannan, Subramaniam (AACR, 2019-10)
    Natural killer (NK) cells generate proinflammatory cytokines that are required to contain infections and tumor growth. However, the posttranscriptional mechanisms that regulate NK cell functions are not fully understood. ...
  • Scherschel, John A.; Soonpaa, Mark H.; Srour, Edward F.; Field, Loren J.; Rubart, Michael (Elsevier, 2008-06-01)
    (BM) cells after being directly transplanted into the ischemically injured heart remains a controversial issue. In this study, we investigated the ability of transplanted BM cells to develop intracellular calcium ...
  • Cohen, Peter A.; Koski, Gary K.; Czernieck, Brian J.; Bunting, Kevin D.; Fu, Xin-Yuan; Wang, Zhengqi; Zhang, Wen-Jun; Carter, Charles S.; Awad, Mohamed; Distel, Christopher A.; Nagem, Hassan; Paustian, Christopher C.; Johnson, Terrence D.; Tisdale, John F.; Shu, Suyu (ASH, 2008-09-01)
    The clinical outcomes of dendritic cell (DC)–based immunotherapy remain disappointing, with DCs often displaying a tenuous capacity to complete maturation and DC1 polarization in the tumor host. Surprisingly, we observed ...
  • Carpio, Victor H.; Aussenac, Florentin; Puebla-Clark, Lucinda; Wilson, Kyle D.; Villarino, Alejandro V.; Dent, Alexander L.; Stephens, Robin (Elsevier, 2020-06-24)
    Hybrid Th1/Tfh cells (IFN-γ+IL-21+CXCR5+) predominate in response to several persistent infections. In Plasmodium chabaudi infection, IFN-γ+ T cells control parasitemia, whereas antibody and IL-21+Bcl6+ T cells effect final ...
  • Xie, Markus M.; Dent, Alexander L. (Elsevier, 2019-10)
    Anaphylaxis, a life-threatening allergic reaction, is dependent on high affinity allergen-specific IgE. Gowthaman et al . now show that a new interleukin (IL)-13-expressing T helper cell subset specifically promotes ...
  • Kim, ByungHyun; Jiang, TingTing; Bae, Jun-Hyun; Yun, Hye Su; Jang, Seong Han; Kim, Jung Hyun; Kim, Jae Deog; Hur, Jin-Hoe; Shibata, Kensuke; Kurokawa, Kenji; Jung, Yunjin; Peschel, Andreas; Bae, Taeok; Lee, Bok Luel (American Society for Microbiology, 2019-11-18)
    Upon microbial infection, host immune cells recognize bacterial cell envelope components through cognate receptors. Although bacterial cell envelope components function as innate immune molecules, the role of the physical ...
  • Kuo, Ping-Chang; Weng, Wen-Tsan; Scofield, Barbara A.; Paraiso, Hallel C.; Brown, Dennis A.; Wang, Pei-Yu; Yu, I-Chen; Yen, Jui-Hung (BMC, 2020-04-29)
    Background: Inflammatory stimuli induce immunoresponsive gene 1 (IRG1) expression that in turn catalyzes the production of itaconate from the tricarboxylic acid cycle. Itaconate has recently emerged as a regulator of immune ...
  • Robinson, Christopher M.; Woods Acevedo, Mikal A.; McCune, Broc T.; Pfeiffer, Julie K. (American Society for Microbiology, 2019-11-13)
    Accumulating evidence suggests that intestinal bacteria promote enteric virus infection in mice. For example, previous work demonstrated that antibiotic treatment of mice prior to oral infection with poliovirus reduced ...
  • Zhang, Yongmei; Zhang, Hu; Zhang, Junjie; Zhang, Jiming; Guo, Haitao (Elsevier Masson, 2019-05)
    Hepatitis B virus (HBV) replicates its DNA genome through reverse transcription of an RNA intermediate. The lack of proofreading capacity of the viral DNA polymerase results in a high mutation rate of HBV genome. Under the ...
  • Xie, Markus M.; Liu, Hong; Corn, Caleb; Koh, Byung-Hee; Kaplan, Mark H.; Turner, Matthew J.; Dent, Alexander L. (American Association of Immunologists, 2019-07-12)
    Autoantibodies can result from excessive T follicular helper (Tfh) cell activity, whereas T follicular regulatory (Tfr) cells negatively regulate autoantibody production. IL-2 knockout (KO) mice on the BALB/c background ...
  • Li, Wei; Xia, Ying; Yang, Jing; Guo, Haitao; Sun, Guoqing; Sanyal, Arun J.; Shah, Vijay H.; Lou, Yongliang; Zheng, Xiaoqun; Chalasani, Naga; Yu, Qigui (Wiley Open Access:, 2020-01-12)
    Alcoholic hepatitis (AH) is a severe inflammatory liver disease that develops in some heavy drinkers. The immune system in patients with AH is hyperactive and yet dysfunctional. Here, we investigated whether this ...

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