Jake Chen

 

Recent Submissions

  • Muhammad, Syed Aun; Fatima, Nighat; Syed, Nawazish-I.-Husain; Wu, Xiaogang; Yang, X. Frank; Chen, Jake Y. (Public Library of Science, 2015)
    Invasive candidiasis is potentially life-threatening systemic fungal infection caused by Candida albicans (C. albicans). Candida enters the blood stream and disseminate throughout the body and it is often observed in ...
  • Yue, Zongliang; Wan, Ping; Huang, Hui; Xie, Zhan; Chen, Jake Y. (Springer (Biomed Central Ltd.), 2014)
    We developed a new computational technique called Step-Level Differential Response (SLDR) to identify genetic regulatory relationships. Our technique takes advantages of functional genomics data for the same species under ...
  • Yue, Zongliang; Kshirsagar, Madhura M.; Nguyen, Thanh; Suphavilai, Chayaporn; Neylon, Michael T.; Zhu, Liugen; Ratliff, Timothy; Chen, Jake Y. (Oxford University Press, 2015-06-15)
    In this article, we described a new database framework to perform integrative "gene-set, network, and pathway analysis" (GNPA). In this framework, we integrated heterogeneous data on pathways, annotated list, and gene-sets ...
  • Ibrahim, Sara; Capouch, Don; Chandorkar, Sujay; Chen, Jake; Saykin, Andrew J.; Wu, Xiaogang; Huang, Hui (Office of the Vice Chancellor for Research, 2012-04-13)
    Network pharmacology has emerged as a new topic of study in recent years. Molecular connectivity maps between drugs and genes/proteins in specific disease contexts can be particularly valuable, since the functional approach ...
  • Chen, Jake (Office of the Vice Chancellor for Research, 2012-04-13)
    In this project researchers developed software that can help extract results from PubMed literature to a comprehensive connectivity map, developing information on the relationships among drugs, proteins, and diseases. The ...
  • Li, Jillian; Zhang, Fan; Chen, Jake Y (2010-07)
    Bone cells can sense physical forces and convert mechanical stimulation conditions into biochemical signals that lead to expression of mechanically sensitive genes and proteins. However, it is still poorly understood how ...