Hua-Chen Chang

 

Recent Submissions

  • Yang, Xiaowei; Zhu, Jingjing; Tung, Chun-Yu; Gardiner, Gail; Wang, Qun; Chang, Hua-Chen; Zhou, Baohua (PLoS, 2015-02-03)
    Lunasin is a naturally occurring peptide isolated from soybeans and has been explored in cancer treatment. Lunasin inhibits NF-κB activation and thus pro-inflammatory cytokine and mediator production in macrophages. In ...
  • Simmons, Sharena J.; Tung, Chun-Yu; Chang, Hua-Chen (Office of the Vice Chancellor for Research, 2015-04-17)
    The innate immune system is the first line of defense against intruding pathogens. Dendritic cells (DCs) act as messengers between the adaptive and innate immune system, which process and present antigens to mature T helper ...
  • Casiano-Rivera, Félix M.; Tung, Chun-Yu; Chang, Hua-Chen (Office of the Vice Chancellor for Research, 2015-04-17)
    Lunasin is a seed peptide containing 43 amino acids, originally isolated from soybeans. Recently, a novel function of lunasin was discovered, as it acts as an immune modulating agent regulating gene expression of various ...
  • Voiles, Larry; Han, Ling; Lupov, Ivan; Chang, Hua-Chen (Office of the Vice Chancellor for Research, 2012-04-13)
    Collagen VI (COL6), an extracellular matrix protein (ECM), is important in maintaining the integrity of the tissue. Our recent findings have demonstrat-ed that excess COL6 is present in the lungs of comorbid patients with ...
  • Lewis, David; Chang, Hua-Chen; Han, Ling; Voiles, Larry; Henriquez, Sarah M.P. (Office of the Vice Chancellor for Research, 2012-04-13)
    Natural killer or (NK) cells are important components of the innate immune system, which play a major role in the rejection of tumors, and virally in-fected cells. By producing pro-inflammatory cytokines such as IFN-gamma, ...
  • Chang, Hua-Chen; Han, Ling; Lewis, David; Tung, Chun-Yu; Srinivasan, Mythily; Robertson, Michael J.; Yeh, Wu-Kuang (Office of the Vice Chancellor for Research, 2013-04-05)
    Immune Peptide Therapeutics (IPT) LLC, an Indiana-based small business and its research partner Indiana University previously identified a novel property of lunasin as a distinct class of immune modulating agent that ...
  • Voiles, Larry; Lewis, David E.; Han, Ling; Lupov, Ivan P.; Lin, Tsang-Long; Robertson, Michael J.; Petrache, Irina; Chang, Hua-Chen (Spandidos, 2014-08)
    Type VI collagen (COL6), an extracellular matrix protein, is important in maintaining the integrity of lung tissue. An increase in COL6 mRNA and protein deposition was found in the lungs of patients with pulmonary fibrosis, ...
  • Shipman, Kaylee; Tung, Chun-Yu; Han, Ling; Patel, Amy; Corn, Caleb; Chang, Hua-Chen (Office of the Vice Chancellor for Research, 2013-04-05)
    Innate immunity is mediated by effector cells, including NK cells, dendritic cells (DCs), macrophages, and polymorphonuclear phagocytes, which can respond immediately after activation through receptors encoded by germ-line ...
  • Chang, Hua-Chen; Tung, Chun-Yu; Lewis, David; Han, Ling; Srinivasan, Mythily; Robertson, Michael J.; Yeh, Wu-Kuang (Office of the Vice Chancellor for Research, 2014-04-11)
    Despite the plethora of immune modulating agents available in cancer treatment, their effectiveness relies on a functional immune system. However, the adverse side effects by chemotherapy impede the therapeutic benefits ...
  • Flores, Sarah; Dong, Melissa; Tung, Chun-Yu; Chang, Hua-Chen (Office of the Vice Chancellor for Research, 2014-04-11)
    Adjuvants enhance the immunogenicity of vaccines and improve the immune responses. Although many adjuvants are currently used in research, FDA approved aluminum salt (Alum) remains the most often used in human vaccines. ...
  • Kyazike, Sharifah; Lewis, David; Tung, Chun-Yu; Han, Ling; Chang, Hua-Chen (Office of the Vice Chancellor for Research, 2014-04-11)
    Cancer immunotherapy is one of the emerging therapeutic strategies to harness the immune system to eradicate chemotherapy-resistant cancerous cells. NK cells can recognize and eliminate cancer cells before adaptive immunity ...