Sunil Badve

 

Recent Submissions

  • Buechler, Steven A.; Gökmen-Polar, Yesim; Badve, Sunil S. (2018)
    Introduction Early stage estrogen receptor (ER)-positive breast cancer may be treated with chemotherapy in addition to hormone therapy. Currently available molecular signatures assess the risk of recurrence and the benefit ...
  • Suarez, Christopher D.; Wu, Junmin; Badve, Sunil S.; Sparano, Joseph A.; Kaliney, William; Littlepage, Laurie E. (Impact Journals, 2017-07-17)
    We previously identified the transcription factor ZNF217 (human) / Zfp217 (mouse) as an oncogene and prognostic indicator of reduced survival, increased metastasis, and reduced response to therapy in breast cancer patients. ...
  • Dieci, Maria Vittoria; Radosevic-Robin, Nina; Fineberg, Susan; van den Eynden, Gert; Ternes, Nils; Penault-Llorca, Frederique; Pruneri, Giancarlo; D’Alfonso, Timothy M.; Demaria, Sandra; Castaneda, Carlos; Sanchez, Joselyn; Badve, Sunil; Michiels, Stefan; Bossuyt, Veerle; Rojo, Federico; Singh, Baljit; Nielsen, Torsten; Viale, Giuseppe; Kim, Seong-Rim; Hewitt, Stephen; Wienert, Stephan; Loibl, Sybille; Rimm, David; Symmans, Fraser; Denkert, Carsten; Adams, Sylvia; Loi, Sherene; Salgado, Roberto (Elsevier, 2017-10-09)
    Morphological evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer is gaining momentum as evidence strengthens the clinical relevance of this immunological biomarker. TILs in the post-neoadjuvant residual ...
  • Rakha, Emad A.; Miligy, Islam; Gorringe, Kylie L.; Toss, Michael S.; Green, Andrew R.; Fox, Stephen B.; Schmitt, Fernando C.; Tan, Puay-Hoon; Tse, Gary M.; Badve, Sunil; Decker, Thomas; Vincent-Salomon, Anne; Dabbs, David J.; Foschini, Maria P.; Moreno, Filipa; Wentao, Yang; Geyer, Felipe C.; Reis-Filho, Jorge S.; Pinder, Sarah E.; Lakhani, Sunil R.; Ellis, Ian O. (Wiley, 2018)
    Despite the significant biological, behavioural and management differences between ductal carcinoma in situ (DCIS) and invasive carcinoma of the breast, they share many morphological and molecular similarities. Differentiation ...
  • Padda, Sukhmani K.; Yao, Xiaopan; Antonicelli, Alberto; Riess, Jonathan W.; Shang, Yue; Shrager, Joseph B.; Korst, Robert; Detterbeck, Frank; Huang, James; Burt, Bryan M.; Wakelee, Heather A.; Badve, Sunil S. (Elsevier, 2017)
    Introduction Thymic epithelial tumors (TETs) are associated with paraneoplastic autoimmune (PN/AI) syndromes. Myasthenia gravis is the most common PN/AI syndrome associated with TETs. Methods The International Thymic ...
  • Kim, Jisun; Geyer, Felipe C.; Martelotto, Luciano G.; Ng, Charlotte K. Y.; Lim, Raymond S.; Selenica, Pier; Li, Anqi; Pareja, Fresia; Fusco, Nicola; Edelweiss, Marcia; Kumar, Rahul; Gularte-Merida, Rodrigo; Forbes, Andre N.; Khurana, Ekta; Mariani, Odette; Badve, Sunil; Vincent-Salomon, Anne; Norton, Larry; Reis-Filho, Jorge S.; Weigelt, Britta (Wiley, 2017)
    Breast adenoid cystic carcinoma (AdCC), a rare type of triple-negative breast cancer, has been shown to be driven by MYB pathway activation, most often underpinned by the MYB–NFIB fusion gene. Alternative genetic mechanisms, ...
  • Radovich, Milan; Solzak, Jeffrey P.; Hancock, Bradley A.; Conces, Madison L.; Atale, Rutuja; Porter, Ryan F.; Zhu, Jin; Glasscock, Jarret; Kesler, Kenneth A.; Badve, Sunil S.; Schneider, Bryan P.; Loehrer, Patrick J. (SpringerNature, 2016-02-16)
    BACKGROUND: Thymomas are one of the most rarely diagnosed malignancies. To better understand its biology and to identify therapeutic targets, we performed next-generation RNA sequencing. METHODS: The RNA was sequenced ...
  • Fusco, Nicola; Geyer, Felipe C.; De Filippo, Maria R.; Martelotto, Luciano G.; Piscuoglio, Salvatore; Guerini-Rocco, Elena; Schultheis, Anne M.; Fuhrmann, Laetitia; Wang, Lu; Jungbluth, Achim A.; Burke, Kathleen A.; Lim, Raymond S.; Vincent-Salomon, Anne; Bamba, Masamichi; Moritani, Suzuko; Badve, Sunil S.; Ichihara, Shu; Ellis, Ian O.; Reis-Filho, Jorge S.; Weigelt, Britta; Ng, Charlotte K.Y. (SpringerNature, 2016-11)
    Adenoid cystic carcinoma of the breast is a rare histologic type of triple-negative breast cancer with an indolent clinical behavior, often driven by the MYB-NFIB fusion gene. Here we sought to define the repertoire of ...
  • Rakha, Emad A.; Badve, Sunil; Eusebi, Vincenzo; Reis-Filho, Jorge S.; Fox, Stephen B.; Dabbs, David J.; Decker, Thomas; Hodi, Zsolt; Ichihara, Shu; Lee, Andrew HS.; Palacios, José; Richardson, Andrea L.; Vincent-Salomon, Anne; Schmitt, Fernando C.; Tan, Puay-Hoon; Tse, Gary M.; Ellis, Ian O. (Wiley, 2016-08-16)
    Breast lesions comprise a family of heterogeneous entities with variable patterns of presentation, morphology and clinical behaviour. The majority of breast lesions are classified traditionally into benign and malignant ...
  • Liu, Jing; Damayanti, Nur P.; Cho, Il-Hoon; Polar, Yesim; Badve, Sunil; Irudayaraj, Joseph M. K. (Society of Photo-Optical Instrumentation Engineers (SPIE), 2015-09)
    Fluorescence-based single molecule techniques to interrogate gene expression in tissues present a very low signal-to-noise ratio due to the strong autofluorescence and other background signals from tissue sections. This ...
  • Bossuyt, V.; Provenzano, E.; Symmans, W. F.; Boughey, J. C.; Coles, C.; Curigliano, G.; Dixon, J. M.; Esserman, L. J.; Fastner, G.; Kuehn, T.; Peintinger, F.; von Minckwitz, G.; White, J.; Yang, W.; Badve, S.; Denkert, C.; MacGrogan, G.; Penault-Llorca, F.; Viale, G.; Cameron, D.; Breast International Group-North American Breast Cancer Group (BIG-NABCG) collaboration (Oxford University Press, 2015-07)
    Neoadjuvant systemic therapy (NAST) provides the unique opportunity to assess response to treatment after months rather than years of follow-up. However, significant variability exists in methods of pathologic assessment ...
  • Westphal, Steven M.; Jani, Manish; Badve, Sunil (Radiology Case Reports U of Washington, 2010)
    We present a case of a 57-year-old woman with a past medical history of end-stage renal disease and a recent history of electrical defibrillation who arrived for her annual mammogram with no breast-related complaints. The ...
  • Bhat-Nakshatri, Poornima; Goswami, Chirayu P.; Badve, Sunil; Magnani, Luca; Lupien, Mathieu; Nakshatri, Harikrishna (AACR, 2016-07)
    The PI3K pathway is activated in approximately 70% of breast cancers. PIK3CA gene mutations or amplifications that affect the PI3K p110α subunit account for activation of this pathway in 20% to 40% of cases, particularly ...
  • Gökmen-Polar, Yesim; Kesler, Kenneth; Loehrer, Patrick J., Sr.; Badve, Sunil (ASCO, 2016-05)
    Thymic carcinomas are rare tumors that arise from the epithelium of the thymus gland and characterized by cytologic atypia, invasiveness, and high risk of relapse and death.1–3 The current WHO schema recognizes at least ...
  • Nakshatri, H.; Appaiah, H. N.; Anjanappa, M.; Gilley, D.; Tanaka, H.; Badve, Sunil; Crooks, P. A.; Mathews, W.; Sweeney, C.; Bhat-Nakshatri, P. (Nature Publishing Group, 2015-01-22)
    The transcription factor nuclear factor-kappaB (NF-κB) is constitutively active in several cancers and is a target of therapeutic development. We recently developed dimethylaminoparthenolide (DMAPT), a clinical grade ...
  • Burnett, Riesa M.; Craven, Kelly E.; Krishnamurthy, Purna; Goswami, Chirayu P.; Badve, Sunil; Crooks, Peter; Mathews, William P.; Bhat-Nakshatri, Poornima; Nakshatri, Harikrishna (Impact Journals, LLC, 2015-05-20)
    Breast cancer metastasizes to bone, visceral organs, and/or brain depending on the subtype, which may involve activation of a host organ-specific signaling network in metastatic cells. To test this possibility, we determined ...
  • Provenzano, Elena; Bossuyt, Veerle; Viale, Giuseppe; Cameron, David; Badve, Sunil; Denkert, Carsten; MacGrogan, Gaëtan; Penault-Llorca, Frédérique; Boughey, Judy; Curigliano, Giuseppe; Dixon, J. Michael; Esserman, Laura; Fastner, Gerd; Kuehn, Thorsten; Peintinger, Florentia; von Minckwitz, Gunter; White, Julia; Yang, Wei; Symmans, W. Fraser (Nature, 2015-07)
    Neoadjuvant systemic therapy is being used increasingly in the treatment of early-stage breast cancer. Response, in the form of pathological complete response, is a validated and evaluable surrogate end point of survival ...
  • Woditschka, Stephan; Evans, Lynda; Duchnowska, Renata; Reed, L. Tiffany; Palmieri, Diane; Qian, Yongzhen; Badve, Sunil; Sledge, George; Gril, Brunilde; Aladjem, Mirit I.; Fu, Haiqing; Flores, Natasha M.; Gökmen-Polar, Yesim; Biernat, Wojciech; Szutowicz-Zielińska, Ewa; Mandat, Tomasz; Trojanowski, Tomasz; Och, Waldemar; Czartoryska-Arlukowicz, Bogumiła; Jassem, Jacek; Mitchell, James B.; Steeg, Patricia S. (Oxford University Press, )
    Background Breast cancer frequently metastasizes to the brain, colonizing a neuro-inflammatory microenvironment. The molecular pathways facilitating this colonization remain poorly understood. Methods Expression ...
  • Duchnowska, Renata; Jassem, Jacek; Goswami, Chirayu Pankaj; Dundar, Murat; Gökmen-Polar, Yesim; Li, Lang; Woditschka, Stephan; Biernat, Wojciech; Sosińska-Mielcarek, Katarzyna; Czartoryska-Arłukowicz, Bogumiła; Radecka, Barbara; Tomasevic, Zorica; Stępniak, Piotr; Wojdan, Konrad; Sledge, George W. Jr.; Steeg, Patricia S.; Badve, Sunil (Springer US, 2015-03)
    The overexpression or amplification of the human epidermal growth factor receptor 2 gene (HER2/neu) is associated with high risk of brain metastasis (BM). The identification of patients at highest immediate risk of BM could ...
  • Radovich, Milan; Clare, Susan E.; Atale, Rutuja; Pardo, Ivanesa; Hancock, Bradley A.; Solzak, Jeffrey P.; Kassem, Nawal; Mathieson, Theresa; V. Storniolo, Anna Maria; Rufenbarger, Connie; Lillemoe, Heather A.; Blosser, Rachel J.; Choi, Mi Ran; Sauder, Candice A.; Doxey, Diane; Henry, Jill E.; Hilligoss, Eric E.; Sakarya, Onur; Hyland, Fiona C.; Hickenbotham, Matthew; Zhu, Jin; Glasscock, Jarret; Badve, Sunil; Ivan, Mircea; Liu, Yunlong; Sledge, George W.; Schneider, Bryan P. (Springer, 2014-01)
    Triple-negative breast cancers (TNBCs) are a heterogeneous set of tumors defined by an absence of actionable therapeutic targets (ER, PR, and HER-2). Microdissected normal ductal epithelium from healthy volunteers represents ...

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