• HIV-Nef Protein Persists in the Lungs of Aviremic Patients with HIV and Induces Endothelial Cell Death 

  Chelvanambi, Sarvesh; Bogatcheva, Natalia V.; Bednorz, Mariola; Agarwal, Stuti; Maier, Bernhard; Alves, Nathan J.; Li, Wei; Syed, Farooq; Saber, Manal M.; Dahl, Noelle; Lu, Hongyan; Day, Richard B.; Smith, Patricia; Jolicoeur, Paul; Yu, Qigui; Dhillon, Navneet K.; Weissmann, Norbert; Twigg, Homer L., III; Clauss, Matthias (ATS, 2019-03)

  It remains a mystery why HIV-associated end-organ pathologies persist in the era of combined antiretroviral therapy (ART). One possible mechanism is the continued production of HIV-encoded proteins in latently HIV-infected ...
• Printed Graphene Electrochemical Biosensors Fabricated by Inkjet Maskless Lithography for Rapid and Sensitive Detection of Organophosphates 

  Hondred, John A.; Breger, Joyce C.; Alves, Nathan J.; Trammell, Scott A.; Walper, Scott A.; Medintz, Igor L.; Claussen, Jonathan C. (ACS, 2018-04-04)

  Solution phase printing of graphene-based electrodes has recently become an attractive low-cost, scalable manufacturing technique to create in-field electrochemical biosensors. Here, we report a graphene-based electrode ...
• Experimental Investigation on the Wave Rotor Constant Volume Combustor 

  Matsutomi, Yu; Meyer, Scott; Wijeyakulasuriya, Sameera; Izzy, Zuhair; Nalim, M. Razi; Shimo, Masayoshi; Kowalkowski, Mike; Snyder, Philip (AIAA, 2010-07-25)

  A wave rotor constant volume combustor was designed and built as a collaborative work of Rolls-Royce, Indiana University-Purdue University Indianapolis (IUPUI), and Purdue University. The experiment was designed to operate ...
• The Role of International Administration [IA] in the Globally Engaged University 

  Diemer, Timothy Todd; Russomanno, David J.; Nalim, M. Razi; Piekarzewska, Agnieszka; Dato, Shaari B. Md Nor (IEEE, 2017)

  This paper describes best practice and effective techniques in international administration (IA) within the Globally Engaged University. The Globally Engaged University is one that continually promotes, communicates, ...
• Numerical Modeling of a Wave Turbine and Estimation of Shaft Work 

  Jagannath, Ravichandra R.; Bane, Sally P. M.; Nalim, M. Razi (ASME, 2018-05)

  Wave rotors are periodic-flow devices that provide dynamic pressure exchange and efficient energy transfer through internal pressure waves generated due to fast opening and closing of ports. Wave turbines are wave rotors ...
• AKT Alters Genome-Wide Estrogen Receptor α Binding and Impacts Estrogen Signaling in Breast Cancer 

  Bhat-Nakshatri, Poornima; Wang, Guohua; Appaiah, Hitesh; Luktuke, Nikhil; Carroll, Jason S.; Geistlinger, Tim R.; Brown, Myles; Badve, Sunil; Liu, Yunlong; Nakshatri, Harikrishna (American Society for Microbiology, 2008-12)

  Estrogen regulates several biological processes through estrogen receptor α (ERα) and ERβ. ERα-estrogen signaling is additionally controlled by extracellular signal activated kinases such as AKT. In this study, we analyzed ...
• Estradiol-regulated microRNAs control estradiol response in breast cancer cells 

  Bhat-Nakshatri, Poornima; Wang, Guohua; Collins, Nikail R.; Thomson, Michael J.; Geistlinger, Tim R.; Carroll, Jason S.; Brown, Myles; Hammond, Scott; Srour, Edward F.; Liu, Yunlong; Nakshatri, Harikrishna (Oxford University Press, 2009-08)

  Estradiol (E2) regulates gene expression at the transcriptional level by functioning as a ligand for estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). E2-inducible proteins c-Myc and E2Fs are required for ...
• Subcellular Localization of Activated AKT in Estrogen Receptor- and Progesterone Receptor-Expressing Breast Cancers 

  Badve, Sunil; Collins, Nikail R.; Bhat-Nakshatri, Poornima; Turbin, Dmitry; Leung, Samuel; Thorat, Mangesh; Dunn, Sandra E.; Geistlinger, Tim R.; Carroll, Jason S.; Brown, Myles; Bose, Shikha; Teitell, Michael A.; Nakshatri, Harikrishna (Elsevier, 2010-05)

  Activated v-AKT murine thymoma viral oncogene homolog 1 (AKT)/protein kinase B (PKB) kinase (pAKT) is localized to the plasma membrane, cytoplasm, and/or nucleus in 50% of cancers. The clinical importance of pAKT localization ...
• ANTXR1, a stem cell enriched functional biomarker, connects collagen signaling to cancer stem-like cells and metastasis in breast cancer 

  Chen, Daohong; Bhat-Nakshatri, Poornima; Goswami, Chirayu; Badve, Sunil; Nakshatri, Harikrishna (American Association for Cancer Research, 2013-09-15)

  Cancer stem-like cells are thought to contribute to tumor recurrence. The anthrax toxin receptor ANTXR1 has been identified as a functional biomarker of normal stem cells and breast cancer stem-like cells. Primary stem ...
• Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-bet 

  McCune, Kasi; Bhat-Nakshatri, Poornima; Thorat, Mangesh A; Nephew, Kenneth P; Badve, Sunil; Nakshatri, Harikrishna (American Association for Cancer Research, 2010-01-15)

  Estrogen receptor alpha (ERα)-positive breast cancers that co-express trans cription factors GATA-3 and FOXA1 have a favorable prognosis. These transcription factors form an autoregulatory hormonal network that influences ...
• Radiation resistance in breast cancer: are CD44+/CD24-/proteosomelow/PKH26+ cells to blame? 

  Nakshatri, Harikrishna (BMC, 2010)

  Identification and characterization of cancer-initiating cells (CICs) enriched for stem cell-like functions and the establishment of a link between CICs and tumor recurrence, chemotherapy resistance and radiation resistance, ...
• Identification of FDA-approved Drugs Targeting Breast Cancer Stem Cells Along With Biomarkers of Sensitivity 

  Bhat-Nakshatri, Poornima; Goswami, Chirayu P.; Badve, Sunil; Sledge, George W.; Nakshatri, Harikrishna (Nature Research, 2013-08-28)

  Recently developed genomics-based tools are allowing repositioning of Food and Drug Administration (FDA)-approved drugs as cancer treatments, which were employed to identify drugs that target cancer stem cells (CSCs) of ...
• A Spectrum Graph-Based Protein Sequence Filtering Algorithm for Proteoform Identification by Top-Down Mass Spectrometry 

  Yang, Runmin; Zhu, Daming; Kou, Qiang; Bhat-Nakshatri, Poomima; Nakshatri, Harikrishna; Wu, Si; Liu, Xiaowen (IEEE, 2017-11)

  Database search is the main approach for identifying proteoforms using top-down tandem mass spectra. However, it is extremely slow to align a query spectrum against all protein sequences in a large database when the target ...
• PROGgene: gene expression based survival analysis web application for multiple cancers 

  Goswami, Chirayu Pankaj; Nakshatri, Harikrishna (Springer, 2013-10-28)

  Background Identification of prognostic mRNA biomarkers has been done for various cancer types. The data that are published from such studies are archived in public repositories. There are hundreds of such datasets available ...
• Emerging Therapeutic Delivery Capabilities and Challenges Utilizing Enzyme/Protein Packaged Bacterial Vesicles 

  Alves, Nathan J.; Turner, Kendrick B.; Medintz, Igor L.; Walker, Scott A. (Future Science, 2015-07)

  Nanoparticle-based therapeutics are poised to play a critical role in treating disease. These complex multifunctional drug delivery vehicles provide for the passive and active targeted delivery of numerous small molecule, ...
• Rationally engineered nanoparticles target multiple myeloma cells, overcome cell-adhesion-mediated drug resistance, and show enhanced efficacy in vivo 

  Kiziltepe, T.; Ashley, J. D.; Stefanick, J. F.; Qi, Y. M.; Alves, Nathan J.; Handlogten, Michael W.; Suckow, M. A.; Navari, R. M.; Bilgicer, B. (Nature, 2012-04)

  In the continuing search for effective cancer treatments, we report the rational engineering of a multifunctional nanoparticle that combines traditional chemotherapy with cell targeting and anti-adhesion functionalities. ...
• Protecting enzymatic function through directed packaging into bacterial outer membrane vesicles 

  Alves, Nathan J.; Turner, Kendrick B.; Medintz, Igor L.; Walper, Scott A. (Nature, 2016-04)

  Bacteria possess innate machinery to transport extracellular cargo between cells as well as package virulence factors to infect host cells by secreting outer membrane vesicles (OMVs) that contain small molecules, proteins, ...
• Harnessing structure-activity relationship to engineer a cisplatin nanoparticle for enhanced antitumor efficacy 

  Paraskar, Abhimanyu S.; Soni, Shivani; Chin, Kenneth T.; Chaudhuri, Padmaparna; Muto, Katherine W.; Berkowitz, Julia; Handlogten, Michael W.; Alves, Nathan J.; Bilgicer, Basar; Dinulescu, Daniela M.; Mashelkar, Raghunath A.; Sengupta, Shiladitya (PNAS, 2010)

  Cisplatin is a first line chemotherapy for most types of cancer. However, its use is dose-limited due to severe nephrotoxicity. Here we report the rational engineering of a novel nanoplatinate inspired by the mechanisms ...
• Synthetic Allergen Design Reveals The Significance of Moderate Affinity Epitopes in Mast Cell Degranulation 

  Handlogten, Michael W.; Kiziltepe, Tanyel; Alves, Nathan J.; Bilgicer, Basar (ACS, 2012)

  This study describes the design of a well-defined homotetravalent synthetic allergen (HTA) system to investigate the effect of hapten–IgE interactions on mast cell degranulation. A library of DNP variants with varying ...
• Antibody Conjugation and Formulation 

  Alves, Nathan J. (Oxford, 2019)

  In an era where ultra-high antibody concentrations, high viscosities, low volumes, auto-injectors, and long storage requirements are already complex problems with the current unconjugated monoclonal antibodies on the market ...

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