Department of Neurology Articles

 

Recent Submissions

  • Salinas, Joel; Sprinkhuizen, Sara M.; Ackerson, Teri; Bernhardt, Julie; Davie, Charlie; George, Mary G.; Gething, Stephanie; Kelly, Adam G.; Lindsay, Patrice; Liu, Liping; Martins, Sheila C. O.; Morgan, Louise; Norrving, Bo; Ribbers, Gerard M.; Silver, Frank L.; Smith, Eric E.; Williams, Linda S.; Schwamm, Lee H. (Ovid Technologies Wolters Kluwer – American Heart Association, 2016-01)
    BACKGROUND AND PURPOSE: Value-based health care aims to bring together patients and health systems to maximize the ratio of quality over cost. To enable assessment of healthcare value in stroke management, an international ...
  • King-Stephens, David; Mirro, Emily; Weber, Peter B.; Laxer, Kenneth D.; Van Ness, Paul C.; Salanova, Vicenta; Spencer, David C.; Heck, Christianne N.; Goldman, Alica; Jobst, Barbara; Shields, Donald C.; Bergey, Gregory K.; Eisenschenk, Stephan; Worrell, Gregory A.; Rossi, Marvin A.; Gross, Robert E.; Cole, Andrew J.; Sperling, Michael R.; Nair, Dileep R.; Gwinn, Ryder P.; Park, Yong D.; Rutecki, Paul A.; Fountain, Nathan B.; Wharen, Robert E.; Hirsch, Lawrence J.; Miller, Ian O.; Barkley, Gregory L.; Edwards, Jonathan C.; Geller, Eric B.; Berg, Michel J.; Sadler, Toni L.; Sun, Felice T.; Morrell, Martha J. (Wiley Blackwell (Blackwell Publishing), 2015-06)
    OBJECTIVE: Patients with suspected mesial temporal lobe (MTL) epilepsy typically undergo inpatient video-electroencephalography (EEG) monitoring with scalp and/or intracranial electrodes for 1 to 2 weeks to localize and ...
  • Matthews, Brandy R. (Wolters Kluwer, 2015-06)
    Purpose of Review:: This article highlights the dissociable human memory systems of episodic, semantic, and procedural memory in the context of neurologic illnesses known to adversely affect specific neuroanatomic structures ...
  • Stahl, Stephanie M.; Yaggi, H. Klar; Taylor, Stanley; Qin, Li; Ivan, Cristina S.; Austin, Charles; Ferguson, Jared; Radulescu, Radu; Tobias, Lauren; Sico, Jason; Vaz Fragoso, Carlos A.; Williams, Linda S.; Lampert, Rachel; Miech, Edward J.; Matthias, Marianne S.; Kapoor, John; Bravata, Dawn M. (Elsevier, 2015-10)
    Background: The literature about the relationship between obstructive sleep apnea (OSA) and stroke location is conflicting with some studies finding an association and others demonstrating no relationship. Among acute ...
  • Sico, Jason J.; Phipps, Michael S.; Concato, John; Brandt, Cynthia; Wells, Carolyn K.; Lo, Albert C.; Nadeau, Stephen E.; Williams, Linda S.; Gorman, Mark; Boice, John L.; Bravata, Dawn M. (Elsevier, 2016-04)
    Background Risk-adjusted poststroke mortality has been proposed for use as a measure of stroke care quality. Although valid measures of stroke severity (e.g., the National Institutes of Health Stroke Scale [NIHSS]) are ...
  • Mackay, Devin D.; Garza, Philip S.; Bruce, Beau B.; Newman, Nancy J.; Biousse, Valérie (Ovid Technologies (Wolters Kluwer) - American Academy of Neurology, 2015-04)
    Ocular funduscopy appears to be a dying art. Physicians and medical students alike lack confidence in the use of an ophthalmoscope. As a result, few clinicians perform ophthalmoscopy, and many who do are unable to reliably ...
  • Zhang, Xiaojie; Lee, Soo Jung; Young, Kelly Z.; Josephson, David A.; Geschwind, Michael D.; Wang, Michael M. (Elsevier, 2014-10-02)
    Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy CADASIL is caused by more than a hundred NOTCH3 mutations. Virtually all encoded mutant proteins contain an odd number of cysteines. ...
  • Gianaris, Thomas; Witt, Thomas; Barbaro, Nicholas M. (Elsevier, 2016-01)
  • Rhee, Kyoung-Suk; Hsueh, Chia-Hsiang; Hellyer, Jessica A.; Park, Hyung Wook; Lee, Young Soo; Garlie, Jason; Onkka, Patrick; Doytchinova, Anisiia T.; Garner, John B.; Patel, Jheel; Chen, Lan S.; Fishbein, Michael C.; Everett 4th, Thomas; Lin, Shien-Fong; Chen, Peng-Sheng (Synapse, 2015-03-24)
    BACKGROUND AND OBJECTIVES: Recent studies showed that, in addition to parasympathetic nerves, cervical vagal nerves contained significant sympathetic nerves. We hypothesized that cervical vagal nerve stimulation (VNS) ...
  • Koo, Brian B.; Won, Christine; Selim, Bernardo J.; Qin, Li; Jeon, Sangchoon; Redeker, Nancy S.; Bravata, Dawn M.; Strohl, Kingman P.; Concato, John; Yaggi, Henry K. (Springer, 2016-05)
    Purpose The goal of the Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study is to develop a prognostic model for cardiovascular outcomes, based on physiologic variables—related to breathing, sleep ...
  • Arling, Greg; Ofner, Susan; Reeves, Mathew J.; Myers, Laura J.; Williams, Linda S.; Daggy, Joanne K.; Phipps, Michael S.; Chumbler, Neale; Bravata, Dawn M. (AHA, 2015-10)
    Background—Recovery after a stroke varies greatly between individuals and is reflected by wide variation in the use of institutional and home care services. This study sought to classify veterans according to their care ...
  • Yokoyama, Jennifer S.; Lee, Allen K.L.; Takada, Leonel T.; Busovaca, Edgar; Bonham, Luke W.; Chao, Steven Z.; Tse, Marian; He, Jing; Schwarz, Christopher G.; Carmichael, Owen T.; Matthews, Brandy R.; Karydas, Anna; Weiner, Michael W.; Coppola, Giovanni; DeCarli, Charles S.; Miller, Bruce L.; Rosen, Howard J. (PLoS, 2016-06-17)
    Studying ethnically diverse groups is important for furthering our understanding of biological mechanisms of disease that may vary across human populations. The ε4 allele of apolipoprotein E (APOE ε4) is a well-established ...
  • Brosch, Jared R.; Matthews, Brandy R. (American Academy of Neurology, 2014-03-04)
    Advances in neuroimaging, biomarkers, and clinical data have led to the hypothesis that the pathologic process of Alzheimer dementia begins decades prior to functional decline and diagnosis.1–3 High-profile clinical trial ...
  • Stahl, Stephanie M.; Mackey, Jason (American Academy of Neurology, 2014-04-01)
    The article “Surveillance neuroimaging and neurologic examinations affect care for intracerebral hemorrhage”1 is reviewed. This review focuses on the methods, results, and limitations and merits of the original article.
  • Lucey, Brendan P.; Gonzales, Celedon; Das, Ujjwas; Li, Jinhe; Siemers, Eric R.; Slemmon, J. Randall; Bateman, Randall J.; Huang, Yafei; Fox, Gerard B.; Claassen, Jurgen A.H.R.; Slats, Diane; Verbeek, Marcel M.; Tong, Gary; Soares, Holly; Savage, Mary J.; Kennedy, Matthew; Forman, Mark; Sjögren, Magnus; Margolin, Richard; Chen, Xia; Farlow, Martin R.; Dean, Robert A.; Waring, Jeffrey F. (BioMed Central, 2015-07-29)
    INTRODUCTION: Amyloid-β (Aβ) has been investigated as a diagnostic biomarker and therapeutic drug target. Recent studies found that cerebrospinal fluid (CSF) Aβ fluctuates over time, including as a diurnal pattern, and ...
  • Farlow, Martin R.; Andreasen, Niels; Riviere, Marie-Emmanuelle; Vostiar, Igor; Vitaliti, Alessandra; Sovago, Judit; Caputo, Angelika; Winblad, Bengt; Graf, Ana (BioMed Central, 2015-04-27)
    INTRODUCTION: CAD106 is designed to stimulate amyloid-β (Aβ)-specific antibody responses while avoiding T-cell autoimmune responses. The CAD106 first-in-human study demonstrated a favorable safety profile and promising ...
  • Doody, Rachelle S.; Raman, Rema; Sperling, Reisa A.; Seimers, Eric; Sethuraman, Gopalan; Mohs, Richard; Farlow, Martin; Iwatsubo, Takeshi; Vellas, Bruno; Sun, Xiaoying; Ernstrom, Karin; Thomas, Ronald G.; Aisen, Paul S. (BioMed Central, 2015-06-10)
    INTRODUCTION: The negative efficacy study examining the γ-secretase inhibitor semagacestat in mild to moderate Alzheimer's disease (AD) included a number of biomarkers of the disease as well as safety outcomes. We ...
  • Fontanilla, Christine V.; Gu, Huiying; Liu, Qingpeng; Zhu, Timothy Z.; Johnstone, Brian H.; March, Keith L.; Pascuzzi, Robert M.; Farlow, Martin R.; Du, Yansheng (Nature Publishing Group, 2015-11-20)
    Adipose stromal cells (ASC) secrete various trophic factors that assist in the protection of neurons in a variety of neuronal death models. In this study, we tested the effects of human ASC conditional medium (ASC-CM) in ...
  • Bidassie, Balmatee; Williams, Linda S.; Woodward-Hagg, Heather; Matthias, Marianne S.; Damush, Teresa M. (Springer (Biomed Central Ltd.), 2015)
    BACKGROUND: Facilitation is a key component for successful implementation in several implementation frameworks; however, there is a paucity of research specifying this component. As part of a stroke quality improvement ...
  • Fu, Xue; Zeng, Andrew; Zheng, Wei; Du, Yansheng (Sage Publications, 2014-02)
    Zinc (Zn) is an essential element for normal brain function; an abnormal Zn homeostasis in brain and the cerebrospinal fluid (CSF) has been implied in the etiology of Alzheimer's disease (AD). However, the mechanisms that ...

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