• Medication for Alzheimer’s Disease and Associated Fall Hazard: a Retrospective Cohort Study from the Alzheimer’s Disease Neuro-Imaging Initiative 

  Epstein, Noam U.; Guo, Rong; Farlow, Martin R.; Singh, Jaswinder P.; Fisher, Morris (Springer, 2014-02)

  BACKGROUND: Falls are common in the elderly, especially in those with cognitive impairment. The elderly are often treated with several medications, which may have both beneficial and deleterious effects. The use and ...
• A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease 

  McGarry, Andrew; McDermott, Michael; Kieburtz, Karl; de Blieck, Elisabeth A.; Beal, Flint; Marder, Karen; Ross, Christopher; Shoulson, Ira; Gibert, Peter; Mallonee, William M.; Guttman, Mark; Wojcieszek, Joanne; Kumar, Rajeev; LeDoux, Mark S.; Jenkins, Mary; Rosas, H. Diana; Nance, Martha; Biglan, Kevin; Como, Peter; Dubinsky, Richard M.; Shannon, Kathleen M.; O'Suilleabhain, Padraig; Chou, Kelvin; Walker, Francis; Martin, Wayne; Wheelock, Vicki L.; McCusker, Elizabeth; Jankovic, Joseph; Singer, Carlos; Sanchez-Ramos, Juan; Scott, Burton; Suchowersky, Oksana; Factor, Stewart A.; Higgins, Donald S., Jr.; Molho, Eric; Revilla, Fredy; Caviness, John N.; Friedman, Joseph H.; Perlmutter, Joel S.; Feigin, Andrew; Anderson, Karen; Rodriguez, Ramon; McFarland, Nikolaus R.; Margolis, Russell L.; Farbman, Eric S.; Raymond, Lynn A.; Suski, Valerie; Kostyk, Sandra; Colcher, Amy; Seeberger, Lauren; Epping, Eric; Esmail, Sherali; Diaz, Nancy; Fung, Wai Lun Alan; Diamond, Alan; Frank, Samuel; Hanna, Philip; Hermanowicz, Neal; Dure, Leon S.; Cudkowicz, Merit (2017-01)

  Objective: To test the hypothesis that chronic treatment of early-stage Huntington disease (HD) with high-dose coenzyme Q10 (CoQ) will slow the progressive functional decline of HD. Methods: We performed a multicenter ...
• Active Aβ immunotherapy CAD106 in Alzheimer's disease: A phase 2b study 

  Vandenberghe, Rik; Riviere, Marie-Emmanuelle; Caputo, Angelika; Sovago, Judit; Maguire, R. Paul; Farlow, Martin; Marotta, Giovanni; Sanchez-Valle, Raquel; Scheltens, Philip; Ryan, J. Michael; Graf, Ana (Elsevier, 2017-01)

  Introduction This randomized, double-blind, placebo-controlled, 90-week study assessed safety, tolerability, and immunogenicity of CAD106 with/without adjuvant in patients with mild Alzheimer's disease. Methods One ...
• Thalamic GABA levels and Occupational Manganese Neurotoxicity: Association with Exposure Levels and Brain MRI 

  Ma, Ruoyun E.; Ward, Eric J.; Yeh, Chien-Lin; Snyder, Sandy; Long, Zaiyang; Yavuz, Fulya Gokalp; Zauber, S. Elizabeth; Dydak, Ulrike (Elsevier, 2017)

  Excessive occupational exposure to Manganese (Mn) has been associated with clinical symptoms resembling idiopathic Parkinson’s disease (IPD), impairing cognitive and motor functions. Several studies point towards an ...
• Mapping the functional connectome traits of levels of consciousness 

  Amico, Enrico; Marinazzo, Daniele; DiPerri, Carol; Heine, Lizette; Annen, Jitka; Martial, Charlotte; Dzemidzic, Mario; Laureys, Steven; Goñi, Joaquín (Elsevier, 2017-03)

  Examining task-free functional connectivity (FC) in the human brain offers insights on how spontaneous integration and segregation of information relate to human cognition, and how this organization may be altered in ...
• American Clinical Neurophysiology Society Guideline 1: Minimum Technical Requirements for Performing Clinical Electroencephalography 

  Sinha, Saurabh R.; Sullivan, Lucy; Sabau, Dragos; San-Juan, Daniel; Dombrowski, Keith; Halford, Jonathan J.; Hani, Abeer; Drislane, Frank W.; Stecker, Mark (Taylor & Francis, 2016)
• Validation of Stroke Meaningful Use Measures in a National Electronic Health Record System 

  Phipps, Michael S.; Fahner, Jeff; Sager, Danielle; Coffing, Jessica; Maryfield, Bailey; Williams, Linda S. (Springer-Verlag, 2016-04)

  BACKGROUND: The Meaningful Use (MU) program has increased the national emphasis on electronic measurement of hospital quality. OBJECTIVE: To evaluate stroke MU and one VHA stroke electronic clinical quality measure (eCQM) ...
• Social Comparisons, Social Support, and Self-Perceptions in Group Exercise for People With Parkinson's Disease 

  Sheehy, Tammy L.; McDonough, Meghan H.; Zauber, S. Elizabeth (Taylor & Francis, 2017)

  People with Parkinson's disease (PD) may experience declining function and limited interaction with others with PD. Group exercise provides opportunities for physical accomplishment and social support, as well as potential ...
• Sex differences in cardiovascular risk profiles of ischemic stroke patients with diabetes in the Greater Cincinnati/Northern Kentucky Stroke Study 

  Madsen, Tracy E.; Khoury, Jane C.; Alwell, Kathleen A.; Moomaw, Charles J.; Demel, Stacie L.; Flaherty, Matthew L.; Woo, Daniel; Mackey, Jason; De Los Rios La Rosa, Felipe; Martini, Sharyl; Ferioli, Simona; Adeoye, Opeolu; Khatri, Pooja; Kissela, Brett M.; Kleindorfer, Dawn O. (Wiley, 2017)

  Background The aim of the present study was to compare sex-specific associations between cardiovascular risk factors and diabetes mellitus (DM) among patients with acute ischemic stroke (AIS) in the Greater Cincinnati/Northern ...
• GDNF secreted from adipose-derived stem cells stimulates VEGF-independent angiogenesis 

  Zhong, Zhaohui; Gu, Huiying; Peng, Jirun; Wang, Wenzheng; Johnstone, Brian H.; March, Keith L.; Farlow, Martin R.; Du, Yansheng (Impact Journals, LLC, 2016-06-14)

  Adipose tissue stroma contains a population of mesenchymal stem cells (MSC) promote new blood vessel formation and stabilization. These adipose-derived stem cells (ASC) promote de novo formation of vascular structures in ...
• Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7 T MRI 

  Blanken, Anna E.; Hurtz, Sona; Zarow, Chris; Biado, Kristina; Honarpisheh, Hedieh; Somme, Johanne; Brook, Jenny; Tung, Spencer; Kraft, Emily; Lo, Darrick; Ng, Denise W.; Vinters, Harry V.; Apostolova, Liana G. (Elsevier, 2017-04-21)

  Hippocampal atrophy, amyloid plaques, and neurofibrillary tangles are established pathologic markers of Alzheimer's disease. We analyzed the temporal lobes of 9 Alzheimer's dementia (AD) and 7 cognitively normal (NC) ...
• Donepezil Plus Solifenacin (CPC-201) Treatment for Alzheimer's Disease 

  Chase, Thomas N.; Farlow, Martin R.; Clarence-Smith, Kathleen (Springer, 2017-04)

  Available cholinergic drugs for treating Alzheimer's disease (AD) provide modest symptomatic benefit. We hypothesized that co-administration of a peripheral anticholinergic to reduce dose-limiting adverse effects (AEs) ...
• Gender and Time to Arrival among Ischemic Stroke Patients in the Greater Cincinnati/Northern Kentucky Stroke Study 

  Madsen, Tracy E.; Sucharew, Heidi; Katz, Brian; Alwell, Kathleen A.; Moomaw, Charles J.; Kissela, Brett M.; Flaherty, Matthew L.; Woo, Daniel; Khatri, Pooja; Ferioli, Simona; Mackey, Jason; Martini, Sharyl; De Los Rios La Rosa, Felipe; Kleindorfer, Dawn O. (Elsevier, 2016-03)

  Background Some studies of stroke patients report longer pre-hospital delays in women, but others conflict; studies vary in their inclusion of factors including age and stroke severity. We aimed to investigate the ...
• Effect of diabetes on caregiver burden in an observational study of individuals with Alzheimer's disease 

  Lebrec, Jeremie; Ascher-Svanum, Haya; Chen, Yun-Fei; Reed, Catherine; Kahle-Wrobleski, Kristin; Hake, Ann Marie; Raskin, Joel; Naderali, Ebrahim; Schuster, Dara; Heine, Robert J.; Kendall, David M. (BioMed Central, 2016-05-03)

  BACKGROUND: The burden on caregivers of patients with Alzheimer's disease (AD) is associated with the patient's functional status and may also be influenced by chronic comorbid medical conditions, such as diabetes. This ...
• AOSSM Early Sport Specialization Consensus Statement 

  LaPrade, Robert F.; Agel, Julie; Baker, Joseph; Brenner, Joel S.; Cordasco, Frank A.; Co te, Jean; Engebretsen, Lars; Feeley, Brian T.; Gould, Daniel; Hainline, Brian; Hewett, Timothy E.; Jayanthi, Neeru; Kocher, Mininder S.; Myer, Gregory D.; Nissen, Carl W.; Philippon, Marc J.; Provencher, Matthew T.; Hainline, Brian (SAGE, 2016-04)

  BACKGROUND: Early sport specialization is not a requirement for success at the highest levels of competition and is believed to be unhealthy physically and mentally for young athletes. It also discourages unstructured ...
• The Cognitive Change Index as a Measure of Self and Informant Perception of Cognitive Decline: Relation to Neuropsychological Tests 

  Rattanabannakit, Chatchawan; Risacher, Shannon L.; Gao, Sujuan; Lane, Kathleen A.; Brown, Steven A.; McDonald, Brenna C.; Unverzagt, Frederick W.; Apostolova, Liana G.; Saykin, Andrew J.; Farlow, Martin R. (IOS Press, 2016-02-25)

  BACKGROUND: The perception of cognitive decline by individuals and those who know them well ("informants") has been inconsistently associated with objective cognitive performance, but strongly associated with depressive ...
• BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer’s disease 

  Lim, Yen Ying; Hassenstab, Jason; Cruchaga, Carlos; Goate, Alison; Fagan, Anne M.; Benzinger, Tammie L. S.; Maruff, Paul; Snyder, Peter J.; Masters, Colin L.; Allegri, Ricardo; Chhatwal, Jasmeer; Farlow, Martin R.; Graff-Radford, Neill R.; Laske, Christoph; Levin, Johannes; McDade, Eric; Ringman, John M.; Rossor, Martin N.; Salloway, Stephen; Schofield, Peter R.; Holtzman, David M.; Morris, John C.; Bateman, Randall J. (Oxford, 2016-10)

  The brain-derived neurotrophic factor ( BDNF ) Val66Met polymorphism is implicated in synaptic excitation and neuronal integrity, and has previously been shown to moderate amyloid-β-related memory decline and hippocampal ...
• Externalizing personality traits, empathy, and gray matter volume in healthy young drinkers 

  Charpentier, Judith; Dzemidzic, Mario; West, John; Oberlin, Brandon G.; Eiler, William J. A. II; Saykin, Andrew J.; Kareken, David A. (Elsevier, 2016-02-28)

  Externalizing psychopathology has been linked to prefrontal abnormalities. While clinically diagnosed subjects show altered frontal gray matter, it is unknown if similar deficits relate to externalizing traits in non-clinical ...
• The apéritif effect: Alcohol's effects on the brain's response to food aromas in women 

  Eiler, William J. A.; Džemidžić, Mario; Case, K. Rose; Soeurt, Christina M.; Armstrong, Cheryl L. H.; Mattes, Richard D.; O'Connor, Sean J.; Harezlak, Jaroslaw; Acton, Anthony J.; Considine, Robert V.; Kareken, David A. (Wiley Blackwell (John Wiley & Sons), 2015-07)

  OBJECTIVE: Consuming alcohol prior to a meal (an apéritif) increases food consumption. This greater food consumption may result from increased activity in brain regions that mediate reward and regulate feeding behavior. ...
• Raloxifene for women with Alzheimer disease: A randomized controlled pilot trial 

  Henderson, Victor W.; Ala, Tom; Sainani, Kristin L.; Bernstein, Allan L.; Stephenson, B. Sue; Rosen, Allyson C.; Farlow, Martin R. (Wolters Kluwer, 2015-12)

  OBJECTIVE: To determine whether raloxifene, a selective estrogen receptor modulator, improves cognitive function compared with placebo in women with Alzheimer disease (AD) and to provide an estimate of cognitive ...

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