• The plasma level changes of VEGF and soluble VEGF receptor‐1 are associated with high‐altitude pulmonary edema 

  Zhang, Shukun; Liu, Juanli; Jiang, Dongmei; Wuren, Tana; Ma, Siqing; Du, Yansheng; Wu, Shizheng (2018)

  Hypoxia‐induced plasma levels of VEGF and sFlt‐1 are responsible for increased vascular permeability occurred in both brain and pulmonary edema. Currently, it remains unclear the exact roles of VEGF and sFlt‐1 in High ...
• Heritability of circle of Willis variations in families with intracranial aneurysms 

  Sánchez van Kammen, Mayte; Moomaw, Charles J.; Schaaf, Irene C. van der; Brown, Robert D., Jr.; Woo, Daniel; Broderick, Joseph P.; Mackey, Jason S.; Rinkel, Gabriël J. E.; Huston, John, III; Ruigrok, Ynte M. (Public Library of Science, 2018-01-29)

  BACKGROUND: Intracranial aneurysms more often occur in the same arterial territory within families. Several aneurysm locations are associated with specific circle of Willis variations. We investigated whether the same ...
• Laquinimod attenuates inflammation by modulating macrophage functions in traumatic brain injury mouse model 

  Katsumoto, Atsuko; Miranda, Aline S.; Butovsky, Oleg; Teixeira, Antônio L.; Ransohoff, Richard M.; Lamb, Bruce T. (BioMed Central, 2018-01-30)

  BACKGROUND: Traumatic brain injury (TBI) is a critical public health and socio-economic problem worldwide. A growing body of evidence supports the involvement of inflammatory events in TBI. It has been reported that ...
• Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer's disease 

  Casali, Brad T.; Reed-Geaghan, Erin G.; Landreth, Gary E. (BioMed Central, 2018-02-15)

  BACKGROUND: Alzheimer's disease (AD) is a highly prevalent neurodegenerative disorder characterized by pathological hallmarks of beta-amyloid plaque deposits, tau pathology, inflammation, and cognitive decline. Treatment ...
• Interactive Voice Response-An Innovative Approach to Post-Stroke Depression Self-Management Support 

  Skolarus, Lesli E.; Piette, John D.; Pfeiffer, Paul N.; Williams, Linda S.; Mackey, Jason; Hughes, Rebecca; Morgenstern, Lewis B. (Springer Nature, 2017-02)

  Automated interactive voice response (IVR) call systems can provide systematic monitoring and self-management support to depressed patients, but it is unknown if stroke patients are able and willing to engage in IVR ...
• Brain Connectivity-Informed Regularization Methods for Regression 

  Karas, Marta; Brzyski, Damian; Dzemidzic, Mario; Goñi, Joaquín; Kareken, David A.; Randolph, Timothy W.; Harezlak, Jaroslaw (Springer, 2017-12-06)

  One of the challenging problems in brain imaging research is a principled incorporation of information from different imaging modalities. Frequently, each modality is analyzed separately using, for instance, dimensionality ...
• Orbital Apex Metastasis from Adenoid Cystic Carcinoma: Acute Loss of Vision and Subsequent Recovery with the Radiation 

  Crawford, Lauren; Sharma, Sanjeev (Cureus, Inc., 2017-11-22)

  Orbital apex metastasis from adenoid cystic carcinoma (ACC) is rare. We present a patient with known metastatic ACC presented with a rapidly declining vision with visual acuity oculus dexter (OD) equal to counting fingers ...
• Disparities and guideline adherence in drugs of abuse screening in intracerebral hemorrhage 

  Tormoehlen, Laura M.; Blatsioris, Ashley D.; Moser, Elizabeth A.S.; Carter, Ravan J.L.; Stevenson, Alec; Ofner, Susan; Hulin, Abigail L.; O’Neill, Darren P.; Cohen-Gadol, Aaron A.; Leipzig, Thomas J.; Williams, Linda S.; Mackey, Jason (American Academy of Neurology, 2017-01-17)

  OBJECTIVE: To characterize the pattern of urine drug screening in a cohort of intracerebral hemorrhage (ICH) patients at our academic centers. METHODS: We identified cases of primary ICH occurring from 2009 to 2011 ...
• Family history of alcoholism and the human brain response to oral sucrose 

  Eiler, William J.A., II; Dzemidzic, Mario; Soeurt, Christina M.; Carron, Claire R.; Oberlin, Brandon G.; Considine, Robert V.; Harezlak, Jaroslaw; Kareken, David A. (Elsevier, 2017-12-12)

  A heightened hedonic response to sweet tastes has been associated with increased alcohol preference and alcohol consumption in both humans and animals. The principal goal of this study was to examine blood oxygenation level ...
• Targeting Neuroinflammation to Treat Alzheimer's Disease 

  Ardura-Fabregat, A.; Boddeke, E. W. G. M.; Boza-Serrano, A.; Brioschi, S.; Castro-Gomez, S.; Ceyzériat, K.; Dansokho, C.; Dierkes, T.; Gelders, G.; Heneka, Michael T.; Hoeijmakers, L.; Hoffmann, A.; Iaccarino, L.; Jahnert, S.; Kuhbandner, K.; Landreth, G.; Lonnemann, N.; Löschmann, P. A.; McManus, R. M.; Paulus, A.; Reemst, K.; Sanchez-Caro, J. M.; Tiberi, A.; Perren, A. van der; Vautheny, A.; Venegas, C.; Webers, A.; Weydt, P.; Wijasa, T. S.; Xiang, X.; Yang, Y. (Springer, 2017-12)

  Over the past few decades, research on Alzheimer's disease (AD) has focused on pathomechanisms linked to two of the major pathological hallmarks of extracellular deposition of beta-amyloid peptides and intra-neuronal ...
• Tau Imaging in Alzheimer's Disease Diagnosis and Clinical Trials 

  Brosch, Jared R.; Farlow, Martin R.; Risacher, Shannon L.; Apostolova, Liana G. (Springer Verlag, 2017-01)

  In vivo imaging of the tau protein has the potential to aid in quantitative diagnosis of Alzheimer's disease, corroborate or dispute the amyloid hypothesis, and demonstrate biomarker engagement in clinical drug trials. A ...
• Stable incidence but declining case-fatality rates of subarachnoid hemorrhage in a population 

  Mackey, Jason; Khoury, Jane C.; Alwell, Kathleen; Moomaw, Charles J.; Kissela, Brett M.; Flaherty, Matthew L.; Adeoye, Opeolu; Woo, Daniel; Ferioli, Simona; De Los Rios La Rosa, Felipe; Martini, Sharyl; Khatri, Pooja; Broderick, Joseph P.; Zuccarello, Mario; Kleindorfer, Dawn (American Academy of Neurology, 2016-11-22)

  Objective: To characterize temporal trends in subarachnoid hemorrhage (SAH) incidence and outcomes over 5 time periods in a large population-based stroke study in the United States. Methods: All SAHs among residents ...
• Age, Sex, and Racial Differences in Neuroimaging Use in Acute Stroke: A Population-Based Study 

  Vagal, A.; Sanelli, P.; Sucharew, H.; Alwell, K. A.; Khoury, J. C.; Khatri, P.; Woo, D.; Flaherty, M.; Kissela, B. M.; Adeoye, O.; Ferioli, S.; De Los Rios La Rosa, F.; Martini, S.; Mackey, Jason; Kleindorfer, D. (2017-10)

  BACKGROUND AND PURPOSE: Limited information is available regarding differences in neuroimaging use for acute stroke work-up. Our objective was to assess whether race, sex, or age differences exist in neuroimaging use and ...
• Widespread white matter and conduction defects in PSEN1-related spastic paraparesis 

  Soosman, Steffan K.; Joseph-Mathurin, Nelly; Braskie, Meredith N.; Bordelon, Yvette M.; Wharton, David; Casado, Maria; Coppola, Giovanni; McCallum, Holly; Nuwer, Marc; Coutin-Churchman, Pedro; Apostolova, Liana G.; Benzinger, Tammie; Ringman, John M. (Elsevier, 2016-11)

  The mechanisms underlying PSEN1 mutation-associated spastic paraparesis (SP) are not clear. We compared diffusion and volumetric magnetic resonance measures between 3 persons with SP associated with the A431E mutation and ...
• Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease 

  Ma, Qiu-Lan; Teng, Edmond; Zuo, Xiaohong; Jones, Mychica; Teter, Bruce; Zhao, Evan Y.; Zhu, Cansheng; Bilousova, Tina; Gylys, Karen H.; Apostolova, Liana G.; LaDu, Mary Jo; Hossain, Mir Ahamed; Frautschy, Sally A.; Cole, Gregory M. (Elsevier, 2018-06)

  Synaptic neurodegeneration is thought to be an early event initiated by soluble β-amyloid (Aβ) aggregates that closely correlates with cognitive decline in Alzheimer disease (AD). Apolipoprotein ε4 (APOE4) is the most ...
• Movement Disorders and Neurometabolic Diseases 

  Christensen, Celanie K.; Walsh, Laurence (Elsevier, 2018)

  Many inherited metabolic disorders cause movement disorders in children. This review focuses on chorea, dystonia, myoclonus, tremor, and parkinsonism. Broad categories commonly responsible for pediatric movement disorders ...
• Reproducibility assessment of brain responses to visual food stimuli in adults with overweight and obesity 

  Sayer, R Drew; Tamer, Gregory G; Chen, Ningning; Tregellas, Jason R; Cornier, Marc-Andre; Kareken, David A; Talavage, Thomas M; McCrory, Megan A; Campbell, Wayne W (Wiley, 2016-10)

  Objective The brain’s reward system influences ingestive behavior and subsequently, obesity risk. Functional magnetic resonance imaging (fMRI) is a common method for investigating brain reward function. We sought to assess ...
• Corticostriatal and dopaminergic response to beer flavor with both fMRI and [11C]raclopride Positron Emission Tomography 

  Oberlin, Brandon G.; Dzemidzic, Mario; Harezlak, Jaroslaw; Kudela, Maria A.; Tran, Stella M.; Soeurt, Christina M.; Yoder, Karmen K.; Kareken, David A. (Wiley, 2016-09)

  Background Cue-evoked drug seeking behavior likely depends on interactions between frontal activity and ventral striatal (VST) dopamine transmission. Using [11C]raclopride (RAC) positron emission tomography (PET), we ...
• Reply: 3,4-diaminopyridine in LEMS: Concerns regarding presentation of previous studies 

  Sanders, Donald B.; Harati, Yadollah; Juel, Vern C.; Lou, Jau-Shin; Marburger, Tessa; Pascuzzi, Robert M.; Peltier, Amanda C.; Richman, David P.; Smith, A. Gordon (Wiley, 2018)
• TREM2 in Neurodegenerative Diseases 

  Jay, Taylor R.; von Saucken, Victoria E.; Landreth, Gary E. (BMC, 2017-08-02)

  TREM2 variants have been identified as risk factors for Alzheimer’s disease (AD) and other neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively expressed on immune cells, identification of these ...

View more