Browsing Department of Biochemistry and Molecular Biology by Subject "Calcium"

Browsing Department of Biochemistry and Molecular Biology by Subject "Calcium"

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  • Otmakhov, Nikolai; Gorbacheva, Elena V.; Regmi, Shaurav; Yasuda, Ryohei; Hudmon, Andy; Lisman, John (PLoS, 2015-03)
    Over-activation of excitatory NMDA receptors and the resulting Ca2+ overload is the main cause of neuronal toxicity during stroke. CaMKII becomes misregulated during such events. Biochemical studies show either a dramatic ...
  • Fieni, Francesca; Johnson, Derrick E.; Hudmon, Andy; Kirichok, Yuriy (Nature Publishing Group, 2014-09-25)
    The influx of cytosolic Ca2+ into mitochondria is mediated primarily by the mitochondrial calcium uniporter (MCU), a small-conductance, Ca2+-selective channel-. MCU modulates intracellular Ca2+ transients and regulates ATP ...
  • Kostic, Sandra; Pan, Bin; Guo, Yuan; Yu, Hongwei; Sapunar, Damir; Kwok, Wai-Meng; Hudmon, Andy; Wu, Hsiang-En; Hogan, Quinn H. (Elsevier, 2014-09)
    Calcium/calmodulin-dependent protein kinase II (CaMKII) is recognized as a key element in encoding depolarization activity of excitable cells into facilitated voltage-gated Ca2+ channel (VGCC) function. Less is known about ...
  • Xiong, Xiwen; Wang, Gaihong; Tao, Rongya; Wu, Pengfei; Kono, Tatsuyoshi; Li, Kevin; Ding, Wen-Xing; Tong, Xin; Tersey, Sarah A.; Harris, Robert A.; Mirmira, Raghavendra G.; Evans-Molina, Carmella; Dong, X. Charlie (Springer, 2016-01)
    AIMS/HYPOTHESIS: Sirtuin 6 (SIRT6) has been implicated in ageing, DNA repair and metabolism; however, its function in pancreatic beta cells is unclear. The aim of this study is to elucidate the role of SIRT6 in pancreatic ...

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