Browsing Department of Biochemistry and Molecular Biology by Subject "Activating transcription factor 4 (ATF4)"

Browsing Department of Biochemistry and Molecular Biology by Subject "Activating transcription factor 4 (ATF4)"

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  • Nikonorova, Inna A.; Al-Baghdadi, Rana J. T.; Mirek, Emily T.; Wang, Yongping; Goudie, Michael P.; Wetstein, Berish B.; Dixon, Joseph L.; Hine, Christopher; Mitchell, James R.; Adams, Christopher M.; Wek, Ronald C.; Anthony, Tracy G. (American Society for Biochemistry and Molecular Biology, 2017-04-21)
    Obesity increases risk for liver toxicity by the anti-leukemic agent asparaginase, but the mechanism is unknown. Asparaginase activates the integrated stress response (ISR) via sensing amino acid depletion by the eukaryotic ...
  • Al-Baghdadi, Rana J. T.; Nikonorova, Inna A.; Mirek, Emily T.; Wang, Yongping; Park, Jinhee; Belden, William J.; Wek, Ronald C.; Anthony, Tracy G. (SpringerNature, 2017-04-28)
    The anti-leukemic agent asparaginase activates the integrated stress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1). The study objective was to investigate the ...

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