Department of Biochemistry & Molecular Biology

Recent Submissions

  • Wu, Yuehan; Lee, Suk-Hee; Williamson, Elizabeth A.; Reinert, Brian L.; Cho, Ju Hwan; Xia, Fen; Jaiswal, Aruna Shanker; Srinivasan, Gayathri; Patel, Bhavita; Brantley, Alexis; Zhou, Daohong; Shao, Lijian; Pathak, Rupak; Hauer-Jensen, Martin; Singh, Sudha; Kong, Kimi; Wu, Xaiohua; Kim, Hyun-Suk; Beissbarth, Timothy; Gaedcke, Jochen; Burma, Sandeep; Nickoloff, Jac A.; Hromas, Robert A. (Public Library of Science (PloS), 2015-12)
    Replication fork stalling and collapse is a major source of genome instability leading to neoplastic transformation or cell death. Such stressed replication forks can be conservatively repaired and restarted using homologous ...
  • Bunda, Severa; Burrell, Kelly; Heir, Pardeep; Zeng, Lifan; Alamsahebpour, Amir; Kano, Yoshihito; Raught, Brian; Zhang, Zhong-Yin; Zadeh, Gelareh; Ohh, Michael (Nature Publishing Group, 2015-11-30)
    Ras is phosphorylated on a conserved tyrosine at position 32 within the switch I region via Src kinase. This phosphorylation inhibits the binding of effector Raf while promoting the engagement of GTPase-activating protein ...
  • Lass, Agnieszka; Cocklin, Ross; Scaglione, Kenneth M.; Skowyra, Michael; Korolev, Sergey; Goebl, Mark; Skowyra, Dorota (BMC, 2016)
  • Lee, Jiyoon; Condello, Salvatore; Yakubov, Bakhtiyor; Emerson, Robert; Caperell-Grant, Andrea; Hitomi, Kiyotaka; Xie, Jingwu; Matei, Daniela (AACR, 2015-10-01)
    Purpose: Aggressive pancreatic cancer is commonly associated with a dense desmoplastic stroma, which forms a protective niche for cancer cells. The objective of the study was to determine the functions of tissue transglutaminase ...
  • Simon, Jeremy M.; Parker, Joel S.; Liu, Feng; Rothbart, Scott B.; Ait-Si-Ali, Slimane; Strahl, Brian D.; Jin, Jian; Davis, Ian J.; Mosley, Amber L.; Pattenden, Samantha G. (ASBMB, 2015-10-23)
    Background: G9a-GLP lysine methyltransferases mono- and di-methylate histone H3 lysine 9 (H3K9me2).Results: Widely interspaced zinc finger (WIZ) regulates H3K9me2 levels through a mechanism that involves retention of G9a ...
  • Chorlian, David B.; Rangaswamy, Madhavi; Manz, Niklas; Kamarajan, Chella; Pandey, Ashwini K.; Edenberg, Howard; Kuperman, Samuel; Porjesz, Bernice (Elsevier, 2015-10-01)
    The developmental trajectories of theta band (4-7 Hz) event-related oscillations (EROs), a key neurophysiological constituent of the P3 response, were assessed in 2170 adolescents and young adults ages 12 to 25. The theta ...
  • Lee, Wan-Hung; Xu, Zhili; Ashpole, Nicole M.; Hudmon, Andy; Kulkarni, Pushkar M.; Thakur, Ganesh A.; Lai, Yvonne Y.; Hohmann, Andrea G. (Elsevier, 2015-10)
    Aberrant increases in NMDA receptor (NMDAR) signaling contributes to central nervous system sensitization and chronic pain by activating neuronal nitric oxide synthase (nNOS) and generating nitric oxide (NO). Because the ...
  • Loh, Kim; Merry, Troy L.; Galic, Sandra; Wu, Ben J.; Watt, Matthew J.; Zhang, Sheng; Zhang, Zhong-Yin; Neel, Benjamin G.; Tiganis, Tony (Springer, 2012-02)
    Aims/Hypothesis: Insulin activates the insulin receptor (IR) protein tyrosine kinase and downstream phosphatidylinositol-3-kinase (PI3K)/Akt signalling in muscle to promote glucose uptake. The IR can serve as a substrate ...
  • Meng, Xiaoyun; Munishkina, Larissa A.; Fink, Anthony L.; Uversky, Vladimir N. (Hindawi, 2010-01-28)
    α-Synuclein aggregation and fibrillation are closely associated with the formation of Lewy bodies in neurons and are implicated in the causative pathogenesis of Parkinson's disease and other synucleinopathies. Currently, ...
  • Lee, Sun Joo; Jeong, Ji Yun; Oh, Chang Joo; Park, Sungmi; Kim, Joon-Young; Kim, Han-Jong; Doo Kim, Nam; Choi, Young-Keun; Do, Ji-Yeon; Go, Younghoon; Ha, Chae-Myung; Choi, Je-Yong; Huh, Seung; Ho Jeoung, Nam; Lee, Ki-Up; Choi, Hueng-Sik; Wang, Yu; Park, Keun-Gyu; Harris, Robert A.; Lee, In-Kyu (Nature Publishing Group, 2015-11-12)
    Vascular calcification, a pathologic response to defective calcium and phosphate homeostasis, is strongly associated with cardiovascular mortality and morbidity. In this study, we have observed that pyruvate dehydrogenase ...
  • Zhao, Heng; Pflug, Beth R.; Lai, Xianyin; Wang, Mu (Wiley, 2016-03)
    Purpose The aim of this study is to investigate the role of n-3 and n-9 fatty acids in crucial processes involved in prostate cancer cell growth through a large-scale proteomic analysis. Experimental design We used ...
  • Lee, Ji-Min; Seo, Woo-Young; Han, Hye-Sook; Oh, Kyoung-Jin; Lee, Yong-Soo; Kim, Don-Kyu; Choi, Seri; Choi, Byeong Hun; Harris, Robert A.; Lee, Chul-Ho; Koo, Seung-Hoi; Choi, Hueng-Sik (ADA, 2016-11)
    The role of a glucagon/cAMP-dependent protein kinase–inducible coactivator PGC-1α signaling pathway is well characterized in hepatic gluconeogenesis. However, an opposing protein kinase B (PKB)/Akt-inducible corepressor ...
  • Birukova, Anna A.; Meng, Fanyong; Tian, Yufeng; Meliton, Angelo; Sarich, Nicolene; Quilliam, Lawrence A.; Birukov, Konstantin G. (Elsevier, 2015-05)
    Protective effects of prostacyclin (PC) or its stable analog beraprost against agonist-induced lung vascular inflammation have been associated with elevation of intracellular cAMP and Rac GTPase signaling which inhibited ...
  • Ramalingam, Latha; Yoder, Stephanie M.; Oh, Eunjin; Thurmond, Debbie C. (Elsevier, 2014-11)
    Insulin resistance, a hallmark of impaired glucose tolerance and type 2 diabetes (T2D), arises from dysfunction of insulin action and subsequent glucose uptake by peripheral tissues, predominantly skeletal muscle and fat. ...
  • Faraggi, Eshel; Zhou, Yaoqi; Kloczkowski, Andrzej (Wiley Blackwell (John Wiley & Sons), 2014-11)
    We present a new approach for predicting the Accessible Surface Area (ASA) using a General Neural Network (GENN). The novelty of the new approach lies in not using residue mutation profiles generated by multiple sequence ...
  • Liu, Degang; Zhou, Donghui; Wang, Bo; Knabe, William Eric; Meroueh, Samy O. (American Chemical Society, 2015-06-19)
    The urokinase receptor (uPAR) is a GPI-anchored cell surface receptor that is at the center of an intricate network of protein-protein interactions. Its immediate binding partners are the serine proteinase urokinase (uPA), ...
  • Kim, Hyun-Suk; Kim, Sung-Kyung; Hromas, Robert; Lee, Suk-Hee (PLOS, 2015-10-05)
    Metnase (also known as SETMAR) is a chimeric SET-transposase protein that plays essential role(s) in non-homologous end joining (NHEJ) repair and replication fork restart. Although the SET domain possesses histone H3 lysine ...
  • Olfson, Emily; Edenberg, Howard J.; Nurnberger Jr., John; Agrawal, Arpana; Bucholz, Kathleen K.; Almasy, Laura A.; Chorlian, David; Dick, Danielle M.; Hesselbrock, Victor M.; Kramer, John R.; Kuperman, Samuel; Porjesz, Bernice; Schuckit, Marc A.; Tischfield, Jay A.; Wang, Jen-Chyong; Wetherill, Leah; Foroud, Tatiana M.; Rice, John; Goate, Alison; Bierut, Laura J. (Wiley Online Library, 2014-10)
    BACKGROUND: Adolescent drinking is an important public health concern, one that is influenced by both genetic and environmental factors. The functional variant rs1229984 in alcohol dehydrogenase 1B (ADH1B) has been ...
  • Yan, Jing; Dunker, A. Keith; Uversky, Vladimir N.; Kurgan, Lukasz (RSC, 2016-03)
    Intrinsically disordered proteins and protein regions offer numerous advantages in the context of protein–protein interactions when compared to the structured proteins and domains. These advantages include ability to ...
  • Kim, Kwangsoo; Jeong, Jae Ho; Lim, Daejin; Hong, Yeongjin; Lim, Hyung-Ju; Kim, Geun-Joong; Shin, So-ra; Lee, Je-Jung; Yun, Misun; Harris, Robert A.; Min, Jung-Joon; Choy, Hyon E. (Nature Publishing Group, 2015)
    Bacteria can be engineered to deliver anticancer proteins to tumors via a controlled expression system that maximizes the concentration of the therapeutic agent in the tumor. L-asparaginase (L-ASNase), which primarily ...

View more