• Towards Understanding the Angiomotin Membrane Fusion Activity 

  Sears, Seth; Evans, Brenner; Kimble-Hill, Ann C. (2021)

  Angiomotins (Amot) are a family of adaptor proteins that regulate cellular differentiation and proliferation signaling. These cellular events are linked to the initiation of invasive ductal carcinoma, the most common form ...
• Connecting Rodent and Human Pharmacokinetic Models for the Design and Translation of Glucose-Responsive Insulin 

  Yang, Jing Fan; Gong, Xun; Bakh, Naveed A.; Carr, Kelley; Phillips, Nelson F.B.; Ismail-Beigi, Faramarz; Weiss, Michael A.; Strano, Michael S. (American Diabetes Association, 2020-08)

  Despite considerable progress, development of glucose-responsive insulins (GRIs) still largely depends on empirical knowledge and tedious experimentation-especially on rodents. To assist the rational design and clinical ...
• Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium 

  Polimanti, Renato; Walters, Raymond K.; Johnson, Emma C.; McClintick, Jeanette N.; Adkins, Amy E.; Adkins, Daniel E.; Bacanu, Silviu-Alin; Bierut, Laura J.; Bigdeli, Tim B.; Brown, Sandra; Bucholz, Kathleen K.; Copeland, William E.; Costello, E. Jane; Degenhardt, Louisa; Farrer, Lindsay A.; Foroud, Tatiana M.; Fox, Louis; Goate, Alison M.; Grucza, Richard; Hack, Laura M.; Hancock, Dana B.; Hartz, Sarah M.; Heath, Andrew C.; Hewitt, John K.; Hopfer, Christian J.; Johnson, Eric O.; Kendler, Kenneth S.; Kranzler, Henry R.; Krauter, Kenneth; Lai, Dongbing; Madden, Pamela A.F.; Martin, Nicholas G.; Maes, Hermine H.; Nelson, Elliot C.; Peterson, Roseann E.; Porjesz, Bernice; Riley, Brien P.; Saccone, Nancy; Stallings, Michael; Wall, Tamara L.; Webb, Bradley T.; Wetherill, Leah (Springer Nature, 2020-08)

  To provide insights into the biology of opioid dependence (OD) and opioid use (i.e., exposure, OE), we completed a genome-wide analysis comparing 4503 OD cases, 4173 opioid-exposed controls, and 32,500 opioid-unexposed ...
• Density and Dichotomous Family History Measures of Alcohol Use Disorder as Predictors of Behavioral and Neural Phenotypes: A Comparative Study Across Gender and Race/Ethnicity 

  Pandey, Gayathri; Seay, Michael J.; Meyers, Jacquelyn L.; Chorlian, David B.; Pandey, Ashwini K.; Kamarajan, Chella; Ehrenberg, Morton; Pitti, Daniel; Kinreich, Sivan; de Viteri, Stacey Subbie-Saenz; Acion, Laura; Anokhin, Andrey; Bauer, Lance; Chan, Grace; Edenberg, Howard; Hesselbrock, Victor; Kuperman, Samuel; McCutcheon, Vivia V.; Bucholz, Kathleen K.; Schuckit, Marc; Porjesz, Bernice (Wiley, 2020-03)

  Background: Family history (FH) is an important risk factor for the development of alcohol use disorder (AUD). A variety of dichotomous and density measures of FH have been used to predict alcohol outcomes; yet, a systematic ...
• Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping 

  Liu, Zhipeng; Zhang, Yang; Graham, Sarah; Wang, Xiaokun; Cai, Defeng; Huang, Menghao; Pique-Regi, Roger; Dong, Xiaocheng Charlie; Chen, Y. Eugene; Willer, Cristen; Liu, Wanqing (Elsevier, 2020-08)

  Background & aims: Non-alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D) and obesity are epidemiologically correlated with each other but the causal inter-relationships between them remain incompletely understood. ...
• β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs 

  Ibrahim, Sara; Johnson, Macey; Hernandez Stephens, Clarissa; Xu, Jerry; Moore, Rachel; Mariani, Andrea; Contreras, Christopher; Syed, Farooq; Mirmira, Raghavendra G.; Anderson, Ryan M.; Sims, Emily K. (Elsevier, 2021-11)

  Objective: β-cell microRNA-21 (miR-21) is increased by islet inflammatory stress but it decreases glucose-stimulated insulin secretion (GSIS). Thus, we sought to define the effects of miR-21 on β-cell function using in ...
• Quantitative Proteomic and Metabolomic Profiling Reveals Altered Mitochondrial Metabolism and Folate Biosynthesis Pathways in the Aging Drosophila Eye 

  Hall, Hana; Cooper, Bruce R.; Qi, Guihong; Wijeratne, Aruna B.; Mosley, Amber L.; Weake, Vikki M. (American Society for Biochemistry and Molecular Biology, 2021)

  Aging is associated with increased risk of ocular disease, suggesting that age-associated molecular changes in the eye increase its vulnerability to damage. Although there are common pathways involved in aging at an ...
• Sestrin Proteins Protect Against Lipotoxicity-Induced Oxidative Stress in the Liver via Suppression of C-Jun N-Terminal Kinases 

  Fang, Zhigang; Kim, Hyeong-Geug; Huang, Menghao; Chowdhury, Kushan; Li, Ming O.; Liangpunsakul, Suthat; Dong, X. Charlie (Elsevier, 2021)

  Background & aims: Sestrin 1/2/3 (Sesn1/2/3) belong to a small family of proteins that have been implicated in the regulation of metabolic homeostasis and oxidative stress. However, the underlying mechanisms remain ...
• Distinct states of proinsulin misfolding in MIDY 

  Haataja, Leena; Arunagiri, Anoop; Hassan, Anis; Regan, Kaitlin; Tsai, Billy; Dhayalan, Balamurugan; Weiss, Michael A.; Liu, Ming; Arvan, Peter (Springer, 2021-08)

  A precondition for efficient proinsulin export from the endoplasmic reticulum (ER) is that proinsulin meets ER quality control folding requirements, including formation of the Cys(B19)-Cys(A20) "interchain" disulfide bond, ...
• Adenomatous Polyposis Coli loss controls cell cycle regulators and response to paclitaxel in MDA-MB-157 metaplastic breast cancer cells 

  Astarita, Emily M.; Maloney, Sara M.; Hoover, Camden A.; Berkeley, Bronwyn J.; VanKlompenberg, Monica K.; Nair, T. Murlidharan; Prosperi, Jenifer R. (PLOS, 2021-08-09)

  Adenomatous Polyposis Coli (APC) is lost in approximately 70% of sporadic breast cancers, with an inclination towards triple negative breast cancer (TNBC). TNBC is treated with traditional chemotherapy, such as paclitaxel ...
• On the roles of intrinsically disordered proteins and regions in cell communication and signaling 

  Bondos, Sarah E.; Dunker, A. Keith; Uversky, Vladimir N. (BMC, 2021-08-30)

  For proteins, the sequence → structure → function paradigm applies primarily to enzymes, transmembrane proteins, and signaling domains. This paradigm is not universal, but rather, in addition to structured proteins, ...
• Best Practices to Diversify Chemistry Faculty 

  Agan, Marie Little Fawn; Joseph, Reni; Rivera-Figueroa, Armando; Chan, Benny C.; O’Connor, Abby R.; Ondrechen, Mary Jo; Jones, Wayne E.; Dorhout, Peter K.; Kimble-Hill, Ann C. (ACS, 2022-01)

  Many academic institutions have looked at various ways to make their faculty a more diverse and inclusive group of people that better reflect the demographic swath of their current and future student bodies. This is even ...
• The yeast Hrq1 helicase stimulates Pso2 translesion nuclease activity and thereby promotes DNA interstrand crosslink repair 

  Rogers, Cody M.; Lee, Chun-Ying; Parkins, Samuel; Buehler, Nicholas J.; Wenzel, Sabine; Martínez-Márquez, Francisco; Takagi, Yuichiro; Myong, Sua; Bochman, Matthew L. (Elsevier, 2020-07-03)

  DNA interstrand crosslink (ICL) repair requires a complex network of DNA damage response pathways. Removal of the ICL lesions is vital, as they are physical barriers to essential DNA processes that require the separation ...
• Inhibition of epidermal growth factor receptor signalling reduces hypercalcaemia induced by human lung squamous-cell carcinoma in athymic mice 

  Lorch, G.; Gilmore, J. L.; Koltz, P. F.; Gonterman, R. M.; Laughner, R.; Lewis, D. A.; Konger, R. L.; Nadella, K. S.; Toribio, R. E.; Rosol, T. J.; Foley, J. (Springer, 2007-07)

  The purpose of this study was to evaluate the role of the epidermal growth factor receptor (EGFR) in parathyroid hormone-related protein (PTHrP) expression and humoral hypercalcaemia of malignancy (HHM), using two different ...
• Lack of EGF receptor contributes to drug sensitivity of human germline cells 

  Park, S.J.; Armstrong, S.; Kim, C.H.; Yu, M.; Robertson, K.; Kelley, Mark R.; Lee, S.H. (Springer, 2005-01)

  Germline mutations have been associated with generation of various types of tumour. In this study, we investigated genetic alteration of germline tumours that affect the drug sensitivity of cells. Although all germline ...
• Ethyl Acetate Fraction of Amomum villosum var. xanthioides Attenuates Hepatic Endoplasmic Reticulum Stress-Induced Non-Alcoholic Steatohepatitis via Improvement of Antioxidant Capacities 

  Cho, Jung-Hyo; Lee, Jong-Suk; Kim, Hyeong-Geug; Lee, Hye Won; Fang, Zhigang; Kwon, Hyeok-Hee; Kim, Dong Woon; Lee, Chang-Min; Jeong, Jin-Woo (MDPI, 2021-06-23)

  Non-alcoholic fatty liver disease (NAFLD), including non-alcoholic steatohepatitis (NASH), affects 25% of the global population. Despite the prevalence of NAFLD worldwide, effective therapeutics are currently lacking. ...
• The Role of Epigenetic Changes in the Progression of Alcoholic Steatohepatitis 

  Kim, Hyeong Geug; Cho, Jung-Hyo; Kim, Jeongkyu; Kim, Seung-Jin (Frontiers Media, 2021-07-16)

  Alcoholic steatohepatitis (ASH) is a progression hepatitis with severe fatty liver and its mortality rate for 30-days in patients are over 30%. Additionally, ASH is well known for one-fifth all alcoholic related liver ...
• Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway 

  Xu, Lin; Zhang, Xinge; Xin, Yue; Ma, Jie; Yang, Chenyan; Zhang, Xi; Hou, Guoqing; Dong, Xiaocheng Charlie; Sun, Zhaoli; Xiong, Xiwen; Cao, Xuan (Springer Nature, 2021-07-15)

  Alcohol-related liver disease (ALD), a condition caused by alcohol overconsumption, occurs in three stages of liver injury including steatosis, hepatitis, and cirrhosis. DEP domain-containing protein 5 (DEPDC5), a component ...
• A parallax view of type 1 diabetes 

  Weaver, Staci A.; Felton, Jamie L.; Evans-Molina, Carmella (Portland press, 2021)

  The year 2021 marks the 100th anniversary of the discovery of insulin, a therapy that transformed type 1 diabetes (T1D) from a once fatal diagnosis into a chronic condition that can be successfully managed with exogenous ...
• Drug screening with zebrafish visual behavior identifies carvedilol as a potential treatment for an autosomal dominant form of retinitis pigmentosa 

  Ganzen, Logan; Ko, Mee Jung; Zhang, Mengrui; Xie, Rui; Chen, Yongkai; Zhang, Liyun; James, Rebecca; Mumm, Jeff; van Rijn, Richard M.; Zhong, Wenxuan; Pang, Chi Pui; Zhang, Mingzhi; Tsujikawa, Motokazu; Leung, Yuk Fai (Springer Nature, 2021-06-01)

  Retinitis Pigmentosa (RP) is a mostly incurable inherited retinal degeneration affecting approximately 1 in 4000 individuals globally. The goal of this work was to identify drugs that can help patients suffering from the ...

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