Department of Biochemistry and Molecular Biology

Department of Biochemistry and Molecular Biology

Recent Submissions

  • Cleves, Ann E.; McGee, Todd P.; Whitters, Eric A.; Champion, Kathleen M.; Aitken, Jacqueline R.; Dowhan, William; Goebl, Mark; Bankaitis, Vytas A. (Cell Press, 1991)
    SEC14p is the yeast phosphatidylinositol (PI)/phosphatidylcholine (PC) transfer protein, and it effects an essential stimulation of yeast Golgi secretory function. We now report that the SEC14p localizes to the yeast Golgi ...
  • Zhang, Fan; Deng, Chris K.; Wang, Mu; Deng, Bin; Barber, Robert; Huang, Gang (BMC, 2020-12-03)
    Background: Alternative splicing isoforms have been reported as a new and robust class of diagnostic biomarkers. Over 95% of human genes are estimated to be alternatively spliced as a powerful means of producing functionally ...
  • Wolf, Eric R.; Mabry, Alexander R.; Damania, Blossom; Mayo, Lindsey D. (Springer Nature, 2020-07)
    Mutations in the tumor suppressor TP53 are rare in renal cell carcinomas. p53 is a key factor for inducing anti-angiogenic genes and RCC are highly vascularized, which suggests that p53 is inactive in these tumors. One ...
  • Dickson, Bradley M.; Tiedemann, Rochelle L.; Chomiak, Alison A.; Cornett, Evan M.; Vaughan, Robert M.; Rothbart, Scott B. (Elsevier, 2020-11-20)
    ChIP followed by next-generation sequencing (ChIP-Seq) is a key technique for mapping the distribution of histone posttranslational modifications (PTMs) and chromatin-associated factors across genomes. There is a perceived ...
  • Doud, Emma H.; Shetty, Trupti; Abt, Melissa; Mosley, Amber L.; Corson, Timothy W.; Mehta, Anand; Yeh, Elizabeth S. (MDPI, 2020-12-12)
    A growing body of evidence indicates that the levels of fucosylation correlate with breast cancer progression and contribute to metastatic disease. However, very little is known about the signaling and functional outcomes ...
  • Wilson, David M.; Deacon, Ashley M.; Duncton, Matthew A. J.; Pellicena, Patricia; Georgiadis, Millie M.; Yeh, Andrew P.; Arvai, Andrew S.; Moiani, Davide; Tainer, John A.; Das, Debanu (Elsevier, 2021-08)
    Cancer will directly affect the lives of over one-third of the population. The DNA Damage Response (DDR) is an intricate system involving damage recognition, cell cycle regulation, DNA repair, and ultimately cell fate ...
  • Mayeuf-Louchart, Alicia; Lancel, Steve; Sebti, Yasmine; Pourcet, Benoit; Loyens, Anne; Delhaye, Stéphane; Duhem, Christian; Beauchamp, Justine; Ferri, Lise; Thorel, Quentin; Boulinguiez, Alexis; Zecchin, Mathilde; Dubois-Chevalier, Julie; Eeckhoute, Jérôme; Vaughn, Logan T.; Roach, Peter J.; Dani, Christian; Pederson, Bartholomew A.; Vincent, Stéphane D.; Staels, Bart; Duez, Hélène (Cell Press, 2019-11-05)
    Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases. ...
  • Iyamu, Iredia D.; Vilseck, Jonah Z.; Yadav, Ravi; Noinaj, Nicholas; Huang, Rong (Wiley, 2022)
    Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide and has been associated with various diseases. Herein, we report the first cell-potent NNMT bisubstrate inhibitor II399, demonstrating a Ki of 5.9 nM in a ...
  • Zhang, Wen; Kim, Seohyun Chris; Tam, Chun Pong; Lelyveld, Victor S.; Bala, Saikat; Chaput, John C.; Szostak, Jack W. (Oxford, 2021-01-25)
    The prebiotic synthesis of ribonucleotides is likely to have been accompanied by the synthesis of noncanonical nucleotides including the threo-nucleotide building blocks of TNA. Here, we examine the ability of activated ...
  • Pugia, Michael J.; Pradhan, Meeta; Qi, Rong; Eastes, Doreen L.; Vorsilak, Anna; Mills, Bradley J.; Baird, Zane; Wijeratne, Aruna; McAhren, Scott M.; Mosley, Amber; Shekhar, Anantha; Robertson, Daniel H. (Probiologists, 2020)
    Background: Diabetes is a complex, multi-symptomatic disease whose complications drives increases in healthcare costs as the diabetes prevalence grows rapidly world-wide. Real-world electronic health records (EHRs) coupled ...
  • Flick, Katelyn F.; Sublette, Chris M.; Maatman, Thomas K.; Colgate, Cameron L.; Yip-Schneider, Michele T.; Soufi, Mazhar; Ceppa, Eugene P.; House, Michael G.; Zyromski, Nicholas J.; Nakeeb, Attila; Schmidt, C. Max (Springer, 2021)
    Background In patients undergoing pancreatoduodenectomy, non-home discharge is common and often results in an unnecessary delay in hospital discharge. This study aimed to develop and validate a preoperative prediction ...
  • Maloney, Sara M.; Hoover, Camden A.; Morejon-Lasso, Lorena V.; Prosperi, Jenifer R. (MDPI, 2020-11)
    The taxane family of chemotherapy drugs has been used to treat a variety of mostly epithelial-derived tumors and remain the first-line treatment for some cancers. Despite the improved survival time and reduction of tumor ...
  • Stefanski, Casey D.; Prosperi, Jenifer R. (MDPI, 2020-10-22)
    Resistance to chemotherapy occurs through mechanisms within the epithelial tumor cells or through interactions with components of the tumor microenvironment (TME). Chemoresistance and the development of recurrent tumors ...
  • Shukla, Kirtikar; Singh, Naveen; Lewis, Joshua E.; Tsang, Allen W.; Boothman, David A.; Kemp, Melissa L. (Frontiers, 2020-11-11)
    Head and Neck Squamous Cell Cancer (HNSCC) presents with multiple treatment challenges limiting overall survival rates and affecting patients' quality of life. Amongst these, resistance to radiation therapy constitutes a ...
  • Kharwadkar, Rakshin; Ulrich, Benjamin J.; Abdul Qayum, Amina; Koh, Byunghee; Licona-Limón, Paula; Flavell, Richard A.; Kaplan, Mark H. (American Association of Immunologists, 2020-05-21)
    Generation of allelic gene reporter mice has provided a powerful tool to study gene function in vivo. In conjunction with imaging technologies, reporter mouse models facilitate studies of cell lineage tracing, live cell ...
  • Kim, Hyeong Geug; Huang, Menghao; Xin, Yue; Zhang, Yang; Zhang, Xinge; Wang, Gaihong; Liu, Sheng; Wan, Jun; Ahmadi, Ali Reza; Sun, Zhaoli; Liangpunsakul, Suthat; Xiong, Xiwen; Dong, Xiaocheng Charlie (Elsevier, 2019-11)
    BACKGROUND & AIMS: As a nicotinamide adenine dinucleotide-dependent deacetylase and a key epigenetic regulator, sirtuin 6 (SIRT6) has been implicated in the regulation of metabolism, DNA repair, and inflammation. However, ...
  • Dong, X. Charlie (Elsevier, 2020-11)
  • Singh, Naveen; Motea, Edward A.; Huang, Xiumei; Starcher, Colton L.; Silver, Jayne; Yeh, I.-Ju; Pay, S. Louise; Su, Xiaolin; Russ, Kristen A.; Boothman, David A.; Bey, Erik A. (InTechOpen, 2020-02-13)
    Developing cancer therapeutics that radiosensitize in a tumor-selective manner remains an ideal. We developed a novel means of radiosensitization, exploiting NAD(P)H:Quinone Oxidoreductase 1 (NQO1) overexpression, and ...
  • Rogers, Cody M.; Sanders, Elsbeth; Nguyen, Phoebe A.; Smith-Kinnaman, Whitney; Mosley, Amber L.; Bochman, Matthew L. (Oxford, 2020-12)
    The human genome encodes five RecQ helicases (RECQL1, BLM, WRN, RECQL4, and RECQL5) that participate in various processes underpinning genomic stability. Of these enzymes, the disease-associated RECQL4 is comparatively ...
  • Liu, Yunjian; Kim, Hyeong Geug; Dong, Edward; Dong, Chuanpeng; Huang, Menghao; Liu, Yunlong; Liangpunsakul, Suthat; Dong, Xiaocheng Charlie (Elsevier, 2019-10-01)
    Sestrin 3 (Sesn3) belongs to a small protein family that has been implicated in multiple biological processes including anti-oxidative stress, anti-aging, cell signaling, and metabolic homeostasis. However, the role of ...

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