• Approach to Acute Heart Failure in the Emergency Department 

  Hunter, Benton R.; Martindale, Jennifer; Abdel-Hafez, Osama; Pang, Peter S. (Elsevier, 2017-09)

  Acute heart failure (AHF) patients rarely present complaining of ‘acute heart failure.’ Rather, they initially present to the emergency department (ED) with a myriad of chief complaints, symptoms, and physical exam findings. ...
• Update: Does Rocuronium Create Better Intubating Conditions Than Succinylcholine for Rapid Sequence Intubation? 

  Welch, Julie L.; Seupaul, Rawle A. (Elsevier, 2017-05)
• Emergency Department Cardiopulmonary Evaluation of Low-Risk Chest Pain Patients with Self-Reported Stress and Anxiety 

  Musey, Paul I., Jr.; Kline, Jeffrey A. (Elsevier, 2017-03)

  Background Chest pain is a high-risk emergency department (ED) chief complaint; the majority of clinical resources are directed toward detecting and treating cardiopulmonary emergencies. However, at follow-up, 80%–95% ...
• Directed Protein Packaging within Outer Membrane Vesicles from Escherichia coli: Design, Production and Purification 

  Alves, Nathan J.; Turner, Kendrick B.; Walper, Scott A. (2016)

  A protocol for the production, purification, and use of enzyme packaged outer membrane vesicles (OMV) providing for enhanced enzyme stability for implementation across diverse applications is presented.
• Affinity purification of bacterial outer membrane vesicles (OMVs) utilizing a His-tag mutant 

  Alves, Nathan J.; Turner, Kendrick B.; DiVito, Kyle A.; Daniele, Michael A.; Walper, Scott A. (Elsevier, 2017-02)

  To facilitate the rapid purification of bacterial outer membrane vesicles (OMVs), we developed two plasmid constructs that utilize a truncated, transmembrane protein to present an exterior histidine repeat sequence. We ...
• Superficial Temporal Artery Pseudoaneurysm Presenting as A Suspected Sebaceous Cyst 

  Rood, Loren K. (Elsevier, 2016-12)

  A 20-year-old man presented to the emergency department (ED) requesting to have a “cyst” on his scalp drained. The patient stated that he had first noticed the cyst about 1.5 years ago, which seemed to develop after he was ...
• Changing Systems Through Effective Teams: A Role for Simulation 

  Rosenman, Elizabeth D.; Fernandez, Rosemarie; Wong, Ambrose H.; Cassara, Michael; Cooper, Dylan D.; Kou, Maybelle; Laack, Torrey A.; Motola, Ivette; Parsons, Jessica R.; Levine, Benjamin R.; Grand, James A. (Wiley, 2017)

  Teams are the building blocks of the healthcare system, with growing evidence linking the quality of health care to team effectiveness, and team effectiveness to team training. Simulation has been identified as an effective ...
• 72-year-old with abdominal wall abscess 

  Leech, Lindsay; Welch, Julie (Elsevier, 2017-01)
• Rationale and Design of the ICON-RELOADED Study: International Collaborative of Nterminal pro-B-type Natriuretic Peptide Re-evaluation of Acute Diagnostic Cut-Offs in the Emergency Department 

  Gaggin, Hanna Kim; Chen-Tournoux, Annabel Angela; Christenson, Robert H.; Doros, Gheorghe; Hollander, Judd Eric; Levy, Phillip David; Nagurney, John Tobias; Nowak, Richard Michael; Pang, Peter S.Pang; Patel, Darshita; Peacock, Willam Frank; Walters, Elizabeth Lea; Januzzi, James Louis (Elsevier, 2017-10)

  Objectives The objectives were to reassess use of amino-terminal pro B-type natriuretic peptide (NT-proBNP) concentrations for diagnosis and prognosis of acute heart failure (HF) in patients with acute dyspnea. Bac ...
• Outpatient treatment of low-risk venous thromboembolism with monotherapy oral anticoagulation: patient quality of life outcomes and clinician acceptance 

  Kline, Jeffrey A.; Kahler, Zachary P.; Beam, Daren M. (Dove Press, 2016-04-15)

  BACKGROUND: Oral monotherapy anticoagulation has facilitated home treatment of venous thromboembolism (VTE) in outpatients. OBJECTIVES: The aim of this study was to measure efficacy, safety, as well as patient and ...
• Targeted temperature management in emergency medicine: current perspectives 

  Hunter, Benton R.; Ellender, Timothy J. (Dove Press, 2015-09-28)

  Landmark trials in 2002 showed that therapeutic hypothermia (TH) after out-of-hospital cardiac arrest due to ventricular tachycardia or ventricular fibrillation resulted in improved likelihood of good neurologic recovery ...
• Medical student use of communication elements and association with patient satisfaction: a prospective observational pilot study 

  Turner, Joseph S.; Pettit, Katie E.; Buente, Bryce B.; Humbert, Aloysius J.; Perkins, Anthony J.; Kline, Jeffrey A. (BioMed Central, 2016-05-23)

  BACKGROUND: Effective communication with patients impacts clinical outcome and patient satisfaction. We measure the rate at which medical students use six targeted communication elements with patients and association ...
• Emergency Physicians Are Able to Detect Right Ventricular Dilation With Good Agreement Compared to Cardiology 

  Rutz, Matt A.; Clary, Julie M.; Kline, Jeffrey A.; Russell, Frances M. (Wiley, 2017-07)

  Objective Focused cardiac ultrasound (FOCUS) is a useful tool in evaluating patients presenting to the emergency department (ED) with acute dyspnea. Prior work has shown that right ventricular (RV) dilation is associated ...
• Treadmill running restores MDMA-mediated hyperthermia prevented by inhibition of the dorsomedial hypothalamus 

  Zaretsky, Dmitry V.; Zaretskaia, Maria V.; Durant, Pamela J.; Rusyniak, Daniel E. (Elsevier, 2015-05-22)

  The contribution of exercise to hyperthermia mediated by MDMA is not known. We recently showed that inhibiting the dorsomedial hypothalamus (DMH) attenuated spontaneous locomotion and hyperthermia and prevented deaths in ...
• Impact of Patient Affect on Physician Estimate of Probability of Serious Illness and Test Ordering 

  Kline, Jeffrey A.; Neumann, Dawn; Raad, Samih; Schriger, David L.; Hall, Cassandra L.; Capito, Jake; Kammer, David (Lippincott, Williams, and Wilkins, 2017)

  Purpose The authors hypothesize patient facial affect may influence clinician pretest probability (PTP) estimate of cardiopulmonary emergency (CPE) and desire to order a computerized tomographic pulmonary angiogram (CTPA). ...
• Day vs night: Does time of presentation matter in acute heart failure? A secondary analysis from the RELAX-AHF trial 

  Pang, Peter S.; Teerlink, John R.; Boer-Martins, Leandro; Gimpelewicz, Claudio; Davison, Beth A.; Wang, Yi; Voors, Adriaan A.; Severin, Thomas; Ponikowski, Piotr; Hua, Tsushung A.; Greenberg, Barry H.; Filippatos, Gerasimos; Felker, G. Michael; Cotter, Gad; Metra, Marco (Elsevier, 2017-05)

  Background Signs and symptoms of heart failure can occur at any time. Differences between acute heart failure (AHF) patients who present at nighttime vs daytime and their outcomes have not been well studied. Our objective ...
• Effects of serelaxin on the outcome of patients with or without substantial peripheral edema: A subgroup analysis from the RELAX-AHF trial 

  Gimpelewicz, Claudio; Metra, Marco; Cleland, John G. F.; Szecsödy, Peter; Chang Wun, Chuan-Chuan; Boer-Martins, Leandro; Cotter, Gad; Davison, Beth A.; Felker, G. Michael; Filippatos, Gerasimos; Greenberg, Barry H.; Pang, Peter; Ponikowski, Piotr; Severin, Thomas; Voors, Adrian A.; Teerlink, John R. (Elsevier, 2017-08)

  Background Acute heart failure (AHF) is a heterogeneous disorder, with most of the patients presenting with breathlessness along with varying degrees of peripheral edema. The presence of peripheral edema suggests that ...
• Characterization of the relationship between spontaneous locomotor activity and cardiovascular parameters in conscious freely moving rats 

  Zaretsky, Dmitry V.; Zaretskaia, Maria V.; DiMicco, Joseph A. (Elsevier, 2016-02)

  In freely behaving rats, variations in heart rate (HR) and blood pressure (BP) are coupled closely with changes in locomotor activity (Act). We have attempted to characterize this relationship mathematically. In 10- and ...
• Differences in health care use and outcomes by the timing of in-hospital worsening heart failure 

  Cooper, Lauren B.; Hammill, Bradley G.; Sharma, Puza P.; DeVore, Adam D.; Mentz, Robert J.; Fonarow, Gregg C.; Pang, Peter S.; Curtis, Lesley H.; Hernandez, Adrian F. (Elsevier, 2015-12)

  BACKGROUND: Patients hospitalized with acute heart failure may experience worsening symptoms requiring escalation of therapy. In-hospital worsening heart failure is associated with worse in-hospital and postdischarge ...
• Cardiac Output Monitoring Managing Intravenous Therapy (COMMIT) to Treat Emergency Department Patients with Sepsis 

  Hou, Peter C.; Filbin, Michael R.; Napoli, Anthony; Feldman, Joseph; Pang, Peter S.; Sankoff, Jeffrey; Lo, Bruce M.; Dickey-White, Howard; Birkhahn, Robert H.; Shapiro, Nathan I. (Wolters Kluwer, 2016-08)

  OBJECTIVE: Fluid responsiveness is proposed as a physiology-based method to titrate fluid therapy based on preload dependence. The objectives of this study were to determine if a fluid responsiveness protocol would ...

View more