• Investigational new drug enabling angiotensin oral-delivery studies to attenuate pulmonary hypertension 

  Daniell, Henry; Mangu, Venkata; Yakubov, Bakhtiyor; Park, Jiyoung; Habibi, Peyman; Shi, Yao; Gonnella, Patricia A.; Fisher, Amanda; Cook, Todd; Zeng, Lily; Kawut, Steven M.; Lahm, Tim (Elsevier, 2020-03)

  Pulmonary arterial hypertension (PAH) is a deadly and uncurable disease characterized by remodeling of the pulmonary vasculature and increased pulmonary artery pressure. Angiotensin Converting Enzyme 2 (ACE2) and its ...
• Disentangling the Gordian knot of local metabolic control of coronary blood flow 

  Tune, Johnathan D.; Goodwill, Adam G.; Kiel, Alexander M.; Baker, Hana E.; Bender, Shawn B.; Merkus, Daphne; Duncker, Dirk J. (American Physiological Society, 2020-01-01)

  Recognition that coronary blood flow is tightly coupled with myocardial metabolism has been appreciated for well over half a century. However, exactly how coronary microvascular resistance is tightly coupled with myocardial ...
• Distinct hemodynamic responses to (pyr)apelin-13 in large animal models 

  Tune, Johnathan D.; Baker, Hana E.; Berwick, Zachary; Moberly, Steven P.; Casalini, Eli D.; Noblet, Jillian N.; Zhen, Eugene; Kowala, Mark C.; Christe, Michael E.; Goodwill, Adam (APS, 2020-04)

  This study tested the hypothesis that (pyr)apelin-13 dose-dependently augments myocardial contractility and coronary blood flow, irrespective of changes in systemic hemodynamics. Acute effects of intravenous (pyr)apelin-13 ...
• Educational disparities in health behaviors among patients with diabetes: the Translating Research Into Action for Diabetes (TRIAD) Study 

  Karter, Andrew J.; Stevens, Mark R.; Brown, Arleen F.; Duru, O. Kenrik; Gregg, Edward W.; Gary, Tiffany L.; Beckles, Gloria L.; Tseng, Chien-Wen; Marrero, David G.; Waitzfelder, Beth; Herman, William H.; Piette, John D.; Safford, Monika M.; Ettner, Susan L. (BioMed Central, 2007-10-29)

  Background Our understanding of social disparities in diabetes-related health behaviors is incomplete. The purpose of this study was to determine if having less education is associated with poorer diabetes-related health ...
• DOC2B promotes insulin sensitivity in mice via a novel KLC1-dependent mechanism in skeletal muscle 

  Zhang, Jing; Oh, Eunjin; Merz, Karla E.; Aslamy, Arianne; Veluthakal, Rajakrishnan; Salunkhe, Vishal A.; Ahn, Miwon; Tunduguru, Ragadeepthi; Thurmond, Debbie C. (Springer Verlag, 2019-05)

  Aims/hypothesis: Skeletal muscle accounts for >80% of insulin-stimulated glucose uptake; dysfunction of this process underlies insulin resistance and type 2 diabetes. Insulin sensitivity is impaired in mice deficient in ...
• Inhibition of sodium–glucose cotransporter-2 preserves cardiac function during regional myocardial ischemia independent of alterations in myocardial substrate utilization 

  Baker, Hana E.; Kiel, Alexander M.; Luebbe, Samuel T.; Simon, Blake R.; Earl, Conner C.; Regmi, Ajit; Roell, William C.; Mather, Kieren J.; Tune, Johnathan D.; Goodwill, Adam G. (Springer, 2019-04-19)

  The goal of the present study was to evaluate the effects of SGLT2i on cardiac contractile function, substrate utilization, and efficiency before and during regional myocardial ischemia/reperfusion injury in normal, ...
• Catechol estrogens stimulate insulin secretion in pancreatic β-cells via activation of the transient receptor potential A1 (TRPA1) channel 

  Ma, Wenzhen; Chen, Xingjuan; Cerne, Rok; Syed, Samreen K.; Ficorilli, James V.; Cabrera, Over; Obukhov, Alexander G.; Efanov, Alexander M. (American Society for Biochemistry and Molecular Biology, 2019-02-22)

  Estrogen hormones play an important role in controlling glucose homeostasis and pancreatic β-cell function. Despite the significance of estrogen hormones for regulation of glucose metabolism, little is known about the roles ...
• Effect of Age on Diabetogenicity of Alloxan in Ossabaw Miniature Swine 

  Badin, Jill K.; Progar, Victor; Pareddy, Anisha; Cagle, Jordan; Alloosh, Mouhamad; Sturek, Michael (American Association for Laboratory Animal Science, 2019-04-01)

  According to a single study in dogs that was conducted in 1949, the diabetic effects of the β-cell toxin alloxan are dependent on age. The current study examined whether this age-dependence of alloxan is present in the ...
• Transgelin Induces Dysfunction of Fetal Endothelial Colony-Forming Cells From Gestational Diabetic Pregnancies 

  Varberg, Kaela M.; Garretson, Rashell O.; Blue, Emily K.; Chu, Chenghao; Gohn, Cassandra R.; Tu, Wanzhu; Haneline, Laura S. (American Physiological Society, 2018-10-01)

  Fetal exposure to gestational diabetes mellitus (GDM) predisposes children to future health complications including hypertension and cardiovascular disease. A key mechanism by which these complications occur is through the ...
• Endothelial Stem and Progenitor Cells for Regenerative Medicine 

  Banno, Kimihiko; Yoder, Mervin C. (Springer, 2019)

  Purpose of Review Vascular endothelial stem cell (VESC) and progenitor cell are emerging as local resident regulators of vascular endothelial repair and replacement in mammalian subjects. However, widely recognized and ...
• Correction to: An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons 

  Canfield, Scott G.; Stebbins, Matthew J.; Faubion, Madeline G.; Gastfriend, Benjamin D.; Palecek, Sean P.; Shusta, Eric V. (BioMed Central, 2019-09-10)

  Abstract Following publication of the original article [1], the author has reported that in Figure 1 (b and c) the y-axis TEER (© x cm2) should be replaced with TEER (Ω x cm2). Erratum for An isogenic neurovascular ...
• CRISPR-Cas9 Mediated Epitope Tagging Provides Accurate and Versatile Assessment of Myocardin 

  Lyu, Qing; Dhagia, Vidhi; Han, Yu; Guo, Bing; Wines-Samuelson, Mary E.; Christie, Christine K.; Yin, Qiangzong; Slivano, Orazio J.; Herring, Paul; Long, Xiaochun; Gupte, Sachin A.; Miano, Joseph M. (American Heart Association, 2018-09)

  Objective- Unreliable antibodies often hinder the accurate detection of an endogenous protein, and this is particularly true for the cardiac and smooth muscle cofactor, MYOCD (myocardin). Accordingly, the mouse Myocd locus ...
• Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction 

  Duan, Yaqian; Beli, Eleni; Calzi, Sergio Li; Quigley, Judith L.; Miller, Rehae C.; Moldovan, Leni; Feng, Dongni; Salazar, Tatiana E.; Hazra, Sugata; Al-Sabah, Jude; Chalam, Kakarla V.; Trinh, Thao Le Phuong; Meroueh, Marya; Markel, Troy A.; Murray, Matthew C.; Vyas, Ruchi J.; Boulton, Michael E.; Parsons-Wingerter, Patricia; Oudit, Gavin Y.; Obukhov, Alexander G.; Grant, Maria B. (Wiley, 2018-09)

  Angiotensin-converting enzyme 2 (ACE2) is the primary enzyme of the vasoprotective axis of the renin angiotensin system (RAS). We tested the hypothesis that loss of ACE2 would exacerbate diabetic retinopathy by promoting ...
• Gastroparesis is associated with decreased FOXF1 and FOXF2 in humans, and loss of FOXF1 and FOXF2 results in gastroparesis in mice 

  Herring, B. Paul; Hoggatt, April M.; Gupta, Anita; Wo, John M. (Wiley, 2019-02)

  Background and Aims The transcription factors FOXF1 and FOXF2 have been implicated in the development of the gastrointestinal tract but their role in adults or in gastrointestinal diseases is poorly understood. We have ...
• Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis 

  Liang, Kaley L.; Bursova, Julia O.; Lam, Frank; Chen, Xingjuan; Obukhov, Alexander G. (Journal of Visualized Experiments, 2019-09-01)

  Dysmenorrhea, or painful cramping, is the most common symptom associated with menses in females and its severity can hinder women's everyday lives. Here, we present an easy and inexpensive method that would be instrumental ...
• Ovarian Cancer Stem Cells: Role in Metastasis and Opportunity for Therapeutic Targeting 

  Zong, Xingyue; Nephew, Kenneth P. (MDPI, 2019-07-03)

  Ovarian cancer (OC) is a heterogeneous disease usually diagnosed at a late stage. Cancer stem cells (CSCs) that exist within the bulk tumor survive first-line chemotherapy and contribute to resistant disease with metastasis. ...
• In Vivo Identification and Manipulation of the Ca2+ Selectivity Filter in the Drosophila Transient Receptor Potential Channel 

  Liu, Che H.; Wang, Tao; Postma, Marten; Obukhov, Alexander G.; Montell, Craig; Hardie, Roger C. (Society for Neuroscience, 2007-01-17)

  Null mutations in the transient receptor potential (trp) gene eliminate the major, Ca2+-selective component of the light-sensitive conductance in Drosophila photoreceptors. Although it is the prototypical member of the TRP ...
• An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons 

  Canfield, Scott G.; Stebbins, Matthew J.; Faubion, Madeline G.; Gastfriend, Benjamin D.; Palecek, Sean P.; Shusta, Eric V. (BioMed Central, 2019-08-07)

  BACKGROUND: Brain microvascular endothelial cells (BMECs) astrocytes, neurons, and pericytes form the neurovascular unit (NVU). Interactions with NVU cells endow BMECs with extremely tight barriers via the expression ...
• Rho kinase collaborates with p21-activated kinase to regulate actin polymerization and contraction in airway smooth muscle 

  Zhang, Wenwu; Bhetwal, Bhupal P.; Gunst, Susan J. (Wiley, 2018-08)

  KEY POINTS: The mechanisms by which Rho kinase (ROCK) regulates airway smooth muscle contraction were determined in tracheal smooth muscle tissues. ROCK may mediate smooth muscle contraction by inhibiting myosin regulatory ...
• Local metabolic hypothesis is not sufficient to explain coronary autoregulatory behavior 

  Kiel, Alexander M.; Goodwill, Adam G.; Baker, Hana E.; Dick, Gregory M.; Tune, Johnathan D. (Springer Nature, 2018-08-02)

  The local metabolic hypothesis proposes that myocardial oxygen tension determines the degree of autoregulation by increasing the production of vasodilator metabolites as perfusion pressure is reduced. Thus, normal physiologic ...

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