• Metabolism of hydrogen sulfide (H2S) and Production of Reactive Sulfur Species (RSS) by superoxide dismutase 

  Olson, Kenneth R.; Gao, Yan; Arif, Faihaan; Arora, Kanika; Patel, Shivali; DeLeon, Eric. R.; Sutton, Thomas R.; Feelisch, Martin; Cortese-Krott, Miriam M.; Straub, Karl D. (Elsevier, 2017-11-20)

  Reactive sulfur species (RSS) such as H2S, HS•, H2Sn, (n = 2–7) and HS2•- are chemically similar to H2O and the reactive oxygen species (ROS) HO•, H2O2, O2•- and act on common biological effectors. RSS were present in ...
• Endothelial Cell-Specific Deletion of P2Y2 Receptor Promotes Plaque Stability in Atherosclerosis-Susceptible ApoE-Null Mice 

  Xingjuan, Chen; Qian, Shaomin; Hoggatt, April; Tang, Hongying; Hacker, Timothy A.; Obukhov, Alexander G.; Herring, Paul B.; Seye, Cheikh I. (American Heart Association, 2017-01)

  OBJECTIVE: Nucleotide P2Y2 receptor (P2Y2R) contributes to vascular inflammation by increasing vascular cell adhesion molecule-1 expression in endothelial cells (EC), and global P2Y2R deficiency prevents fatty streak ...
• Molecular Determinants of the Sensitivity to Gq/11-Phospholipase C-dependent Gating, Gd3+ Potentiation, and Ca2+ Permeability in the Transient Receptor Potential Canonical Type 5 (TRPC5) Channel 

  Chen, Xingjuan; Li, Wennan; Riley, Ashley M.; Soliman, Mario; Chakraborty, Saikat Chakrabort; Stamatkin, Christopher W.; Obukhov, Alexander G. (American Society for Biochemistry and Molecular Biology, 2017-01-20)

  Transient receptor potential canonical type 5 (TRPC5) is a Ca2+-permeable cation channel that is highly expressed in the brain and is implicated in motor coordination, innate fear behavior, and seizure genesis. The channel ...
• Rho Kinase (ROCK) collaborates with Pak to Regulate Actin Polymerization and Contraction in Airway Smooth Muscle 

  Zhang, Wenwu; Bhetwal, Bhupal P.; Gunst, Susan J. (Wiley, 2018)

  Rho kinase (ROCK), a RhoA GTPase effector, can regulate the contraction of airway and other smooth muscle tissues. In some tissues, ROCK can inhibit myosin regulatory light chain (RLC) phosphatase, which increases the ...
• Focal adhesion kinase (FAK) and mechanical stimulation negatively regulate the transition of airway smooth muscle tissues to a synthetic phenotype 

  Wu, Yidi; Huang, Youliang; Gunst, Susan J. (American Physiological Society, 2016-11-01)

  The effects of mechanical forces and focal adhesion kinase (FAK) in regulating the inflammatory responses of airway smooth muscle (ASM) tissues to stimulation with interleukin (IL)-13 were investigated. Canine tracheal ...
• Regulation of myocardial oxygen delivery in response to graded reductions in hematocrit: Role of K+ channels 

  Kiel, Alexander M.; Goodwill, Adam G.; Noblet, Jillian N.; Barnard, April L.; Sassoon, Daniel J.; Tune, Johnathan D. (Springer, 2017-11)

  This study was designed to identify mechanisms responsible for coronary vasodilation in response to progressive decreases in hematocrit. Isovolemic hemodilution was produced in open-chest, anesthetized swine via concurrent ...
• SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity 

  Tong, Xin; Kono, Tatsuyoshi; Anderson-Baucum, Emily K.; Yamamoto, Wataru; Gilon, Patrick; Lebeche, Djamel; Day, Richard N.; Shull, Gary E.; Evans-Molina, Carmella (American Diabetes Association, 2016-10)

  The sarcoendoplasmic reticulum (ER) Ca2+ ATPase 2 (SERCA2) pump is a P-type ATPase tasked with the maintenance of ER Ca2+ stores. Whereas β-cell SERCA2 expression is reduced in diabetes, the role of SERCA2 in the regulation ...
• Direct Evidence for P2Y2 Receptor Involvement in Vascular Response to Injury 

  Agca, Yuksel; Qian, Shaomin; Agca, Cansu; Seye, Cheikh I. (Karger Publishers, 2016)

  Objectives Extracellular nucleotide release at the site of arterial injury mediates proliferation and migration of vascular smooth muscle cells (SMC). Our aim was to investigate the role of the P2Y2 nucleotide receptor ...
• A novel role for RhoA GTPase in the regulation of airway smooth muscle contraction 

  Zhang, Wenwu; Huang, Youliang; Wu, Yidi; Gunst, Susan J. (Canadian Science Publishing, 2015-02)

  Recent studies have demonstrated a novel molecular mechanism for the regulation of airway smooth muscle (ASM) contraction by RhoA GTPase. In ASM tissues, both myosin light chain (MLC) phosphorylation and actin polymerization ...
• In praise of scientific review officers 

  Elahi, Dariush; Mirmira, Raghavendra G.; Kushner, Jake A. (Oxford University Press, 2014-07)
• Endogenous Transmembrane TNF-Alpha Protects Against Premature Senescence in Endothelial Colony Forming Cells 

  Green, Linden A.; Njoku, Victor; Mund, Julie; Case, Jaime; Yoder, Mervin; Murphy, Michael P.; Clauss, Matthias (American Heart Association, 2016-05)

  RATIONALE: Transmembrane tumor necrosis factor-α (tmTNF-α) is the prime ligand for TNF receptor 2, which has been shown to mediate angiogenic and blood vessel repair activities in mice. We have previously reported that ...
• Exercise training prevents skeletal muscle plasma membrane cholesterol accumulation, cortical actin filament loss, and insulin resistance in C57BL/6J mice fed a western‐style high‐fat diet 

  Ambery, Ashley G.; Tackett, Lixuan; Penque, Brent A.; Brozinick, Joseph T.; Elmendorf, Jeffrey S. (Wiley, 2017-08-15)

  Insulin action and glucose disposal are enhanced by exercise, yet the mechanisms involved remain imperfectly understood. While the causes of skeletal muscle insulin resistance also remain poorly understood, new evidence ...
• p21‐Activated kinase (Pak) regulates airway smooth muscle contraction by regulating paxillin complexes that mediate actin polymerization 

  Zhang, Wenwu; Huang, Youliang; Gunst, Susan J. (Wiley, 2016-09-01)

  In airway smooth muscle, tension development caused by a contractile stimulus requires phosphorylation of the 20 kDa myosin light chain (MLC), which activates crossbridge cycling and the polymerization of a pool of ...
• Combining varenicline (Chantix) with naltrexone decreases alcohol drinking more effectively than does either drug alone in a rodent model of alcoholism 

  Froehlich, Janice C.; Fischer, Stephen M.; Dilley, Julian E.; Nicholson, Emily; Smith, Teal; Filosa, Nick; Rademacher, Logan (Wiley, 2016-09)

  Background This study examined whether varenicline (VAR), or naltrexone (NTX), alone or in combination, reduces alcohol drinking in alcohol-preferring (P) rats with a genetic predisposition toward high voluntary alcohol ...
• Mucosal Perfusion Preservation by a Novel Shapeable Tissue Expander for Oral Reconstruction 

  Barwinska, Daria; Garner, John; Davidson, Darrell D.; Cook, Todd G.; Eckert, George J.; Tholpady, Sunil S.; March, Keith L.; Park, Kinam; Barco, Clark T. (Wolters Kluwer, 2017-08-28)

  Background: There are few methods for expanding oral mucosa, and these often cause complications such as tissue necrosis and expander eruption. This study examines mucosal blood perfusion following insertion of a novel ...
• Critical contribution of KV1 channels to the regulation of coronary blood flow 

  Goodwill, Adam G.; Noblet, Jillian N.; Sassoon, Daniel; Fu, Lijuan; Kassab, Ghassan S.; Schepers, Luke; Herring, B. Paul; Rottgen, Trey S.; Tune, Johnathan D.; Dick, Gregory M. (Springer, 2016-09)

  Ion channels in smooth muscle control coronary vascular tone, but the mechanisms require further investigation. The purpose of this study was to evaluate the functional role of KV1 channels on porcine coronary blood flow ...
• Real-time intravascular photoacoustic-ultrasound imaging of lipid-laden plaque at speed of video-rate level 

  Hui, Jie; Cao, Yingchun; Zhang, Yi; Kole, Ayeeshik; Wang, Pu; Yu, Guangli; Eakins, Gregory; Sturek, Michael; Chen, Weibiao; Cheng, Ji-Xin (SPIE, 2017)

  Intravascular photoacoustic-ultrasound (IVPA-US) imaging is an emerging hybrid modality for the detection of lipidladen plaques by providing simultaneous morphological and lipid-specific chemical information of an artery ...
• Delineation of Molecular Pathways Involved in Cardiomyopathies Caused by Troponin T Mutations 

  Gilda, Jennifer E.; Lai, Xianyin; Witzmann, Frank A.; Gomes, Aldrin V. (American Society for Biochemistry and Molecular Biology, 2016-06)

  Familial hypertrophic cardiomyopathy (FHC) is associated with mild to severe cardiac problems and is the leading cause of sudden death in young people and athletes. Although the genetic basis for FHC is well-established, ...
• Spectral analysis assisted photoacoustic imaging for lipid composition differentiation 

  Cao, Yingchun; Kole, Ayeeshik; Lan, Lu; Wang, Pu; Hui, Jie; Sturek, Michael; Cheng, Ji-Xin (Elsevier, 2017-06-06)

  Recent advances in atherosclerotic plaque detection have shown that not only does lipid core size and depth play important roles in plaque rupture and thrombi formation, but lipid composition, especially cholesterol ...
• Biphasic alterations in coronary smooth muscle Ca2+ regulation in a repeat cross-sectional study of coronary artery disease severity in metabolic syndrome 

  McKenney-Drake, Mikaela L.; Rodenbeck, Stacey D.; Owen, Meredith K.; Schultz, Kyle A.; Alloosh, Mouhamad; Tune, Johnathan D.; Sturek, Michael (Elsevier, 2016-06)

  BACKGROUND AND AIMS: Coronary artery disease (CAD) is progressive, classified by stages of severity. Alterations in Ca(2+) regulation within coronary smooth muscle (CSM) cells in metabolic syndrome (MetS) have been ...

View more