• Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells 

  Thompson, Kayla; Chen, Jonathan; Luo, Qianyi; Xiao, Yucheng; Cummins, Theodore R.; Bhatwadekar, Ashay D. (PLOS, 2018-02-23)

  Diabetic retinopathy (DR) is a major cause of adult blindness. Retinal Müller cells maintain water homeostasis and potassium concentration via inwardly rectifying Kir4.1 channels. Accumulation of advanced glycation end ...
• Primary open-angle glaucoma in patients of Middle Eastern descent 

  Alshawa, Loor; Harris, Alon; Gross, Josh; Snyder, Alex; Rao, Ambika; Siesky, Brent (Elsevier, 2017)
• Dysthyroid optic neuropathy: update on pathogenesis, diagnosis, and management 

  Blandford, Alexander D.; Zhang, Dalia; Chundury, Rao V.; Perry, Julian D. (Taylor & Francis, 2017)

  INTRODUCTION: Dysthyroid optic neuropathy (DON) is a severe manifestation of thyroid eye disease (TED) that can result in permanent vision loss. Management is complex, multidisciplinary, and involves medical and/or ...
• Hematopoietic stem/progenitor involvement in retinal microvascular repair during diabetes: Implications for bone marrow rejuvenation 

  Bhatwadekar, Ashay D.; Duan, Yaqian; Korah, Maria; Thinschmidt, Jeffrey S.; Hu, Ping; Leley, Sameer P.; Caballero, Sergio; Shaw, Lynn; Busik, Julia; Grant, Maria B. (Elsevier, 2017-10)

  The widespread nature of diabetes affects all organ systems of an individual including the bone marrow. Long-term damage to the cellular and extracellular components of the bone marrow leads to a rapid decline in the bone ...
• Prediction of Anti-VEGF Response in Diabetic Macular Edema After 1 Injection 

  Shah, Ankoor R.; Yonekawa, Yoshihiro; Todorich, Bozho; Van Laere, Lily; Hussain, Rehan; Woodward, Maria A.; Abbey, Ashkan M.; Wolfe, Jeremy D. (2017-05)

  Purpose With multiple anti-vascular endothelial growth factor and steroid therapies available for diabetic macular edema (DME), there is a need for early determination of the best treatment for a particular patient ...
• Long-term efficacy of endoscopic cyclophotocoagulation in the management of glaucoma following cataract surgery in children 

  Cantor, Adam J.; Wang, Jingyun; Li, Shanshan; Neely, Daniel E.; Plager, David A. (Elsevier, 2018)

  Purpose To report the long-term efficacy of endoscopic cyclophotocoagulation (ECP) in pediatric glaucoma following cataract surgery (GFCS). Methods ECP was performed on 35 eyes of 25 patients <16 years of age with ...
• Gene Therapy for Inherited Retinal and Optic Nerve Degenerations 

  Moore, Nicholas A.; Morral, Nuria; Ciulla, Thomas A.; Bracha, Peter (Taylor & Francis, 2018)

  Introduction: The eye is a target for investigational gene therapy due to the monogenic nature of many inherited retinal and optic nerve degenerations (IRD), its accessibility, tight blood-ocular barrier, the ability to ...
• CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes 

  Beli, Eleni; Dominguez, James M.; Hu, Ping; Thinschmidt, Jeffrey S.; Caballero, Sergio; Calzi, Sergio Li; Luo, Defang; Shanmugam, Sumathi; Salazar, Tatiana; Duan, Yaqian; Boulton, Michael E.; Mohr, Susanna; Abcouwer, Steven F.; Saban, Daniel R.; Harrison, Jeffrey K.; Grant, Maria B. (Springer, 2016-11)

  In this study, the role of CX3CR1 in the progression of diabetic retinopathy (DR) was investigated. The retinas of wild type (WT), CX3CR1 null (CX3CR1gfp/gfp, KO) and heterozygous (CX3CR1+/gfp, Het) mice were compared in ...
• Sensitivity Analysis in Poro-Elastic and Poro-Visco-Elastic Models with Respect to Boundary Data 

  Banks, Harvey Thomas; Bekele-Maxwell, Kidist; Bociu, Lorena; Noorman, M.; Guidoboni, Giovanna (AMS, 2017)

  In this article we consider poro-elastic and poro-visco-elastic models inspired by problems in medicine and biology, and we perform sensitivity analysis on the solutions of these fluid-solid mixture problems with respect ...
• Induced pluripotent stem cell-based therapy for age-related macular degeneration 

  Bracha, Peter; Moore, Nicholas A.; Ciulla, Thomas A. (Taylor & Francis, 2017)

  Introduction: In age-related macular degeneration (AMD), stem cells could possibly replace or regenerate disrupted pathologic retinal pigment epithelium (RPE), and produce supportive growth factors and cytokines such as ...
• Comparison of matrix frequency-doubling technology perimetry and standard automated perimetry in monitoring the development of visual field defects for glaucoma suspect eyes 

  Hu, Rongrong; Wang, Chenkun; Racette, Lyne (PLOS, 2017-05-18)

  BACKGROUND: Perimetry is indispensable for the clinical management of glaucoma suspects. Our goal is to compare the performance of standard automated perimetry (SAP) and Matrix frequency-doubling technology (FDT) perimetry ...
• Ocular hypotensive effect of the novel EP3/FP agonist ONO-9054 versus Xalatan: results of a 28-day, double-masked, randomised study 

  Miller Ellis, Eydie; Berlin, Michael S; Ward, Caroline L; Sharpe, John A; Jamil, Alam; Harris, Alon (BMJ Journals, 2017-06)

  Background/aims ONO-9054 is being developed for the reduction of intraocular pressure (IOP) in patients with ocular hypertension (OHT) and open-angle glaucoma (OAG). This study compared the novel dual EP3/FP agonist ...
• Reductions in retrobulbar and retinal capillary blood flow strongly correlate with changes in optic nerve head and retinal morphology over four years in open-angle glaucoma patients of African descent compared to patients of European descent 

  Siesky, Brent; Harris, Alon; Carr, Joseph; Vercellin, Alice Verticchio; Hussain, Rehan; Hembree, Priyanka Parekh; Wentz, Scott; Isaacs, Michael; Eckert, George; Moore, Nicholas A. (Wolters Kluwer, 2016-09)

  Purpose To investigate the relationship of changes in ocular blood flow with optic nerve head and retinal morphology in open-angle glaucoma patients of African versus European descent over four years. Materials and ...
• Long-term spironolactone treatment reduces coronary TRPC expression, vasoconstriction, and atherosclerosis in metabolic syndrome pigs 

  Li, Wennan; Chen, Xingjuan; Riley, Ashley M.; Hiett, S. Christopher; Temm, Constance J.; Beli, Eleni; Long, Xin; Chakraborty, Saikat; Alloosh, Mouhamad; White, Fletcher A.; Grant, Maria B.; Sturek, Michael; Obukhov, Alexander G. (Springer, 2017)

  Coronary transient receptor potential canonical (TRPC) channel expression is elevated in metabolic syndrome (MetS). However, differential contribution of TRPCs to coronary pathology in MetS is not fully elucidated. We ...
• Cost-Comparison of Two Trabecular Micro-Bypass Stents Versus Selective Laser Trabeculoplasty or Medications Only for Intraocular Pressure Control for Patients with Open-Angle Glaucoma 

  Berdahl, John P.; Khatana, Anup K.; Katz, L. Jay; Herndon, Leon; Layton, Andrew J.; Yu, Tiffany M.; Bauer, Matthew J.; Cantor, Louis B. (Taylor & Francis, 2017)

  Aim: Patients with open-angle glaucoma (OAG) whose intraocular pressure is not adequately controlled by one medication have several treatment options in the US. This analysis evaluated direct costs of unilateral eye treatment ...
• Macula Retinal Vasculitis and Choroiditis Associated with Granulomatosis with Polyangiitis 

  Lim, Lik Thai; Vasudevan, Vinaya; Shelton, Julie; Vitale, Albert T.; Moorthy, Ramana (Wolters Kluwer, 2017)

  Purpose: To report a case series of two cases of granulomatosis with polyangiitis, previously known as Wegener granulomatosis, which developed macular necrosis, not previously associated with granulomatosis with polyangiitis, ...
• Neomycin, polymyxin B, and dexamethasone allergic reactions following periocular surgery 

  Moore, Nicholas A.; Czyz, Craig N.; Carter, Tracy D.; Foster, Jill A.; Cahill, Kenneth V. (Springer Open, 2017-12)

  BACKGROUND: The aim of this study was to evaluate the rate of periocular allergic skin reactions to topical neomycin, polymyxin B, and dexamethasone (NPD) ophthalmic ointment. METHODS: A consecutive patient prospective ...
• Role of the ACE2/Angiotensin 1-7 Axis of the Renin-Angiotensin System in Heart Failure 

  Patel, Vaibhav B.; Zhong, Jiu-Chang; Grant, Maria B.; Oudit, Gavin Y. (Ovid Technologies Wolters Kluwer - American Heart Association, 2016-04-15)

  Heart failure (HF) remains the most common cause of death and disability, and a major economic burden, in industrialized nations. Physiological, pharmacological, and clinical studies have demonstrated that activation of ...
• Adeno-Associated Virus Overexpression of Angiotensin-Converting Enzyme-2 Reverses Diabetic Retinopathy in Type 1 Diabetes in Mice 

  Dominguez, James M., II; Hu, Ping; Caballero, Sergio; Moldovan, Leni; Verma, Amrisha; Oudit, Gavin Y.; Li, Qiuhong; Grant, Maria B. (Elsevier, 2016)

  Angiotensin-converting enzyme (ACE)-2 is the primary enzyme of the vasoprotective axis of the renin angiotensin system that regulates the classic renin angiotensin system axis. We aimed to determine whether local retinal ...
• The acute and chronic effects of intravitreal anti-vascular endothelial growth factor injections on intraocular pressure: A review 

  Bracha, Peter; Moore, Nicholas A.; Ciulla, Thomas A.; WuDunn, Darrell; Cantor, Louis B. (Elsevier, 2017)

  The acute and chronic effects of repeated intravitreal antivascular endothelial growth factor (VEGF) injections on intraocular pressure have not been fully characterized, and the development of sustained ocular hypertension ...

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