• Stargardt macular dystrophy and evolving therapies 

  Hussain, Rehan M.; Ciulla, Thomas A.; Berrocal, Audina M.; Gregori, Ninel Z.; Flynn, Harry W.; Lam, Byron L. (Taylor & Francis, 2018)

  Introduction: Stargardt macular dystrophy (STGD1) is a hereditary retinal degeneration that lacks effective treatment options. Gene therapy, stem cell therapy, and pharmacotherapy with visual cycle modulators (VCMs) and ...
• Pharmacotherapy of retinal disease with visual cycle modulators 

  Hussain, Rehan M.; Gregori, Ninel Z.; Ciulla, Thomas A.; Lam, Byron L. (Taylor & Francis, 2018)

  Introduction: Pharmacotherapy with visual cycle modulators (VCMs) is under investigation for retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), Stargardt macular dystrophy (SMD) and nonexudative age-related macular ...
• Effects of Sex Hormones on Ocular Blood Flow and Intraocular Pressure in Primary Open Angle Glaucoma: A Review 

  Patel, Pooja; Harris, Alon; Toris, Carol; Lang, Matthew; Tobe, Leslie; Belamkar, Aditya; Ng, Adrienne; Verticchio Vercellin, Alice C.; Matthew, Sunu; Siesky, Brent (Wolters Kluwer, 2018-10)

  Primary open-angle glaucoma (POAG) is a multifactorial optic neuropathy characterized by progressive retinal ganglion cell death and visual field loss. Some speculate that gender plays a role in the risk of developing POAG ...
• Increase in acid sphingomyelinase level in human retinal endothelial cells and CD34+ circulating angiogenic cells isolated from diabetic individuals is associated with dysfunctional retinal vasculature and vascular repair process in diabetes 

  Kady, Nermin; Yan, Yuanqing; Salazar, Tatiana; Wang, Qi; Chakravarthy, Harshini; Huang, Chao; Beli, Eleni; Navitskaya, Svetlana; Grant, Maria; Busik, Julia (Elsevier, 2017-05)

  BACKGROUND: Diabetic retinopathy is a microvascular disease that results from retinal vascular degeneration and defective repair due to diabetes-induced endothelial progenitor dysfunction. OBJECTIVE: Understanding ...
• Electroacupuncture Promotes Central Nervous System-Dependent Release of Mesenchymal Stem Cells 

  Salazar, Tatiana E.; Richardson, Matthew R.; Beli, Eleni; Ripsch, Matthew S.; George, John; Kim, Youngsook; Duan, Yaqian; Moldovan, Leni; Yan, Yuanqing; Bhatwadekar, Ashay; Jadhav, Vaishnavi; Smith, Jared A.; McGorray, Susan; Bertone, Alicia L.; Traktuev, Dmitri O.; March, Keith L.; Colon-Perez, Luis M.; Avin, Keith; Sims, Emily; Mund, Julie A.; Case, Jamie; Deng, Shaolin; Kim, Min Su; McDavitt, Bruce; Boulton, Michael E.; Thinschmidt, Jeffrey; Calzi, Sergio Li; Fitz, Stephanie D.; Fuchs, Robyn K.; Warden, Stuart J.; McKinley, Todd; Shekhar, Anantha; Febo, Marcelo; Johnson, Phillip L.; Chang, Lung Ji; Gao, Zhanguo; Kolonin, Mikhail G.; Lai, Song; Ma, Jinfeng; Dong, Xinzhong; White, Fletcher A.; Xie, Huisheng; Yoder, Mervin C.; Grant, Maria B. (Wiley, 2017-05)

  Electroacupuncture (EA) performed in rats and humans using limb acupuncture sites, LI-4 and LI-11, and GV-14 and GV-20 (humans) and Bai-hui (rats) increased functional connectivity between the anterior hypothalamus and the ...
• A hybrid technique to address exposure keratopathy secondary to facial nerve paresis: A combination of a lateral tarsorrhaphy and lateral wedge resection 

  Fu, Roxana; Moore, Nicholas; Shipchandler, Taha Z.; Ting, Jonathan Y.; Tollefson, Travis; Rabbani, Cyrus; Moorthy, Meena; Nunery, William R.; Lee, H. B. Harold (Elsevier, 2018-09)

  Purpose To present the results of treating combined lower eyelid laxity, retraction and midface descent secondary to facial nerve weakness with a hybrid surgical procedure. Materials and methods A retrospective analysis ...
• Systemic Injection of RPE65-Programmed Bone Marrow-Derived Cells Prevents Progression of Chronic Retinal Degeneration 

  Qi, Xiaoping; Pay, S. Louise; Yan, Yuanqing; Thomas, James, Jr.; Lewin, Alfred S.; Chang, Lung-Ji; Grant, Maria B.; Boulton, Michael E. (Elsevier, 2017-04-05)

  Bone marrow stem and progenitor cells can differentiate into a range of non-hematopoietic cell types, including retinal pigment epithelium (RPE)-like cells. In this study, we programmed bone marrow-derived cells (BMDCs) ...
• Delivery of Intraocular Triamcinolone Acetonide in the Treatment of Macular Edema 

  Pickrell, Aaron; Harris, Alon; Ngo, Sandra; Amireskandari, Annahita; Stewart, Erin; Siesky, Brent (MDPI, 2012-03-15)

  Macular edema (ME) is one of the eventual outcomes of various intraocular and systemic pathologies. The pathogenesis for ME is not yet entirely understood; however, some of the common risk factors for its development have ...
• The Effect of Diluted Penetration Enhancer in Nebulized Mist versus Liquid Drop Preparation Forms on Retrobulbar Blood Flow in Healthy Human Subjects 

  Primus, Sally; Januleviciene, Ingrida; Siesky, Brent; Gerber, Austin; Egan, Patrick; Amireskandari, Annahita; Siaudvytyte, Lina; Barsauskaite, Ruta; Harris, Alon (MDPI, 2012-08-08)

  The aim of this study was to compare the effects of nebulized mist and liquid drop applications on retrobulbar blood flow. A prospective, non-randomized clinical trial was used to collect data from 40 healthy human eyes. ...
• Surgical approach to limiting skin contracture following protractor myectomy for essential blepharospasm 

  Clark, Jeremy; Randolph, John; Sokol, Jason A.; Moore, Nicholas A.; Lee, Hui Bae H.; Nunery, William R. (Massachusetts Eye and Ear Infirmary, 2017-11-05)

  Purpose: To report our experience with protractor myectomy in patients with benign essential blepharospasm who did not respond to serial botulinum toxin injection, and to describe intra- and postoperative techniques ...
• Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells 

  Thompson, Kayla; Chen, Jonathan; Luo, Qianyi; Xiao, Yucheng; Cummins, Theodore R.; Bhatwadekar, Ashay D. (PLOS, 2018-02-23)

  Diabetic retinopathy (DR) is a major cause of adult blindness. Retinal Müller cells maintain water homeostasis and potassium concentration via inwardly rectifying Kir4.1 channels. Accumulation of advanced glycation end ...
• Primary open-angle glaucoma in patients of Middle Eastern descent 

  Alshawa, Loor; Harris, Alon; Gross, Josh; Snyder, Alex; Rao, Ambika; Siesky, Brent (Elsevier, 2017)
• Dysthyroid optic neuropathy: update on pathogenesis, diagnosis, and management 

  Blandford, Alexander D.; Zhang, Dalia; Chundury, Rao V.; Perry, Julian D. (Taylor & Francis, 2017)

  INTRODUCTION: Dysthyroid optic neuropathy (DON) is a severe manifestation of thyroid eye disease (TED) that can result in permanent vision loss. Management is complex, multidisciplinary, and involves medical and/or ...
• Hematopoietic stem/progenitor involvement in retinal microvascular repair during diabetes: Implications for bone marrow rejuvenation 

  Bhatwadekar, Ashay D.; Duan, Yaqian; Korah, Maria; Thinschmidt, Jeffrey S.; Hu, Ping; Leley, Sameer P.; Caballero, Sergio; Shaw, Lynn; Busik, Julia; Grant, Maria B. (Elsevier, 2017-10)

  The widespread nature of diabetes affects all organ systems of an individual including the bone marrow. Long-term damage to the cellular and extracellular components of the bone marrow leads to a rapid decline in the bone ...
• Prediction of Anti-VEGF Response in Diabetic Macular Edema After 1 Injection 

  Shah, Ankoor R.; Yonekawa, Yoshihiro; Todorich, Bozho; Van Laere, Lily; Hussain, Rehan; Woodward, Maria A.; Abbey, Ashkan M.; Wolfe, Jeremy D. (2017-05)

  Purpose With multiple anti-vascular endothelial growth factor and steroid therapies available for diabetic macular edema (DME), there is a need for early determination of the best treatment for a particular patient ...
• Long-term efficacy of endoscopic cyclophotocoagulation in the management of glaucoma following cataract surgery in children 

  Cantor, Adam J.; Wang, Jingyun; Li, Shanshan; Neely, Daniel E.; Plager, David A. (Elsevier, 2018)

  Purpose To report the long-term efficacy of endoscopic cyclophotocoagulation (ECP) in pediatric glaucoma following cataract surgery (GFCS). Methods ECP was performed on 35 eyes of 25 patients <16 years of age with ...
• Gene Therapy for Inherited Retinal and Optic Nerve Degenerations 

  Moore, Nicholas A.; Morral, Nuria; Ciulla, Thomas A.; Bracha, Peter (Taylor & Francis, 2018)

  Introduction: The eye is a target for investigational gene therapy due to the monogenic nature of many inherited retinal and optic nerve degenerations (IRD), its accessibility, tight blood-ocular barrier, the ability to ...
• CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes 

  Beli, Eleni; Dominguez, James M.; Hu, Ping; Thinschmidt, Jeffrey S.; Caballero, Sergio; Calzi, Sergio Li; Luo, Defang; Shanmugam, Sumathi; Salazar, Tatiana; Duan, Yaqian; Boulton, Michael E.; Mohr, Susanna; Abcouwer, Steven F.; Saban, Daniel R.; Harrison, Jeffrey K.; Grant, Maria B. (Springer, 2016-11)

  In this study, the role of CX3CR1 in the progression of diabetic retinopathy (DR) was investigated. The retinas of wild type (WT), CX3CR1 null (CX3CR1gfp/gfp, KO) and heterozygous (CX3CR1+/gfp, Het) mice were compared in ...
• Sensitivity Analysis in Poro-Elastic and Poro-Visco-Elastic Models with Respect to Boundary Data 

  Banks, Harvey Thomas; Bekele-Maxwell, Kidist; Bociu, Lorena; Noorman, M.; Guidoboni, Giovanna (AMS, 2017)

  In this article we consider poro-elastic and poro-visco-elastic models inspired by problems in medicine and biology, and we perform sensitivity analysis on the solutions of these fluid-solid mixture problems with respect ...
• Induced pluripotent stem cell-based therapy for age-related macular degeneration 

  Bracha, Peter; Moore, Nicholas A.; Ciulla, Thomas A. (Taylor & Francis, 2017)

  Introduction: In age-related macular degeneration (AMD), stem cells could possibly replace or regenerate disrupted pathologic retinal pigment epithelium (RPE), and produce supportive growth factors and cytokines such as ...

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