• Health-related quality of life in children with untreated intermittent exotropia and their parents 

  Holmes, Jonathan M.; Hercinovic, Amra; Melia, B. Michele; Leske, David A.; Hatt, Sarah R.; Chandler, Danielle L.; Dean, Trevano W.; Kraker, Raymond T.; Enyedi, Laura B.; Wallace, David K.; Mohney, Brian G.; Cotter, Susan A. (Elsevier, 2021)

  Purpose To determine whether health-related quality of life (HRQOL) scores improved or worsened over 3 years of observation in childhood intermittent exotropia without treatment. Methods A total of 111 children aged ...
• Mitochondrial Heme Synthesis Enzymes as Therapeutic Targets in Vascular Diseases 

  Shetty, Trupti; Corson, Timothy W. (Frontiers, 2020-07-15)
• Branch Retinal Artery Occlusion Associated with Toxoplasma Retinitis 

  Neiweem, Ashley E.; Jusufbegovic, Denis (The Korean Ophthalmological Society, 2020-07-31)
• Heme Synthesis Inhibition Blocks Angiogenesis via Mitochondrial Dysfunction 

  Shetty, Trupti; Sishtla, Kamakshi; Park, Bomina; Repass, Matthew J.; Corson, Timothy W. (Elsevier, 2020-07-19)

  The relationship between heme metabolism and angiogenesis is poorly understood. The final synthesis of heme occurs in mitochondria, where ferrochelatase (FECH) inserts Fe2+ into protoporphyrin IX to produce proto-heme IX. ...
• Modulating a summer ophthalmology research experience for medical students during the COVID-19 pandemic 

  Corson, Timothy W.; Wallace, David K. (2021-02)
• Enantioselective Synthesis of Homoisoflavanones by Asymmetric Transfer Hydrogenation and Their Biological Evaluation for Antiangiogenic Activity 

  Heo, Myunghoe; Lee, Bit; Sishtla, Kamakshi; Fei, Xiang; Lee, Sanha; Park, Soojun; Yuan, Yue; Lee, Seul; Kwon, Sangil; Lee, Jungeun; Kim, Sanghee; Corson, Timothy W.; Seo, Seung-Yong (ACS Publications, 2019-08-05)

  Neovascular eye diseases are a major cause of blindness. Excessive angiogenesis is a feature of several conditions, including wet age-related macular degeneration, proliferative diabetic retinopathy, and retinopathy of ...
• Pharmacological Potential of Small Molecules for Treating Corneal Neovascularization 

  Barry, Zachary; Park, Bomina; Corson, Timothy W. (MDPI, 2020-07-08)

  Under healthy conditions, the cornea is an avascular structure which allows for transparency and optimal visual acuity. Its avascular nature is maintained by a balance of proangiogenic and antiangiogenic factors. An imbalance ...
• Quantitatively comparing weekly changes in retinal vascular characteristics of eyes eventually treated versus not treated for retinopathy of prematurity 

  Hong, Gloria J.; Koerner, Jagger C.; Weinert, Marguerite C.; Stinnett, Sandra S.; Freedman, Sharon F.; Wallace, David K.; Riggins, J. Wayne; Gallaher, Keith J.; Prakalapakorn, S. Grace (Elsevier, 2021)

  Purpose To quantitatively compare retinal vascular characteristics over time in eyes eventually treated versus not treated for retinopathy of prematurity (ROP), using ROPtool analysis of narrow-field retinal images. Me ...
• Metformin Corrects Abnormal Circadian Rhythm and Kir4.1 Channels in Diabetes 

  Alex, Alpha; Luo, Qianyi; Mathew, Deepa; Di, Rong; Bhatwadekar, Ashay D. (The Association for Research in Vision and Ophthalmology, 2020-06-22)

  Purpose Diabetic retinopathy (DR) is a leading cause of visual impairment. Müller cells in DR are dysfunctional due to downregulation of the inwardly rectifying potassium channel Kir4.1. Metformin, a commonly used oral ...
• Outflow Facility Effects of 3 Schlemm’s Canal Microinvasive Glaucoma Surgery Devices 

  Toris, Carol B.; Pattabiraman, Padmanabhan P.; Tye, George; Samuelson, Thomas W.; Rhee, Douglas J. (Elsevier, 2020-03)

  Purpose To study the effect of 3 Schlemm’s canal (SC) microinvasive glaucoma surgery (MIGS) devices on outflow facility. Design Paired comparisons, randomized design, baseline-controlled study. Participants Thirty-six ...
• Conjunctival Fungal Ball Mimicking Melanoma 

  Chuang, Katherine; Vortmeyer, Alexander; Liu, Shaohui (Elsevier, 2020-04)
• Programmed switch in the mitochondrial degradation pathways during human retinal ganglion cell differentiation from stem cells is critical for RGC survival 

  Das, Arupratan; Bell, Claire M.; Berlinicke, Cynthia A.; Marsh-Armstrong, Nicholas; Zack, Donald J. (Elsevier, 2020-04-20)

  Retinal ganglion cell (RGC) degeneration is the root cause for vision loss in glaucoma as well as in other forms of optic neuropathy. A variety of studies have implicated abnormal mitochondrial quality control (MQC) as ...
• The Role of the Ocular Tissue in SARS-CoV-2 Transmission 

  Peng, Michael; Dai, Jiannong; Sugali, Chenna Kesavulu; Rayana, Naga Pradeep; Mao, Weiming (Dove Medical Press, 2020-10-02)

  The current global pandemic of coronavirus disease 2019 (COVID-19) has affected over 21 million people and caused over half a million deaths within a few months. COVID-19 has become one of the most severe public health ...
• Gender Differences in Case Volume Among Ophthalmology Residents 

  Gong, Dan; Winn, Bryan J.; Beal, Casey J.; Blomquist, Preston H.; Chen, Royce W.; Culican, Susan M.; Dagi Glass, Lora R.; Domeracki, Gary F.; Goshe, Jeffrey M.; Jones, Jeremy K.; Khouri, Albert S.; Legault, Gary L.; Martin, Timothy J.; Mitchell, Kelly T.; Naseri, Ayman; Oetting, Thomas A.; Olson, Joshua H.; Pettey, Jeff H.; Reinoso, Maria A.; Reynolds, Andrew L.; Siatkowski, R. Michael; SooHoo, Jeffrey R.; Sun, Grace; Syed, Misha F.; Tao, Jeremiah P.; Taravati, Parisa; WuDunn, Darrell; Al-Aswad, Lama A. (American Medical Association, 2019-07-18)

  Question Do differences in cataract surgery and total procedural volume exist between US male and female residents during ophthalmology residency training? Findings This analysis of the case logs of 1271 ophthalmology ...
• Practice patterns to decrease myopia progression differ among paediatric ophthalmologists around the world 

  Leshno, Ari; Farzavandi, Sonal K.; Gomez-de-Liaño, Rosario; Sprunger, Derek T.; Wygnanski-Jaffe, Tamara; Mezer, Eedy (BMJ, 2020)

  Introduction Myopia is a worldwide epidemic. Plethora of treatments are offered to decrease myopia progression. In this study, we compared between different geographical areas worldwide the practice patterns used by ...
• Dynamic assessment of the tear film muco-aqueous and lipid layers using a novel tear film imager (TFI) 

  Segev, Fani; Geffen, Noa; Galor, Anat; Cohen, Yoel; Gefen, Raanan; Belkin, Avner; Arieli, Yoel; Epshtein, Shlomi; Oren, Anat; Harris, Alon (BMJ, 2020)

  Purpose The objective of the study was to assess a new technology, the tear film imager (TFI), which can dynamically image the muco-aqueous and lipid layers. Methods Prospective pilot case series of individuals with and ...
• A theoretical study of aqueous humor secretion based on a continuum model coupling electrochemical and fluid-dynamical transmembrane mechanisms 

  Sala, Lorenzo; Mauri, Aurelio Giancarlo; Sacco, Riccardo; Messenio, Dario; Guidoboni, Giovanna; Harris, Alon (MSP, 2019)

  Intraocular pressure, resulting from the balance of aqueous humor (AH) production and drainage, is the only approved treatable risk factor in glaucoma. AH production is determined by the concurrent function of ion pumps ...
• Case Report: Ocular Toxocariasis: A Report of Three Cases from the Mississippi Delta 

  Inagaki, Kengo; Kirmse, Brian; Bradbury, Richard S.; Moorthy, Ramana S.; Arguello, Irene; McGuffey, Charles D.; Tieu, Brian; Hobbs, Charlotte V. (American Society of Tropical Medicine and Hygiene, 2019-03-11)

  Ocular toxocariasis can be vision threatening, and is commonly reported from tropical or subtropical regions. Knowledge of clinical manifestations from the United States, particularly in underserved areas such as the ...
• Intense versus standard regimens of intermittent occlusion therapy for unilateral moderate amblyopia in children: study protocol for a randomized controlled trial 

  Wang, Jingyun; Malik, Ayesha; Jin, Jing; Pang, Yi; Yin, Kelly; Allen, Megan; Grigorian, Adriana; Scombordi, Brandy; Bailey, Joann; Aljohani, Saeed; Funari, Katharine; Shoge, Ruth; Meiyeppen, Siva; Myung, Jenny; Soni, Ajay; Neely, Daniel E. (BMC, 2020-04-28)

  Background: We reported that in our previous study that wearing intermittent occlusion therapy glasses (IO-therapy) for 4 hours (h) was non-inferior to patching for 2 h in 3 to 8-year-old children with amblyopia. We ...
• Total Synthesis of Naturally Occurring 5,7,8-Trioxygenated Homoisoflavonoids 

  Kwon, Sangil; Lee, Sanha; Heo, Myunghoe; Lee, Bit; Fei, Xiang; Corson, Timothy W.; Seo, Seung-Yong (American Chemical Society, 2020-05-06)

  Homoisoflavonoids are in the subclass of the larger family of flavonoids but have one more alkyl carbon than flavonoids. Among them, 5,7,8-trioxygenated homoisoflavonoids have not been extensively studied for synthesis and ...

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