• Adeno-Associated Virus Overexpression of Angiotensin-Converting Enzyme-2 Reverses Diabetic Retinopathy in Type 1 Diabetes in Mice 

  Dominguez, James M., II; Hu, Ping; Caballero, Sergio; Moldovan, Leni; Verma, Amrisha; Oudit, Gavin Y.; Li, Qiuhong; Grant, Maria B. (Elsevier, 2016)

  Angiotensin-converting enzyme (ACE)-2 is the primary enzyme of the vasoprotective axis of the renin angiotensin system that regulates the classic renin angiotensin system axis. We aimed to determine whether local retinal ...
• The acute and chronic effects of intravitreal anti-vascular endothelial growth factor injections on intraocular pressure: A review 

  Bracha, Peter; Moore, Nicholas A.; Ciulla, Thomas A.; WuDunn, Darrell; Cantor, Louis B. (Elsevier, 2017)

  The acute and chronic effects of repeated intravitreal antivascular endothelial growth factor (VEGF) injections on intraocular pressure have not been fully characterized, and the development of sustained ocular hypertension ...
• Depressed basal hypothalamic neuronal activity in type-1 diabetic mice is correlated with proinflammatory secretion of HMBG1 

  Thinschmidt, Jeffrey S.; Colon-Perez, Luis M.; Febo, Marcelo; Caballero, Sergio; King, Michael A.; White, Fletcher A.; Grant, Maria B. (Elsevier, 2016-02-26)

  We recently found indicators of hypothalamic inflammation and neurodegeneration linked to the loss of neuroprotective factors including insulin-like growth factor (IGF-1) and IGF binding protein-2 (IGFBP-3) in mice made ...
• Retinoblastoma 

  Dimaras, Helen; Corson, Timothy W.; Cobrinik, David; White, Abby; Zhao, Junyang; Munier, Francis L.; Abramson, David H.; Shields, Carol L.; Chantada, Guillermo L.; Njuguna, Festus; Gallie, Brenda L. (Springer, 2015)

  Retinoblastoma is a rare cancer of the infant retina that is diagnosed in approximately 8,000 children each year worldwide. It forms when both retinoblastoma gene (RB1) alleles are mutated in a susceptible retinal cell, ...
• The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor 

  Hammer, Sandra S.; Beli, Eleni; Kady, Nermin; Wang, Qi; Wood, Kiana; Lydic, Todd A.; Malek, Goldis; Saban, Daniel R.; Wang, Xiaoxin X.; Hazra, Sugata; Levi, Moshe; Busik, Julia V.; Grant, Maria B. (Elsevier, 2017-08)

  Diabetic retinopathy (DR) is a complication secondary to diabetes and is the number one cause of blindness among working age individuals worldwide. Despite recent therapeutic breakthroughs using pharmacotherapy, a cure for ...
• Interplay between CCN1 and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy 

  Lee, Sangmi; Elaskandrany, Menna; Lau, Lester F.; Lazzaro, Douglas; Grant, Maria B.; Chaqour, Brahim (SpringerNature, 2017-05-03)

  CYR61-CTGF-NOV (CCN)1 is a dynamically expressed extracellular matrix (ECM) protein with critical functions in cardiovascular development and tissue repair. Angiogenic endothelial cells (ECs) are a major cellular source ...
• Systemic Vascular Transduction by Capsid Mutant Adeno-Associated Virus After Intravenous Injection 

  Lipinski, Daniel M.; Reid, Chris A.; Boye, Sanford L.; Peterson, James J.; Qi, Xiaoping; Boye, Shannon E.; Boulton, Michael E.; Hauswirth, William W. (Mary Ann Liebert, 2015-11)

  The ability to effectively deliver genetic material to vascular endothelial cells remains one of the greatest unmet challenges facing the development of gene therapies to prevent diseases with underlying vascular etiology, ...
• Chorioretinal Coloboma Complications: Retinal Detachment and Choroidal Neovascular Membrane 

  Hussain, Rehan M.; Abbey, Ashkan M.; Shah, Ankoor R.; Drenser, Kimberly A.; Trese, Michael T.; Capone Jr., Antonio (Wolters Kluwer, 2017-01)

  PURPOSE: To report the chorioretinal coloboma, and its association with increased risk of retinal detachment (RD) and choroidal neovascularization (CNV). METHODS: This retrospective case series included eyes with ...
• Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy 

  Song, Chunjuan; Mitter, Sayak K.; Qi, Xiaoping; Beli, Eleni; Rao, Haripriya V.; Ding, Jindong; Ip, Colin S.; Gu, Hongmei; Akin, Debra; Dunn, William A. Jr.; Bowes Rickman, Catherine; Lewin, Alfred S.; Grant, Maria B.; Boulton, Michael E. (Plos, 2017-02-21)

  p62 is a scaffolding adaptor implicated in the clearance of protein aggregates by autophagy. Reactive oxygen species (ROS) can either stimulate or inhibit NFκB-mediated gene expression influencing cellular fate. We studied ...
• A pilot randomized clinical trial of intermittent occlusion therapy liquid crystal glasses versus traditional patching for treatment of moderate unilateral amblyopia 

  Wang, Jingyun; Neely, Daniel E.; Galli, Jay; Schliesser, Joshua; Graves, April; Damarjian, Tina G.; Kovarik, Jessica; Bowsher, James; Smith, Heather A.; Donaldson, Dana; Haider, Kathryn M.; Roberts, Gavin J.; Sprunger, Derek T.; Plager, David A. (Elsevier, 2016-08)

  PURPOSE: To compare the effectiveness of intermittent occlusion therapy (IO therapy) using liquid crystal glasses and continuous occlusion therapy using traditional adhesive patches for treating amblyopia. METHODS: Children ...
• Reply: To PMID 25077835 

  Plager, David A.; Buckley, Edward G.; Wilson, M. Edward; Lambert, Scott R. (Elsevier, 2014-12)

  Complications in the first 5 years following cataract surgery in infants with and without intraocular lens implantation in the Infant Aphakia Treatment Study. [Am J Ophthalmol. 2014] Complications in the first 5 years ...
• Ataxia Telangiectasia Mutated Dysregulation Results in Diabetic Retinopathy 

  Bhatwadekar, Ashay D.; Duan, Yaqian; Chakravarthy, Harshini; Korah, Maria; Caballero, Sergio; Busik, Julia V.; Grant, Maria B. (Wiley Blackwell (John Wiley & Sons), 2016-02)

  Ataxia telangiectasia mutated (ATM) acts as a defense against a variety of bone marrow (BM) stressors. We hypothesized that ATM loss in BM-hematopoietic stem cells (HSCs) would be detrimental to both HSC function and ...
• Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy 

  Wert, Katherine; Mahajan, Minit B.; Zhang, Lijuan; Yan, Yuanqing; Li, Yao; Tosi, Joaquin; Hsu, Chun Wei; Nagasaki, Takayuki; Janisch, Kerstin M.; Grant, Maria B.; Mahajan, MaryAnn; Bassuk, Alexander G.; Tsang, Stephen H. (SpringerNature, 2016)

  Diabetic retinopathy (DR) affects approximately one-third of diabetic patients and, if left untreated, progresses to proliferative DR (PDR) with associated vitreous hemorrhage, retinal detachment, iris neovascularization, ...
• Type IV Duane Syndrome 

  Schliesser, Joshua A.; Sprunger, Derek T.; Helveston, Eugene M. (Elsevier, 2016-08)

  Purpose To identify cases of synergistic divergence whose characteristics suggest that this entity is a form of Duane syndrome. Methods The records of all patients with a Duane syndrome diagnosis, including ...
• Synthesis of Natural Homoisoflavonoids Having Either 5,7-Dihydroxy-6-methoxy or 7-Hydroxy-5,6-dimethoxy Groups 

  Lee, Hyungjun; Yuan, Yue; Rhee, Inmoo; Corson, Timothy W.; Seo, Seung-Yong (MDPI, 2016-08)

  Naturally occurring homoisoflavonoids containing either 5,7-dihydroxy-6-methoxy or 7-hydroxy-5,6-dimethoxy groups such as the antiangiogenic homoisoflavanone, cremastranone, were synthesized via three or four linear steps ...
• Ferrochelatase is a therapeutic target for ocular neovascularization 

  Basavarajappa, Halesha D.; Sulaiman, Rania S.; Qi, Xiaoping; Shetty, Trupti; Babu, Sardar Sheik Pran; Sishtla, Kamakshi L.; Lee, Bit; Quigley, Judith; Alkhairy, Sameerah; Briggs, Christian M.; Gupta, Kamna; Tang, Buyun; Shadmand, Mehdi; Grant, Maria B.; Boulton, Michael E.; Seo, Seung-Yong; Corson, Timothy W. (Wiley, 2017)

  Ocular neovascularization underlies major blinding eye diseases such as “wet” age-related macular degeneration (AMD). Despite the successes of treatments targeting the vascular endothelial growth factor (VEGF) pathway, ...
• The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase-1 and Notch signaling 

  Chintala, Hemabindu; Krupska, Izabela; Yan, Lulu; Lau, Lester; Grant, Maria; Chaqour, Brahim (The Company of Biologists, 2015-07-01)

  Physiological angiogenesis depends on the highly coordinated actions of multiple angiogenic regulators. CCN1 is a secreted cysteine-rich and integrin-binding matricellular protein required for proper cardiovascular ...
• Neovascular glaucoma in a child: an unusual presentation of medulloepithelioma 

  Kassa, Enoch; Li, Helen; Sun, Yang (GMS, 2014-04-17)

  A healthy 12 month old infant without significant medical history presented with left eye redness for one week. Ophthalmic examination showed elevated intraocular pressure with iris neovascularization in the affected eye ...
• Differences in Ocular Blood Flow Between People of African and European Descent With Healthy Eyes 

  Kaskan, Betül; Ramezani, Koosha; Harris, Alon; Siesky, Brent; Olinde, Carine; WuDunn, Darrell; Eikenberry, Jennifer; Tobe, Leslie A.; Racette, Lyne (Lippincott, Williams, and Wilkins, 2016-09)

  Purpose: To investigate differences in ocular blood flow between people of African descent (AD) and European descent (ED) with healthy eyes. Materials and Methods: Retrobulbar and retinal capillary blood flow was assessed ...
• Single and Compound Knock-outs of MicroRNA (miRNA)-155 and Its Angiogenic Gene Target CCN1 in Mice Alter Vascular and Neovascular Growth in the Retina via Resident Microglia 

  Yan, Lulu; Lee, Sangmi; Lazzaro, Douglas R.; Aranda, Jacob; Grant, Maria B.; Chaqour, Brahim (American Society for Biochemistry & Molecular Biology, 2015-09-18)

  The response of the retina to ischemic insult typically leads to aberrant retinal neovascularization, a major cause of blindness. The epigenetic regulation of angiogenic gene expression by miRNAs provides new prospects for ...

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