• The Relationship of Age and Other Baseline Factors to Outcome of Initial Surgery for Intermittent Exotropia 

  Repka, Michael X.; Chandler, Danielle L.; Holmes, Jonathan M.; Donahue, Sean P.; Hoover, Darren L.; Mohney, Brian G.; Phillips, Paul H.; Stout, Ann U.; Ticho, Benjamin H.; Wallace, David K. (Elsevier, 2020-04)

  Purpose: To determine whether age at surgery is associated with surgical outcome of intermittent exotropia (IXT) at 3 years. Design: Secondary analysis of pooled data from a randomized trial. Methods: A total of 197 ...
• Management of Peripapillary Choroidal Neovascular Membrane in Patients with Idiopathic Intracranial Hypertension 

  Ozgonul, Cem; Moinuddin, Omar; Munie, Metasebia; Lee, Michael S.; Bhatti, M. Tariq; Landau, Klara; Van Stavern, Gregory P.; Mackay, Devin D.; Lebas, Maud; DeLott, Lindsey B.; Cornblath, Wayne T.; Besirli, Cagri G. (Wolters Kluwer, 2019-12)

  Objective: To report the clinical features and treatment outcomes of patients with peripapillary choroidal neovascular membrane (CNVM) secondary to idiopathic intracranial hypertension (IIH). Methods: Retrospective, ...
• The utility and risks of therapeutic nanotechnology in the retina 

  Scheive, Melanie; Yazdani, Saeed; Hajrasouliha, Amir R. (Sage, 2021-03-22)

  The clinical application of nanotechnology in medicine is promising for therapeutic, diagnostic, and surgical improvements in the near future. Nanotechnologies in nano-ophthalmology are in the early stages of application ...
• Defective INPP5E distribution in NPHP1‐related Senior–Loken syndrome 

  Ning, Ke; Song, Emilie; Sendayen, Brent E.; Prosseda, Philipp P.; Chang, Kun-Che; Ghaffarieh, Alireza; Alvarado, Jorge A.; Wang, Biao; Haider, Kathryn M.; Berbari, Nicolas F.; Hu, Yang; Sun, Yang (Wiley, 2021-01)

  Background: Senior-Loken syndrome is a rare genetic disorder that presents with nephronophthisis and retinal degeneration, leading to end-stage renal disease and progressive blindness. The most frequent cause of juvenile ...
• Patient Perception of Physician Attire in a Military Ophthalmology Clinic 

  Scheive, Melanie; Gillis, John, II.; Gillis, Sarah; Legault, Gary L. (Cureus, 2021-01-04)

  The purpose of this study is to investigate patient preferences of physician attire in an outpatient military ophthalmology clinic to determine how these preferences affect patients' perceptions of physician competence and ...
• Intravitreal sirolimus for persistent, exudative age-related macular degeneration: a Pilot Study 

  Minturn, Robert J.; Bracha, Peter; Klein, Margaret J.; Chhablani, Jay; Harless, Ashley M.; Maturi, Raj K. (BMC, 2021-02-16)

  Background and objective: To evaluate the safety and efficacy of intravitreal sirolimus for persistent, exudative age-related macular degeneration (AMD). Methods: This institutional review board approved, registered ...
• Visual acuity outcomes and anti-VEGF therapy intensity in diabetic macular oedema: a real-world analysis of 28 658 patient eyes 

  Ciulla, Thomas A.; Pollack, John S.; Williams, David F. (BMJ, 2021-02)

  Background/aim: To assess visual acuity (VA) outcomes and antivascular endothelial growth factor (anti-VEGF) treatment intensity in diabetic macular oedema (DMO). Methods: Retrospective analysis was performed in ...
• Noninvasive Monitoring and Neurointerventional Management of Idiopathic Intracranial Hypertension 

  Lang, Matthew; Mathew, Sunu; Harris, Alon; Tejada, Juan; Kovoor, Jerry M. (Thieme, 2020-04)

  Idiopathic intracranial hypertension (IIH) is characterized by isolated rise in intracranial pressure (ICP) leading to chronic, debilitating headaches, tinnitus, and vision loss. Conventional diagnostics and monitoring ...
• Outcomes of Bilateral Cataract Surgery in Infants 7 to 24 Months of Age Using the Toddler Aphakia and Pseudophakia Treatment Study Registry 

  Bothun, Erick D.; Wilson, M. Edward; Vanderveen, Deborah K.; Plager, David A.; Freedman, Sharon F.; Trivedi, Rupal H.; Traboulsi, Elias I.; Anderson, Jill S.; Loh, Allison R.; Yen, Kimberly G.; Weil, Natalie C.; Morrison, David; Lambert, Scott R. (Elsevier, 2021-02)

  Purpose To evaluate outcomes of bilateral cataract surgery in children aged 7 to 24 months and compare rates of adverse events (AEs) with other Toddler Aphakia and Pseudophakia Study (TAPS) registry outcomes. Design R ...
• Small molecule target identification using photo-affinity chromatography 

  Seo, Seung-Yong; Corson, Timothy W. (Elsevier, 2019)

  Identification of the protein targets of bioactive small molecules is a routine challenge in chemical biology and phenotype-based drug discovery. Recent years have seen an explosion of approaches to meeting this challenge, ...
• Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments 

  Sharma, Tasneem P.; Curry, Stacy M.; Lohawala, Husain; McDowell, Colleen (JoVE, 2020)

  There is a current unmet need for a new preclinical human model that can target disease etiology ex vivo using intracranial pressure (ICP) and intraocular pressure (IOP) which can identify various pathogenic paradigms ...
• Ferrochelatase regulates retinal neovascularization 

  Pran Babu, Sardar Pasha Sheik; White, Darcy; Corson, Timothy W. (Wiley, 2020)

  Ferrochelatase (FECH) is the terminal enzyme in heme biosynthesis. We previously showed that FECH is required for endothelial cell growth in vitro and choroidal neovascularization in vivo. But FECH has not been explored ...
• Inhibition of APE1/Ref-1 for Neovascular Eye Diseases: From Biology to Therapy 

  Hartman, Gabriella D.; Lambert-Cheatham, Nathan A.; Kelley, Mark R.; Corson, Timothy W. (MDPI, 2021-09)

  Proliferative diabetic retinopathy (PDR), neovascular age-related macular degeneration (nvAMD), retinopathy of prematurity (ROP) and other eye diseases are characterized by retinal and/or choroidal neovascularization, ...
• Small-molecule inhibitors of ferrochelatase are antiangiogenic agents 

  Sishtla, Kamakshi; Lambert-Cheatham, Nathan; Lee, Bit; Han, Duk Hee; Park, Jaehui; Sardar Pasha, Sheik Pran Babu; Lee, Sanha; Kwon, Sangil; Muniyandi, Anbukkarasi; Park, Bomina; Odell, Noa; Waller, Sydney; Park, Il Yeong; Lee, Soo Jae; Seo, Seung-Yong; Corson, Timothy W. (Elsevier, 2022-01-31)

  Activity of the heme synthesis enzyme ferrochelatase (FECH) is implicated in multiple diseases. In particular, it is a mediator of neovascularization in the eye and thus an appealing therapeutic target for preventing ...
• APE1/Ref-1 as a Novel Target for Retinal Diseases 

  Heisel, Curtis; Yousif, Jonah; Mijiti, Mahmut; Charizanis, Kostas; Brigell, Mitchel; Corson, Timothy W.; Kelley, Mark R. (Scientific Archives, 2021)

  APE1/Ref-1 (also called Ref-1) has been extensively studied for its role in DNA repair and reduction-oxidation (redox) signaling. The review titled: “The multifunctional APE1 DNA repair-redox signaling protein as a drug ...
• Retinal Phenotyping of Ferrochelatase Mutant Mice Reveals Protoporphyrin Accumulation and Reduced Neovascular Response 

  Sardar Pasha, S. P. B.; Shetty, Trupti; Lambert-Cheatham, Nathan A.; Sishtla, Kamakshi; Mathew, Deepa; Muniyandi, Anbukkarasi; Patwari, Neeta; Bhatwadekar, Ashay D.; Corson, Timothy W. (ARVO, 2021-02-01)

  Purpose: Heme depletion, through inhibition of ferrochelatase (FECH), blocks retinal and choroidal neovascularization. Both pharmacologic FECH inhibition and a partial loss-of-function Fech mutation (Fechm1Pas) are associated ...
• Measurement of mitochondrial respiration in the murine retina using a Seahorse extracellular flux analyzer 

  Shetty, Trupti; Park, Bomina; Corson, Timothy W. (Elsevier, 2021-06)

  Mitochondrial metabolism is a critical mechanism that is deregulated in numerous retinal diseases. Here, we elaborate a protocol to quantify oxygen consumption rate as a measure of mitochondrial respiration directly from ...
• Bufadienolides and anti-angiogenic homoisoflavonoids from Rhodocodon cryptopodus, Rhodocodon rotundus and Rhodocodon cyathiformis 

  Whitmore, Hannah; Sishtla, Kamakshi; Knirsch, Walter; Andriantiana, Jacky L.; Schwikkard, Sianne; Mas-Claret, Eduard; Nassief, Sarah M.; Isyaka, Sani M.; Corson, Timothy W.; Mulholland, Dulcie A. (Elsevier, 2020)

  Background Homoisoflavonoids have been shown to have potent anti-proliferative activities in endothelial cells over other cell types and have demonstrated a strong antiangiogenic potential in vitro and in vivo in animal ...
• Patient preferences in retinal drug delivery 

  Jacobs, Brandon; Palmer, Nicholas; Shetty, Trupti; Dimaras, Helen; Hajrasouliha, Amir; Jusufbegovic, Denis; Corson, Timothy W. (Nature, 2021)

  Retinal vascular diseases (RVDs) are often treated with intravitreally (IVT) injected drugs, with relatively low patient compliance and potential risks. Ongoing research explores alternative RVD treatments, including eye ...
• Spontaneously Regressed Corneal Intrastromal Cyst 

  Fox, Allison; Pineda, Roberto; Liu, Shaohui (Elsevier, 2020-10)

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