Sharp, Sacha; Hixson, Ashley; Stumpff, Julia C; Williamson, Francesca(2022-06-14)
Background: Few research studies examine medical students and residents with intersectional
identities. In the emerging literature, data on Black women’s experiences may be misrepresented
and misinterpreted as studies ...
In the Accreditation Council on Graduate Medical Education’s (ACGME) 2016 national report of the Clinical Learning Environment (CLE) Review, it was reported that across most CLEs, education and training on health care ...
Medical Education Objectives for the Social Science Thread (Now:Culturally Appropriate & Socially Responsive Care [CASRC] Thread): 1) The primary goal of the CASRC Thread is not to develop specific sessions for presentation ...
Sharp, Sacha; Hixson, Ashley; Stumpff, Julia C.; Williamson, Francesca(2022-04-23)
Few research studies examine medical students and residents with intersectional identities. In the emerging literature, data on Black women’s experiences may be misrepresented and misinterpreted as studies aggregate data ...
Easler, Jeffrey James(Korean Association of Internal Medicine, 2021-01)
Pancreatic necrosis is among the most frequently encountered local complications of acute pancreatitis and associates with severe disease. Infected pancreatic necrosis further enhances the risk for morbidity and mortality. ...
Biruete, Annabel; Hill Gallant, Kathleen M.; Lindemann, Stephen R.; Wiese, Gretchen; Chen, Neal; Moe, Sharon(Elsevier, 2020-01)
Phosphate binders are commonly prescribed in patients with end-stage kidney disease to prevent and treat hyperphosphatemia. These binders are usually associated with gastrointestinal distress, may bind molecules other than ...
While delirium is associated with cognitive decline and dementia, there is limited evidence to support causality for this relationship. Clarification of how delirium may cause cognitive decline, perhaps through evidence ...
Cheng, Tik-Chee; Philip, Jennifer L.; Tabima, Diana M.; Kumari, Santosh; Yakubov, Bakhtiyor; Frump, Andrea L.; Hacker, Timothy A.; Bellofiore, Alessandro; Li, Rongbo; Sun, Xin; Goss, Kara N.; Lahm, Tim; Chesler, Naomi C.(American Physiological Society, 2020-12)
Although women are more susceptible to pulmonary arterial hypertension (PAH) than men, their right ventricular (RV) function is better preserved. Estrogen receptor-α (ERα) has been identified as a likely mediator for ...
Lumbar discitis caused by Clostridium perfringens is extremely rare. There have only been 7 published cases of confirmed discitis caused by Clostridium perfringens. We write this report to underscore this unusual relationship ...
Background: Existing studies have demonstrated that the integrative analysis of histopathological images and genomic data can be used to better understand the onset and progression of many diseases, as well as identify new ...
Background: Renal cell carcinoma (RCC) is a complex disease and is comprised of several histological subtypes, the most frequent of which are clear cell renal cell carcinoma (ccRCC), papillary renal cell carcinoma (PRCC) ...
Scioli-Salter, Erica R.; Smith, Brian N.; McSheffrey, Savannah; Bair, Matthew J.; Sillice, Marie A.; Driscoll, Mary; Higgins, Diana M.; Allsup, Kelly; Amalathas, Aneline; Gerber, Megan R.(Sage, 2020-01)
Objective. While multimodal treatment approaches for fibromyalgia (FM), incorporating exercise, have been found most effective, information about factors associated with exercise adoption and maintenance is lacking. Design, ...
Romanoski, Casey E.; Qi, Xinshuai; Sangam, Shreya; Vanderpool, Rebecca R.; Stearman, Robert S.; Conklin, Austin; Gonzalez-Garay, Manuel; Rischard, Franz; Ayon, Ramon J.; Wang, Jian; Simonson, Tatum; Babicheva, Aleksandra; Shi, Yinan; Tang, Haiyang; Makino, Ayako; Kanthi, Yogendra; Geraci, Mark W.; Garcia, Joe G.N.; Yuan, Jason X.-J.; Desai, Ankit A.(Sage, 2020-12-07)
Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially ...
Berlacher, Michelle; Mercer, Timothy; Apondi, Edith O.; Mwangi, Winfred; Were, Edwin; McHenry, Megan S.(Global Health and Education Projects, 2021)
Background: Health systems integration is becoming increasingly important as the global health community transitions from acute, disease-specific health programming to models of care built for chronic diseases, primarily ...
This review covers the last 80 years of remarkable progress in the development of mineralocorticoid receptor (MR) antagonists (MRAs) from synthesis of the first mineralocorticoid to trials of nonsteroidal MRAs. The MR is ...
Shugg, Tyler; Hudmon, Andy; Overholser, Brian R.(American Heart Association, 2020-09-15)
Heart failure (HF) results in sustained alterations in neurohormonal signaling, including enhanced signaling through the sympathetic nervous system and renin-angiotensin-aldosterone system pathways. While enhanced sympathetic ...
Fibrosis is a pathognomonic feature of structural heart disease and counteracted by distinct cardioprotective mechanisms, e.g. activation of the phosphoinositide 3-kinase (PI3K) / AKT pro-survival pathway. The Cullin-RING ...
Voss, Martin H.; Gordon, Michael S.; Mita, Monica; Rini, Brian; Makker, Vicky; Macarulla, Teresa; Smith, David C.; Cervantes, Andrés; Puzanov, Igor; Pili, Roberto; Wang, Ding; Jalal, Shadia; Pant, Shubham; Patel, Manish R.; Neuwirth, Rachel l.; Enke, Aaron; Shou, Yaping; Sedarati, Farhad; Faller, Douglas V.; Burris, Howard A., III(Springer Nature, 2020-11)
Background: This Phase 1 dose-escalation/expansion study assessed safety/tolerability of sapanisertib, an oral, highly selective inhibitor of mTORC1/mTORC2, in advanced solid tumours.
Methods: Eligible patients received ...
Shovlin, Claire L.; Simeoni, Ilenia; Downes, Kate; Frazer, Zoe C.; Megy, Karyn; Bernabeu-Herrero, Maria E.; Shurr, Abigail; Brimley, Jennifer; Patel, Dilipkumar; Kell, Loren; Stephens, Jonathan; Turbin, Isobel G.; Aldred, Micheala A.; Penkett, Christopher J.; Ouwehand, Willem H.; Jovine, Luca; Turro, Ernest(American Society of Hematology, 2020-10-22)
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular dysplasia. Care delivery for HHT patients is impeded by the need for laborious, repeated phenotyping and gaps in knowledge regarding the ...