• Characterization of intrinsically disordered proteins with electrospray ionization mass spectrometry: conformational heterogeneity of alpha-synuclein 

  Frimpong, Agya K.; Abzalimov, Rinat R.; Uversky, Vladimir N.; Kaltashov, Igor A. (Wiley, 2010-02-15)

  Conformational heterogeneity of alpha-synuclein was studied with electrospray ionization mass spectrometry by analyzing protein ion charge state distributions, where the extent of multiple charging reflects compactness of ...
• Interaction between the patatin-like phospholipase domain-containing protein 3 genotype and coffee drinking and the risk for acute alcoholic hepatitis 

  Liangpunsakul, Suthat; Beaudoin, James J.; Shah, Vijay H.; Puri, Puneet; Sanyal, Arun J.; Kamath, Patrick S.; Lourens, Spencer G.; Tang, Qing; Katz, Barry P.; Crabb, David W.; Chalasani, Naga P. (Wiley, 2017-11-11)

  Only a subset of subjects with excessive alcohol consumption develops alcoholic liver disease (ALD). One of the major risk factors for ALD is the genetic variant of the patatin-like phospholipase domain-containing protein ...
• LncRNA AK054921 and AK128652 are potential serum biomarkers and predictors of patient survival with alcoholic cirrhosis 

  Yang, Zhihong; Ross, Ruth A.; Zhao, Shi; Tu, Wanzhu; Liangpunsakul, Suthat; Wang, Li (Wiley, 2017-08)

  Background: Alcoholic liver disease (ALD) is one of the leading causes of chronic liver disease. Recent studies have demonstrated the roles of long noncoding RNAs (lncRNAs) in the pathogenesis of several disease processes. ...
• Nursing Home Regulations Redefined: Implications for Providers 

  Unroe, Kathleen T.; Ouslander, Joseph G.; Saliba, Debra (Wiley, 2018-01)

  The Centers for Medicare and Medicaid Services (CMS) finalized a comprehensive update to nursing home requirements of participation in October 2016. Nearly 10,000 public comments were received regarding the proposed rule, ...
• Video-based Assessments of Colonoscopy Inspection Quality Correlate with Quality Metrics and Highlight Areas for Improvement 

  Duloy, Anna; Yadlapati, Rena H.; Benson, Mark; Gawron, Andrew J.; Kahi, Charles J.; Kaltenbach, Tonya R.; McClure, Jessica; Gregory, Dyanna L.; Keswani, Rajesh N. (Elsevier, 2018)

  Background & Aims Adenoma detection rate (ADR) and serrated polyp detection rate (SDR) vary significantly among colonoscopists. Colonoscopy inspection quality (CIQ) is the quality with which a colonoscopist inspects for ...
• Sudden Cardiac Arrest in a Young Patient with Severe Pectus Excavatum 

  Rachwan, Rayan Jo; Purpura, Andrea K.; Kahwash, Basil M. (Elsevier, 2018)

  We report a case of sudden cardiac arrest in the setting of ventricular fibrillation in a previously healthy 19-year-old male. Chest imaging demonstrated severe pectus excavatum with Pectus Severity Index of 22.7. Extensive ...
• A critical appraisal of guidelines for electronic communication between patients and clinicians: the need to modernize current recommendations 

  Lee, Joy L.; Matthias, Marianne S.; Menachemi, Nir; Frankel, Richard M.; Weiner, Michael (Oxford, 2018-04)

  Background Patient-provider electronic communication has proliferated in recent years, yet there is a dearth of published research either leading to, or including, recommendations that improve clinical care and prevent ...
• How we resect colorectal polyps <20 mm in size 

  Rex, Douglas K.; Dekker, Evelien (Elsevier, 2018)

  We review our approach to resection of colorectal polyps <20 mm in size. Careful inspection of all lesions is appropriate to assess the type of lesion (adenoma vs serrated) and evaluate the risk of cancer, which is highly ...
• Different endoscopic management of 2 cases of acute buried bumper syndrome 

  Hajj, Ihab I. El; Watkins, James; Easler, Jeffrey; Fogel, Evan; Sherman, Stuart; Lehman, Glen A. (Elsevier, 2017-11-01)
• Predictive Analytics for Identification of Patients at Risk for QT Interval Prolongation – A Systematic Review 

  Muensterman, Elena Tomaselli; Tisdale, James E. (Wiley, 2018)

  Prolongation of the heart rate‐corrected QT (QTc) interval increases the risk for torsades de pointes (TdP), a potentially fatal arrhythmia. The likelihood of TdP is higher in patients with risk factors, which include ...
• A Comparison of the Safety and Efficacy of HX575 (Epoetin Alfa Proposed Biosimilar) with Epoetin Alfa in Patients with End-Stage Renal Disease 

  Weir, M. R.; Pergola, P. E.; Agarwal, Rajiv; Fink, J.; Kopyt, N.; Singh, A.; Kumar, J.; Schmitt, S.; Schaffar, G.; Rudy, A.; McKay, J.; Kanceva, R. (Karger, 2017-11)

  Background: HX575 (biosimilar epoetin alfa) was approved in Europe in 2007 for the treatment of chronic kidney disease (CKD)-related anemia. This study assessed the clinical equivalence of HX575 with the US-licensed reference ...
• Lower objectively measured physical activity is linked with perceived risk of hypoglycemia in type 1 diabetes 

  Keshawarz, Amena; Piropato, Andrew R.; Brown, Talia L.; Duca, Lindsey M.; Sippl, Rachel M.; Wadwa, R. Paul; Snell-Bergeon, Janet K. (Elsevier, 2018)

  Aims Compare physical activity (PA) levels in adults with and without type 1 diabetes and identify diabetes-specific barriers to PA. Methods Forty-four individuals with type 1 diabetes and 77 non-diabetic controls in ...
• Central precocious puberty: From genetics to treatment 

  Schneider Aguirre, Rebecca; Eugster, Erica A. (Elsevier, 2018)

  Central precocious puberty (CPP) results from early activation of the hypothalamic - pituitary -gonadal (HPG) axis and follows the same sequence as normal puberty. While many factors involved in pubertal initiation remain ...
• Healthcare-associated Infections: The Hallmark of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) With Review of the Literature 

  Al-Tawfiq, Jaffar A.; Auwaerter, Paul G. (Elsevier, 2018)

  The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a coronavirus capable of causing acute respiratory illness. Laboratory confirmed MERS-CoV cases may be asymptomatic, have mild disease or life-threatening ...
• Development of a Modified Lymphocyte Transformation Test for Diagnosing Drug Induced Liver Injury Associated with an Adaptive Immune Response 

  Whritenour, Jessica; Ko, Mira; Zong, Qing; Wang, Jianying; Tartaro, Karrie; Schneider, Patricia; Olson, Ellen; Van Volkenburg, Maria; Serrano, Jose; Hayashi, Paul; Fontana, Robert; Chalasani, Naga; Bonkovsky, Herbert L. (Taylor & Francis, 2017-12)

  Drug induced liver injury (DILI) is a growing problem. Diagnostic methods to differentiate DILI caused by an adaptive immune response from liver injury of other causes or to identify the responsible drug in patients ...
• Fecal microbiota transplant in severe and severe-complicated Clostridium difficile: A promising treatment approach 

  Fischer, Monika; Sipe, Brian; Cheng, Yao-Wen; Phelps, Emmalee; Rogers, Nicholas; Sagi, Sashidhar; Bohm, Matthew; Xu, Huiping; Kassam, Zain (Taylor & Francis, 2016-12-21)

  Severe and severe-complicated Clostridium difficile infection (CDI) is associated with high morbidity and mortality. Colectomy is standard of care; however, post-surgical mortality rates approach 50%. Case reports suggest ...
• Metabolomics analysis revealed distinct cyclic changes of metabolites altered by chronic ethanol-plus-binge and Shp-deficiency 

  Tran, Melanie; Yang, Zhihong; Liangpunsakul, Suthat; Wang, Li (Wiley, 2016-12)

  Background Chronic ethanol consumption causes alcoholic liver disease (ALD) and disruption of the circadian system facilitates the development of ALD. Small heterodimer partner (SHP) is a nuclear receptor and critical ...
• A Multi-Institutional Longitudinal Faculty Development Program in Humanism Supports the Professional Development of Faculty Teachers 

  Branch, William T.; Frankel, Richard M.; Hafler, Janet P.; Weil, Amy B.; Gilligan, MaryAnn C.; Litzelman, Debra K.; Plews-Ogan, Margaret; Rider, Elizabeth A.; Osterberg, Lars G.; Dunne, Dana; May, Natalie B.; Derse, Arthur R. (Lippincott, Williams & Wilkins, 2017-12)

  Supplemental Digital Content is available in the text., The authors describe the first 11 academic years (2005–2006 through 2016–2017) of a longitudinal, small-group faculty development program for strengthening humanistic ...
• Cyclin D2 is sufficient to drive β cell self-renewal and regeneration 

  Tschen, Shuen-ing; Zeng, Chun; Field, Loren; Dhawan, Sangeeta; Bhushan, Anil; Georgia, Senta (Taylor & Francis, 2017-11-03)

  Diabetes results from an inadequate mass of functional β cells, due to either β cell loss caused by autoimmune destruction (type I diabetes) or β cell failure in response to insulin resistance (type II diabetes). Elucidating ...
• REST regulates the cell cycle for cardiac development and regeneration 

  Zhang, Donghong; Wang, Yidong; Lu, Pengfei; Wang, Ping; Yuan, Xinchun; Yan, Jianyun; Cai, Chenleng; Chang, Ching-Pin; Zheng, Deyou; Wu, Bingruo; Zhou, Bin (Nature Publishing group, 2017-12-07)

  Despite the importance of cardiomyocyte proliferation in cardiac development and regeneration, the mechanisms that promote cardiomyocyte cell cycle remain incompletely understood. RE1 silencing transcription factor (REST) ...

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