• Operational Definitions related to Pediatric Ventilator Liberation 

  Abu-Sultaneh, Samer; Iyer, Narayan Prabhu; Fernández, Analía; Gaies, Michael; González-Dambrauskas, Sebastián; Hotz, Justin Christian; Kneyber, Martin C.J.; López-Fernández, Yolanda M.; Rotta, Alexandre T.; Werho, David K.; Baranwal, Arun Kumar; Blackwood, Bronagh; Craven, Hannah J.; Curley, Martha A.Q.; Essouri, Sandrine; Fioretto, Jose Roberto; Hartmann, Silvia M.M.; Jouvet, Philippe; Korang, Steven Kwasi; Rafferty, Gerrard F.; Ramnarayan, Padmanabhan; Rose, Louise; Tume, Lyvonne N.; Whipple, Elizabeth C.; Wong, Judith Ju Ming; Emeriaud, Guillaume; Mastropietro, Christopher W.; Napolitano, Natalie; Newth, Christopher J.L.; Khemani, Robinder G. (Elsevier, 2022-12-20)

  BACKGROUND: Common, operational definitions are crucial to assess interventions and outcomes related to pediatric mechanical ventilation. These definitions can reduce unnecessary variability amongst research and quality ...
• Working Group Recommendations for an Indiana University Research Data Commons 

  Simon, Kosali; Dallis-Comentale, Diane; Fang, Shiaofen; Huang, Kun; Link, Matt; Maupome, Gerardo; Menczer, Filippo; Neal, Aaron; Perry, Brea; Plale, Beth; Raymond, Angie; Wiehe, Sarah (2022-06-30)

  Starting on April 28, 2022, our Working Group set out to make recommendations for an Indiana University Research Data Commons (IU-RDCom), a strategy to identify and meet the growing needs associated with research data at ...
• Sleep and Negative Affect Across Toddlerhood in the Context of Stress 

  Sperber, Jessica F.; McQuillan, Maureen E.; Hoyniak, Caroline P.; Staples, Angela D.; Rudasill, Kathleen M.; Molfese, Victoria J.; Bates, John E. (Springer, 2022-06)

  Negative affect is associated with both high stress and poor sleep, but questions remain about the direction of these associations across time and interactions between stress and sleep, especially in early childhood. The ...
• Survival outcomes of in-hospital cardiac arrest in pediatric patients in the USA 

  Hamzah, Mohammed; Othman, Hasan F.; Almasri, Murad; Al-Subu, Awni; Lutfi, Riad (Springer, 2021-08)

  We report on in-hospital cardiac arrest outcomes in the USA. The data were obtained from the National (Nationwide) Inpatient Sample datasets for the years 2000–2017, which includes data from participating hospitals in 47 ...
• Epigenetics and Heart Development 

  George, Rajani M.; Firulli, Anthony B. (Frontiers Media, 2021-05-06)

  Epigenetic control of gene expression during cardiac development and disease has been a topic of intense research in recent years. Advances in experimental methods to study DNA accessibility, transcription factor occupancy, ...
• Immature teratoma in an adolescent with Proteus syndrome: A novel association 

  Underwood, John S.; Ours, Christopher; Burns, R. Cartland; Ferguson, Michael J. (Wiley, 2021-05-04)

  Proteus syndrome (PS) is a complex disorder characterized by variable clinical findings of overgrowth and tumor susceptibility. This report presents the first known association between PS and an ovarian germ cell tumor in ...
• Deletion of a Hand1 lncRNA-Containing Septum Transversum Enhancer Alters lncRNA Expression but Is Not Required for Hand1 Expression 

  George, Rajani M.; Firulli, Anthony B. (MDPI, 2021-05-04)

  We have previously identified a Hand1 transcriptional enhancer that drives expression within the septum transversum, the origin of the cells that contribute to the epicardium. This enhancer directly overlaps a common exon ...
• Acute Peroneal Neuropathy and Foot Drop in Two Adolescent Female Athletes with New-Onset Diabetes 

  Jaeger, Joel A.; Gohil, Anisha; Nebesio, Todd D. (Wolters Kluwer, 2022-02)

  The common peroneal nerve is derived from the sciatic nerve. It travels superficially along the lateral aspect of the knee near the fibular head where it bifurcates into the superficial and deep peroneal nerves. These ...
• Anemia as a Marker of Social Determinants of Health: Then and Now 

  Sherwin, Nomi K.; Ott, Mary A. (Elsevier, 2022-10)
• Curing Hemophilia: Repeated Treatments versus a One-Off Fix 

  Li, Ning; Kaczmarek, Radoslaw (Elsevier, 2020-05-06)
• Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis 

  Dittrich, Gesine M.; Froese, Natali; Wang, Xue; Kroeger, Hannah; Wang, Honghui; Szaroszyk, Malgorzata; Malek‑Mohammadi, Mona; Cordero, Julio; Keles, Merve; Korf‑Klingebiel, Mortimer; Wollert, Kai C.; Geffers, Robert; Mayr, Manuel; Conway, Simon J.; Dobreva, Gergana; Bauersachs, Johann; Heineke, Joerg (Springer, 2021-04-19)

  Heart failure due to high blood pressure or ischemic injury remains a major problem for millions of patients worldwide. Despite enormous advances in deciphering the molecular mechanisms underlying heart failure progression, ...
• Dynamic modulation of spleen germinal center reactions by gut bacteria during Plasmodium infection 

  Mandal, Rabindra K.; Denny, Joshua E.; Namazzi, Ruth; Opoka, Robert O.; Datta, Dibyadyuti; John, Chandy C.; Schmidt, Nathan W. (Cell Press, 2021-05-11)

  Gut microbiota educate the local and distal immune system in early life to imprint long-term immunological outcomes while maintaining the capacity to dynamically modulate the local mucosal immune system throughout life. ...
• Equivalent Behavioral Facilitation to Tactile Cues in Children with Autism Spectrum Disorder 

  Kadlaskar, Girija; Bergmann, Sophia; McNally Keehn, Rebecca; Seidl, Amanda; Keehn, Brandon (MDPI, 2021-05-13)

  The alerting network, a subcomponent of attention, enables humans to respond to novel information. Children with ASD have shown equivalent alerting in response to visual and/or auditory stimuli compared to typically ...
• Predictors of pulmonary exacerbation treatment in cystic fibrosis 

  Sanders, Don B.; Ostrenga, Joshua S.; Rosenfeld, Margaret; Fink, Aliza K.; Schechter, Michael S.; Sawicki, Gregory S.; Flume, Patrick A.; Morgan, Wayne J. (Elsevier, 2020-05)

  Background: Most studies of pulmonary exacerbations (PEx) in cystic fibrosis (CF) focus on intravenous (IV)-treated PEx, though most PEx are treated with oral antibiotics. Our objectives were to describe predictors of ...
• Assessing Needs and Experiences of Preparing for Medical Emergencies Among Children with Cancer and Their Caregivers 

  Mueller, Emily L.; Cochrane, Anneli R.; Moore, Courtney M.; Jenkins, Kelli B.; Bauer, Nerissa S.; Wiehe, Sarah E. (Wolters Kluwer, 2020-11)

  Background: Caregivers of children with cancer can experience stress when seeking care in the emergency department (ED). We sought to assess how caregivers prepare for and manage a medical emergency that arises in the ...
• d-Cystine di(m)ethyl ester reverses the deleterious effects of morphine on ventilation and arterial blood gas chemistry while promoting antinociception 

  Gaston, Benjamin; Baby, Santhosh M.; May, Walter J.; Young, Alex P.; Grossfield, Alan; Bates, James N.; Seckler, James M.; Wilson, Christopher G.; Lewis, Stephen J. (Springer Nature, 2021-05-11)

  We have identified thiolesters that reverse the negative effects of opioids on breathing without compromising antinociception. Here we report the effects of d-cystine diethyl ester (d-cystine diEE) or d-cystine dimethyl ...
• Heterogeneous Liver on Research Ultrasound Identifies Children with Cystic Fibrosis at High Risk of Advanced Liver Disease: Interim Results of a Prospective Observational Case-Controlled Study 

  Siegel, Marilyn J.; Freeman, A. Jay; Ye, Wen; Palermo, Joseph J.; Molleston, Jean P.; Paranjape, Shruti M.; Stoll, Janis; Leung, Daniel; Masand, Prakash; Karmazyn, Boaz; Harned, Roger; Ling, Simon C.; Navarro, Oscar M.; Karnsakul, Wikrom; Alazraki, Adina; Schwarzenberg, Sarah Jane; Seidel, F. Glen; Towbin, Alex; Alonso, Estella M.; Nicholas, Jennifer L.; Murray, Karen F.; Otto, Randolph K.; Sherker, Averell H.; Magee, John C.; Narkewicz, Michael R. (Elsevier, 2020-04)

  Objective: To assess if a heterogeneous pattern on research liver ultrasound examination can identify children at risk for advanced cystic fibrosis (CF) liver disease. Study design: Planned 4-year interim analysis of a ...
• Urine Gastrin Releasing Peptide in the First Week Correlates with BPD and Post-Prematurity Respiratory Disease 

  Voynow, Judith A.; Fisher, Kimberley; Sunday, Mary E.; Cotton, C. Michael; Hamvas, Aaron; Hendricks-Muñoz, Karen D.; Poindexter, Brenda B.; Pryhuber, Gloria S.; Ren, Clement L.; Ryan, Rita M.; Sharp, Jack K.; Young, Sarah P.; Zhang, Haoyue; Greenberg, Rachel G.; Herring, Amy H.; Davis, Stephanie D. (Wiley, 2020-04)

  Rationale: Bronchopulmonary dysplasia (BPD) is associated with post-prematurity respiratory disease (PRD) in survivors of extreme preterm birth. Identifying early biomarkers that correlate with later development of BPD and ...
• SOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2 

  Mehta, Gaurav A.; Angus, Steven P.; Khella, Christen A.; Tong, Kevin; Khanna, Pooja; Dixon, Shelley A.H.; Verzi, Michael P.; Johnson, Gary L.; Gatza, Michael L. (Springer Nature, 2021-04-09)

  Dysregulation of PI3K/Akt signaling is a dominant feature in basal-like or triple-negative breast cancers (TNBC). However, the mechanisms regulating this pathway are largely unknown in this subset of aggressive tumors. ...
• Development of a Mobile, Self-Sovereign Identity Approach for Facility Birth Registration in Kenya 

  Freytsis, Maria; Barclay, Iain; Radha, Swapna Krishnakumar; Czajka, Adam; Siwo, Geoffery H.; Taylor, Ian; Bucher, Sherri (Frontiers, 2021-02)

  Birth registration is a critical element of newborn care. Increasing the coverage of birth registration is an essential part of the strategy to improve newborn survival globally, and is central to achieving greater health, ...

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