• Reprogrammed CD4+ T Cells That Express FoxP3+ Control Inhibitory Antibody Formation in Hemophilia A Mice 

  Herzog, Roland W.; Kuteyeva, Veronica; Saboungi, Rania; Terhorst, Cox; Biswas, Moanaro (Frontiers Media, 2019-02-20)

  Coagulation Factor VIII (FVIII) replacement therapy in hemophilia A patients is complicated by the development of inhibitory antibodies, which often render the treatment ineffective. Previous studies demonstrated a strong ...
• Nonesophageal Eosinophilic Gastrointestinal Disorders: Clinical Care and Future Directions 

  Naramore, Sara; Gupta, Sandeep K. (Wolters Kluwer, 2018-09)

  Eosinophilic gastrointestinal disorders are a set of conditions with a wide range of clinical manifestations and treatment modalities. The disorders are suspected to result from an abnormal inflammatory response to ...
• Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells 

  Yang, Kai; Blanco, Daniel Bastardo; Chen, Xiang; Dash, Pradyot; Neale, Geoffrey; Rosencrance, Celeste; Easton, John; Chen, Wenan; Cheng, Changde; Dhungana, Yogesh; Kc, Anil; Awad, Walid; Guo, Xi-Zhi J.; Thomas, Paul G.; Chi, Hongbo (American Association for the Advancement of Science, 2018-07-06)

  Wiring metabolic signaling circuits in thymocytes Cell differentiation is often accompanied by metabolic changes. Yang et al. report that generation of double-positive (DP) thymocytes from double-negative (DN) cells ...
• Exposure: Staphylococcus aureus skin colonization predisposes to food allergy in the Learning Early about Allergy to Peanut (LEAP) and LEAP-On studies 

  Cook-Mills, Joan M.; Kaplan, Mark H.; Turner, Matthew J.; Kloepfer, Kirsten M.; Kumar, Rajesh (Elsevier, 2019-08)
• Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis 

  Snider, Paige L.; Snider, Elizabeth; Simmons, Olga; Conway, Simon J. (MDPI, 2019-06-22)

  Mammalian Kiaa1211 and Kiaa1211-like are a homologous pair of uncharacterized, highly conserved genes cloned from fetal and adult brain cDNA libraries. Herein we map the in utero spatiotemporal expression of mKiaa1211 and ...
• Weed Pollen Season Trends In Relation To Atmospheric Co2 Changes In Indiana And Ohio 

  Vitalpur, Girish; Ahmad, Hassan A.; Slaven, James E. (Elsevier, 2019-09)
• Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits 

  Glicksberg, Benjamin S.; Amadori, Letizia; Akers, Nicholas K.; Sukhavasi, Katyayani; Franzén, Oscar; Li, Li; Belbin, Gillian M.; Akers, Kristin L.; Shameer, Khader; Badgeley, Marcus A.; Johnson, Kipp W.; Readhead, Ben; Darrow, Bruce J.; Kenny, Eimear E.; Betsholtz, Christer; Ermel, Raili; Skogsberg, Josefin; Ruusalepp, Arno; Schadt, Eric E.; Dudley, Joel T.; Ren, Hongxia; Kovacic, Jason C.; Giannarelli, Chiara; Li, Shuyu D.; Björkegren, Johan L. M.; Chen, Rong (Biomed Central, 2019-07-25)

  BACKGROUND: Genetic loss-of-function variants (LoFs) associated with disease traits are increasingly recognized as critical evidence for the selection of therapeutic targets. We integrated the analysis of genetic and ...
• Plasma exosomes from children with juvenile dermatomyositis are taken up by human aortic endothelial cells and are associated with altered gene expression in those cells 

  Jiang, Kaiyu; Karasawa, Rie; Hu, Zihua; Chen, Yanmin; Holmes, Lucy; O’Neil, Kathleen M.; Jarvis, James N. (Biomed Central, 2019-07-12)

  BACKGROUND: The pathology of juvenile dermatomyositis (JDM) is characterized by prominent vessel wall and perivascular inflammation. This feature of the disease has remained unexplained and under-investigated. We have ...
• Development and validation of a pragmatic natural language processing approach to identifying falls in older adults in the emergency department 

  Patterson, Brian W.; Jacobsohn, Gwen C.; Shah, Manish N.; Song, Yiqiang; Maru, Apoorva; Venkatesh, Arjun K.; Zhong, Monica; Taylor, Katherine; Hamedani, Azita G.; Mendonça, Eneida A. (Biomed Central, 2019-07-22)

  BACKGROUND: Falls among older adults are both a common reason for presentation to the emergency department, and a major source of morbidity and mortality. It is critical to identify fall patients quickly and reliably ...
• Comparative analysis of diagnostic platforms for measurement of differentially methylated insulin DNA 

  Farr, Ryan J.; Wong, Wilson K. M.; Maynard, Cody-lee; Tersey, Sarah A.; Mirmira, Raghavendra G.; Hardikar, Anandwardhan A.; Joglekar, Mugdha V. (POL Scientific, 2019)

  Circulating cell-free DNA (cfDNA) has been intensively investigated as a diagnostic and prognostic marker for various cancers. In recent years, presence of unmethylated insulin cfDNA in the circulation has been correlated ...
• Hemogenic Endothelial Cells Can Transition to Hematopoietic Stem Cells through a B-1 Lymphocyte-Biased State during Maturation in the Mouse Embryo 

  Kobayashi, Michihiro; Tarnawsky, Stefan P.; Wei, Haichao; Mishra, Akansha; Azevedo Portilho, Nathalia; Wenzel, Pamela; Davis, Brian; Wu, Jiaqian; Hadland, Brandon; Yoshimoto, Momoko (Elsevier, 2019-07-09)

  Precursors of hematopoietic stem cells (pre-HSCs) have been identified as intermediate precursors during the maturation process from hemogenic endothelial cells to HSCs in the aorta-gonad-mesonephros (AGM) region of the ...
• Type 1 diabetes 

  DiMeglio, Linda A.; Evans-Molina, Carmella; Oram, Richard A. (Elsevier, 2018-06-16)

  Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding ...
• PU.1 controls fibroblast polarization and tissue fibrosis 

  Wohlfahrt, Thomas; Rauber, Simon; Uebe, Steffen; Luber, Markus; Soare, Alina; Ekici, Arif; Weber, Stefanie; Matei, Alexandru-Emil; Chen, Chih-Wei; Maier, Christiane; Karouzakis, Emmanuel; Kiener, Hans P.; Pachera, Elena; Dees, Clara; Beyer, Christian; Daniel, Christoph; Gelse, Kolja; Kremer, Andreas E.; Naschberger, Elisabeth; Stürzl, Michael; Butter, Falk; Sticherling, Michael; Finotto, Susetta; Kreuter, Alexander; Kaplan, Mark H.; Jüngel, Astrid; Gay, Steffen; Nutt, Stephen L.; Boykin, David W.; Poon, Gregory M. K.; Distler, Oliver; Schett, Georg; Distler, Jörg H. W.; Ramming, Andreas (Springer Nature, 2019-02)

  Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant amounts of extracellular matrix, which induces ...
• What causes severe malaria and its complications in children? Lessons learned over the past 15 years 

  Conroy, Andrea L.; Datta, Dibyadyuti; John, Chandy C. (BMC, 2019-03-07)

  Over the past 15 years, malaria mortality has reduced by approximately 50%. However, malaria still causes more than 400,000 deaths annually, most of which occur in African children under 5 years of age. Significant advances ...
• Steroids in pediatric eosinophilic esophagitis 

  Contreras, Emily M.; Gupta, Sandeep K. (Elsevier, 2014-06)

  Swallowed fluticasone and oral viscous budesonide are effective first-line therapies for eosinophilic esophagitis in children. Side effects are minimal without evidence of Cushing syndrome, as seen in treatment with systemic ...
• Early life growth patterns persist for 12 years and impact pulmonary outcomes in cystic fibrosis 

  Sanders, Don B.; Zhang, Zhumin; Farrell, Philip M.; Lai, HuiChuan J. (Elsevier, 2018-07)

  BACKGROUND: In children with cystic fibrosis (CF), recovery from growth faltering within 2 years of diagnosis (Responders) is associated with better growth and less lung disease at age 6 years. This study examined whether ...
• Prevalence of Depression Among Fathers at the Pediatric Well-Child Care Visit 

  Cheng, Erika R.; Downs, Stephen M.; Carroll, Aaron E. (American Medical Association, 2018-09)

  This study estimates the prevalence of paternal depression using the Child Health Improvement Through Computer Automation system in fathers attending well-child care visits. Approximately 24% of mothers experience depression ...
• Clinically Actionable Hypercholesterolemia and Hypertriglyceridemia in Children with Nonalcoholic Fatty Liver Disease 

  Harlow, Kathryn E.; Africa, Jonathan A.; Wells, Alan; Belt, Patricia H.; Behling, Cynthia A.; Jain, Ajay K.; Molleston, Jean P.; Newton, Kimberly P.; Rosenthal, Philip; Vos, Miriam B.; Xanthakos, Stavra A.; Lavine, Joel E.; Schwimmer, Jeffrey B. (Elsevier, 2018-07)

  OBJECTIVE: To determine the percentage of children with nonalcoholic fatty liver disease (NAFLD) in whom intervention for low-density lipoprotein cholesterol or triglycerides was indicated based on National Heart, Lung, ...
• Physician decision making in selection of second-line treatments in immune thrombocytopenia in children. 

  Grace, Rachael F.; Despotovic, Jenny M.; Bennett, Carolyn M.; Bussel, James B.; Neier, Michelle; Neunert, Cindy; Crary, Shelley E.; Pastore, Yves D.; Klaassen, Robert J.; Rothman, Jennifer A.; Hege, Kerry; Breakey, Vicky R.; Rose, Melissa J.; Shimano, Kristin A.; Buchanan, George R.; Geddis, Amy; Haley, Kristina M.; Lorenzana, Adonis; Thompson, Alexis; Jeng, Michael; Neufeld, Ellis J.; Brown, Travis; Forbes, Peter W.; Lambert, Michele P. (Wiley, 2018-07)

  Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder which presents with isolated thrombocytopenia and risk of hemorrhage. While most children with ITP promptly recover with or without drug therapy, ...
• SAT-158 Offspring Exposed to Maternal High Fat Diet Exhibits Systemic Inflammation and Pancreatic Islet Dysfunction 

  Casasnovas, Jose; Pineros, Annie; Jarrell, James; Kua, Kok Lim (Oxford University Press, 2019-04-15)

  Offspring born to overweight mothers are more likely to develop dysregulated immune response1, obesity1 and pancreatic islet dysfunction2. These offspring have increased inflammation at birth3 and at least until childhood4. ...

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