Browsing Department of Medical and Molecular Genetics by Title

Browsing Department of Medical and Molecular Genetics by Title

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  • Wu, Xi; Tanaka, Hiromi (Impact Journals, 2015-10-06)
    Excessive telomere shortening is observed in breast cancer lesions when compared to adjacent non-cancerous tissues, suggesting that telomere length may represent a key biomarker for early cancer detection. Because ...
  • Nuytemans, Karen; Inchausti, Vanessa; Beecham, Gary W.; Wang, Liyong; Dickson, Dennis W.; Trojanowski, John Q.; Lee, Virginia M.-Y.; Mash, Deborah C.; Frosch, Matthew P.; Foroud, Tatiana M.; Honig, Lawrence S.; Montine, Thomas J.; Dawson, Ted M.; Martin, Eden R.; Scott, William K.; Vance, Jeffery M. (Wiley, 2014-05)
    BACKGROUND: We have reported that intermediate repeat lengths of the C9ORF72 repeat are a risk factor for Parkinson's disease (PD) in a clinically diagnosed data set. Because 10% to 25% of clinically diagnosed PD have ...
  • Cornetta, Kenneth; Duffy, Lisa; Turtle, Cameron J.; Jensen, Michael; Forman, Stephen; Binder-Scholl, Gwendolyn; Fry, Terry; Chew, Anne; Maloney, David G.; June, Carl H. (Elsevier, 2017)
    Exposure to replication-competent lentivirus (RCL) is a theoretical safety concern for individuals treated with lentiviral gene therapy. For certain ex vivo gene therapy applications, including cancer immunotherapy trials, ...
  • Lombardi, Anne J.; Hoskins, Elizabeth E.; Foglesong, Grant D.; Wikenheiser-Brokamp, Kathryn A.; Wiesmüller, Lisa; Hanenberg, Helmut; Andreassen, Paul R.; Jacobs, Allison J.; Olson, Susan B.; Keeble, Winifred W.; Hays, Laura E.; Wells, Susanne I. (American Association for Cancer Research, 2015-04-15)
    PURPOSE: Fanconi anemia is an inherited disorder associated with a constitutional defect in the Fanconi anemia DNA repair machinery that is essential for resolution of DNA interstrand crosslinks. Individuals with Fanconi ...
  • Horgusluoglu, Emrin; Nudelman, Kelly; Nho, Kwangsik; Saykin, Andrew J. (Wiley, 2017-01)
    New neurons are generated throughout adulthood in two regions of the brain, the olfactory bulb and dentate gyrus of the hippocampus, and are incorporated into the hippocampal network circuitry; disruption of this process ...
  • Zhao, Zhongming; Liu, Yunlong; Huang, Yufei; Huang, Kun; Ruan, Jianhua (BioMed Central, 2016-08-26)
    The 2015 International Conference on Intelligent Biology and Medicine (ICIBM 2015) was held on November 13-15, 2015 in Indianapolis, Indiana, USA. ICIBM 2015 included eight scientific sessions, three tutorial sessions, one ...
  • Tanaka, Hiromi; Phipps, Elizabeth A.; Wei, Ting; Wu, Xi; Goswami, Chirayu; Liu, Yunlong; Sledge, George W., Jr.; Mina, Lida; Herbert, Brittney-Shea (Wiley, 2018)
    Telomere dysfunction resulting from telomere shortening and deregulation of shelterin components has been linked to the pathogenesis of age-related disorders, including cancer. Recent evidence suggests that BRCA1/2 (BRCA1 ...
  • Beecham, Gary W.; Bis, J.C.; Martin, E.R.; Choi, S.-H.; DeStefano, A. L.; van Duijn, C.M.; Fornage, M.; Gabriel, S.B.; Koboldt, D.C.; Larson, D.E.; Naj, A.C.; Psaty, B.M.; Salerno, W.; Bush, W.S.; Foroud, T.M.; Wijsman, E.; Farrer, L.A.; Goate, A.; Haines, J.L.; Pericak-Vance, Margaret A.; Boerwinkle, E.; Mayeux, R.; Seshadri, S.; Schellenberg, G. (Lippincott, Williams & Wilkins, 2017-10-13)
  • Butler, Merlin G.; Meaney, F. John; Opitz, John M.; Reynolds, James F. (Wiley, 1987-02)
    Weight, height, sitting height, and 24 other anthropometric variables (5 body circumferences, skinfolds at 7 sites, 4 head dimensions, and 8 hand and foot measurements) were obtained on 38 Prader-Labhart-Willi syndrome ...
  • Nudelman, Kelly N. H.; Risacher, Shannon L.; West, John D.; McDonald, Brenna C.; Gao, Sujuan; Saykin, Andrew J. (2014-10)
    Epidemiological studies show a reciprocal inverse association between cancer and Alzheimer's disease (AD). The common mechanistic theory for this effect posits that cells have an innate tendency toward apoptotic or survival ...
  • Wetherill, Leah; Agrawal, Arpana; Kapoor, Manav; Bertelsen, Sarah; Bierut, Laura J.; Brooks, Andrew; Dick, Danielle; Hesselbrock, Michie; Hesselbrock, Victor; Koller, Daniel L.; Le, Nhung; Nurnberger Jr., John I.; Salvatore, Jessica E.; Schuckit, Marc; Tischfield, Jay A.; Wang, Jen-Chyong; Xuei, Xiaoling; Edenberg, Howard J.; Porjesz, Bernice; Bucholz, Kathleen; Goate, Alison M.; Foroud, Tatiana (Wiley, 2015-05)
    Alcohol and drug use disorders are individually heritable (50%). Twin studies indicate that alcohol and substance use disorders share common genetic influences, and therefore may represent a more heritable form of addiction ...
  • Schwantes-An, Tae-Hwi; Zhang, Juan; Chen, Li-Shiun; Hartz, Sarah M.; Culverhouse, Robert C.; Chen, Xiangning; Coon, Hilary; Frank, Josef; Kamens, Helen M.; Konte, Bettina; Kovanen, Leena; Latvala, Antti; Legrand, Lisa N.; Maher, Brion S.; Melroy, Whitney E.; Nelson, Elliot C.; Reid, Mark W.; Robinson, Jason D.; Shen, Pei-Hong; Yang, Bao-Zhu; Andrews, Judy A.; Aveyard, Paul; Beltcheva, Olga; Brown, Sandra A.; Cannon, Dale S.; Cichon, Sven; Corley, Robin P.; Dahmen, Norbert; Degenhardt, Louisa; Foroud, Tatiana; Gaebel, Wolfgang; Giegling, Ina; Glatt, Stephen J.; Grucza, Richard A.; Hardin, Jill; Hartmann, Annette M.; Heath, Andrew C.; Herms, Stefan; Hodgkinson, Colin A.; Hoffmann, Per; Hops, Hyman; Huizinga, David; Ising, Marcus; Johnson, Eric O.; Johnstone, Elaine; Kaneva, Radka P.; Kendler, Kenneth S.; Kiefer, Falk; Kranzler, Henry R.; Krauter, Ken S.; Levran, Orna; Lucae, Susanne; Lynskey, Michael T.; Maier, Wolfgang; Mann, Karl; Martin, Nicholas G.; Mattheisen, Manuel; Montgomery, Grant W.; Müller-Myhsok, Bertram; Murphy, Michael F.; Neale, Michael C.; Nikolov, Momchil A.; Nishita, Denise; Nöthen, Markus M.; Nurnberger, John; Partonen, Timo; Pergadia, Michele L.; Reynolds, Maureen; Ridinger, Monika; Rose, Richard J.; Rouvinen-Lagerström, Noora; Scherbaum, Norbert; Schmäl, Christine; Soyka, Michael; Stallings, Michael C.; Steffens, Michael; Treutlein, Jens; Tsuang, Ming; Wallace, Tamara L.; Wodarz, Norbert; Yuferov, Vadim; Zill, Peter; Bergen, Andrew W.; Chen, Jingchun; Cinciripini, Paul M.; Edenberg, Howard J.; Ehringer, Marissa A.; Ferrell, Robert E.; Gelernter, Joel; Goldman, David; Hewitt, John K.; Hopfer, Christian J.; Iacono, William G.; Kaprio, Jaakko; Kreek, Mary Jeanne; Kremensky, Ivo M.; Madden, Pamela A.F.; McGue, Matt; Munafò, Marcus R.; Philibert, Robert A.; Rietschel, Marcella; Roy, Alec; Rujescu, Dan; Saarikoski, Sirkku T.; Swan, Gary E.; Todorov, Alexandre A.; Vanyukov, Michael M.; Weiss, Robert B.; Bierut, Laura J.; Saccone, Nancy L. (Springer, 2016-03)
    The mu1 opioid receptor gene, OPRM1, has long been a high-priority candidate for human genetic studies of addiction. Because of its potential functional significance, the non-synonymous variant rs1799971 (A118G, Asn40Asp) ...
  • Cheng, Lijun; Schneider, Bryan P.; Li, Lang (Oxford Academic, 2016-07)
    Cancer has been extensively characterized on the basis of genomics. The integration of genetic information about cancers with data on how the cancers respond to target based therapy to help to optimum cancer treatment. ...
  • Wang, Guohua; Liu, Yunlong; Zhu, Dongxiao; Klau, Gunnar W.; Feng, Weixing (Hindawi, 2015-09-07)
  • Cornetta, Kenneth (MDPI, 2013-12)
    The development of biologic agents for therapeutic purposes, or biomedicines, has seen an active area of research both at the bench and in clinical trials. There is mounting evidence that biologic products can provide ...
  • Hodes, M.E.; Butler, Merlin G.; Keitges, Elisabeth A.; Mirkin, L. David; Wills, Edward R. (Wiley, 1983-01)
    We describe a postmature anencephalic infant with atrophy of the abdominal musculature (prune belly syndrome). Other associations of these conditions are noted.
  • Nair, Neha; Calle, Anna Sanchez; Zahra, Maram Hussein; Prieto-Vila, Marta; Oo, Aung Ko Ko; Hurley, Laura; Vaidyanath, Arun; Seno, Akimasa; Masuda, Junko; Iwasaki, Yoshiaki; Tanaka, Hiromi; Kasai, Tomonari; Seno, Masaharu (Nature Publishing group, 2017-07-28)
    Cancer-associated fibroblasts (CAFs) are one of the most prominent cell types in the stromal compartment of the tumor microenvironment. CAFs support multiple aspects of cancer progression, including tumor initiation, ...
  • Shah, Kavita; Lahiri, Debomoy (The Company of Biologists, 2014-06-01)
    Cyclin dependent kinase-5 (Cdk5), a family member of the cyclin-dependent kinases, plays a pivotal role in the central nervous system. During embryogenesis, Cdk5 is indispensable for brain development and, in the adult ...
  • Puntambekar, Shweta S.; Saber, Maha; Lamb, Bruce T.; Kokiko-Cochran, Olga N. (Elsevier, 2018)
    Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide, and has emerged as a critical risk factor for multiple neurodegenerative diseases, particularly Alzheimer’s disease (AD). How the ...
  • Mittal, Karuna; Choi, Da Hoon; Klimov, Sergey; Pawar, Shrikant; Kaur, Ramneet; Mitra, Anirban K.; Gupta, Meenakshi V.; Sams, Ralph; Cantuaria, Guilherme; Rida, Padmashree C. G.; Aneja, Ritu (BioMed Central, 2016-03-18)
    Background Amplified centrosomes are widely recognized as a hallmark of cancer. Although supernumerary centrosomes would be expected to compromise cell viability by yielding multipolar spindles that results in death-inducing ...

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