• Metacognition in the Middle: Mismatch between Anticipated and Actual Exam Grades of Allied Health Anatomy Students 

  Cale, Andrew S.; McNulty, Margaret A. (2021-04-22)

  INTRODUCTION: Accurate evaluation of one’s knowledge and performance is a key metacognitive skill critical to success in the classroom. Students who lack this skill may over-estimate their knowledge and under-prepare for ...
• Intraperitoneal injection of lipopolysaccharide prevents seizure-induced respiratory arrest in a DBA/1 mouse model of SUDEP 

  Adhikari, Yadav; Jin, Xiaoming (Wiley, 2020-05-31)

  Objective Sudden unexpected death in epilepsy (SUDEP) is the cause of premature death of 50% patients with chronic refractory epilepsy. Respiratory failure during seizures is regarded as an important mechanism of SUDEP. ...
• PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes 

  Konttinen, Henna; Gureviciene, Irina; Oksanen, Minna; Grubman, Alexandra; Loppi, Sanna; Huuskonen, Mikko T.; Korhonen, Paula; Lampinen, Riikka; Keuters, Meike; Belaya, Irina; Tanila, Heikki; Kanninen, Katja M.; Goldsteins, Gundars; Landreth, Gary; Koistinaho, Jari; Malm, Tarja (Wiley, 2018-11-19)

  Astrocytes are the gatekeepers of neuronal energy supply. In neurodegenerative diseases, bio-energetics demand increases and becomes reliant upon fatty acid oxidation as a source of energy. Defective fatty acid oxidation ...
• Osteocytic miR21 deficiency improves bone strength independent of sex despite having sex divergent effects on osteocyte viability and bone turnover 

  Davis, Hannah M.; Deosthale, Padmini J.; Pacheco‐Costa, Rafael; Essex, Alyson L.; Atkinson, Emily G.; Aref, Mohammad W.; Dilley, Julian E.; Bellido, Teresita; Ivan, Mircea; Allen, Matthew R.; Plotkin, Lilian I. (Wiley, 2019-09-18)

  Osteocytes play a critical role in mediating cell-cell communication and regulating bone homeostasis, and osteocyte apoptosis is associated with increased bone resorption. miR21, an oncogenic microRNA, regulates bone ...
• Excess membrane cholesterol is an early contributing reversible aspect of skeletal muscle insulin resistance in C57BL/6NJ mice fed a Western-style high-fat diet 

  Grice, Brian A.; Barton, Kelly J.; Covert, Jacob D.; Kreilach, Alec M.; Tackett, Lixuan; Brozinick, Joseph T.; Elmendorf, Jeffrey S. (American Physiological Society, 2019-08-06)

  Skeletal muscle insulin resistance manifests shortly after high-fat feeding, yet mechanisms are not known. Here we set out to determine whether excess skeletal muscle membrane cholesterol and cytoskeletal derangement known ...
• Sensitive detection of Cre-mediated recombination using droplet digital PCR reveals Tg(BGLAP-Cre) and Tg(DMP1-Cre) are active in multiple non-skeletal tissues 

  Dasgupta, Krishnakali; Lessard, Samantha; Hann, Steven; Fowler, Megan A.; Robling, Alexander G.; Warman, Matthew L. (Elsevier, 2021-01)

  In humans, somatic activating mutations in PIK3CA are associated with skeletal overgrowth. In order to determine if activated PI3K signaling in bone cells causes overgrowth, we used Tg(BGLAP-Cre) and Tg(DMP1-Cre) mouse ...
• Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration 

  Lim, Kyung-Eun; Bullock, Whitney A.; Horan, Daniel J.; Williams, Bart O.; Warman, Matthew L.; Robling, Alexander G. (Elsevier, 2021-02)

  The cysteine knot protein sclerostin is an osteocyte-derived secreted inhibitor of the Wnt co-receptors LRP5 and LRP6. LRP5 plays a dominant role in bone homeostasis, but we previously reported that Sost/sclerostin suppression ...
• Impaired Glutamate Receptor Function Underlies Early Activity Loss of Ipsilesional Motor Cortex after Closed-Head Mild Traumatic Brain Injury 

  Nguyen, Tyler; Al-Juboori, Mohammed Haider; Walerstein, Jakub; Xiong, Wenhui; Jin, Xiaoming (Liebert, 2021)

  Although mild traumatic brain injury (mTBI) accounts for the majority of TBI patients, the effects and cellular and molecular mechanisms of mTBI on cortical neural circuits are still not well understood. Given the transient ...
• Insulin Resistance Does Not Impair Mechanical Overload-Stimulated Glucose Uptake, but Does Alter the Metabolic Fate of Glucose in Mouse Muscle 

  Weyrauch, Luke A.; McMillin, Shawna L.; Witczak, Carol A. (MDPI, 2020-07-01)

  Skeletal muscle glucose uptake and glucose metabolism are impaired in insulin resistance. Mechanical overload stimulates glucose uptake into insulin-resistant muscle; yet the mechanisms underlying this beneficial effect ...
• Differences in the Role of HDACs 4 and 5 in the Modulation of Processes Regulating MAFbx and MuRF1 Expression during Muscle Unloading 

  Mochalova, Ekaterina P.; Belova, Svetlana P.; Kostrominova, Tatiana Y.; Shenkman, Boris S.; Nemirovskaya, Tatiana L. (MDPI, 2020-07-07)

  Unloading leads to skeletal muscle atrophy via the upregulation of MuRF-1 and MAFbx E3-ligases expression. Reportedly, histone deacetylases (HDACs) 4 and 5 may regulate the expression of MuRF1 and MAFbx. To examine the ...
• A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy 

  Taylor, Xavier; Cisternas, Pablo; You, Yanwen; You, Yingjian; Xiang, Shunian; Marambio, Yamil; Zhang, Jie; Vidal, Ruben; Lasagna-Reeves, Cristian A. (BMC, 2020-07-25)

  Background Cerebral amyloid angiopathy (CAA) is typified by the cerebrovascular deposition of amyloid. The mechanisms underlying the contribution of CAA to neurodegeneration are not currently understood. Although CAA is ...
• Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease 

  Curry, Joshua N.; Saurette, Matthew; Askari, Masomeh; Pei, Lei; Filla, Michael B.; Beggs, Megan R.; Rowe, Peter S. N.; Fields, Timothy; Sommer, Andre J.; Tanikawa, Chizu; Kamatani, Yoichiro; Evan, Andrew P.; Totonchi, Mehdi; Alexander, R. Todd; Matsuda, Koichi; Yu, Alan S. L. (American Society for Clinical Investigation, 2020-03-09)

  The major risk factor for kidney stone disease is idiopathic hypercalciuria. Recent evidence implicates a role for defective calcium reabsorption in the renal proximal tubule. We hypothesized that claudin-2, a paracellular ...
• An in vivo demonstration of efficacy and acute safety of burst wave lithotripsy using a porcine model 

  Wang, Yak-Nam; Kreider, Wayne; Hunter, Chris; Cunitz, Bryan W.; Thiel, Jeff; Starr, Frank; Dai, Jessica C.; Nazari, Yasser; Lee, Donghoon; Williams, James C.; Bailey, Micheal R.; Maxwell, Adam D. (Acoustical Society of America, 2019-02-06)

  Burst wave lithotripsy (BWL) is a new non-invasive method for stone comminution using bursts of sub-megahertz ultrasound. A porcine model of urolithiasis and techniques to implement BWL treatment has been developed to ...
• Impact of stone type on cavitation in burst wave lithotripsy 

  Hunter, Christopher; Maxwell, Adam D.; Cunitz, Bryan; Dunmire, Barbrina; Sorensen, Mathew D.; Williams, James C.; Randad, Akshay; Bailey, Michael; Kreider, Wayne (Acoustical Society of America, 2018-12-26)

  Non-invasive kidney stone treatments such as shock wave lithotripsy (SWL) and burst wave lithotripsy (BWL) rely on the delivery of pressure waves through tissue to the stone. In both SWL and BWL, the potential to hinder ...
• CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis 

  Sheridan, Carol; Kishimoto, Hiromitsu; Fuchs, Robyn K.; Mehrotra, Sanjana; Bhat-Nakshatri, Poornima; Turner, Charles H.; Goulet Jr., Robert; Badve, Sunil; Nakshatri, Harikrishna (BioMed Central, 2006-10-24)

  Introduction A subpopulation (CD44+/CD24-) of breast cancer cells has been reported to have stem/progenitor cell properties. The aim of this study was to investigate whether this subpopulation of cancer cells has the ...
• The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes 

  Adu-Agyeiwaah, Yvonne; Grant, Maria B.; Obukhov, Alexander G. (MDPI, 2020)

  The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 (COVID-19) pandemic, with more than 50 million cases reported globally. Findings have consistently ...
• Short-term pharmacologic RAGE inhibition differentially affects bone and skeletal muscle in middle-aged mice 

  Davis, Hannah M.; Essex, Alyson L.; Valdez, Sinai; Deosthale, Padmini J.; Aref, Mohammad W.; Allen, Matthew R.; Bonetto, Andrea; Plotkin, Lilian I. (Elsevier, 2019-04-24)

  Loss of bone and muscle mass are two major clinical complications among the growing list of chronic diseases that primarily affect elderly individuals. Persistent low-grade inflammation, one of the major drivers of aging, ...
• Animal Models for COVID-19: More to the Picture Than ACE2, Rodents, Ferrets, and Non-human Primates. A Case for Porcine Respiratory Coronavirus and the Obese Ossabaw Pig 

  Heegaard, Peter M. H.; Sturek, Michael; Alloosh, Mouhamad; Belsham, Graham J. (Frontiers Media, 2020-09-25)

  The ongoing COVID-19 pandemic caused by infection with SARS-CoV-2 has created an urgent need for animal models to enable study of basic infection and disease mechanisms and for development of vaccines, therapeutics, and ...
• The mTORC2 Component Rictor Is Required for Load-Induced Bone Formation in Late-Stage Skeletal Cells 

  Lewis, Karl J.; Yi, Xin; Wright, Christian S.; Pemberton, Emily Z.; Bullock, Whitney A.; Thompson, William R.; Robling, Alexander G. (Wiley, 2020-04-17)

  Bone relies on mechanical cues to build and maintain tissue composition and architecture. Our understanding of bone cell mechanotransduction continues to evolve, with a few key signaling pathways emerging as vital. ...
• An osteocalcin-deficient mouse strain without endocrine abnormalities 

  Diegel, Cassandra R.; Hann, Steven; Ayturk, Ugur M.; Hu, Jennifer C. W.; Lim, Kyung-eun; Droscha, Casey J.; Madaj, Zachary B.; Foxa, Gabrielle E.; Izaguirre, Isaac; Core, VAI Vivarium and Transgenics; Paracha, Noorulain; Pidhaynyy, Bohdan; Dowd, Terry L.; Robling, Alexander G.; Warman, Matthew L.; Williams, Bart O. (PLOS, 2020-05-28)

  Osteocalcin (OCN), the most abundant noncollagenous protein in the bone matrix, is reported to be a bone-derived endocrine hormone with wide-ranging effects on many aspects of physiology, including glucose metabolism and ...

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