• Incorporating tissue anisotropy and heterogeneity in finite element models of trabecular bone altered predicted local stress distributions 

  Hammond, Max A.; Wallace, Joseph M.; Allen, Matthew R.; Siegmund, Thomas (Springer, 2018-04)

  Trabecular bone is composed of organized mineralized collagen fibrils, which results in heterogeneous and anisotropic mechanical properties at the tissue level. Recently, biomechanical models computing stresses and strains ...
• Estrogen depletion alters mineralization regulation mechanisms in an ovariectomized monkey animal model 

  Paschalis, E. P.; Gamsjaeger, S.; Condon, Keith; Klaushofer, K.; Burr, David (Elsevier, 2019-03)

  Ovariectomized animal models have been extensively used in osteoporosis research due to the resulting loss of bone mass. The purpose of the present study was to test the hypothesis that estrogen depletion alters mineralization ...
• Effects of daily restraint with and without injections on skeletal properties in C57BL/6NHsd mice 

  Larsen, Rachel A.; Peveler, Jessica L.; Klutzke, Joshuah B.; Hickman, Debra L.; Aref, Mohammad W.; Wallace, Joseph M.; Brown, Drew M.; Allen, Matthew R. (Nature, 2017-06)
• Aberrantly elevated Wnt signaling is responsible for cementum overgrowth and dental ankylosis 

  Wu, Yan; Yuan, Xue; Perez, Kristy C.; Hyman, Sydnee; Wang, Liao; Pellegrini, Gretel; Salmon, Benjamin; Bellido, Teresita; Helms, Jill A. (Elsevier, 2018)

  Vertebrate teeth are attached to the jawbones using a variety of methods but in mammals, a fibrous connection is the norm. This fibrous periodontal ligament (PDL) allows teeth to move in the jawbones in response to natural ...
• Induction of Lrp5 HBM-causing mutations in Cathepsin-K expressing cells alters bone metabolism 

  Kang, Kyung Shin; Hong, Jung Min; Horan, Daniel J.; Lim, Kyung-Eun; Bullock, Whitney A.; Bruzzaniti, Angela; Hann, Steven; Warman, Matthew L.; Robling, Alexander G. (Elsevier, 2019-03)

  High-bone-mass (HBM)-causing missense mutations in the low density lipoprotein receptor-related protein-5 (Lrp5) are associated with increased osteoanabolic action and protection from disuse- and ovariectomy-induced ...
• Recent Advances in Understanding Bisphosphonate Effects on Bone Mechanical Properties 

  Allen, Matthew R. (Springer, 2018-04)

  Purpose of the Review Bisphosphonates have well-established effects on suppressing bone resorption and slowing bone loss, yet the effects on bone mechanical properties are less clear. We review recent data from pre-clinical ...
• MLO-Y4 osteocytic cell clones express distinct gene expression patterns characteristic of different stages of osteocyte differentiation 

  Atkinson, Emily G.; Marcial, Alejandro; Sánchez, Zuleima; Porter, Christian; Plotkin, Lilian I. (2017-09)

  Osteocytes are the most abundant bone cell and are formed when osteoblasts become embedded in the bone matrix. Through changes in gene expression and paracrine effects, osteocytes regulate the number of osteoblasts, bone ...
• Recurrence rates of urinary calculi according to stone composition and morphology 

  Daudon, Michel; Jungers, Paul; Bazin, Dominique; Williams, James C., Jr. (Springer, 2018-10)

  Few studies have examined the relative risk of recurrence of different stone types. The object of the present study was to evaluate the tendency for stone recurrence as a function of major mineral composition of the stones ...
• Experiences of Female and Male Medical Students With Death, Dying, and Palliative Care: One Size Does Not Fit All 

  Hoffman, Leslie A.; Mehta, Rakesh; Vu, T. Robert; Frankel, Richard M. (Sage, 2018-06)

  Background: Medical students learn about death, dying, and palliative care (DDPC) through formal curricular offerings and informal clinical experiences; however, the lessons learned in the clinic may be at odds with the ...
• Difference in regional neural fluctuations and functional connectivity in Crohn’s disease: a resting-state functional MRI study 

  Bao, Chunhui; Liu, Peng; Liu, Huirong; Jin, Xiaoming; Shi, Yin; Wu, Luyi; Zeng, Xiaoqing; Zhang, Jianye; Wang, Di; Calhoun, Vince D.; Tian, Jie; Wu, Huangan (Springer, 2018)

  Patients with Crohn’s disease (CD) are shown to have abnormal changes in brain structures. This study aimed to further investigate whether these patients have abnormal brain activities and network connectivity. Sixty ...
• Using Helical CT to Predict Stone Fragility in Shock Wave Lithotripsy (SWL). 

  Williams, James C., Jr.; Zarse, Chad A.; Jackson, Molly E.; Lingeman, James E.; McAteer, James A. (AIP Publishing, 2007)

  Great variability exists in the response of urinary stones to SWL, and this is true even for stones composed of the same mineral. Efforts have been made to predict stone fragility to shock waves using computed tomography ...
• Vhl deficiency in osteocytes produces high bone mass and hematopoietic defects 

  Loots, Gabriela G.; Robling, Alexander G.; Chang, Jiun C.; Murugesh, Deepa K.; Bajwa, Jamila; Carlisle, Cameron; Manilay, Jennifer O.; Wong, Alice; Yellowley, Clare E.; Genetos, Damian C. (Elsevier, 2018)

  Tissue oxygen (O2) levels vary during development and disease; adaptations to decreased O2 (hypoxia) are mediated by hypoxia-inducible factor (HIF) transcription factors. HIFs are active in the skeleton, and stabilizing ...
• New Insights Into the Local and Systemic Functions of Sclerostin: Regulation of Quiescent Bone Lining Cells and Beige Adipogenesis in Peripheral Fat Depots 

  Delgado-Calle, Jesus; Bellido, Teresita (Wiley, 2017-05)
• HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage 

  Loppi, S.; Kolosowska, N.; Kärkkäinen, O.; Korhonen, P.; Huuskonen, M.; Grubman, A.; Dhungana, H.; Wojciechowski, S.; Pomeshchik, Y.; Giordano, M.; Kagechika, H.; White, A.; Auriola, S.; Koistinaho, J.; Landreth, Gary E.; Hanhineva, K.; Kanninen, K.; Malm, T. (Elsevier, 2018-10)

  Ischemic stroke is amongst the leading causes of death and disabilities. The available treatments are suitable for only a fraction of patients and thus novel therapies are urgently needed. Blockage of one of the cerebral ...
• Lithobates Pipiens (Northern Leopard Frog). Malformation 

  Rabe, Allison; Lannoo, Michael; Beachy, Christopher K. (Ssar, 2013-06)
• β-aminoisobutyric Acid, L-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor 

  Kitase, Yukiko; Vallejo, Julian A.; Gutheil, William; Vemula, Harika; Jähn, Katharina; Yi, Jianxun; Zhou, Jingsong; Brotto, Marco; Bonewald, Lynda F. (Cell Press, 2018-02-06)

  Exercise has beneficial effects on metabolism and on tissues. The exercise-induced muscle factor β-aminoisobutyric acid (BAIBA) plays a critical role in the browning of white fat and in insulin resistance. Here we show ...
• The Role of the Osteocyte in Bone and Non-bone Disease 

  Bonewald, Lynda F. (Elsevier, 2017-03)

  When normal physiological functions go awry, disorders and disease occurs. This is universal, even for the osteocyte, a cell embedded within the mineralized matrix of bone. It was once thought that this cell was simply ...
• Idiopathic hypercalciuria and formation of calcium renal stones 

  Coe, Fredric L.; Worcester, Elaine M.; Evan, Andrew P. (Nature Publishing group, 2016-09)

  The most common presentation of nephrolithiasis is idiopathic calcium stones in patients without systemic disease. Most stones are primarily composed of calcium oxalate and form on a base of interstitial apatite deposits, ...
• Preoperative Bladder Urine Culture as a Predictor of Intraoperative Stone Culture Results: Clinical Implications and Relationship to Stone Composition 

  Paonessa, Jessica E.; Gnessin, Ehud; Bhojani, Naeem; Williams, James C.; Lingeman, James E. (Elsevier, 2016-09)

  Purpose We examine the relationship between urine and stone cultures in a large cohort of patients undergoing percutaneous stone removal and compare the findings in infectious vs metabolic calculi. Materials and ...
• Role and mechanism of action of Sclerostin in bone 

  Delgado-Calle, Jesus; Sato, Amy Y.; Bellido, Teresita (Elsevier, 2017-03)

  After discovering that lack of Sost/sclerostin expression is the cause of the high bone mass human syndromes Van Buchem disease and sclerosteosis, extensive animal experimentation and clinical studies demonstrated that ...

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