• STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice 

  Baum, Rebecca; Sharma, Shruti; Organ, Jason M.; Jakobs, Christopher; Hornung, Veit; Burr, David B.; Marshak-Rothstein, Ann; Fitzgerald, Katherine A.; Gravallese, Ellen M. (Wiley, 2017-02)

  OBJECTIVE: Cytosolic DNA sensors detect microbial DNA and promote type I interferon (IFN) and proinflammatory cytokine production through the adaptor stimulator of IFN genes (STING) to resolve infection. Endogenous DNA ...
• Preclinical Models for Skeletal Research: How Commonly Used Species Mimic (or Don’t) Aspects of Human Bone 

  Allen, Matthew R. (Sage, 2017-10)

  Preclinical studies play an indispensable role in exploring the biological regulation of the musculoskeletal system. They are required in all drug development pipelines where both small and large animal models are needed ...
• Carbon nanotube multilayered nanocomposites as multifunctional substrates for actuating neuronal differentiation and functions of neural stem cells 

  Shao, Han; Li, Tingting; Zhu, Rong; Xu, Xiaoting; Yu, Jiandong; Chen, Shengfeng; Song, Li; Ramakrishna, Seeram; Lei, Zhigang; Ruan, Yiwen; He, Liumin (Elsevier, 2018-08)

  Carbon nanotubes (CNTs) have shown potential applications in neuroscience as growth substrates owing to their numerous unique properties. However, a key concern in the fabrication of homogeneous composites is the serious ...
• Cx43 Overexpression in Osteocytes Prevents Osteocyte Apoptosis and Preserves Cortical Bone Quality in Aging Mice 

  Davis, Hannah M.; Aref, Mohammad W.; Aguilar‐Perez, Alexandra; Pacheco‐Costa, Rafael; Allen, Kimberly; Valdez, Sinai; Herrera, Carmen; Atkinson, Emily G.; Mohammad, Arwa; Lopez, David; Harris, Marie A.; Harris, Stephen E.; Allen, Matthew; Bellido, Teresita; Plotkin, Lilian I. (Wiley, 2018-02-26)

  Young, skeletally mature mice lacking Cx43 in osteocytes exhibit increased osteocyte apoptosis and decreased bone strength, resembling the phenotype of old mice. Further, the expression of Cx43 in bone decreases with age, ...
• Calcium Tartrate Tetrahydrate, Case Report of a Novel Human Kidney Stone 

  Kleinguetl, Colin; Williams, James C.; Ibrahim, Samar A.; Daudon, Michel; Bird, Erin T.; El Tayeb, Marawan M. (Mary Ann Liebert, 2017-12-01)

  Background: Calcium tartrate tetrahydrate has been reported as the main mineral in urinary stones in rats that have significant tartrate in their diet, but in humans, there has been only one mention of calcium tartrate ...
• Development of a Novel Magnetic Resonance Imaging Acquisition and Analysis Workflow for the Quantification of Shock Wave Lithotripsy-Induced Renal Hemorrhagic Injury 

  Handa, Rajash K.; Territo, Paul R.; Blomgren, Philip M.; Persohn, Scott A.; Lin, Chen; Johnson, Cynthia D.; Jiang, Lei; Connors, Bret A.; Hutchins, Gary D. (Springer, 2017-10)

  Introduction The current accepted standard for quantifying shock wave lithotripsy (SWL)-induced tissue damage is based on morphometric detection of renal hemorrhage in serial tissue sections from fixed kidneys. This ...
• Zoledronate treatment has different effects in mouse strains with contrasting baseline bone mechanical phenotypes 

  Aref, Mohammad W.; McNerny, Erin M.B.; Brown, Drew; Jepsen, Karl J.; Allen, Matthew R. (Springer, 2016-12)

  Aref, M. W., McNerny, E. M. B., Brown, D., Jepsen, K. J., & Allen, M. R. (2016). Zoledronate treatment has different effects in mouse strains with contrasting baseline bone mechanical phenotypes. Osteoporosis International : ...
• Cis‐acting allele specific expression (ASE) differences induced by alcohol and impacted by sex as well as parental genotype of origin 

  Lo, Chiao-Ling; Lumeng, Lawrence; Bell, Richard L.; Liang, Tiebing; Lossie, Amy C.; Muir, Williams M.; Zhou, Feng C. (Wiley, 2018)

  Background Alcohol use disorders (AUDs) are influenced by complex interactions between the genetics of the individual and their environment. We have previously identified hundreds of polygenic genetic variants between the ...
• Quantitative prediction of stone fragility from routine single and dual energy CT: proof of feasibility 

  Ferrero, Andrea; Montoya, Juan C.; Vaughan, Lisa E.; Huang, Alice E.; McKeag, Ian O.; Enders, Felicity T.; Williams, James C.; McCollough, Cynthia H. (Elsevier, 2016-12)

  Rationale and Objectives Previous studies have demonstrated a qualitative relationship between stone fragility and internal stone morphology. The goal of this study was to quantify morphological features from dual-energy ...
• Conditional Deletion of Sost in MSC‐derived lineages Identifies Specific Cell Type Contributions to Bone Mass and B Cell Development 

  Yee, Cristal S.; Manilay, Jennifer O.; Chang, Jiun C.; Hum, Nicholas R.; Murugesh, Deepa K.; Bajwa, Jamila; Mendez, Melanie E.; Economides, Aris E.; Horan, Daniel J.; Robling, Alexander G.; Loots, Gabriela G. (Wiley, 2018)

  Sclerostin (Sost) is a negative regulator of bone formation and blocking its function via antibodies has shown great therapeutic promise by increasing both bone mass in humans and animal models. Sclerostin deletion in Sost ...
• Loss of the nutrient sensor TAS1R3 leads to reduced bone resorption 

  Eaton, Michael S.; Weinstein, Nicholas; Newby, Jordan B.; Plattes, Maggie M.; Foster, Hanna E.; Arthur, Jon W.; Ward, Taylor D.; Shively, Stephen R.; Shor, Ryann; Nathan, Justin; Davis, Hannah M.; Plotkin, Lilian I.; Wauson, Eric M.; Dewar, Brian J.; Broege, Aaron; Lowery, Jonathan W. (Springer, 2018-02)

  The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids ...
• Degeneration of the osteocyte network in the C57BL/6 mouse model of aging 

  Tiede-Lewis, LeAnn M.; Xie, Yixia; Hulbert, Molly A.; Campos, Richard; Dallas, Mark R.; Dusevich, Vladimir; Bonewald, Lynda F.; Dallas, Sarah L. (Impact Journals, 2017-10-26)

  Age-related bone loss and associated fracture risk are major problems in musculoskeletal health. Osteocytes have emerged as key regulators of bone mass and as a therapeutic target for preventing bone loss. As aging is ...
• Anxiogenic CO2 Stimulus Elicits Exacerbated Hot Flash-like Responses in a Rat Menopause Model and Hot Flashes in Menopausal Women 

  Federici, Lauren M.; Roth, Sarah Dorsey; Krier, Connie; Fitz, Stephanie D.; Skaar, Todd; Shekhar, Anantha; Carpenter, Janet S.; Johnson, Philip L. (Lippincott, Williams & Wilkins, 2016-11)

  Objective Since longitudinal studies determined that anxiety is a strong risk factor for hot flashes, we hypothesized that an anxiogenic stimulus that signals air hunger (hypercapnic, normoxic gas) would trigger an ...
• DNA Methylation program in normal and alcohol-induced thinning cortex 

  Öztürk, Nail Can; Resendiz, Marisol; Öztürk, Hakan; Zhou, Feng C. (Elsevier, 2017-05)

  While cerebral underdevelopment is a hallmark of fetal alcohol spectrum disorders (FASD), the mechanism(s) guiding the broad cortical neurodevelopmental deficits are not clear. DNA methylation is known to regulate early ...
• Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus 

  Medina-Gomez, Carolina; Kemp, John P.; Dimou, Niki L.; Kreiner, Eskil; Chesi, Alessandra; Zemel, Babette S.; Bønnelykke, Klaus; Boer, Cindy G.; Ahluwalia, Tarunveer S.; Bisgaard, Hans; Evangelou, Evangelos; Heppe, Denise H.M.; Bonewald, Lynda F.; Gorski, Jeffrey P.; Ghanbari, Mohsen; Demissie, Serkalem; Duque, Gustavo; Maurano, Matthew T.; Kiel, Douglas P.; Hsu, Yi-Hsiang; Eerden, Bram C.J. van der; Ackert-Bicknell, Cheryl; Reppe, Sjur; Gautvik, Kaare M.; Raastad, Truls; Karasik, David; Peppel, Jeroen van de; Jaddoe, Vincent W.V.; Uitterlinden, André G.; Tobias, Jonathan H.; Grant, Struan F.A.; Bagos, Pantelis G.; Evans, David M.; Rivadeneira, Fernando (Nature Publishing Group, 2017-07-25)

  Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed a bivariate GWAS ...
• Effects of knee loading on obesity‐related nonalcoholic fatty liver disease in an ovariectomized mouse model with high fat diet 

  Tan, Nian; Li, Xinle; Zhai, Lidong; Liu, Daquan; Li, Jie; Yokota, Hiroki; Zhang, Ping (Wiley, 2018)

  Aim Hormonal and nutritional disorders are the main causes of obesity and nonalcoholic fatty liver disease, especially in the elderly and postmenopausal women. Although physical activity may alleviate these disorders, the ...
• Preliminary Report on Stone Breakage and Lesion Size Produced by a New Extracorporeal Electrohydraulic (Sparker Array) Discharge Device 

  Connors, Bret A.; Schaefer, Ray B.; Gallagher, John J.; Johnson, Cynthia D.; Li, Guangyan; Handa, Rajash K.; Evan, Andrew P. (Elsevier, 2018)

  Objective To determine if an innovative extracorporeal electrohydraulic shock wave device (sparker array) can effectively fracture artificial stones in vitro and in vivo, and if sparker array treatment produces a renal ...
• Postnatal β-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation 

  Kang, Kyung Shin; Hong, Jung Min; Robling, Alexander G. (Elsevier, 2016-07)

  Mechanical signal transduction in bone tissue begins with load-induced activation of several cellular pathways in the osteocyte population. A key pathway that participates in mechanotransduction is Wnt/Lrp5 signaling. A ...
• Neuroprotective Mechanisms of Lycium barbarum Polysaccharides Against Ischemic Insults by Regulating NR2B and NR2A Containing NMDA Receptor Signaling Pathways 

  Shi, Zhongshan; Zhu, Lihui; Li, Tingting; Tang, Xiaoya; Xiang, Yonghui; Han, Xinjia; Xia, Luoxing; Zeng, Ling; Nie, Junhua; Huang, Yongxia; Tsang, Chi Kwan; Wang, Ying; Lei, Zhigang; Xu, Zaocheng; So, Kwok-fai; Ruan, Yiwen (Frontiers, 2017-09-27)

  Glutamate excitotoxicity plays an important role in neuronal death after ischemia. However, all clinical trials using glutamate receptor inhibitors have failed. This may be related to the evidence that activation of different ...
• Simultaneous visualisation of calcified bone microstructure and intracortical vasculature using synchrotron X-ray phase contrast-enhanced tomography 

  Núñez, Juan A.; Goring, Alice; Hesse, Eric; Thurner, Philipp J.; Schneider, Philipp; Clarkin, Claire E. (Nature Publishing group, 2017-10-16)

  3D imaging of the bone vasculature is of key importance in the understanding of skeletal disease. As blood vessels in bone are deeply encased in the calcified matrix, imaging techniques that are applicable to soft tissues ...

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