• Functional Effects of Nanoparticle Exposure on Calu-3 Airway Epithelial Cells 

  Banga, Amiraj; Witzmann, Frank A.; Petrache, Horia I.; Blazer-Yost, Bonnie (2012)

  High concentrations of manufactured carbon nanoparticles (CNP) are known to cause oxidative stress, inflammatory responses and granuloma formation in respiratory epithelia. To examine the effects of lower, more physiologically ...
• Lysophosphatidic acid is a modulator of cyst growth in autosomal dominant polycystic kidney disease., Lysophosphatidic Acid is a Modulator of Cyst Growth in Autosomal Dominant Polycystic Kidney Disease 

  Blazer-Yost, Bonnie; Blacklock, B. J.; Flaig, S.; Bacallao, R. L.; Gattone, V. H. (2011)

  Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the slow growth of multiple fluid-filled cysts predominately in the kidney tubules and liver bile ducts. Elucidation of mechanisms that control cyst ...
• Pioglitazone Attenuates Cystic Burden in the PCK Rodent Model of Polycystic Kidney Disease 

  Blazer-Yost, Bonnie; Haydon, Julie; Eggleston-Gulyas, Tracy; Chen, Jey-Hsin; Wang, Xiaofang; Gattone, Vincent; Torres, Vicente E. (2010)

  Polycystic kidney disease (PKD) is a genetic disorder characterized by growth of fluid-filled cysts predominately in kidney tubules and liver bile ducts. Currently, the clinical management of PKD is limited to cyst aspiration, ...
• A human polymorphism affects NEDD4L subcellular targeting by leading to two isoforms that contain or lack a C2 domain 

  Garrone, Nicholas F.; Blazer-Yost, Bonnie; Weiss, Robert B.; Lalouel, Jean-Marc; Rohrwasser, Andreas (2009)

  BACKGROUND: Ubiquitination serves multiple cellular functions, including proteasomal degradation and the control of stability, function, and intracellular localization of a wide variety of proteins. NEDD4L is a member of ...
• 60kDa Lysophospholipase, a New Sgk1 Molecular Partner Involved in the Regulation of ENaC 

  Menniti, Miranda; Iuliano, Rodolfo; Föller, Michael; Sopjani, Mentor; Alesutan, Ioana; Mariggiò, Stefania; Nofziger, Charity; Perri, Angela M.; Amato, Rosario; Blazer-Yost, Bonnie; Corda, Daniela; Lang, Florian; Perrotti, Nicola (2010)

  The serum- and glucocorticoid-regulated kinase (Sgk1) is essential for hormonal regulation of ENaC-mediated sodium transport and is involved in the transduction of growth-factor-dependent cell survival and proliferation. ...
• PPAR Agonists: Blood Pressure and Edema 

  Blazer-Yost, Bonnie (2010)

  Peroxisome proliferator activated receptor gamma (PPARgamma) agonists are widely used in the treatment of type 2 diabetes. Side effects of drug treatment include both fluid retention and a lowering of blood pressure. Data ...
• PPARγ Agonists, Modulation of Ion Transporters, and Fluid Retention 

  Nofziger, Charity; Blazer-Yost, Bonnie (2009)
• Lack of the serum and glucocorticoid-inducible kinase SGK1 attenuates the volume retention after treatment with the PPARγ agonist pioglitazone 

  Artunc, Ferruh; Sandulache, Diana; Nasir, Omaima; Boini, Krishna M.; Friedrich, Björn; Beier, Norbert; Dicks, Edith; Pötzsch, Sven; Klingel, Karin; Amann, Kerstin; Blazer-Yost, Bonnie; Scholz, Wolfgang; Risler, Teut; Kuhl, Dietmar; Lang, Florian (2008-05)

  PPARgamma-agonists enhance insulin sensitivity and improve glucose utilization in diabetic patients. Adverse effects of PPARgamma-agonists include volume retention and edema formation. Recent observations pointed to the ...
• Structural and Functional Analyses of Liver Cysts from the BALB/c-cpk Mouse Model of Polycystic Kidney Disease 

  Muchatuta, Monalisa N.; Gattone, Vincent H.; Witzmann, Frank A.; Blazer-Yost, Bonnie (2009)

  Liver cysts arising from hepatic bile ducts are a common extra-renal pathology associated with both autosomal dominant and recessive polycystic kidney disease in humans. To elucidate the functional and structural changes ...
• Vasopressin Regulates the Phosphorylation State of AMP-activated Protein Kinase (AMPK) in MDCK-C7 Cells 

  Nofziger, Charity; Kalsi, Kameljit; West, T. Aaron; Baines, Deborah; Blazer-Yost, Bonnie (2008)

  AMP-activated protein kinase (AMPK) is a regulatory kinase coupling cellular metabolism with ion transport. Madin-Darby Canine Kidney-Clone 7 (MDCK-C7) cells possess characteristics of the renal principal cell type, express ...
• Hormonal regulation of the epithelial Na+ channel: From amphibians to mammals 

  Shane, Michael Anne; Nofziger, Charity; Blazer-Yost, Bonnie (2006-05)

  High-resistance epithelia derived from amphibian sources such as frog skin, toad urinary bladder, and the A6 Xenopus laevis kidney cell line have been widely used to elucidate the underlying mechanisms involved in the ...
• Characterization of the ion transport responses to ADH in the MDCK-C7 cell line 

  Lahr, Thomas F.; Record, Rae D.; Hoover, Diane K.; Hughes, Cynthia L.; Blazer-Yost, Bonnie (2000-03)

  The Madin-Darby canine kidney (MDCK) cell line expresses many characteristics of the renal collecting duct. The MDCK-C7 subclone forms a high-resistance, hormone-responsive model of the principal cells, which are found in ...
• THE ROLE OF THE PHOSPHOINOSITIDE PATHWAY IN HORMONAL REGULATION OF THE EPITHELIAL SODIUM CHANNEL 

  Blazer-Yost, Bonnie; Nofziger, Charity (2004)

  In summary, insulin and aldosterone stimulate phosphatidylinositol phosphorylation, thus indicating the existence of a regulated protein at or before the PI3-kinase step. Aldosterone induces the synthesis of sgk, a downstream ...
• PPARγ agonists do not directly enhance basal or insulin-stimulated Na+ transport via the epithelial Na+ channel 

  Nofziger, Charity; Chen, Lihong; Shane, Michael Anne; Smith, Chari D.; Brown, Kathleen K.; Blazer-Yost, Bonnie (2005-12)

  Selective agonists of peroxisome proliferator-activated receptor gamma (PPARgamma) are anti-diabetic drugs that enhance cellular responsiveness to insulin. However, in some patients, fluid retention, plasma volume expansion, ...
• Phosphoinositide lipid second messengers: new paradigms for transepithelial signal transduction 

  Blazer-Yost, Bonnie; Nofziger, Charity (Bonnie Blazer-Yost and Charity Nofziger. Phosphoinositide lipid second messengers: new paradigms for transepithelial signal transduction. Pflügers Archiv - European Journal of Physiology. (2005)., 2005-03)

  Multiple forms of phosphatidylinositol are generated by differential phosphorylation of the inositol headgroup. These phosphoinositides, specifically PI(4,5)P2, have been implicated as modulators in a variety of transport ...
• Effect of the mycotoxin, ochratoxin A, on hormone-stimulated ion transport in a cultured cell model of the renal principal cell 

  Blazer-Yost, Bonnie; West, T. Aaron; Stack, Jamie; Peck, Kerrie; Lahr, Thomas F.; Gekle, Michael (2005-04)

  The mycotoxin ochratoxin A (OTA) is a common contaminant of many foodstuffs and, consequently, is present in a large proportion of tested populations of humans and commercial animals. The predominant effects of OTA are ...
• Modulation of basal and peptide hormone-stimulated Na transport by membrane cholesterol content in the A6 epithelial cell line 

  West, Aaron; Blazer-Yost, Bonnie (2005)

  These studies examined the effect of altering plasma membrane cholesterol on basal Na+ flux as well as on the natriferic responses to the peptide hormones, insulin and anti-diuretic hormone (ADH) in the A6 model renal cell ...
• Time-dependent stimulation by aldosterone of blocker-sensitive ENaCs in A6 epithelia 

  Helman, Sandy I.; Liu, Xuehong; Baldwin, Kieron; Blazer-Yost, Bonnie; Els, Willem J. (1998-04)

  To study and define the early time-dependent response (< or = 6 h) of blocker-sensitive epithelial Na+ channels (ENaCs) to stimulation of Na+ transport by aldosterone, we used a new modified method of blocker-induced noise ...
• Phosphatidylinositol 3-kinase activation is required for insulin-stimulated sodium transport in A6 cells 

  Record, Rae D.; Froelich, Larry L.; Vlahos, Chris J.; Blazer-Yost, Bonnie (1998-04)

  Insulin stimulates amiloride-sensitive sodium transport in models of the distal nephron. Here we demonstrate that, in the A6 cell line, this action is mediated by the insulin receptor tyrosine kinase and that activation ...
• Characterization of hormone-stimulated Na+ transport in a high-resistance clone of the MDCK cell line 

  Blazer-Yost, Bonnie; Record, Rae D.; Oberleithner, Hans (1996-08)

  The Madin-Darby canine kidney (MDCK) cell line forms an epithelial monolayer which expresses many of the morphological and functional properties of the renal collecting duct. The C7 subclone of the parent line forms an ...

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