Browsing Department of Biomedical Engineering by Title
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- Browsing Department of Biomedical Engineering by Title
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Browsing Department of Biomedical Engineering by Title
Now showing items 1-20 of 156
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(PLOS, 2016)Aims: The 3D geometry of individual vascular smooth muscle cells (VSMCs), which are essential for understanding the mechanical function of blood vessels, are currently not available. This paper introduces a new 3D segmentation ...
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6'-Methoxy Raloxifene-analog enhances mouse bone properties with reduced estrogen receptor binding (Elsevier, 2020-01-17)Raloxifene (RAL) is an FDA-approved drug used to treat osteoporosis in postmenopausal women. RAL suppresses bone loss primarily through its role as a selective estrogen receptor modulator (SERM). This hormonal estrogen ...
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(Wiley, 2015-09-01)Intramuscular electrodes developed over the past 80 years can record the concurrent activity of only a few motor units active during a muscle contraction. We designed, produced and tested a novel multi-channel intramuscular ...
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(American Physiological Society (APS), 2014-09-15)Sex differences in baroreflex (BRx) function are well documented. Hormones likely contribute to this dimorphism, but many functional aspects remain unresolved. Our lab has been investigating a subset of vagal sensory neurons ...
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(2012-01)Scanning probe microscopy (SPM) has been in use for 30 years, and the form of SPM known as atomic force microscopy (AFM) has been around for 25 of those years. AFM has been used to produce high resolution images of a variety ...
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(Nature Publishing Group, 2018-04-03)Bone is a frequent site of metastasis from breast cancer. To understand the potential role of osteocytes in bone metastasis, we investigated tumor-osteocyte interactions using two cell lines derived from the MDA-MB-231 ...
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(American Physiological Society (APS), 2013-12-01)The microstructural deformation-mechanical loading relation of the blood vessel wall is essential for understanding the overall mechanical behavior of vascular tissue in health and disease. We employed simultaneous mechanical ...
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(ASEE, 2020-06)Introduction: The undergraduate biomedical engineering (BME) curriculum should prepare students to confidently approach complex problems, as graduates will enter the workforce in an environment of rising healthcare costs, ...
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(ASEE, 2018)Funded by a National Science Foundation S-STEM grant, the CLEAR Scholars in Engineering program provides financial support, mentoring, and leadership and career development to undergraduate students with demonstrated ...
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(2014)Raloxifene is an FDA approved agent used to treat bone loss and decrease fracture risk. In clinical trials and animal studies, raloxifene reduces fracture risk and improves bone mechanical properties, but the mechanisms ...
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(Springer, 2016-09)Prevention of fracture through improved bone mechanical strength is of great importance given the large number of bone disease-related fractures each year, the decreased quality of life associated with fractures, and the ...
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(Elsevier, 2008)Weight-bearing bone is constantly adapting its structure and function to mechanical environments. Loading through routine exercises stimulates bone formation and prevents bone loss, but unloading through bed rest and cast ...
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(Elsevier, 2019-02-04)The achievement of proper bone mass and architecture, and their maintenance throughout life requires the concerted actions of osteoblasts, the bone forming cells, and osteoclasts, the bone resorbing cells. The differentiation ...
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(Elsevier, 2020-04-15)A therapeutic nanocarrier capable of cell targeting has the potential to reduce off-target effects of otherwise effective drugs. Nanoparticle surface modification can be tailored for specific cells, however multistep surface ...
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(Wiley, 2017-03)Photopolymerization techniques have been widely used to create hydrogels for biomedical applications. Visible light-based photopolymerizations are commonly initiated by type II (i.e., noncleavage-type) photoinitiator in ...
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Comparison of Biomaterial-Dependent and -Independent Bioprinting Methods for Cardiovascular Medicine (Elsevier, 2017)There is an increasing need of human organs for transplantation, of alternatives to animal experimentation, and of better in vitro tissue models for drug testing. All these needs create unique opportunities for the development ...
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(Elsevier, 2015-03)Studies in human and non-human primates have confirmed the compensatory enlargement or positive remodeling (Glagov phenomenon) of coronary vessels in the presence of focal stenosis. To our knowledge, this is the first study ...
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(PLoS, 2014-12-31)Diverse tree structures such as blood vessels, branches of a tree and river basins exist in nature. The constructal law states that the evolution of flow structures in nature has a tendency to facilitate flow. This study ...
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(2014-06)Chronic kidney disease (CKD), which leads tocortical bone loss and increasedporosity,increases therisk of fracture. Animal models have confirmed that these changes compromise whole bone mechanical properties. Estimates ...
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(Springer Nature, 2020-08-20)After the transition to online instruction in response to the COVID-19 pandemic, students in our program lamented the loss of connection to their peers, more so than diminished access to faculty, teaching assistants, or ...
Now showing items 1-20 of 156