• Photoinhibition of Streptococcus mutans Biofilm-Induced Lesions in Human Dentin by Violet-Blue Light 

  Felix Gomez, Grace Gomez; Lippert, Frank; Ando, Masatoshi; Zandona, Andrea F.; Andrea F., George J.; Gregory, Richard L. (MDPI, 2019-12-11)

  This in vitro study determined the effectiveness of violet-blue light on Streptococcus mutans (UA159) biofilm induced dentinal lesions. Biofilm was formed on human dentin specimens in a 96-well microtiter plate and incubated ...
• C-Mpl Is Expressed on Osteoblasts and Osteoclasts and Is Important in Regulating Skeletal Homeostasis 

  Meijome, Tomas E.; Baughman, Jenna T.; Hooker, R. Adam; Cheng, Ying-Hua; Ciovacco, Wendy A.; Balamohan, Sanjeev M.; Srinivasan, Trishya L.; Chitteti, Brahmananda R.; Eleniste, Pierre P.; Horowitz, Mark C.; Srour, Edward F.; Bruzzaniti, Angela; Fuchs, Robyn K.; Kacena, Melissa A. (Wiley, 2016-04)

  C-Mpl is the receptor for thrombopoietin (TPO), the main megakaryocyte (MK) growth factor, and c-Mpl is believed to be expressed on cells of the hematopoietic lineage. As MKs have been shown to enhance bone formation, it ...
• Influence of cavosurface angle on the stress concentration and gaps formation in class V resin composite restorations 

  Correia, Ayla Macyelle de Oliveira; Pereira, Victoria Elisa Maciel; Bresciani, Eduardo; Platt, Jeffrey A.; Borges, Alexandre Luiz Souto; Caneppele, Taciana Marco Ferraz (Elsevier, 2019-09)

  The study aimed to evaluate the influence of cavosurface angle on stress concentration and gap formation in class V restorations. Cylindrical cavities 3 mm in diameter were prepared in forty-five bovine incisors, changing ...
• Pyk2 deficiency potentiates osteoblast differentiation and mineralizing activity in response to estrogen or raloxifene 

  Posritong, Sumana; Hong, Jung Min; Eleniste, Pierre P.; McIntyre, Patrick W.; Wu, Jennifer L.; Himes, Evan R.; Patel, Vruti; Kacena, Melissa A.; Bruzzaniti, Angela (Elsevier, 2018-10-15)

  Bone remodeling is controlled by the actions of bone-degrading osteoclasts and bone-forming osteoblasts (OBs). Aging and loss of estrogen after menopause affects bone mass and quality. Estrogen therapy, including selective ...
• A Pyk2 Inhibitor Incorporated into a PEGDA-Gelatin Hydrogel Promotes Osteoblast Activity and Mineral Deposition 

  Posritong, Sumana; Chavez, Regina Flores; Chu, Tien-Min Gabriel; Bruzzaniti, Angela (IOP, 2019-03)

  Pyk2 is a non-receptor tyrosine kinase that belongs to the family of focal adhesion kinases. Studies from our laboratory and others demonstrated that mice lacking the Pyk2 gene (Ptk2B) have high bone mass, which was due ...
• Systemic Dental Pulp Stem Cell Secretome Therapy in a Mouse Model of Amyotrophic Lateral Sclerosis 

  Wang, Junmei; Zuzzio, Kirstin; Walker, Chandler L. (MDPI, 2019-07-14)

  Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron (MN) disease with no cure. Accumulating evidence indicates ALS involves a complex interaction between central glia and the peripheral immune response and ...
• Adipose-derived stem cell conditioned medium for the treatment of amyotrophic lateral sclerosis: pre-clinical evidence and potential for clinical application 

  Walker, Chandler L. (Medknow Publications, 2019-09)
• Impact of Continuing Education on Clinicians' Self- Reported Knowledge of Tobacco Dependence and Tobacco Control Interventions 

  Romito, Laura M.; Coan, Lorinda (JScholar, 2018-10-20)

  Purpose: To assess a tobacco cessation continuing education (CE) program for Indiana dental and medical providers. Methods: A 26-item immediate post-CE survey and a 19-item 3-month follow-up survey assessed changes in ...
• Aging negatively impacts the ability of megakaryocytes to stimulate osteoblast proliferation and bone mass 

  Maupin, Kevin A.; Himes, Evan R.; Plett, Artur P.; Chua, Hui Lin; Singh, Pratibha; Ghosh, Joydeep; Mohamad, Safa F.; Abeysekera, Irushi; Fisher, Alexa; Sampson, Carol; Hong, Jung-Min; Childress, Paul; Alvarez, Marta; Srour, Edward F.; Bruzzaniti, Angela; Pelus, Louis M.; Orschell, Christie M.; Kacena, Melissa A. (Elsevier, 2019)

  Osteoblast number and activity decreases with aging, contributing to the age-associated decline of bone mass, but the mechanisms underlying changes in osteoblast activity are not well understood. Here, we show that the ...
• Sh3bp2 Gain-Of-Function Mutation Ameliorates Lupus Phenotypes in B6.MRL-Faslpr Mice 

  Nagasu, Akiko; Mukai, Tomoyuki; Iseki, Masanori; Kawahara, Kyoko; Tsuji, Shoko; Nagasu, Hajime; Ueki, Yasuyoshi; Ishihara, Katsuhiko; Kashihara, Naoki; Morita, Yoshitaka (MDPI, 2019-04-30)

  SH3 domain-binding protein 2 (SH3BP2) is an adaptor protein that is predominantly expressed in immune cells, and it regulates intracellular signaling. We had previously reported that a gain-of-function mutation in SH3BP2 ...
• MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production 

  Delgado-Calle, Jesus; Hancock, Benjamin; Likine, Elive F.; Sato, Amy Y.; McAndrews, Kevin; Sanudo, Carolina; Bruzzaniti, Angela; Riancho, Jose A.; Tonra, James R.; Bellido, Teresita (Federation of American Societies for Experimental Biology, 2018-05)

  Parathyroid hormone (PTH) affects the skeleton by acting on osteocytes (Ots) in bone through yet unclear mechanisms. We report that matrix metalloproteinase 14 (MMP14) expression/activity are increased in bones from mice ...
• Doxycycline-loaded nanotube-modified adhesives inhibit MMP in a dose-dependent fashion 

  Palasuk, Jadesada; Windsor, L. Jack; Platt, Jeffrey A.; Lvov, Yuri; Geraldeli, Saulo; Bottino, Marco C. (Springer Nature, 2018-04)

  OBJECTIVES: This article evaluated the drug loading, release kinetics, and matrix metalloproteinase (MMP) inhibition of doxycycline (DOX) released from DOX-loaded nanotube-modified adhesives. DOX was chosen as the model ...
• Clindamycin-modified Triple Antibiotic Nanofibers: A Stain-free Antimicrobial Intracanal Drug Delivery System 

  Karczewski, Ashley; Feitosa, Sabrina A.; Hamer, Ethan I.; Pankajakshan, Divya; Gregory, Richard L.; Spolnik, Kenneth J.; Bottino, Marco C. (Elsevier, 2018-01)

  INTRODUCTION: A biocompatible strategy to promote bacterial eradication within the root canal system after pulpal necrosis of immature permanent teeth is critical to the success of regenerative endodontic procedures. ...
• The Radiopacity and Antimicrobial Properties of Different Radiopaque Double Antibiotic Pastes Used in Regenerative Endodontics 

  Verma, Rohan; Fischer, Benjamin I.; Gregory, Richard L.; Yassen, Ghaeth H. (Elsevier, 2018-09)

  Introduction We evaluated the radiopacity and antibacterial properties of various concentrations of double antibiotic paste (DAP) containing barium sulfate (BaSO4) or zirconium oxide (ZrO2) radiopaque agents. Methods The ...
• Tetracycline-incorporated polymer nanofibers as a potential dental implant surface modifier 

  Bottino, Marco C.; Münchow, Eliseau A.; Albuquerque, Maria T.P.; Kamocki, Krzysztof; Shahi, Rana; Gregory, Richard L.; Chu, Tien-Min G.; Pankajakshan, Divya (Wiley, 2017-10)

  This study investigated the antimicrobial and osteogenic properties of titanium (Ti) disks superficially modified with tetracycline (TCH)-incorporated polymer nanofibers. The experiments were carried out in two phases. The ...
• Advanced Scaffolds for Dental Pulp and Periodontal Regeneration 

  Bottino, Marco C.; Pankajakshan, Divya; Nör, Jacques E. (Elsevier, 2017-10)

  No current therapy promotes root canal disinfection and regeneration of the pulp-dentin complex in cases of pulp necrosis. Antibiotic pastes used to eradicate canal infection negatively affect stem cell survival. ...
• Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype 

  Olivos III, David J.; Alvarez, Marta; Cheng, Ying-Hua; Hooker, R. Adam; Ciovacco, Wendy A.; Bethel, Monique; McGough, Haley; Yim, Christopher; Chitteti, Brahmananda R.; Eleniste, Pierre P.; Horowitz, Mark C.; Srour, Edward F.; Bruzzaniti, Angela; Fuchs, Robyn K.; Kacena, Melissa A. (Wiley, 2017-08)

  The Lnk adapter protein negatively regulates the signaling of thrombopoietin (TPO), the main megakaryocyte (MK) growth factor. Lnk-deficient (-/-) mice have increased TPO signaling and increased MK number. Interestingly, ...
• Recent Advances in Adhesive Bonding - The Role of Biomolecules, Nanocompounds, and Bonding Strategies in Enhancing Resin Bonding to Dental Substrates 

  Münchow, Eliseu A.; Bottino, Marco C. (Springer Nature, 2017-09)

  Purpose of review: To present an overview on the main agents (i.e., biomolecules and nanocompounds) and/or strategies currently available to amplify or stabilize resin-dentin bonding. Recent findings: According to ...
• Antimicrobial Efficacy of Triple Antibiotic-Eluting Polymer Nanofibers against Multispecies Biofilm 

  Albuquerque, Maria T.P.; Nagata, Juliana; Bottino, Marco C. (Elsevier, 2017-09)

  The elimination of microbial flora in cases of immature permanent teeth with necrotic pulp is both key and a challenging goal for the long-term success of regenerative therapy. Recent research has focused on the development ...
• Novel bioactive tetracycline-containing electrospun polymer fibers as a potential antibacterial dental implant coating 

  Shahi, R. G.; Albuquerque, M. T. P.; Münchow, E. A.; Blanchard, S. B.; Gregory, R. L.; Bottino, M. C. (SpringerLink, 2017-07)

  The purpose of this investigation was to determine the ability of tetracycline-containing fibers to inhibit biofilm formation of peri-implantitis-associated pathogens [i.e., Porphyromonas gingivalis (Pg), Fusobacterium ...

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