• Adipose-derived stem cell conditioned medium for the treatment of amyotrophic lateral sclerosis: pre-clinical evidence and potential for clinical application 

  Walker, Chandler L. (Medknow Publications, 2019-09)
• Impact of Continuing Education on Clinicians' Self- Reported Knowledge of Tobacco Dependence and Tobacco Control Interventions 

  Romito, Laura M.; Coan, Lorinda (JScholar, 2018-10-20)

  Purpose: To assess a tobacco cessation continuing education (CE) program for Indiana dental and medical providers. Methods: A 26-item immediate post-CE survey and a 19-item 3-month follow-up survey assessed changes in ...
• Sh3bp2 Gain-Of-Function Mutation Ameliorates Lupus Phenotypes in B6.MRL-Faslpr Mice 

  Nagasu, Akiko; Mukai, Tomoyuki; Iseki, Masanori; Kawahara, Kyoko; Tsuji, Shoko; Nagasu, Hajime; Ueki, Yasuyoshi; Ishihara, Katsuhiko; Kashihara, Naoki; Morita, Yoshitaka (MDPI, 2019-04-30)

  SH3 domain-binding protein 2 (SH3BP2) is an adaptor protein that is predominantly expressed in immune cells, and it regulates intracellular signaling. We had previously reported that a gain-of-function mutation in SH3BP2 ...
• Doxycycline-loaded nanotube-modified adhesives inhibit MMP in a dose-dependent fashion 

  Palasuk, Jadesada; Windsor, L. Jack; Platt, Jeffrey A.; Lvov, Yuri; Geraldeli, Saulo; Bottino, Marco C. (Springer Nature, 2018-04)

  OBJECTIVES: This article evaluated the drug loading, release kinetics, and matrix metalloproteinase (MMP) inhibition of doxycycline (DOX) released from DOX-loaded nanotube-modified adhesives. DOX was chosen as the model ...
• Clindamycin-modified Triple Antibiotic Nanofibers: A Stain-free Antimicrobial Intracanal Drug Delivery System 

  Karczewski, Ashley; Feitosa, Sabrina A.; Hamer, Ethan I.; Pankajakshan, Divya; Gregory, Richard L.; Spolnik, Kenneth J.; Bottino, Marco C. (Elsevier, 2018-01)

  INTRODUCTION: A biocompatible strategy to promote bacterial eradication within the root canal system after pulpal necrosis of immature permanent teeth is critical to the success of regenerative endodontic procedures. ...
• The Radiopacity and Antimicrobial Properties of Different Radiopaque Double Antibiotic Pastes Used in Regenerative Endodontics 

  Verma, Rohan; Fischer, Benjamin I.; Gregory, Richard L.; Yassen, Ghaeth H. (Elsevier, 2018-09)

  Introduction We evaluated the radiopacity and antibacterial properties of various concentrations of double antibiotic paste (DAP) containing barium sulfate (BaSO4) or zirconium oxide (ZrO2) radiopaque agents. Methods The ...
• Tetracycline-incorporated polymer nanofibers as a potential dental implant surface modifier 

  Bottino, Marco C.; Münchow, Eliseau A.; Albuquerque, Maria T.P.; Kamocki, Krzysztof; Shahi, Rana; Gregory, Richard L.; Chu, Tien-Min G.; Pankajakshan, Divya (Wiley, 2017-10)

  This study investigated the antimicrobial and osteogenic properties of titanium (Ti) disks superficially modified with tetracycline (TCH)-incorporated polymer nanofibers. The experiments were carried out in two phases. The ...
• Advanced Scaffolds for Dental Pulp and Periodontal Regeneration 

  Bottino, Marco C.; Pankajakshan, Divya; Nör, Jacques E. (Elsevier, 2017-10)

  No current therapy promotes root canal disinfection and regeneration of the pulp-dentin complex in cases of pulp necrosis. Antibiotic pastes used to eradicate canal infection negatively affect stem cell survival. ...
• Recent Advances in Adhesive Bonding - The Role of Biomolecules, Nanocompounds, and Bonding Strategies in Enhancing Resin Bonding to Dental Substrates 

  Münchow, Eliseu A.; Bottino, Marco C. (Springer Nature, 2017-09)

  Purpose of review: To present an overview on the main agents (i.e., biomolecules and nanocompounds) and/or strategies currently available to amplify or stabilize resin-dentin bonding. Recent findings: According to ...
• Antimicrobial Efficacy of Triple Antibiotic-Eluting Polymer Nanofibers against Multispecies Biofilm 

  Albuquerque, Maria T.P.; Nagata, Juliana; Bottino, Marco C. (Elsevier, 2017-09)

  The elimination of microbial flora in cases of immature permanent teeth with necrotic pulp is both key and a challenging goal for the long-term success of regenerative therapy. Recent research has focused on the development ...
• Novel bioactive tetracycline-containing electrospun polymer fibers as a potential antibacterial dental implant coating 

  Shahi, R. G.; Albuquerque, M. T. P.; Münchow, E. A.; Blanchard, S. B.; Gregory, R. L.; Bottino, M. C. (SpringerLink, 2017-07)

  The purpose of this investigation was to determine the ability of tetracycline-containing fibers to inhibit biofilm formation of peri-implantitis-associated pathogens [i.e., Porphyromonas gingivalis (Pg), Fusobacterium ...
• Carboxyl-terminal modulator protein regulates Akt signaling during skeletal muscle atrophy in vitro and a mouse model of amyotrophic lateral sclerosis 

  Wang, Junmei; Fry, Colin M. E.; Walker, Chandler L. (Springer Nature, 2019-03-08)

  Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease involving motor neuron death, paralysis and, ultimately, respiratory failure. Motor neuron dysfunction leads to target skeletal muscle atrophy ...
• Effect of phototherapy on the metabolism of Streptococcus mutans biofilm based on a colorimetric tetrazolium assay 

  Gomez, Grace F.; Huang, Ruijie; Eckert, George; Gregory, Richard L. (JST, 2018-06)

  The aim of this in vitro study was to determine the effect of violet-blue light on the metabolic activity of early Streptococcus mutans biofilm, reincubated at 0, 2, and 6 h after 5 min of violet-blue light treatment. S. ...
• Use of Internet for General and Dental Health along Acculturation Features in a Sample of Mexican Americans 

  Aguirre, Odette; Mariño, Rodrigo; Medina-Solís, Carlo; Maupomé, Gerardo (International Society on Hypertension in Blacks, 2017-12-07)

  The objectives of this study were to explore self-reported Internet and electronic platforms used to search for and store medical and dental information among people of Mexican origin. A sample of adults self-identified ...
• Cohousing Male Mice with and without Segmental Bone Defects 

  Rytlewski, Jeffrey D; Childress, Paul J; Scofield, David C; Khan, Faisal; Alvarez, Marta B; Tucker, Aamir T; Harris, Jonathan S; Peveler, Jessica L; Hickman, Debra L; Chu, Tien-Min G; Kacena, Melissa A (American Association for Laboratory Animal Science, 2018-04)

  Spaceflight results in bone loss like that associated with osteoporosis or decreased weight-bearing (for example, high-energy trauma such as explosive injuries and automobile accidents). Thus, the unique spaceflight ...
• Enhancement of osteoblast activity on nanostructured NiTi/hydroxyapatite coatings on additive manufactured NiTi metal implants by nanosecond pulsed laser sintering 

  Deng, Biwei; Bruzzaniti, Angela; Cheng, Gary J. (Dove Press, 2018)

  Background: The osteoinductive behaviors of nitinol (NiTi)-based metal implants for bone regeneration are largely dependent on their surface composition and topology. Continuous-mode laser sintering often results in complete ...
• A fast-degrading thiol–acrylate based hydrogel for cranial regeneration 

  Emmakah, Arbi M.; Arman, Hussain E.; Bragg, John Campbell; Greene, T.; Alvarez, Marta B.; Childress, Paul J.; Goebel, William S.; Kacena, Melissa A.; Lin, Chien-Chi; Chu, Tien-Min Gabriel (IOP, 2017-04)

  Successful regeneration of the cranium in patients suffering from cranial bone defects is an integral step to restore craniofacial function. However, restoration of craniofacial structure has been challenging due to its ...
• Adipose-derived stem cell conditioned medium impacts asymptomatic peripheral neuromuscular denervation in the mutant superoxide dismutase (G93A) transgenic mouse model of amyotrophic lateral sclerosis 

  Walker, Chandler L.; Meadows, Rena M.; Merfeld-Clauss, Stephanie; Du, Yansheng; March, Keith L.; Jones, Kathryn J. (IOS, 2018-09)

  Background:Amyotrophic lateral sclerosis (ALS) is devastating, leading to paralysis and death. Disease onset begins pre-symptomatically through spinal motor neuron (MN) axon die-back from musculature at ∼47 days of age in ...
• The Impact of Nicotine and Cigarette Smoke Condensate on Metabolic Activity and Biofilm Formation of Candida albicans on Acrylic Denture Material 

  Alzayer, Yasmin Mohammed; Gomez, Grace F.; Eckert, George J.; Levon, John A.; Gregory, Richard L. (Wiley, 2018)

  Purpose Smokers have increased denture stomatitis caused primarily by Candida albicans. The primary aim of this study was to demonstrate the impact of a wide range of nicotine and cigarette smoke condensate (CSC) ...
• Oral Sciences PhD Program Enrollment, Graduates, and Placement: 1994 to 2016 

  Herzog, C. R.; Berzins, D. W.; DenBesten, P.; Gregory, Richard L.; Hargreaves, K. M.; Messer, R. L. W.; Mina, M.; Mooney, M. P.; Paine, M. L.; Phillips, C.; Presland, R. B.; Quivey, R. G.; Scannapieco, F. A.; Sheridan, J. F.; Svoboda, K. K. H.; Trackman, P. C.; Walker, M. P.; Walker, S. G.; Wang, C. Y.; Hu, J. C. C. (Sage, 2018-05)

  For decades, dental schools in the United States have endured a significant faculty shortage. Studies have determined that the top 2 sources of dental faculty are advanced education programs and private practice. Those who ...

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