Browsing Open Access Policy Articles by Title

Browsing Open Access Policy Articles by Title

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  • Safa, A. R. (Morion, 2012-10)
    Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is a master anti-apoptotic regulator and resistance factor that suppresses tumor necrosis factor-α (TNF-α), Fas-L, and TNF-related apoptosis-inducing ...
  • Meijome, Tomas E.; Baughman, Jenna T.; Hooker, R. Adam; Cheng, Ying-Hua; Ciovacco, Wendy A.; Balamohan, Sanjeev M.; Srinivasan, Trishya L.; Chitteti, Brahmananda R.; Eleniste, Pierre P.; Horowitz, Mark C.; Srour, Edward F.; Bruzzaniti, Angela; Fuchs, Robyn K.; Kacena, Melissa A. (Wiley, 2016-04)
    C-Mpl is the receptor for thrombopoietin (TPO), the main megakaryocyte (MK) growth factor, and c-Mpl is believed to be expressed on cells of the hematopoietic lineage. As MKs have been shown to enhance bone formation, it ...
  • Zhou, Zhijun; Xia, Guanggai; Xiang, Zhen; Liu, Mingyang; Wei, Zhewei; Yan, Jie; Chen, Wei; Zhu, Jintao; Awasthi, Niranjan; Sun, Xiaotian; Fung, Kar-Ming; He, Yulong; Li, Min; Zhang, Changhua (AACR, 2019-06)
    Purpose: C-X-C chemokine receptor type 2 (CXCR2) is a key regulator that drives immune suppression and inflammation in tumor microenvironment. CXCR2-targeted therapy has shown promising results in several solid tumors. ...
  • Collins, Cailin; Wang, Jingya; Miao, Hongzhi; Bronstein, Joel; Nawer, Humaira; Xu, Tao; Figueroa, Maria; Muntean, Andrew G.; Hess, Jay L. (PNAS, 2014-07-08)
    Homeobox A9 (HOXA9) is a homeodomain-containing transcription factor that plays a key role in hematopoietic stem cell expansion and is commonly deregulated in human acute leukemias. A variety of upstream genetic alterations ...
  • Pellman, Jessica J.; Hamilton, James; Brustovetsky, Tatiana; Brustovetsky, Nickolay (Wiley, 2015-08)
    We investigated Ca(2+) handling in isolated brain synaptic and non-synaptic mitochondria and in cultured striatal neurons from the YAC128 mouse model of Huntington's disease. Both synaptic and non-synaptic mitochondria ...
  • Andrews, Michelle; Huizinga, David H.; Crowell, Dring N. (BMC, 2010-06-18)
    Background Protein prenylation is a common post-translational modification in metazoans, protozoans, fungi, and plants. This modification, which mediates protein-membrane and protein-protein interactions, is characterized ...
  • Pin, Fabrizio; Barreto, Rafael; Couch, Marion E.; Bonetto, Andrea; O'Connell, Thomas M. (Wiley, 2019-01-24)
    Background Cancer cachexia is a metabolic disorder involving perturbed energy balance and altered mitochondrial function. Chemotherapy is a primary treatment option for many types of cancer, but there is substantial evidence ...
  • Liu, Qin; Marrs, James A.; Londraville, Richard L.; Wilson, Amy L. (Springer, 2008-10)
    Cadherin cell adhesion molecules play crucial roles in vertebrate development. Most studies have focused on examining the functions of classical type I cadherins (e.g., cadherin-2) in the development of vertebrates. Little ...
  • Katner, Simon N.; Bredhold, Kristin E.; Steagall, Kevin B., III; Bell, Richard L.; Neal-Beliveau, Bethany S.; Cheong, Mi C.; Engleman, Eric A. (Elsevier, 2019-06)
    Alcohol use disorders (AUDs) cause serious problems in society and few effective treatments are available. Caenorhabditis elegans (C. elegans) is an excellent invertebrate model to study the neurobiological basis of human ...
  • Engleman, Eric A.; Katner, Simon N.; Neal-Beliveau, Bethany S. (Elsevier, 2016)
    Drug addiction takes a massive toll on society. Novel animal models are needed to test new treatments and understand the basic mechanisms underlying addiction. Rodent models have identified the neurocircuitry involved in ...
  • Engleman, Eric A.; Steagall II, Kevin B.; Bredhold, Kristin E.; Breach, Michaela; Kline, Hannah L.; Bell, Richard L.; Katner, Simon N.; Neal-Beliveau, Bethany S. (Frontiers, 2018-08-30)
    The nematode Caenorhabditis elegans (C. elegans) is a popular invertebrate model organism to study neurobiological disease states. This is due in part to the intricate mapping of all neurons and synapses of the entire ...
  • Franklin, Kelle M.; Hauser, Sheketha R.; Bell, Richard L.; Engleman, Eric A. (OMICS, 2013-08)
    Alcohol use disorders are pervasive in society and their impact affects quality of life, morbidity and mortality, as well as individual productivity. Alcohol has detrimental effects on an individual’s physiology and nervous ...
  • Bitar, Abbas; Mastouri, Ronald; Kreutz, Rolf P. (Public Library of Science, 2015)
    BACKGROUND: Current guidelines recommend that caffeinated products should be avoided for at least 12 hours prior to regadenoson administration. We intended to examine the effect of caffeine consumption and of timing of ...
  • Wu, Shaowei; Han, Jiali; Song, Fengju; Cho, Eunyoung; Gao, Xiang; Hunter, David J.; Qureshi, Abrar A. (Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins, 2015-11)
    BACKGROUND: Caffeine has been shown to prevent ultraviolet radiation-induced carcinogenesis and to inhibit growth of melanoma cells in experimental studies. We evaluated the association among caffeine intake, coffee ...
  • Merrigan, Stephanie L.; Park, Bomina; Ali, Zaheer; Jensen, Lasse D.; Corson, Timothy W.; Kennedy, Breandán N. (Impact Journals, 2020-02-04)
    Aberrant ocular angiogenesis can underpin vision loss in leading causes of blindness, including neovascular age-related macular degeneration and proliferative diabetic retinopathy. Current pharmacological interventions ...
  • Newman, Christopher L.; Tian, Nannan; Hammond, Max A.; Wallace, Joseph M.; Brown, Drew M.; Chen, Neal X.; Moe, Sharon M.; Allen, Matthew R. (Karger, 2016)
    BACKGROUND: Chronic kidney disease (CKD) leads to complex metabolic changes and an increased risk of fracture. Currently, calcitriol is the standard of care as it effectively suppresses parathyroid hormone (PTH) levels ...
  • Moe, Sharon M. (Elsevier, 2017-07)
    Disordered calcium balance and homeostasis are common in patients with chronic kidney disease. Such alterations are commonly associated with abnormal bone remodeling, directly and indirectly. Similarly, positive calcium ...
  • Mehrotra, Purvi; Sturek, Michael; Neyra, Javier A.; Basile, David P. (American Society for Clinical Investigation, 2019-11-01)
    We hypothesized that the store-operated calcium entry (SOCE) channel, Orai1, participates in the activation of Th17 cells and influences renal injury. In rats, following renal ischemia/reperfusion (I/R), there was a rapid ...
  • Santulli, Gaetano; Pagano, Gennaro; Sardu, Celestino; Xie, Wenjun; Reiken, Steven; D'Ascia, Salvatore Luca; Cannone, Michele; Marziliano, Nicola; Trimarco, Bruno; Guise, Theresa A.; Lacampagne, Alain; Marks, Andrew R. (2015-04)
    The type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on the endoplasmic reticulum (ER) of several types of cells, including cardiomyocytes and pancreatic β cells. In cardiomyocytes, RyR2-dependent Ca2+ release ...
  • Kleinguetl, Colin; Williams, James C.; Ibrahim, Samar A.; Daudon, Michel; Bird, Erin T.; El Tayeb, Marawan M. (Mary Ann Liebert, 2017-12-01)
    Background: Calcium tartrate tetrahydrate has been reported as the main mineral in urinary stones in rats that have significant tartrate in their diet, but in humans, there has been only one mention of calcium tartrate ...

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