Browsing Open Access Faculty Articles by Subject "C. elegans"

Browsing Open Access Faculty Articles by Subject "C. elegans"

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  • Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration 
    Taylor, Laura M.; McMillan, Pamela J.; Liachko, Nicole F.; Strovas, Timothy J.; Ghetti, Bernardino; Bird, Thomas D.; Keene, C. Dirk; Kraemer, Brian C. (BioMed Central, 2018-02-06)
    BACKGROUND: Progressive neuron loss in the frontal and temporal lobes of the cerebral cortex typifies frontotemporal lobar degeneration (FTLD). FTLD sub types are classified on the basis of neuronal aggregated protein ...
  • Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality 
    Rangaraju, Sunitha; Solis, Gregory M.; Thompson, Ryan C.; Gomez-Amaro, Rafael L.; Kurian, Leo; Encalada, Sandra E.; Niculescu, Alexander B., III; Salomon, Daniel R.; Petrascheck, Michael (2015-12)
    Longevity mechanisms increase lifespan by counteracting the effects of aging. However, whether longevity mechanisms counteract the effects of aging continually throughout life, or whether they act during specific periods ...

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