About | Contact Us | Send Feedback
University Library

THE EFFECT OF ENDODONTIC REGENERATION MEDICAMENTS ON MECHANICAL PROPERTIES OF RADICULAR DENTIN

Show full item record


Title: THE EFFECT OF ENDODONTIC REGENERATION MEDICAMENTS ON MECHANICAL PROPERTIES OF RADICULAR DENTIN
Author: Yassen, Ghaeth H.
Advisor: Platt, Jeffrey A., 1958- Chair
Chu, Tien-Min Gabriel
Murray, Peter E.
Allen, Matthew R.
Vail, Mychel Macapagal, 1969-
Degree: Ph.D.
Degree Year: 2013
Department: School of Dentistry
Grantor: Indiana University
Permanent Link: http://hdl.handle.net/1805/3226
Abstract: Endodontic regeneration treatment of necrotic immature teeth has gained popularity in recent years. The approach suggests a biological alternative to induce a continuous root development. In this project, three in vitro experiments were conducted to investigate the effect of three medicaments used in endodontic regeneration on mechanical properties and chemical structure of radicular dentin. In the first experiment, we investigated longitudinally the effect of medicaments on the indentation properties of the root canal surface of immature teeth using a novel BioDent reference point indenter. A significant difference in the majority of indentation parameters between all groups was found after one-week and one-month application of medicaments (p<0.0001): triple antibiotic paste (TAP) > double antibiotic paste (DAP) > control > calcium hydroxide [Ca(OH)2]. The four-week exposure of dentin to TAP and DAP caused 43% and 31% increase in total indentation distance outcome, respectively. In the second experiment, we investigated longitudinally the effect of medicaments on the chemical structure of immature radicular dentin by measuring the phosphate/amide I ratios of dentin using Attenuated Total Reflection Fourier Transform Infrared Spectroscopy. Phosphate/amide I ratios were significantly different between the four groups after one week, two weeks and four week application of medicaments (p<0.0001): Ca(OH)2-treated dentin > untreated dentin > DAP-treated dentin > TAP-treated dentin. In the third experiment, we investigated longitudinally the effect of medicaments on root fracture resistance and microhardness of radicular dentin. For the microhardness, the two-way interaction between group and time was significant (p<0.001). TAP and DAP caused a significant and continuous decrease in dentin microhardness after one and three month application, respectively. The three-month intracanal application of Ca(OH)2 significantly increased the microhardness of root dentin. The time factor had a significant effect on fracture resistance (p<0.001). All medicaments caused significant decrease in fracture resistance ranging between 19%-30% after three month application compared to one week application. The three medicaments used in endodontic regeneration caused significant change in the chemical integrity of the superficial radicular dentin and significantly affected the indentation properties of the root canal surface. Furthermore, the three month intracanal application of medicaments significantly reduced the fracture resistance of roots.
Keywords: Endodontic regenration
Triple antibiotic paste
Calcium hydroxide
Mechanical properties
Double antibiotic paste
MeSH Subjects: Endodontics -- methods
Regeneration -- chemistry
Dental Pulp Necrosis -- therapy
Dentin -- drug effects
Calcium Hydroxide -- adverse effects
Anti-Bacterial Agents -- adverse effects
Date: 2013-02-22
Description: Indiana University-Purdue University Indianapolis (IUPUI)
Appears in Collections: Dentistry School Theses and Dissertations


 

Files in this item

View File Dissertation (4.212Mb - application/pdf)

    Items in IUPUIScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Show full item record

Search Repository


Advanced Search

Browse


My Account

Statistics

Information