Harikrishna Nakshatri

 

Recent Submissions

  • Beg, Faheemullah; Wang, Ruizhong; Saeed, Zeb; Devaraj, Srikant; Masoor, Kamalesh; Nakshatri, Harikrishna (BMC, 2017-12-19)
    Objective MiR-486 and miR-146a are cardiomyocyte-enriched microRNAs that control cell survival and self-regulation of inflammation. These microRNAs are released into circulation and are detected in plasma or in circulating ...
  • Welch, Danny R.; Antalis, Toni M.; Burnstein, Kerry; Vona-Davis, Linda; Jensen, Roy A.; Nakshatri, Harikrishna; Riegel, Anna; Spitz, Douglas R.; Watson, Dennis K.; Weiner, George J. (American Association for Cancer Research, 2015-12-15)
    Modern cancer therapy/care involves the integration of basic, clinical, and population-based research professionals using state-of-the-art science to achieve the best possible patient outcomes. A well-integrated team of ...
  • Bhat-Nakshatri, Poornima; Goswami, Chirayu P.; Badve, Sunil; Magnani, Luca; Lupien, Mathieu; Nakshatri, Harikrishna (AACR, 2016-07)
    The PI3K pathway is activated in approximately 70% of breast cancers. PIK3CA gene mutations or amplifications that affect the PI3K p110α subunit account for activation of this pathway in 20% to 40% of cases, particularly ...
  • Nakshatri, H.; Appaiah, H. N.; Anjanappa, M.; Gilley, D.; Tanaka, H.; Badve, Sunil; Crooks, P. A.; Mathews, W.; Sweeney, C.; Bhat-Nakshatri, P. (Nature Publishing Group, 2015-01-22)
    The transcription factor nuclear factor-kappaB (NF-κB) is constitutively active in several cancers and is a target of therapeutic development. We recently developed dimethylaminoparthenolide (DMAPT), a clinical grade ...
  • Burnett, Riesa M.; Craven, Kelly E.; Krishnamurthy, Purna; Goswami, Chirayu P.; Badve, Sunil; Crooks, Peter; Mathews, William P.; Bhat-Nakshatri, Poornima; Nakshatri, Harikrishna (Impact Journals, LLC, 2015-05-20)
    Breast cancer metastasizes to bone, visceral organs, and/or brain depending on the subtype, which may involve activation of a host organ-specific signaling network in metastatic cells. To test this possibility, we determined ...
  • Finnearty, Courtney; Shajahan-Haq, Ayesha; Nakshatri, Hari; Sandusky, George E. (Office of the Vice Chancellor for Research, 2016-04-08)
    Approximately 1 out of 8 women in the United States will develop invasive breast cancer over the course of their lifetime. Breast cancer has a greater potential of being cured if diagnosed in the earlier phases. We evaluated ...
  • Goswami, Chirayu Pankaj; Nakshatri, Harikrishna (Springer (Biomed Central Ltd.), 2014)
    BACKGROUND: We recently published PROGgene, a tool that can be used to study prognostic implications of genes in various cancers. The first version of the tool had several areas for improvement. In this paper we present ...
  • Chen, Daohong; Goswami, Chirayu P; Burnett, Riesa M; Anjanappa, Manjushree; Bhat-Nakshatri, Poornima; Muller, William; Nakshatri, Harikrishna (American Association for Cancer Research, 2014-08-15)
    Circulating microRNAs are emerging as important biomarkers of various diseases including cancer. Intriguingly, circulating levels of several microRNAs are lower in cancer patients compared with healthy individuals. In this ...
  • Loganathan, Jagadish; Jiang, Jiahua; Smith, Amanda; Jedinak, Andrej; Thyagarajan-Sahu, Anita; Sandusky, George E.; Nakshatri, Harikrishna; Sliva, Daniel (Spandidos, 2014-06)
    Breast cancer metastasis is one of the major reasons for the high morbidity and mortality of breast cancer patients. In spite of surgical interventions, chemotherapy, radiation therapy and targeted therapy, some patients ...
  • Nakshatri, Harikrishna; Anjanappa, Manjushree; Bhat-Nakshatri, Poornima (Nature Publishing Group, 2015-08-27)
    Recent reports of widespread genetic variation affecting regulation of gene expression raise the possibility of significant inter-individual differences in stem-progenitor-mature cell hierarchy in adult organs. This has ...
  • Sledge Jr., George W.; Badve, Sunil; Bales, Casey; Gill, Erin M.; Gilley, David P.; Goswami, Chirayu; Wells, Clark D.; Ziner, Kim W.; Nakshatri, Harikrishna (Office of the Vice Chancellor for Research, 2012-04-13)
    Abstract The Indiana Center for Breast Cancer Research (ICBCR) was funded under the IUPUI Signature Center Initiative in 2010. Its mission is to address the full range of prevention, early detection, and treatment of ...
  • Nakshatri, Harikrishna; Sledge, George W., Jr.; Badve, Sunil; Bales, Casey; Gilley, David P.; Goswami, Chirayu; Wells, Clark D.; Guise, Theresa; Ziner, Kim W. (Office of the Vice Chancellor for Research, 2013-04-05)
    The mission of IUPUI breast cancer center is to address prevention, early detection, and treatment of breast cancer through translational projects, supportive cores, and synergistic programs. This poster details our efforts ...
  • Nakshatri, Harikrishna; Gilley, David P.; Wells, Clark D.; Nephew, Kenneth; Radovich, Milan; Guise, Theresa; Bales, Casey; Perkins, Susan; Badve, Sunil; Vladislav, Ioan Tudor; Miller, Kathy (Office of the Vice Chancellor for Research, 2014-04-11)
    The mission of IUPUI breast cancer signature center is to address prevention, early detection, and treatment of breast cancer through translational projects, supportive cores, and synergistic programs. This poster details ...