• The role of mig6 in pancreas development and diabetes 

  El, Kimberley Mei Ling (2018-08-14)

  Diabetes occurs as a result of the failure of pancreatic insulin-producing β cells. The preservation or renewal of β cells is a strategy that can prevent diabetes by targeted manipulation of mechanisms associated with ...
• DOC2B enhancement of beta cell function and survival 

  Aslamy, Arianne (2018-03-08)

  Diabetes mellitus is a complex metabolic disease that currently affects an estimated 422 million people worldwide, with incidence rates rising annually. Type 1 diabetes (T1D) accounts for 5-10% of these cases. Its complications ...
• Damaging effects of cigarette smoke on organs and stem/progenitor cells and the restorative potential of cell therapy 

  Barwinska, Daria (2017-06-23)

  Cigarette smoking (CS) continues to be a significant modifiable factor contributing to a variety of diseases including cardiovascular, pulmonary and renal pathologies. It was suggested that smoking have detrimental effect ...
• Endoplasmic reticulum calcium dynamics and insulin secretion in pancreatic β cells 

  Yamamoto, Wataru (2017-08-15)

  Under normal conditions, ER Ca2+ levels are estimated to be at least three orders of magnitude higher than intracellular Ca2+. This steep Ca2+ concentration gradient is maintained by the balance of Ca2+ uptake into the ER ...
• Mitochondrial protein acetylation and left ventricular function in a model of hypertrophic cardiomyopathy and heart failure 

  Stram, Amanda R. (2017-05-23)

  Rationale: The childhood heart disease of Friedreich’s Ataxia (FRDA) is characterized by hypertrophy and failure. It is caused by loss of frataxin (FXN), a mitochondrial protein involved in energy homeostasis. FRDA ...
• Mesenchyme homeobox 2 regulation of fetal endothelial progenitor cell function 

  Gohn, Cassandra Rebekah (2017-06-19)

  In the United States, 10% of pregnancies are complicated by diabetes mellitus (DM). Intrauterine DM exposure can have long-lasting implications for the fetus, including cardiovascular morbidity. Previously, we showed ...
• Kinetic vasculogenic analyses of endothelial colony forming cells exposed to intrauterine diabetes 

  Varberg, Kaela Margaret (2017-05-11)

  Vasculogenesis is a complex process by which endothelial stem and progenitor cells undergo de novo vessel formation. Quantitative assessment of vasculogenesis is a central readout of endothelial progenitor cell ...
• Stress-activated MIG6 compromises hepatic metabolism during diet-induced obesity 

  Lutkewitte, Andrew John (2016-07-25)

  Obesity-induced hepatic fat accumulation or nonalcoholic fatty liver disease (NAFLD) is the leading cause of liver disease in the United States. Unfortunately, NALFD patients are at higher risk of cardiovascular disease ...
• A Nutrient Network Regulating Cellular Cholesterol and Glucose Metabolism 

  Pattar, Guruprasad R. (2014)

  Insulin resistance, a hallmark of type 2 diabetes (T2D), is associated with accompanying derangements such as hyperinsulinemia that promote the progression of insulin resistance, yet a mechanism(s) is imperfectly understood. ...
• Regulation of endoplasmic reticulum calcium homeostasis in pancreatic β cells 

  Tong, Xin (2016-06-21)

  Diabetes mellitus is a group of metabolic diseases characterized by disordered insulin secretion from the pancreatic β cell and chronic hyperglycemia. In order to maintain adequate levels of insulin secretion, the β cell ...
• Obesity alters global response to ischemia and GLP-1 agonism 

  Sassoon, Daniel Jay (2016-05-13)

  Glucagon-like peptide 1 (GLP-1) receptor agonists are a class of incretin based therapeutics which aid in blood glucose management in Type II diabetes mellitus (T2DM). Recent studies have demonstrated direct cardiovascular ...
• Coronary artery disease in metabolic syndrome: a role for the sarcoplasmic reticulum Ca2+ ATPase 

  Rodenbeck, Stacey Dineen (2016-05-10)

  Coronary artery disease (CAD) is a leading cause of death among Americans and is fueled by underlying metabolic syndrome (MetS). The prevalence and lethality of CAD necessitates rigorous investigations into its underlying ...
• Coronary perivascular adipose tissue and vascular smooth muscle function: influence of obesity 

  Noblet, Jillian Nicole (2016-03-22)

  Factors released from coronary perivascular adipose tissue (PVAT), which surrounds large coronary arteries, have been implicated in the development of coronary disease. However, the precise contribution of coronary ...
• The roles of pancreatic hormones in regulating pancreas development and beta cell regeneration 

  Ye, Lihua (2015-06-16)

  Diabetes mellitus is a group of related metabolic diseases that share a common pathological mechanism: insufficient insulin signaling. Insulin is a hormone secreted from pancreatic β cells that promotes energy storage and ...
• PDK regulated Warburg effect protects differentiated adipocytes against ROS 

  Roell, William Christopher (2014-10-06)

  Literature has demonstrated the ability of human adipose tissue to generate large amounts of lactate. However, it is not understood why adipose tissue produces lactate, how the production of lactate is regulated, and what ...
• Mechanisms of transcriptional regulation in the maintenance of β cell function 

  Maganti Vijaykumar, Aarthi (2015-05-08)

  The islet β cell is central to the maintenance of glucose homeostasis as the β cell is solely responsible for the synthesis of Insulin. Therefore, better understanding of the molecular mechanisms governing β cell function ...
• Coronary artery disease progression and calcification in metabolic syndrome 

  McKenney, Mikaela Lee (2014)

  For years, the leading killer of Americans has been coronary artery disease (CAD), which has a strong correlation to the U.S. obesity epidemic. Obesity, along with the presence of other risk factors including hyperglycemia, ...
• Novel Roles of p21 in Apoptosis During Beta-Cell Stress in Diabetes 

  Hernández-Carretero, Angelina M. (2014)

  Type 2 diabetes manifests from peripheral insulin resistance and a loss of functional beta cell mass due to decreased beta cell function, survival, and/or proliferation. Beta cell stressors impair each of these factors ...
• Stress-inducible Mig6 promotes pancreatic beta cell destruction in the pathogenesis of diabetes 

  Chen, Yi-Chun (2014-12-08)

  Pancreatic insulin-secreting beta cell failure is central to the development of diabetes. Therapeutic applications targeted at understanding and manipulating beta cell destruction mechanisms should enhance the preservation ...
• Mechanisms of translational regulation in the pancreatic β cell stress response 

  Templin, Andrew Thomas (2014)

  The islet beta cell is unique in its ability to synthesize and secrete insulin for use in the body. A number of factors including proinflammatory cytokines, free fatty acids, and islet amyloid are known to cause beta cell ...

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