• Pancreatic Beta Cell Identity Regulated by the Endoplasmic Reticulum Calcium Sensor Stromal Interaction Molecule 1 

  Sohn, Paul (2021-12)

  Type 2 diabetes mellitus is a chronic disorder characterized by hyperglycemia, insulin resistance, and insufficient insulin secretion from the pancreatic β cells. To maintain adequate levels of insulin secretion, β cells ...
• Neutrophil Diversity in the Pathogenesis of Ischemic Acute Kidney Injury 

  Winfree, Seth (2020-09)

  Acute kidney injury (AKI) affects millions of patients worldwide yet has few treatment options. There is a critical need to identify novel interventions for AKI, especially approaches targeting cell types that are central ...
• The Exploration of an Effective Medical Countermeasure Enhancing Survival and Hematopoietic Recovery and Preventing Immune Insufficiency in Lethally-Irradiated Mice 

  Wu, Tong (2020-08)

  There is an urgent demand for effective medical countermeasures (MCM) in the event of high-dose radiation exposure ranging from nuclear plant disasters to potential nuclear warfare. Victims of lethal-dose radiation exposure ...
• Mechanisms Underlying Cardiovascular Benefits of Sodium Glucose Co-Transporter-2 Inhibitors: Myocardial Substrate or Sodium/Hydrogen Exchanger? 

  Baker, Hana Elisabeth (2020-01)

  Recent clinical outcome studies demonstrate that Sodium glucose cotransporter 2 inhibitors (SGLT2i) significantly reduce major adverse cardiovascular events and heart failure outcomes in subjects with type 2 diabetes ...
• Cellular & Molecular Mechanisms That Contribute to the Early Development of Skeletal Muscle & Systemic Insulin Resistance 

  Grice, Brian A. (2019-10)

  Insulin resistance starts years before type 2 diabetes (T2D) diagnosis, even before recognition of prediabetes. Mice on a high fat diet have a similar early onset of insulin resistance, yet the mechanism remains unknown. ...
• Understanding the Integrated Pathophysiological Role of a Moonlighting Protein in Lung Development 

  Lee, Dong Il (2019-08)

  Sensing, integrating, and relaying signals from the environment through proteins, metabolites, and lipids to the lung are critical for proper development. Moonlighting proteins, such as AIMP1, are a unique subset that ...
• Coronary Smooth Muscle Cell Cytodifferentiation and Intracellular Ca2+ Handling in Coronary Artery Disease 

  Badin, Jill Kimberly (2019-08)

  Metabolic syndrome (MetS) affects 1/3 of all Americans and is the clustering of three or more of the following cardiometabolic risk factors: obesity, hypertension, dyslipidemia, glucose intolerance, and insulin resistance. ...
• Mechanisms of HIV-Nef Induced Endothelial Cell Stress: Implications of HIV-Nef Protein Persistence in Aviremic HIV Patients 

  Chelvanambi, Sarvesh (2019-05)

  HIV-associated cardio-pulmonary vascular pathologies such as coronary artery disease, pulmonary hypertension and emphysema remain a major issue in the HIVinfected population even in the era of antiretroviral therapy ...
• The role of mig6 in pancreas development and diabetes 

  El, Kimberley Mei Ling (2018-08-14)

  Diabetes occurs as a result of the failure of pancreatic insulin-producing β cells. The preservation or renewal of β cells is a strategy that can prevent diabetes by targeted manipulation of mechanisms associated with ...
• DOC2B enhancement of beta cell function and survival 

  Aslamy, Arianne (2018-03-08)

  Diabetes mellitus is a complex metabolic disease that currently affects an estimated 422 million people worldwide, with incidence rates rising annually. Type 1 diabetes (T1D) accounts for 5-10% of these cases. Its complications ...
• Damaging effects of cigarette smoke on organs and stem/progenitor cells and the restorative potential of cell therapy 

  Barwinska, Daria (2017-06-23)

  Cigarette smoking (CS) continues to be a significant modifiable factor contributing to a variety of diseases including cardiovascular, pulmonary and renal pathologies. It was suggested that smoking have detrimental effect ...
• Endoplasmic reticulum calcium dynamics and insulin secretion in pancreatic β cells 

  Yamamoto, Wataru (2017-08-15)

  Under normal conditions, ER Ca2+ levels are estimated to be at least three orders of magnitude higher than intracellular Ca2+. This steep Ca2+ concentration gradient is maintained by the balance of Ca2+ uptake into the ER ...
• Mitochondrial protein acetylation and left ventricular function in a model of hypertrophic cardiomyopathy and heart failure 

  Stram, Amanda R. (2017-05-23)

  Rationale: The childhood heart disease of Friedreich’s Ataxia (FRDA) is characterized by hypertrophy and failure. It is caused by loss of frataxin (FXN), a mitochondrial protein involved in energy homeostasis. FRDA ...
• Mesenchyme homeobox 2 regulation of fetal endothelial progenitor cell function 

  Gohn, Cassandra Rebekah (2017-06-19)

  In the United States, 10% of pregnancies are complicated by diabetes mellitus (DM). Intrauterine DM exposure can have long-lasting implications for the fetus, including cardiovascular morbidity. Previously, we showed ...
• Kinetic vasculogenic analyses of endothelial colony forming cells exposed to intrauterine diabetes 

  Varberg, Kaela Margaret (2017-05-11)

  Vasculogenesis is a complex process by which endothelial stem and progenitor cells undergo de novo vessel formation. Quantitative assessment of vasculogenesis is a central readout of endothelial progenitor cell ...
• Stress-activated MIG6 compromises hepatic metabolism during diet-induced obesity 

  Lutkewitte, Andrew John (2016-07-25)

  Obesity-induced hepatic fat accumulation or nonalcoholic fatty liver disease (NAFLD) is the leading cause of liver disease in the United States. Unfortunately, NALFD patients are at higher risk of cardiovascular disease ...
• A Nutrient Network Regulating Cellular Cholesterol and Glucose Metabolism 

  Pattar, Guruprasad R. (2014)

  Insulin resistance, a hallmark of type 2 diabetes (T2D), is associated with accompanying derangements such as hyperinsulinemia that promote the progression of insulin resistance, yet a mechanism(s) is imperfectly understood. ...
• Regulation of endoplasmic reticulum calcium homeostasis in pancreatic β cells 

  Tong, Xin (2016-06-21)

  Diabetes mellitus is a group of metabolic diseases characterized by disordered insulin secretion from the pancreatic β cell and chronic hyperglycemia. In order to maintain adequate levels of insulin secretion, the β cell ...
• Obesity alters global response to ischemia and GLP-1 agonism 

  Sassoon, Daniel Jay (2016-05-13)

  Glucagon-like peptide 1 (GLP-1) receptor agonists are a class of incretin based therapeutics which aid in blood glucose management in Type II diabetes mellitus (T2DM). Recent studies have demonstrated direct cardiovascular ...
• Coronary artery disease in metabolic syndrome: a role for the sarcoplasmic reticulum Ca2+ ATPase 

  Rodenbeck, Stacey Dineen (2016-05-10)

  Coronary artery disease (CAD) is a leading cause of death among Americans and is fueled by underlying metabolic syndrome (MetS). The prevalence and lethality of CAD necessitates rigorous investigations into its underlying ...

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