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ItemOnline Prenatal Nutrition Education: Helping Pregnant Women Eat Healthfully Using MyPyramid.gov(Elsevier, 2011-02) Shieh, Carol; Carter, AmyThe web-based MyPyramid developed by the U.S. Department of Agriculture is a nutrition education program. Care providers can use the MyPyramid to enhance nutrition information delivery and foster healthy eating behaviors in their patients. Three interactive tools are available in the MyPyramid for pregnant women, including the “MyPyramid plan for Moms,” the “MyPyramid Menu Planner for Moms,” and the “MyPyramid Tracker.” These tools help pregnant women learn about nutritional needs for pregnancy, menu planning, and dietary monitoring. ItemPhysiologically based pharmacokinetic modelling in pregnancy: Model reproducibility and external validation(Wiley, 2021-08) Silva, Larissa L.; Silvola, Rebecca M.; Haas, David M.; Quinney, Sara K.; Medicine, School of MedicineAims Physiologically based pharmacokinetic (PBPK) models have been previously developed for betamethasone and buprenorphine for pregnant women. The goal of this work was to replicate and reassess these models using data from recently completed studies. Methods Betamethasone and buprenorphine PBPK models were developed in Simcyp V19 based on prior publications using V17 and V15. Ability to replicate models was verified by comparing predictions in V19 to those previously published. Once replication was verified, models were reassessed by comparing predictions to observed data from additional studies in pregnant women. Model performance was based upon visual inspection of concentration vs. time profiles, and comparison of pharmacokinetic parameters. Models were deemed reproducible if parameter estimates were within 10% of previously reported values. External validations were considered acceptable if the predicted area under the concentration–time curve (AUC) and peak plasma concentration fell within 2-fold of the observed. Results The betamethasone model was successfully replicated using Simcyp V19, with ratios of reported (V17) to reproduced (V19) peak plasma concentration of 0.98–1.04 and AUC of 0.95–1.07. The model-predicted AUC ratios ranged from 0.98–1.79 compared to external data. The previously published buprenorphine PBPK model was not reproducible, as we predicted intravenous clearance of 70% that reported previously (both in Simcyp V15). Conclusion While high interstudy variability was observed in the newly available clinical data, the PBPK model sufficiently predicted changes in betamethasone exposure across gestation. Model reproducibility and reassessment with external data are important for the advancement of the discipline. PBPK modelling publications should contain sufficient detail and clarity to enable reproducibility. ItemPREGMED: Indiana University Center for Pharmacogenetics and Therapeutics Research in Maternal and Child Health(Office of the Vice Chancellor for Research, 2010-04-09) Haas, D.M.; Denne, S.C.; Flockhart, D.F.; Haneline, L.S.; Renbarger, J.L.Many illnesses occur in pregnant women and children that can significantly impact health. These conditions require drug therapy but the clinical pharmacology and pharmacogenomics of most medications used during pregnancy and childhood are poorly characterized. This compromises the effective and individualized treatment of multiple conditions specific to these populations such as nausea and vomiting of pregnancy, preterm labor, diabetes, and depression in pregnant women and childhood cancers in pediatric patients. Furthermore, drug disposition in these populations is known to be different from that observed in non-pregnant adults. We have developed PREGMED a unique center whose central mission is to improve the pharmacotherapy for women and children using a personalized medicine approach that builds on the strengths of Indiana University in the areas of pharmacogenomics and clinical obstetrics and pediatrics. The center’s multidisciplinary activities focus on developing new paradigms for the treatment of the multiple important conditions that affect pregnant women and children. ItemSome basic facts on combination therapy(Association of Kenya Physicians, 2007) Kokwaro, Gilbert; Association of Kenya Physicians Scientific Conference (11th : Mar. 2007 : Eldoret, Kenya)What are the problems with malaria? • The disease • The drugs • The policies • The finance COMBINATION THERAPY: DEFINITION • CT is the simultaneous use of two or more blood schizonticidal drugs with independent modes of action and different biochemical targets in the parasites • • CTs can be either fixed ratio combinations or multiple-drug therapy, in which components are co-administered in separate tablets or capsules. ItemThe Value of a Learner’s Stance: Lessons Learned from Pregnant and Parenting Women(Office of the Vice Chancellor for Research, 2010-04-09) Humbert, Larry; Roberts, Theresa L.The voices, perspectives, and experiences of pregnant and parenting women are vital sources of information often overlooked or not understood by professionals. By the end of the poster presentation participants will: (1) understand access to maternal and child health services from the perspectives of diverse consumers; (20) utilize patients direct quotes and experiences to identify strategies to enhance the quality of access; and, (3) identify key dimensions influencing patient experiences, including health status and needs, significant others, cultural beliefs, and provider and organizational factors. Twenty-four focus groups were conducted with 143 urban women, ages 14-45, who were primarily Medicaid consumers. Maternal and child health organizations in Marion and Lake Counties providing primary or secondary services recruited African American, Caucasian, and Latina pregnant and parenting women. When possible, groups were stratified by race, ethnicity and age to encourage their engagement. The following five themes on access and quality of participants’ maternal and child health experiences emerged: (1) the primary role that personable and caring health providers and staff played in accessing services; (2) provider recommendations were oftentimes discounted as irrelevant; (3) alternative health practices were motivated by a genuine desire to help themselves or their children; (4) agency practices and policies were sometimes perceived as potentially discriminatory; and , (5) consumers identified unresolved feelings regarding pregnancy. These findings can assist providers to develop genuine relationships and address the unique cultural needs of their patients. Recommended actions include assuming a learner’s stance as a way of developing an increased understanding of patients’ underlying motives, perceptions of alternative health practices of their patients, and identifying the role and impact of their patient’s social network.