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ItemOral Lichen Planus: Clinical Presentation and Management(2002-09) Edwards, Paul C.; Kelsch, Robert ItemGene-enhanced tissue engineering for dental hard tissue regeneration: (I) dentin-pulp and periodontal regeneration(2006-05-15) Edwards, Paul C.; Mason, James M.Gene-based therapies for tissue regeneration involve delivering a specific gene to a target tissue with the goal of changing the phenotype or protein expression profile of the recipient cell; the ultimate goal being to form specific tissues required for regeneration. One of the principal advantages of this approach is that it provides for a sustained delivery of physiologic levels of the growth factor of interest. This manuscript will review the principals of gene-enhanced tissue engineering and the techniques of introducing DNA into cells. Part 2 will review recent advances in gene-based therapies for dental hard tissue regeneration, specifically as it pertains to dentin regeneration/pulp capping and periodontal regeneration. ItemReview of long-term adverse effects associated with the use of chemically-modified animal and nonanimal source hyaluronic acid dermal fillers(2007) Edwards, Paul C.; Fantasia, John E.Abstract: Although only recently introduced, chemically-modified hyaluronic acid dermal fillers have gained widespread acceptance as “rede- fining” dermal fillers in the fields of dermatology and cosmetic facial surgery. Although hyaluronic acid-based dermal fillers have a low overall incidence of long term side effects, occasional adverse outcomes, ranging from chronic lymphoplasmacytic inflammatory reactions to classic foreign body-type granulomatous reactions have been documented. These long-term adverse events are reviewed. ItemContemporary Issues in Head and Neck Pathology and Radiology(2010-03-02) Edwards, Paul C.; Kanjirath, Preetha P.; Saini, Tarnjit; Norton, Neil S. ItemThe prevalence of concha bullosa and nasal septal deviation and their relationship to maxillary sinusitis by volumetric tomography(2010-08-24) Edwards, Paul C.; Smith, Kyle D.; Saini, Tarnjit S.; Norton, Neil S.The objective of this study was to determine the prevalence of concha bullosa and nasal septal deviation and their potential relationships to maxillary sinusitis. 883 CT scans taken at Creighton University School of Dentistry from 2005 to 2008 were retrospectively reviewed for the presence of concha bullosa, nasal septal deviation, and maxillary sinusitis. 67.5% of patients exhibited pneumatization of at least one concha, 19.4% of patients had a deviated septum, and 50.0% had mucosal thickening consistent with maxillary sinusitis. 49.3% of patients who had concha bullosa also had evidence of maxillary sinusitis. Only 19.5% of patients with concha bullosa also had nasal septal deviation, whereas 19.7% of patients with sinusitis also presented with nasal septal deviation. Although concha bullosa is a common occurrence in the nasal cavity, there did not appear to be a statistically significant relationship between the presence of concha bullosa or nasal septal deviation and maxillary sinusitis. Item“Meth Mouth”: Rampant Caries in methamphetamine abusers(2006-03) Edwards, Paul C.; Shaner, John W.; Kimmes, N.; Saini, Tarnjit S.Rampant dental caries is a characteristic finding in methamphetamine abusers. The popularity of methamphetamine, particularly among the gay community where it is linked to the spread of HIV, its ready availability, and rapid spread across the nation have placed methamphetamine use in an epidemic status in many communities unaccustomed to dealing with drug abuse. We present a case of a 25-year-old male “meth” abuser of unknown HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) status to promote recognition by the health care team of the association of rampant dental caries with methamphetamine abuse for appropriate intervention to ensure successful treatment and prevention of disease progression. ItemSinonasal undifferentiated carcinoma of the maxillary sinus(2006) Edwards, Paul C.; Hess, Stephen J.; Saini, TarnjitWe describe the case of a 43-year-old man who was referred to our dental school’s acute care clinic with pain and swelling of presumed dental origin in the left maxillary quadrant. Radiographic examination revealed extensive dental decay and periodontal disease. On questioning, the patient admitted to paresthesia of recent onset. Paresthesia associated with pain or swelling of the jaws is an ominous sign that should alert the clinician to the possibility of an underlying aggressive neoplasm. In this case, biopsy of the lesion confirmed that the patient had a rare malignant tumour of maxillary sinus origin,a sinonasal undifferentiated carcinoma. ItemAssessment of p63 expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and basal cell and canalicular adenomas(2004-05) Edwards, Paul C.; Bhuiya, Tawfiqul; Kelsch, Robert DPurpose The purpose of this study was to determine the extent of p63 immunoreactivity in the malignant salivary gland neoplasms adenoid cystic carcinoma (ACC) and polymorphous low-grade adenocarcinoma (PLGA) and to compare this to the expression of this marker in the benign salivary gland tumors canalicular adenoma and basal cell adenoma. Few studies on the expression of p63 in head and neck salivary gland tumors have been published to date. P63, a selective immunohistochemical marker of basal/stem cells of stratified epithelium and of myoepithelial cells, is a p53 homologue that plays an essential role in both morphogenesis of epidermis and limb development. P63 immunoreactivity has been demonstrated in squamous cell and urothelial carcinomas. It is generally absent in most nonsquamous cell carcinomas. Study design Formalin-fixed paraffin-embedded sections from 49 salivary gland neoplasms, representing 6 canalicular adenomas, 11 basal cell adenomas, 17 PLGA and 15 ACC accessioned from 1989 to 2002 by the Department of Pathology, Long Island Jewish Medical Center, New Hyde Park, NY, were stained with an anti-p63 monoclonal antibody. Results Nuclear p63 reactivity was uniformly positive in PLGA (17/17, 100%). Positive reactivity was also identified in the majority of cases of ACC (13/15, 87%), primarily in the nonluminal myoepithelial-like cells surrounding luminal cells. Canalicular adenoma did not exhibit any p63 immunoreactivity. All basal cell adenomas of parotid origin stained strongly for p63, with staining localized to the peripheral tumor cells situated adjacent to the connective tissue stroma. None of the basal cell adenomas originating in the upper lip stained with p63. In native adjacent salivary gland tissue, p63 reactivity was identified focally in the nuclei of myoepithelial and basal duct cells. Conclusions P63 is strongly expressed in basal cell adenoma of parotid origin, and in ACC and PLGA. Canalicular adenoma did not demonstrate p63 staining, consistent with this tumor's putative luminal ductal cell differentiation. Our results suggest that the neoplastic cells in PLGA may represent either a population of p63-positive epithelial stem/reserve cells similar to the basal cells of stratified epithelium, or modified myoepithelial cells. Given the staining pattern of the tumors examined, p63 does not appear to be an ideal marker for distinguishing between ACC, PLGA, and basal cell adenoma. ItemTwenty-eight-year-old woman with recent onset of painful oral erosions(2010-08) Edwards, Paul C.; Hess, Stephen; Saini, Tarnjit; Norton, Neil ItemConsidering That This Is Such A Rare Condition, Should We Really Be Expected To Recognize It?(2011-08) Edwards, Paul C.