Wu, Howard H.Alruwaii, FatimahZeng, Bao-RungCramer, Harvey M.Lai, Chiung-RuHang, Jen-Fan2020-08-122020-08-122019-06Wu, H. H., Alruwaii, F., Zeng, B.-R., Cramer, H. M., Lai, C.-R., & Hang, J.-F. (2019). Application of the Milan System for Reporting Salivary Gland Cytopathology: A Retrospective 12-Year Bi-institutional Study. American Journal of Clinical Pathology, 151(6), 613–621. https://doi.org/10.1093/ajcp/aqz006https://hdl.handle.net/1805/23594Objectives Multi-institutional studies are required for the validation of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC). Methods A total of 1,560 fine-needle aspirations of the salivary glands were retrieved from two institutions for a 12-year period. The diagnoses were reclassified based on the MSRSGC. Risk of malignancy (ROM) for each category was calculated based on 694 histologic follow-up cases. Results The ROM for each category was: 18.3% for nondiagnostic, 8.9% for nonneoplastic, 37.5% for atypia of undetermined significance (AUS), 2.9% for benign neoplasm, 40.7% for salivary gland neoplasm of uncertain malignant potential (SUMP), 100% for suspicious for malignancy, and 98.3% for malignant. The sensitivity, specificity, positive predictive rate, and negative predictive rates were 89%, 99%, 98%, and 96%, respectively. Conclusions The results of the current study are in keeping with the MSRSGC. The indeterminate categories of AUS and SUMP showed intermediate ROMs at 37.5% and 40.7%, respectively.enPublisher Policyfine‐needle aspirationMilan System for Reporting Salivary Gland Cytopathologysalivary glandsArticle