Wright, Laura E.Guise, Theresa A.2016-04-202016-04-202014-06-01Wright, L. E., & Guise, T. A. (2014). The Microenvironment Matters: Estrogen Deficiency Fuels Cancer Bone Metastases. Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 20(11), 2817–2819. http://doi.org/10.1158/1078-0432.CCR-14-05761078-0432https://hdl.handle.net/1805/9350Factors released during osteoclastic bone resorption enhance disseminated breast cancer cell progression by stimulating invasiveness, growth, and a bone-resorptive phenotype in cancer cells. Postmenopausal bone loss may accelerate progression of breast cancer growth in bone, explaining the anticancer benefit of the bone-specific antiresorptive agent zoledronic acid in the postmenopausal setting. Clin Cancer Res; 20(11); 2817-9. ©2014 AACR.en-USPublisher PolicyBone NeoplasmssecondaryBreast NeoplasmspathologyEstrogensdeficiencyOsteoporosis, PostmenopausalTumor MicroenvironmentArticle