Duarte, SimonePanariello, Beatriz H.D.2020-09-032020-09-032020-08-26Duarte, S., & Panariello, B. H. D. (2020). Comprehensive biomedical applications of low temperature plasmas. Archives of Biochemistry and Biophysics, 693. https://doi.org/10.1016/j.abb.2020.1085600003-9861https://hdl.handle.net/1805/23752This article is made available for unrestricted research re-use and secondary analysis in any form or be any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.The main component of plasma medicine is the use of low-temperature plasma (LTP) as a powerful tool for biomedical applications. LTP generates high reactivity at low temperatures and can be activated with noble gases with molecular mixtures or compressed air. LTP reactive species are quickly produced, and are a remarkably good source of reactive oxygen and nitrogen species including singlet oxygen (O2), ozone (O3), hydroxyl radicals (OH), nitrous oxide (NO), and nitrogen dioxide (NO2). Its low gas temperature and highly reactive non-equilibrium chemistry make it appropriate for the alteration of inorganic surfaces and delicate biological systems. Treatment of oral biofilm-related infections, treatment of wounds and skin diseases, assistance in cancer treatment, treatment of viruses’ infections (e.g. herpes simplex), and optimization of implants surfaces are included among the extensive plasma medicine applications. Each of these applications will be discussed in this review article.en-USPublic Health EmergencyCOVID-19Plasma MedicineLow-Temperature Plasma (LTP)TherapeuticsBiomedicineArticle