Akil, AymanZhang, QingMumaw, Christen L.Raiker, NishaYu, Jeffreyde Mendizabal, Nieves VelezHaneline, Laura S.Robertson, Kent A.Skiles, JodiDiaz-Ricart, MaribelCarreras, EnricRenbarger, JamieHanash, SamirBies, Robert R.Paczesny, Sophie2016-12-082016-12-082015-10Akil, A., Zhang, Q., Mumaw, C. L., Raiker, N., Yu, J., Velez de Mendizabal, N., … Paczesny, S. (2015). Biomarkers for Diagnosis and Prognosis of Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation, 21(10), 1739–1745. https://doi.org/10.1016/j.bbmt.2015.07.0041083-8791 1523-6536https://hdl.handle.net/1805/11572Reliable, non-invasive methods for diagnosing and prognosing sinusoidal obstruction syndrome (SOS) early after hematopoietic cell transplantation (HCT) are needed. We used a quantitative mass spectrometry-based proteomics approach to identify candidate biomarkers of SOS by comparing plasma pooled from 20 patients with and 20 patients without SOS. Of 494 proteins quantified, we selected six proteins [L-Ficolin, vascular-cell-adhesion-molecule-1 (VCAM1), tissue-inhibitor of metalloproteinase-1, von Willebrand factor, intercellular-adhesion-molecule-1, and CD97] based on a differential heavy/light isotope ratio of at least 2 fold, information from the literature, and immunoassay availability. Next, we evaluated the diagnostic potential of these six proteins and five selected from the literature [suppression of tumorigenicity-2 (ST2), angiopoietin-2 (ANG2), hyaluronic acid (HA), thrombomodulin, and plasminogen activator inhibitor-1] in samples from 80 patients. The results demonstrate that together ST2, ANG2,en-USCC-BY-NC-NDBiomarkersProteomicsSOSSinusoidal obstruction syndromeVODVeno-occlusive diseaseArticle